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Showing 1–24 of 167 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Carbon Dioxide Clear all
Completed Phase 1 Interventional Accepts healthy volunteers

Evaluation of Substance P Neurotransmission in Panic Disorder by PET Imaging of NK1 Receptors With [18F]SPA-RQ

NCT00088738
View directory record Official record
Conditions
Panic Disorder, Healthy
Interventions
[18F] SPA-RQ
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 65 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2008
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Jul 22, 2026, 5:01 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Comparative Clinical Study to Assess Pain Score and Wound Healing Following Fractional Ablation With a DFG Laser and CO2 Laser

NCT06295471
View directory record Official record
Conditions
Healthy
Interventions
DFG Laser, CO2 Laser, Optical coherence tomography (OCT)
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Jul 22, 2026, 5:01 AM EDT
Withdrawn Not applicable Interventional

Dehydrated Human Amnion/Chorion Membrane (dHACM) for Recovery After Fractionated Ablative CO2 Laser Resurfacing of the Face

NCT01995604
View directory record Official record
Conditions
Scarring
Interventions
Application of Sterile 0.9% Saline Solution, Application of dHACM
Other
Lead sponsor
MiMedx Group, Inc.
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 12, 2014 · Synced Jul 22, 2026, 5:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Breathing Regulation Training for Individuals With Panic Disorder

NCT00183521
View directory record Official record
Conditions
Panic Disorder
Interventions
Raise-CO2 breathing regulation training, Lower-CO2 breathing regulation training, Control
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 60 Years
Enrollment
136 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Dec 1, 2011 · Synced Jul 22, 2026, 5:01 AM EDT
Completed Not applicable Interventional

Fractional CO2 Laser Therapy for Survivors of Breast Malignancies

NCT03307044
View directory record Official record
Conditions
Breast Carcinoma, Cancer Survivor, Cervical Carcinoma, Dyspareunia, Vaginal Dryness
Interventions
Laser Therapy, Questionnaire Administration
Procedure · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
Female only
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 19, 2023 · Synced Jul 22, 2026, 5:01 AM EDT
Not listed Not applicable Interventional

Cholangiography Using Carbon Dioxide Versus Iodinated Contrast in ERCP

NCT02611453
View directory record Official record
Conditions
Choledocholithiasis, Bile Duct Diseases, Bile Duct Carcinoma
Interventions
"Air" contrast cholangiography using carbon dioxide gas
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2024
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 2, 2024 · Synced Jul 22, 2026, 5:01 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Central Sleep Apnea : Physiologic Mechanisms to Inform Treatment

NCT04118387
View directory record Official record
Conditions
Sleep Disordered Breathing, Able Bodied
Interventions
Acetazolamide + supplemental oxygen + PAP therapy, Zolpidem + PAP therapy, Buspirone + PAP therapy
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 19, 2026 · Synced Jul 22, 2026, 5:01 AM EDT
Completed Not applicable Interventional

Effects of Pulsed Dye and CO2 Laser in Treatment of Hypertrophic Burn Scars.

NCT04769089
View directory record Official record
Conditions
Hypertrophic Scar
Interventions
Treatment with Pulse Dye Laser, Treatment with CO2 Laser, Treatment with combination of pulse dye laser and CO2 laser., Control
Procedure · Other
Lead sponsor
The Metis Foundation
Other
Eligibility
18 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 23, 2021 · Synced Jul 22, 2026, 5:01 AM EDT
Completed Phase 3 Interventional

A Randomized Trial of Surgical Treatments for Vulvar and Vaginal Dysplasia

NCT00394758
View directory record Official record
Conditions
Vulvar Dysplasia, Vaginal Dysplasia
Interventions
CO2 laser surgery, ultrasonic surgical aspiration
Procedure
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2005
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 11, 2022 · Synced Jul 22, 2026, 5:01 AM EDT
Completed Not applicable Interventional

The Effect of Embryo Culture Under a Continuous CO2 Setting Versus a Sequential CO2 Setting

NCT04693806
View directory record Official record
Conditions
Infertility
Interventions
Continuous CO2 Level
Other
Lead sponsor
Reproductive Medicine Associates of New Jersey
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Basking Ridge, New Jersey
Source: ClinicalTrials.gov public record
Updated May 2, 2023 · Synced Jul 22, 2026, 5:01 AM EDT
Completed Not applicable Interventional

Comparison of Methods to Distend the Colon During Insertion: CO2, Air Insufflation, Water-aided Colonoscopy

NCT01954862
View directory record Official record
Conditions
Pain, Colorectal Adenomas, Colorectal Cancer
Interventions
Air Insufflation method., CO2 insufflation, Water Immersion/CO2, Water Exchange/CO2, Water Immersion/AI, Water Exchange/AI
Other
Lead sponsor
Presidio Ospedaliero Santa Barbara
Other
Eligibility
18 Years to 85 Years
Enrollment
624 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 30, 2014 · Synced Jul 22, 2026, 5:01 AM EDT
Recruiting No phase listed Observational

Waveform Capnography Compared to Colorimetric Carbon Dioxide Detection During Tracheal Intubation of Critically Ill Adults

NCT06934876
View directory record Official record
Conditions
Acute Respiratory Failure
Interventions
Colorimetric carbon dioxide (CO2) detection, Waveform capnography
Diagnostic Test
Lead sponsor
Brian Driver
Other
Eligibility
18 Years and older
Enrollment
2,092 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
9
States / cities
Chicago, Illinois • Burlington, Massachusetts • Minneapolis, Minnesota + 6 more
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Jul 22, 2026, 5:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Carbon Dioxide (CO2) and Cognitive Impairment

