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ClinicalTrials.gov public records Last synced Oct 23, 2026, 1:49 PM EDT

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Showing 1–24 of 73 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Calcifications, Vascular Clear all
Active, not recruiting Not applicable Interventional

Modification of Coronary Calcium With Laser Based Intravascular Lithotripsy for Coronary Artery Disease (FRACTURE)

NCT06181240
View directory record Official record
Conditions
Coronary Artery Disease, Coronary Artery Calcification
Interventions
Intravascular lithotripsy
Device
Lead sponsor
Bolt Medical
Industry
Eligibility
18 Years and older
Enrollment
426 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
31
States / cities
La Jolla, California • Los Angeles, California • Riverside, California + 26 more
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 23, 2026, 1:49 PM EDT
Recruiting No phase listed Observational

A Real-World Registry of Chronic Wounds and Ulcers

NCT02280733
View directory record Official record
Conditions
Diabetic Foot, Pressure Ulcer, Surgical Wound Dehiscence, Vasculitis, Skin Ulcer, Leg Ulcer, Pyoderma, Peripheral Arterial Disease, Lymphedema, Surgical Complication, Venous Leg Ulcers (VLUs), Calciphylaxis, Sickle Cell Ulcer, Pressure Ulcer (PU), Diabetic Foot Ulcers (DFUs), Pressure Injury, Arterial Ulcers, Soft Tissue Radionecrosis (STRN), Traumatic Wounds, Chronic Ulcer
Interventions
Usual care
Other
Lead sponsor
U.S. Wound Registry
Other
Eligibility
Not listed
Enrollment
300,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2030
U.S. locations
1
States / cities
The Woodlands, Texas
Source: ClinicalTrials.gov public record
Updated Jul 16, 2025 · Synced Oct 23, 2026, 1:49 PM EDT
Active, not recruiting Not applicable Interventional

Impact of Patient-Centered Approach for Communicating Coronary Calcium on Cardiovascular Health

NCT06055972
View directory record Official record
Conditions
Coronary Artery Disease, Cardiovascular Diseases, Smoking
Interventions
Educational Letter Post CT Examination
Other
Lead sponsor
American College of Radiology
Other
Eligibility
50 Years to 80 Years
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
2
States / cities
Ann Arbor, Michigan • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 6, 2024 · Synced Oct 23, 2026, 1:49 PM EDT
Active, not recruiting Not applicable Interventional

Intravascular Lithotripsy With or Without Rotational Atherectomy for Coronary Calcified Nodule Treatment

NCT07000045
View directory record Official record
Conditions
Coronary Artery Disease, Coronary Calcification
Interventions
Intravascular lithotripsy, Rotational atherectomy
Device
Lead sponsor
Annapoorna Kini
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 8, 2026 · Synced Oct 23, 2026, 1:49 PM EDT
Completed No phase listed Observational

Study of People With Generalized Arterial Calcification of Infancy (GACI) or Autosomal Recessive Hypophosphatemic Rickets Type 2 (ARHR2)

NCT03478839
View directory record Official record
Conditions
Generalized Arterial Calcification of Infancy, Autosomal Recessive Hypophosphatemic Rickets Type2
Interventions
Not listed
Lead sponsor
National Human Genome Research Institute (NHGRI)
NIH
Eligibility
1 Year to 110 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Oct 23, 2026, 1:49 PM EDT
Completed Phase 4 Interventional Results available

The Jetstream G3™ Calcium Study

NCT01273623
View directory record Official record
Conditions
Peripheral Arterial Disease
Interventions
Jetstream Atherectomy System
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years to 100 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
5
States / cities
Phoenix, Arizona • Atlanta, Georgia • Detroit, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated Nov 18, 2015 · Synced Oct 23, 2026, 1:49 PM EDT
Not listed Not applicable Interventional

Incidental Coronary Calcification Quality Improvement Project

NCT04789278
View directory record Official record
Conditions
Atherosclerotic Cardiovascular Disease, Coronary Artery Disease
Interventions
Notification
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 85 Years
Enrollment
173 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jul 29, 2022 · Synced Oct 23, 2026, 1:49 PM EDT
Terminated Phase 2 Interventional

ADAPT Study: Long-term Safety Study of INZ-701 in Patients With ENPP1 Deficiency and ABCC6 Deficiency

