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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Caffeine Clear all
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Caffeine and Cocaine

NCT00733993
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Caffeine 150 MG, Placebo, Amphetamine, Caffeine 300 MG
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 55 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 21, 2017 · Synced Jul 22, 2026, 5:05 PM EDT
Terminated Phase 3 Interventional Results available

Moderately Preterm Infants With Caffeine at Home for Apnea (MoCHA) Trial

NCT03340727
View directory record Official record
Conditions
Apnea of Prematurity
Interventions
Caffeine Citrate, Placebo
Drug
Lead sponsor
NICHD Neonatal Research Network
Network
Eligibility
29 Weeks to 33 Weeks
Enrollment
827 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
16
States / cities
Birmingham, Alabama • Palo Alto, California • Atlanta, Georgia + 12 more
Source: ClinicalTrials.gov public record
Updated Jul 30, 2024 · Synced Jul 22, 2026, 5:05 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Combined Effects of Alcohol and Caffeine

NCT01289561
View directory record Official record
Conditions
Alcohol or Other Drugs Effects
Interventions
Alcohol + Caffeine Beverage, Alcohol + Caffeine-placebo
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years to 50 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 23, 2016 · Synced Jul 22, 2026, 5:05 PM EDT
Terminated Phase 2Phase 3 Interventional Results available

Paracetamol With Caffeine to Treat Episodic Tension Type Headache

NCT01755702
View directory record Official record
Conditions
Headache, Tension-Type
Interventions
Placebo, Experimental paracetamol + caffeine formulation, ibuprofen marketed formulation, Paracetamol marketed formulation
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
7
States / cities
Pembroke Pines, Florida • Springfield, Massachusetts • Wellesley Hills, Massachusetts + 4 more
Source: ClinicalTrials.gov public record
Updated Mar 26, 2015 · Synced Jul 22, 2026, 5:05 PM EDT
Completed Phase 3 Interventional Results available

Efficacy and Safety of Ibuprofen and Caffeine in Dental Pain

NCT01929031
View directory record Official record
Conditions
Pain, Postoperative, Tooth Diseases
Interventions
ibuprofen + caffeine, ibuprofen, caffeine, placebo
Drug
Lead sponsor
Boehringer Ingelheim
Industry
Eligibility
18 Years to 55 Years
Enrollment
562 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Nov 15, 2016 · Synced Jul 22, 2026, 5:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

1-Week Dispensing Evaluation of REVIVE™ Toric Soft Contact Lenses

NCT06053736
View directory record Official record
Conditions
Refractive Ametropia
Interventions
REVIVE Contact Lens
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jan 4, 2024 · Synced Jul 22, 2026, 5:05 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Testing Potential Synergistic Effects of Albuterol and Caffeine on Metabolic Rate

NCT02135965
View directory record Official record
Conditions
Healthy Volunteers
Interventions
2mg of Albuterol, 4mg of Albuterol, 100mg of Caffeine, 200mg of Caffeine, Albuterol 2mg & Caffeine 100mg, Albuterol 2mg and Caffeine 200mg, Albuterol 4mg and Caffeine 100mg, Albuterol 4mg and Caffeine 200mg
Drug
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
18 Years to 50 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Dec 17, 2015 · Synced Jul 22, 2026, 5:05 PM EDT
Enrolling by invitation No phase listed Observational

Tornier HRS (Humeral Reconstruction System) Study (REVIVE)

NCT05500066
View directory record Official record
Conditions
Rheumatoid Arthritis, Osteoarthritis Shoulder, Fractures Humerus, Avascular Necrosis, Correction of Functional Deformity, Traumatic Arthritis, Revision of Other Devices if Sufficient Bone Stock Remains, Rotator Cuff Tears
Interventions
Tornier HRS (HUMERAL RECONSTRUCTION SYSTEM) shoulder system
Device
Lead sponsor
Stryker Trauma and Extremities
Industry
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2036
U.S. locations
4
States / cities
Denver, Colorado • Bradenton, Florida • Tampa, Florida + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Jul 22, 2026, 5:05 PM EDT
Completed Not applicable Interventional

Fluids Affecting Bladder Urgency and Lower Urinary Symptoms

NCT03625492
View directory record Official record
Conditions
Overactive Bladder, Urinary Urgency, Urinary Bladder, Overactive, Urinary Incontinence, Urge, Caffeine, Alcohol Drinking, Lower Urinary Tract Symptoms
Interventions
Reducing Potentially Irritating Beverages, Adopting the USDA Healthy Eating Habits
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older · Female only
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 13, 2019 · Synced Jul 22, 2026, 5:05 PM EDT
Active, not recruiting Phase 2 Interventional

REVIVE: Replens Versus Intra-Vaginal Estrogen for the Treatment of Vaginal Dryness on Aromatase Inhibitor Therapy

NCT01984138
View directory record Official record
Conditions
Estrogen Receptor Positive Breast Cancer, Breast Cancer
Interventions
ESTRING, Replens, Vagifem
Drug
Lead sponsor
Polly A. Niravath, MD
Other
Eligibility
18 Years and older · Female only
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Jul 22, 2026, 5:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Efficacy of Energy Shots and Caffeine for Energy and Wakefulness Levels

NCT01755299
View directory record Official record
Conditions
Focus: to Compare a Commercially Available Energy Drink, B Vitamins, Caffeine Alone, and Placebo for Effectiveness on Perceived Energy Level and Wakefulness
Interventions
Regular "5-hour Energy", Decaf "5-hour Energy", Compounded concentrated caffeine liquid, Flavored bottled water
Other
Lead sponsor
ProMedica Health System
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Sylvania, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 8, 2013 · Synced Jul 22, 2026, 5:05 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Radicle Revive™: A Study Assessing the Impact of Health and Wellness Products on Menopausal-Related Health Issues Associated Health Outcomes and Related Health Outcomes

