A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity
Public ClinicalTrials.gov record NCT02655354. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The overarching goal of this UH2-UH3 proposal is to work with the NIH Health Care Systems Research Collaboratory to develop and implement a large scale, cluster randomized pragmatic clinical trial demonstration project that directly informs national trauma care system policy targeting injured patients with presentations of Posttraumatic Stress Disorder (PTSD) and related comorbidity. Each year in the United States (US), over 30 million individuals present to trauma centers, emergency departments, and other acute care medical settings for the treatment of physical injuries. Multiple chronic conditions including enduring PTSD, alcohol and drug use problems, depression and associated suicidal ideation, pain and somatic symptom amplification, and chronic medical conditions (e.g., hypertension, coronary artery disease, diabetes, and pulmonary diseases) are endemic among physical trauma survivors with and without traumatic brain injuries (TBI). Evidence-based, collaborative care/care management treatment models for PTSD and related comorbidities exist. These care management models have the potential to be flexibly implemented in order to prevent the development of chronic PTSD and depressive symptoms, alcohol use problems, and enduring physical disability in survivors of both TBI and non-TBI injuries; care management models may also be effective in mitigating the impact of the acute injury event on symptom exacerbations in the large subpopulation of injury survivors who already carry a substantial pre-injury burden of multiple chronic medical conditions.
Study identification
- NCT ID
- NCT02655354
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 635 participants
Conditions and interventions
Conditions
Interventions
- Motivational Interviewing Behavioral
- Cognitive Behavioral Therapy Elements Behavioral
- Care Management Behavioral
- Fluoxetine Drug
- Fluvoxamine Drug
- Paroxetine Drug
- Sertraline Drug
- Citalopram Drug
- Venlafaxine Drug
- Duloxetine Drug
- Mirtazapine Drug
- Diphenhydramine Drug
- Trazodone Drug
- Prazosin Drug
Behavioral · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 2015 (Type not available)
- Primary completion
- Nov 2019 (Actual)
- Completion
- Nov 2019 (Actual)
- Last update posted
- Jul 2, 2021
2015 – 2019
United States locations
- U.S. sites
- 24
- U.S. states
- 17
- U.S. cities
- 23
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Honor Health | Scottsdale | Arizona | 85251 | — |
| Cedars Sinai | Beverly Hills | California | 90211 | — |
| U.C. Davis | Sacramento | California | 95816 | — |
| Santa Clara Valley Medical Center | San Jose | California | 95128 | — |
| U.C.L.A. Harbor | Torrance | California | 90509 | — |
| Hartford Hospital | Hartford | Connecticut | 06102 | — |
| Georgia Regents | Augusta | Georgia | 30912 | — |
| Eskenazi Health | Indianapolis | Indiana | 46202 | — |
| University of Iowa | Iowa City | Iowa | 52242 | — |
| University of Kentucky | Lexington | Kentucky | 40536 | — |
| Louisiana State University | New Orleans | Louisiana | 70112 | — |
| Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| Jacobi Medical Center | The Bronx | New York | 10461 | — |
| Wake Forest | Winston-Salem | North Carolina | 27157 | — |
| University of Cincinnati | Cincinnati | Ohio | 45267 | — |
| Ohio State University | Columbus | Ohio | 43210 | — |
| Baylor Health Care System | Dallas | Texas | 75204 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75390 | — |
| University of Texas Medical Branch at Galveston | Galveston | Texas | 77555 | — |
| The University of Utah | Salt Lake City | Utah | 84132 | — |
| The University of Vermont | Burlington | Vermont | 05405 | — |
| Inova Trauma Center | Falls Church | Virginia | 22042 | — |
| The University of Wisconsin Madison | Madison | Wisconsin | 53715 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02655354, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 2, 2021 · Synced Oct 23, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02655354 live on ClinicalTrials.gov.