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Showing 1–24 of 831 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Cognitive Impairment, Mild Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

KNA Proof-of-Concept

NCT04968041
View directory record Official record
Conditions
Adherence, Treatment, Retention, Cognitive Impairment, Mild
Interventions
Motivational Interviewing-Cognitive Behavioral Therapy Ketogenic Nutrition Adherence Program
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
60 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Feb 29, 2024 · Synced Sep 23, 2026, 1:20 AM EDT
Completed Not applicable Interventional

Treating Cancer-Related Fatigue Through Systematic Light Exposure

NCT01873794
View directory record Official record
Conditions
Hematopoietic Stem Cell Transplantation, Breast Cancer, Fatigue, Mild Cognitive Impairment, Light, Quality of Life, Sleep
Interventions
Bright white light, Dim red light
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
2
States / cities
Hackensack, New Jersey • New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 10, 2017 · Synced Sep 23, 2026, 1:20 AM EDT
Completed Not applicable Interventional

The Combined Aerobic Exercise and Cognitive Training (ACT) Trial: The ACT Trial

NCT03313895
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Aerobic & Cognitive Training (ACT), Cycling Only, Cognitive Training Only, Stretching and Mental Stimulating Activities
Behavioral
Lead sponsor
Arizona State University
Other
Eligibility
65 Years and older
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
4
States / cities
Phoenix, Arizona • Stanford, California • Minneapolis, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 24, 2025 · Synced Sep 23, 2026, 1:20 AM EDT
Completed Phase 2 Interventional Results available

A Study of LY3372689 to Assess the Safety, Tolerability, and Efficacy in Participants With Alzheimer's Disease

NCT05063539
View directory record Official record
Conditions
Alzheimer Disease
Interventions
LY3372689, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
60 Years to 85 Years
Enrollment
327 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
35
States / cities
Canoga Park, California • Fresno, California • Irvine, California + 30 more
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Sep 23, 2026, 1:20 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Speech, Linguistic and Acoustic Markers in Parkinson's Disease

NCT04273672
View directory record Official record
Conditions
Parkinson Disease, Cognitive Impairment, Mild, Speech
Interventions
Cognitive Battery, Voice, Speech and Language Analysis, Questionnaires and Clinical Assessments, DNA Analysis
Diagnostic Test · Behavioral · Genetic
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years and older
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 9, 2025 · Synced Sep 23, 2026, 1:20 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

A Study of MK-2214 in Adults With Mild Cognitive Impairment or Mild-to-Moderate Alzheimer's Disease (MK-2214-002)

NCT05466422
View directory record Official record
Conditions
Alzheimer Disease
Interventions
MK-2214, Placebo
Biological · Drug
Lead sponsor
Merck Sharp & Dohme LLC
Industry
Eligibility
50 Years to 80 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
12
States / cities
Glendale, California • Los Alamitos, California • Orange, California + 9 more
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Sep 23, 2026, 1:20 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Implications of Amyloid Pathology

NCT00900770
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
Not listed
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
60 Years to 90 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 28, 2009 · Synced Sep 23, 2026, 1:20 AM EDT
Recruiting Not applicable Interventional

Anxiety Sensitivity Treatment to Reduce Anxiety in Alzheimer's

NCT05748613
View directory record Official record
Conditions
Anxiety, Mild Cognitive Impairment, Alzheimer Disease, Dementia
Interventions
Computerized Anxiety Sensitivity Treatment, Health Education Control
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
60 Years and older
Enrollment
388 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
3
States / cities
Tallahassee, Florida • Athens, Ohio • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 4, 2026 · Synced Sep 23, 2026, 1:20 AM EDT
Completed Not applicable Interventional

Auburn University Research on Olive Oil for Alzheimer's Disease (AU-ROOAD)

NCT03824197
View directory record Official record
Conditions
Alzheimer Disease, Cerebral Amyloid Angiopathy
Interventions
EVOO, OO
Other
Lead sponsor
Auburn University
Other
Eligibility
55 Years to 75 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Auburn, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 1, 2021 · Synced Sep 23, 2026, 1:20 AM EDT
Recruiting Not applicable Interventional

Molecular and Structural Imaging in Alzheimer's Disease: A Longitudinal Study

NCT02740634
View directory record Official record
Conditions
Atypical Alzheimer's Disease, Logopenic Progressive Aphasia (LPA), Posterior Cortical Atrophy (PCA), Alzheimer Disease, Alzheimer Disease, Early Onset, Amnestic Disorder, Amnestic Symptoms, Amnestic Mild Cognitive Disorder
Interventions
F-18 AV 1451, C-11 PiB
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
21 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 23, 2026, 1:20 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Modulation of Micro-RNA Pathways by Gemfibrozil in Predementia Alzheimer Disease

NCT02045056
View directory record Official record
Conditions
Preclinical Alzheimer's Disease
Interventions
Gemfibrozil, Placebo
Drug
Lead sponsor
Gregory Jicha, 323-5550
Other
Eligibility
65 Years to 90 Years
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 7, 2019 · Synced Sep 23, 2026, 1:20 AM EDT
Terminated Phase 2 Interventional Results available