NCT07548307
View directory record Official record
Conditions
Cognitive Function
Interventions
Revive Product Placebo Control, Revive Active Product 1
Dietary Supplement
Lead sponsor
Radicle Science
Industry
Eligibility
40 Years to 105 Years · Female only
Enrollment
990 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Del Mar, California
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Jul 22, 2026, 5:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Gender Difference in Response to Caffeine in Children and Adolescents

NCT02119416
View directory record Official record
Conditions
Healthy
Interventions
Placebo Administration first, Low Caffeine Administration first (1mg/kg body weight), High Caffeine Administration first (2mg/kg body weight)
Drug
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
8 Years to 17 Years
Enrollment
101 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Aug 16, 2022 · Synced Jul 22, 2026, 5:05 PM EDT
Completed No phase listed Observational

Effect of Feedings on Caffeine in Premature Infants

NCT02293824
View directory record Official record
Conditions
Apnea of Prematurity, Premature Newborn, Caffeine
Interventions
Caffeine
Drug
Lead sponsor
Duke University
Other
Eligibility
Up to 15 Days
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
2
States / cities
Chapel Hill, North Carolina • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 12, 2017 · Synced Jul 22, 2026, 5:05 PM EDT
Completed Phase 3 Interventional Results available

Effects of Caffeine on Intermittent Hypoxia in Infants Born Preterm

NCT01875159
View directory record Official record
Conditions
Hypoxia
Interventions
Caffeine citrate 6 mg/kg/day
Drug
Lead sponsor
American SIDS Institute
Other
Eligibility
33 Weeks to 37 Weeks
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 16, 2015 · Synced Jul 22, 2026, 5:05 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

"Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat

NCT00377975
View directory record Official record
Conditions
Obesity
Interventions
Ephedrine, Pioglitazone, Caffeine
Drug
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
18 Years to 50 Years
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2004
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Jan 24, 2016 · Synced Jul 22, 2026, 5:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Exercise-Induced Rates of Fat Oxidation with and Without Ingestion of a Caffeine-Based Energy Drink

NCT06308731
View directory record Official record
Conditions
Substrate Oxidation, Energy Expenditure, Reaction Time, Cognition, Exercise Performance
Interventions
Caffeine-Based Energy Drink, Placebo
Dietary Supplement · Other
Lead sponsor
Lindenwood University
Other
Eligibility
18 Years to 50 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Saint Charles, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 16, 2024 · Synced Jul 22, 2026, 5:05 PM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

EIMD Mechanisms Causing Force Loss

NCT02125643
View directory record Official record
Conditions
Healthy
Interventions
Caffeine, Flour
Drug · Other
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 35 Years
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Norman, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jun 4, 2017 · Synced Jul 22, 2026, 5:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Dose Effect of a Plant Extract on Fatigue

NCT03870126
View directory record Official record
Conditions
Mental Energy, Physical Performance
Interventions
Flavored beverage
Other
Lead sponsor
PepsiCo Global R&D
Industry
Eligibility
18 Years to 49 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 17, 2020 · Synced Jul 22, 2026, 5:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Theanine and Caffeine on Neurophysiology of Attention

NCT02770105
View directory record Official record
Conditions
L-theanine
Interventions
Theanine, Caffeine, Theanine-Caffeine Combination, Placebo
Other
Lead sponsor
Texas Tech University
Other
Eligibility
18 Years to 60 Years · Male only
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Sep 1, 2016 · Synced Jul 22, 2026, 5:05 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Effects of Coffee

NCT00336271
View directory record Official record
Conditions
Healthy Subjects
Interventions
Not listed
Lead sponsor
American University
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Mar 14, 2007 · Synced Jul 22, 2026, 5:05 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study to Evaluate the Drug-Drug Interaction of EDP-323 With Midazolam, Caffeine, and Rosuvastatin in Healthy Participants

NCT06917508
View directory record Official record
Conditions
RSV Infection, Drug Drug Interaction
Interventions
EDP-323, Midazolam, Caffeine, Rosuvastatin
Drug
Lead sponsor
Enanta Pharmaceuticals, Inc
Industry
Eligibility
18 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jun 30, 2025 · Synced Jul 22, 2026, 5:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

EaseAlert: Tactile Firefighter Alerting System

NCT05641194
View directory record Official record
Conditions
Heart Rate, Sleep Habit, Sleep
Interventions
Legacy Alerting System, Intervention 2: EaseAlert Standalone
Device
Lead sponsor
Embry-Riddle Aeronautical University
Other
Eligibility
18 Years and older
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
2
States / cities
Blue Springs, Missouri • Stillwater, Oklahoma
Source: ClinicalTrials.gov public record
Updated Mar 12, 2025 · Synced Jul 22, 2026, 5:05 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Acute and Residual Effects of Caffeinated Beer

NCT00515294
View directory record Official record
Conditions
Neurobehavioral Manifestations, Drug Related Sleep Disturbance, Alcohol Intoxication
Interventions
Caffeinated Alcoholic Beer, Non-Caffeinated Alcoholic Beer, Caffeinated Non-Alcoholic Beer, Non-Caffeinated, Non-Alcoholic Beer
Drug · Other
Lead sponsor
Boston University
Other
Eligibility
21 Years to 30 Years
Enrollment
154 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 27, 2017 · Synced Jul 22, 2026, 5:05 PM EDT