NCT06462547
View directory record Official record
Conditions
Gene Mutations, Pseudoxanthoma Elasticum, Arterial Calcification, Ectonucleotide Pyrophosphatase/phosphodiesterase1 Deficiency, Autosomal Recessive Hypophosphatemic Rickets Type 2
Interventions
INZ-701
Drug
Lead sponsor
Inozyme Pharma
Industry
Eligibility
1 Year and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
Rochester, Minnesota • Eatontown, New Jersey
Source: ClinicalTrials.gov public record
Updated Oct 19, 2026 · Synced Oct 23, 2026, 1:49 PM EDT
Withdrawn Not applicable Interventional

Association of Bone Quality and Quantity With Vascular Calcification

NCT00892853
View directory record Official record
Conditions
Vascular Calcification, Atherosclerosis, Bone Density
Interventions
CT of the bones
Procedure
Lead sponsor
University of Michigan
Other
Eligibility
30 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 12, 2014 · Synced Oct 23, 2026, 1:49 PM EDT
Completed Phase 2 Interventional Results available

Effect of SNF472 on Progression of Cardiovascular Calcification in End-Stage-Renal-Disease (ESRD) Patients on Hemodialysis (HD)

NCT02966028
View directory record Official record
Conditions
Cardiovascular Diseases, Cardiovascular Abnormalities, Calcifications, Vascular, Endstage Renal Disease, ESRD, Coronary Artery Calcification
Interventions
SNF472, Placebo
Drug
Lead sponsor
Sanifit Therapeutics S. A.
Other
Eligibility
18 Years to 80 Years
Enrollment
274 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
46
States / cities
Bakersfield, California • Chula Vista, California • Escondido, California + 42 more
Source: ClinicalTrials.gov public record
Updated Apr 15, 2021 · Synced Oct 23, 2026, 1:49 PM EDT
Completed Not applicable Interventional Results available

Shockwave C2+ 2Hz Coronary IVL Catheter in Calcified Coronary Arteries (Disrupt CAD DUO)

NCT05966662
View directory record Official record
Conditions
Coronary Artery Disease, Myocardial Infarction
Interventions
IVL with Shockwave C2+ 2Hz Coronary IVL Catheter
Device
Lead sponsor
Shockwave Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
18
States / cities
Huntsville, Alabama • La Jolla, California • Washington D.C., District of Columbia + 15 more
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Oct 23, 2026, 1:49 PM EDT
Completed No phase listed Observational

Feasibility of Orbital Atherectomy System in Calcified Bifurcation Lesion

NCT03058510
View directory record Official record
Conditions
Coronary Artery Disease
Interventions
Frequency domain optical coherence tomography
Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 8, 2017 · Synced Oct 23, 2026, 1:49 PM EDT
Completed No phase listed Observational Results available

Multi-center Prospective Study to Evaluate Outcomes of the Moderate to Severely Calcified Coronary Lesions (MACE)

NCT01930214
View directory record Official record
Conditions
Coronary Artery Disease
Interventions
Percutaneous Coronary Intervention
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
34
States / cities
Little Rock, Arkansas • Glendale, California • Hartford, Connecticut + 30 more
Source: ClinicalTrials.gov public record
Updated Jul 18, 2023 · Synced Oct 23, 2026, 1:49 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Identification of Genetic Causes of Calcific Aortic Valve Disease

NCT04149600
View directory record Official record
Conditions
Calcific Aortic Stenosis, Calcific Aortic Stenosis - Bicuspid Valve, Aortic Valve Disease, Aortic Valve Calcification, Aortic Diseases, Aortic Aneurysm, Aortic Valve Cusp Abnormality, Aortic Valve Disease Mixed, Aortic Valve Insufficiency
Interventions
Patients scheduled to undergo aortic valve replacement or aortic surgery at BIDMC will be approached for participation in this study.
Procedure
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
20 Years and older
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Oct 23, 2026, 1:49 PM EDT
Completed Phase 1 Interventional

Arterial Imaging of Inflammation and Resolution After Endovascular Surgery

NCT03590769
View directory record Official record
Conditions
Peripheral Arterial Disease, Claudication, Intermittent, Claudication, PAD, SFA - Superficial Femoral Artery Stenosis, Iliac Artery Disease, Vascular Calcification
Interventions
18F-FDG
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
40 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 30, 2020 · Synced Oct 23, 2026, 1:49 PM EDT
Completed Not applicable Interventional Results available