NCT05292378
View directory record Official record
Conditions
Healthy
Interventions
2500 ppm Carbon Dioxide, 600 ppm Carbon Dioxide
Other
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 30 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Piscataway, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 15, 2026 · Synced Jul 22, 2026, 5:01 AM EDT
Terminated Phase 2 Interventional

The Effect of Nasal Carbon Dioxide in the Treatment of Moderate to Severe Migraine

NCT01253915
View directory record Official record
Conditions
Migraine
Interventions
Nasal Carbon Dioxide, Placebo
Drug
Lead sponsor
Capnia, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
3
States / cities
San Diego, California • Bethesda, Maryland • Portsmouth, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 30, 2013 · Synced Jul 22, 2026, 5:01 AM EDT
Active, not recruiting Not applicable Interventional

Pedi-Cap CO2 Detector for Face-mask Ventilation in the Delivery Room

NCT06258187
View directory record Official record
Conditions
Neonatal Resuscitation, Neonatal Disease
Interventions
Pedi-Cap
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
30 Weeks and older
Enrollment
632 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 1, 2026 · Synced Jul 22, 2026, 5:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Wearing Masks on End-tidal Carbon Dioxide and Pulse Oximetry

NCT05114993
View directory record Official record
Conditions
Carbon Dioxide
Interventions
wearing a disposable surgical mask
Device
Lead sponsor
Patrick Brooks
Other
Eligibility
2 Years to 80 Years
Enrollment
119 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Springfield, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 23, 2022 · Synced Jul 22, 2026, 5:01 AM EDT
Withdrawn Not applicable Interventional

A Single-Blind, Randomized Study to Compare fCO2 Laser Therapy Versus Sham for Treatment of SUI in Women

NCT04253067
View directory record Official record
Conditions
Stress Urinary Incontinence, Urinary Incontinence
Interventions
Active fCO2 laser treatment, Sham fCO2 laser treatment
Device
Lead sponsor
Corewell Health East
Other
Eligibility
18 Years to 75 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Royal Oak, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 16, 2020 · Synced Jul 22, 2026, 5:01 AM EDT
Completed Not applicable Interventional

A Trial of Supplemental CO2 Versus Room Air in Percutaneous Endoscopic Gastrostomy

NCT02619656
View directory record Official record
Conditions
Pneumoperitoneum
Interventions
CO2 insufflation, Ambient air insufflation
Procedure
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Dec 1, 2015 · Synced Jul 22, 2026, 5:01 AM EDT
Withdrawn Phase 2 Interventional

Laser Assisted Delivery of Minoxidil in Androgenetic Alopecia

NCT03852992
View directory record Official record
Conditions
Male Pattern Hair Loss, Androgenetic Alopecia, Male Pattern Baldness
Interventions
Post-Laser Minoxidil 2%, At-Home Minoxidil 5%, Laser, Post-laser 5mg minoxidil, Post-laser 10mg minoxidil, Post-laser 20mg minoxidil
Drug · Device
Lead sponsor
University of Minnesota
Other
Eligibility
21 Years to 65 Years · Male only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 12, 2023 · Synced Jul 22, 2026, 5:01 AM EDT
Terminated Not applicable Interventional Results available

Polar Wand Carbon Dioxide Cryotherapy for Barrett's Esophagus

NCT01477177
View directory record Official record
Conditions
Barrett's Esophagus
Interventions
Polar Wand carbon dioxide cryotherapy
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 98 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated May 14, 2019 · Synced Jul 22, 2026, 5:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CO2 Laser vs Lidocaine for Vestibulodynia in Premenopausal Women

NCT05336825
View directory record Official record
Conditions
Vulvodynia
Interventions
CO2 laser, Lidocaine patch 5%
Device · Drug
Lead sponsor
Atlantic Health System
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Denville, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 19, 2022 · Synced Jul 22, 2026, 5:01 AM EDT
Completed No phase listed Observational

End-Tidal Carbon Dioxide as a Measure of Carboxyhemoglobin in Carbon Monoxide Poisoning

NCT01859156
View directory record Official record
Conditions
Carbon Monoxide Exposure
Interventions
Not listed
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
18 Years and older
Enrollment
151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2014
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 28, 2014 · Synced Jul 22, 2026, 5:01 AM EDT
Completed Not applicable Interventional

Fractional CO2 Laser Therapy in Minimizing Genitourinary Syndrome of Menopause in Gynecological Cancer Survivors

NCT03372720
View directory record Official record
Conditions
Cervical Carcinoma, Dyspareunia, Endometrial Carcinoma, Ovarian Carcinoma, Vaginal Carcinoma, Vaginal Dryness, Vulvar Carcinoma
Interventions
Laser Therapy, Questionnaire Administration, Sham Intervention
Procedure · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
Female only
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
4
States / cities
Baltimore, Maryland • Rochester, Minnesota • Fargo, North Dakota + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 21, 2022 · Synced Jul 22, 2026, 5:01 AM EDT
Completed Phase 2 Interventional

The Effect of Nasal Carbon Dioxide (CO2) Used As-Needed in the Symptomatic Treatment of Seasonal Allergic Rhinitis

NCT00917020
View directory record Official record
Conditions
Seasonal Allergic Rhinitis
Interventions
Nasal CO2, Inactive Placebo Gas
Drug
Lead sponsor
Capnia, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 14, 2012 · Synced Jul 22, 2026, 5:01 AM EDT