11C-Acetate PET/CT Imaging As a Biomarker of Amyloid-Induced Neuroinflammation

NCT02811744
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
11C-acetate
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
65 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 10, 2024 · Synced Sep 23, 2026, 1:20 AM EDT
Completed No phase listed Observational

C-SMART: Cognitive Strategies, Mindfulness, and Rehabilitation Therapy for Patients With Primary Brain Tumors

NCT05984667
View directory record Official record
Conditions
Glioma, Mixed, Mild Neurocognitive Disorder, Brain Tumor
Interventions
C-SMART
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Sep 23, 2026, 1:20 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Functional Magnetic Resonance Imaging (fMRI) of Anosognosia in Amnestic Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD)

NCT00908999
View directory record Official record
Conditions
Anosognosia, Alzheimer's Disease, Mild Cognitive Impairment
Interventions
Not listed
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
60 Years to 90 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 28, 2011 · Synced Sep 23, 2026, 1:20 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Development of a Database to Investigate Digital and Blood-Based Biomarkers and Their Relationship to Tau and Amyloid PET Imaging in Older Participants Who Are Cognitively Normal (CN), Have Mild Cognitive Impairment (MCI), or Have Mild-to-Moderate AD Dementia

NCT06584357
View directory record Official record
Conditions
Mild Cognitive Impairment, Alzheimer's Disease, Alzheimer's Disease, Early Onset, Memory Loss, Memory Disorders, Memory Impairment
Interventions
Biomarker Data Collection, MK6240
Other · Radiation
Lead sponsor
GAP Innovations, PBC
Industry
Eligibility
60 Years to 90 Years
Enrollment
1,200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
22
States / cities
Atlantis, Florida • Aventura, Florida • Clermont, Florida + 19 more
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Sep 23, 2026, 1:20 AM EDT
Completed Not applicable Interventional Results available

Cognitive Fitness for Depression in Older Adults

NCT04790630
View directory record Official record
Conditions
Depression Mild, Depressive Disorder, Major, Mild Cognitive Impairment
Interventions
Computerized Cognitive Remediation of Executive Functioning (CCR-EF), Active Control
Other
Lead sponsor
UConn Health
Other
Eligibility
60 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Sep 23, 2026, 1:20 AM EDT
Active, not recruiting Not applicable Interventional

The "Let's Talk Tech" Tool to Support Decision Making About Technology Use

NCT06817122
View directory record Official record
Conditions
Dementia, Mild, Mild Cognitive Impairment (MCI)
Interventions
Let's Talk Tech
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Sep 23, 2026, 1:20 AM EDT
Completed Phase 4 Interventional Results available

Mild Cognitive Impairment in Parkinson's Disease

NCT01519271
View directory record Official record
Conditions
Parkinson's Disease, Mild Cognitive Impairment
Interventions
Exelon Patch (rivastigmine transdermal system), Placebo Patches
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
40 Years to 85 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 6, 2017 · Synced Sep 23, 2026, 1:20 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Tau Imaging With JNJ067

NCT03926702
View directory record Official record
Conditions
Alzheimer Disease, Mild Cognitive Impairment, Progressive Supranuclear Palsy
Interventions
Radiopharmaceuticals
Drug
Lead sponsor
University of California, Berkeley
Other
Eligibility
50 Years and older
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Aug 30, 2022 · Synced Sep 23, 2026, 1:20 AM EDT
Recruiting Not applicable Interventional

Transcranial Magnetic Stimulation for MCI

NCT05992831
View directory record Official record
Conditions
Mild Cognitive Impairment, Depression
Interventions
Accelerated iTBS, Sham Comparator
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
60 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Sep 23, 2026, 1:20 AM EDT
Completed No phase listed Observational

Remote Cognitive Assessment for Surgical Patients

NCT05566275
View directory record Official record
Conditions
Mild Cognitive Impairment, Delirium
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
65 Years to 99 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 11, 2025 · Synced Sep 23, 2026, 1:20 AM EDT
Active, not recruiting Phase 3 Interventional

A Double-blind Dual Study Assessing Safety and Efficacy of Buntanetap in Participants With Early AD

NCT06709014
View directory record Official record
Conditions
Early Alzheimers Disease
Interventions
buntanetap/posiphen, Placebo
Drug
Lead sponsor
Annovis Bio Inc.
Industry
Eligibility
55 Years to 85 Years
Enrollment
760 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
78
States / cities
Chandler, Arizona • Phoenix, Arizona • Scottsdale, Arizona + 72 more
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced Sep 23, 2026, 1:20 AM EDT
Completed Not applicable Interventional Results available

Indiana University Dementia Screening Trial

NCT01699503
View directory record Official record
Conditions
Dementia, Alzheimer's Disease, Mild Cognitive Impairment
Interventions
Collaborative Dementia Care Program
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
65 Years and older
Enrollment
4,005 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
3
States / cities
Indianapolis, Indiana • West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 22, 2019 · Synced Sep 23, 2026, 1:20 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

LEADing Dementia End-of-Life Planning Conversations

NCT05909189
View directory record Official record
Conditions
Alzheimer Disease, Mild Cognitive Impairment
Interventions
LEADing Dementia End-of-Life Planning Conversations
Other
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Sep 23, 2026, 1:20 AM EDT