Disrupt CAD III With the Shockwave Coronary IVL System

NCT03595176
View directory record Official record
Conditions
Coronary Artery Disease, Myocardial Infarction
Interventions
Lithotripsy
Device
Lead sponsor
Shockwave Medical, Inc.
Industry
Eligibility
Not listed
Enrollment
431 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
39
States / cities
Scottsdale, Arizona • La Jolla, California • Orange, California + 32 more
Source: ClinicalTrials.gov public record
Updated May 19, 2023 · Synced Oct 23, 2026, 1:49 PM EDT
Completed No phase listed Observational

Bone Health in Patients With Overgrowth

NCT02561182
View directory record Official record
Conditions
Bone Mineral Density, Vascular Malformations
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
5 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 25, 2022 · Synced Oct 23, 2026, 1:49 PM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

CRICKET Study, Coronary Calcium Scores in Patients With Chronic Kidney Disease

NCT00142636
View directory record Official record
Conditions
Chronic Kidney Disease
Interventions
Not listed
Lead sponsor
United States Naval Medical Center, San Diego
Federal
Eligibility
18 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2005
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Aug 1, 2025 · Synced Oct 23, 2026, 1:49 PM EDT
Completed No phase listed Observational

Natural History Study: ENPP1 Deficiency or the Early-Onset Form of ABCC6 Deficiency

NCT07745179
View directory record Official record
Conditions
Ectonucleotide Pyrophosphatase/phosphodiesterase1 Deficiency, ATP-Binding Cassette Subfamily C Member 6 Deficiency, Generalized Arterial Calcification of Infancy, Autosomal Recessive Hypophosphatemic Rickets, PXE (Pseudoxanthoma Elasticum)
Interventions
Not listed
Lead sponsor
Inozyme Pharma
Industry
Eligibility
1 Day and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Oct 23, 2026, 1:49 PM EDT
Completed Not applicable Interventional Results available

Side Branch FFR After Provisional Stenting

NCT03115580
View directory record Official record
Conditions
Coronary Artery Disease
Interventions
Rotational atherectomy, Cutting Balloon Angioplasty
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 14, 2020 · Synced Oct 23, 2026, 1:49 PM EDT
Completed Not applicable Interventional Results available

Rotational Atherectomy Combined With Cutting Balloon to Optimize Stent Expansion in Calcified Lesions

NCT04865588
View directory record Official record
Conditions
Coronary Artery Disease, Atherosclerosis
Interventions
rotational atherectomy, cutting balloon, plain old balloon
Procedure · Device
Lead sponsor
Samin Sharma, M.D., F.A.C.C., M.S.C.A.I.
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
2
States / cities
New York, New York • Roslyn, New York
Source: ClinicalTrials.gov public record
Updated May 22, 2024 · Synced Oct 23, 2026, 1:49 PM EDT
Recruiting Not applicable Interventional

The THOR IDE Study

NCT05916950
View directory record Official record
Conditions
Peripheral Artery Disease, Peripheral Artery Stenosis, Peripheral Artery Calcification, PAD
Interventions
Thor laser atherectomy
Device
Lead sponsor
Philips Clinical & Medical Affairs Global
Industry
Eligibility
18 Years and older
Enrollment
155 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
29
States / cities
St. Helena, California • Aurora, Colorado • Bradenton, Florida + 24 more
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Oct 23, 2026, 1:49 PM EDT
Completed Phase 2 Interventional Results available

Bone Mass and Strength After Kidney Transplantation

NCT02224144
View directory record Official record
Conditions
End Stage Renal Disease, Kidney Transplantation, Bone Loss, Fractures, Vascular Calcifications
Interventions
Vitamin D3, Calcitriol, Placebo
Drug
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 7, 2025 · Synced Oct 23, 2026, 1:49 PM EDT
Completed Not applicable Interventional Results available

Shockwave Medical Peripheral Lithoplasty System Study for PAD (Disrupt PAD III)

NCT02923193
View directory record Official record
Conditions
Peripheral Arterial Disease
Interventions
Shockwave Lithoplasty® Peripheral Lithoplasty System, Medtronic IN.PACT (DCB)
Device · Drug
Lead sponsor
Shockwave Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
306 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
40
States / cities
Little Rock, Arkansas • Palo Alto, California • Aurora, Colorado + 33 more
Source: ClinicalTrials.gov public record
Updated Dec 20, 2023 · Synced Oct 23, 2026, 1:49 PM EDT