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ClinicalTrials.gov public records Last synced May 22, 2026, 12:49 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Coma Clear all
Active, not recruiting Not applicable Interventional
View directory record Official record
Conditions
Cardiac Arrest, Out-Of-Hospital, Hypothermia, Induced, Hypoxia-Ischemia, Brain
Interventions
Therapeutic Hypothermia
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
1,158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
76
States / cities
Birmingham, Alabama • Tucson, Arizona • Los Angeles, California + 57 more
Source: ClinicalTrials.gov public record
Updated Jun 24, 2025 · Synced May 22, 2026, 12:49 AM EDT
Withdrawn Not applicable Interventional
View directory record Official record
Conditions
Ischemic Stroke, Ischaemic Stroke With Coma, Intracerebral Hemorrhage, Hemorrhagic Stroke
Interventions
Decision Aid
Other
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
2
States / cities
New Haven, Connecticut • Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 14, 2021 · Synced May 22, 2026, 12:49 AM EDT
Completed No phase listed Observational Accepts healthy volunteers
View directory record Official record
Conditions
Consciousness Disorder, Coma, Brain Injuries, Traumatic
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
79 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 20, 2024 · Synced May 22, 2026, 12:49 AM EDT
Terminated No phase listed Observational
View directory record Official record
Conditions
Acute and Chronic Hepatic Failure With Developing Coma
Interventions
Not listed
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 24, 2023 · Synced May 22, 2026, 12:49 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Hepatic Failure, Hepatic Impairment, Chronic Hepatitis C Infection With Hepatic Coma
Interventions
2.0mg Buprenorphine/0.5mg Naloxone, Promethazine
Drug
Lead sponsor
Indivior Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
3
States / cities
Hialeah, Florida • Orlando, Florida • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Oct 23, 2016 · Synced May 22, 2026, 12:49 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Disorder of Consciousness, Comatose, Coma; Prolonged, Vegetative State, Minimally Conscious State
Interventions
Functional MRI (fMRI)
Diagnostic Test
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2029
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 19, 2025 · Synced May 22, 2026, 12:49 AM EDT
Not yet recruiting Not applicable Interventional
View directory record Official record
Conditions
Caregiver Distress, Emotional Distress, Caregivers, Resilience, Coma, Brain Injury
Interventions
Coma Family Program 1, Coma Family Program 2
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
3
States / cities
Baltimore, Maryland • Boston, Massachusetts • Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced May 22, 2026, 12:49 AM EDT
Completed No phase listed Observational
View directory record Official record
Conditions
Brain Death
Interventions
Not listed
Lead sponsor
The Cleveland Clinic
Other
Eligibility
15 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 26, 2016 · Synced May 22, 2026, 12:49 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury
Interventions
Low-intensity focused ultrasound
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 79 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
2
States / cities
Boston, Massachusetts • Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced May 22, 2026, 12:49 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury
Interventions
The Brainsonix BX Pulsar 1002 was designed to deliver low-intensity focused ultrasound pulsations (LIFUP) to the human brain.
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 79 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
4
States / cities
Los Angeles, California • Pomona, California • Boston, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 9, 2025 · Synced May 22, 2026, 12:49 AM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Brain Death
Interventions
enteral feeding with Oxepa® and Glutasolve®
Dietary Supplement
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
14 Years to 65 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 25, 2014 · Synced May 22, 2026, 12:49 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Coma, Emotional Distress
Interventions
COMA-F
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 24, 2025 · Synced May 22, 2026, 12:49 AM EDT
Active, not recruiting Phase 1 Interventional Results available
View directory record Official record
Conditions
Brain Injury Traumatic Severe (Diagnosis), Coma, Consciousness, Level Altered, Anoxic Brain Injury
Interventions
Methylphenidate
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced May 22, 2026, 12:49 AM EDT
Withdrawn Early Phase 1 Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Brain Death, Anoxic Brain Injury, Cardiac Arrest, Sedative Intoxication, Narcotic Intoxication
Interventions
Flumazenil, Naloxone
Drug
Lead sponsor
Prisma Health-Midlands
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 30, 2024 · Synced May 22, 2026, 12:49 AM EDT
Enrolling by invitation Not applicable Interventional
View directory record Official record
Conditions
Comatose
Interventions
Transcutaneous electrical stimulation, Standard of Care (SOC)
Device · Other
Lead sponsor
Markey Olson
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 7, 2024 · Synced May 22, 2026, 12:49 AM EDT
Terminated Phase 2 Interventional
View directory record Official record
Conditions
Organ Transplantation From Brain-dead Donors
Interventions
Cold isotonic fluid and central venous hypothermia catheter
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 6, 2018 · Synced May 22, 2026, 12:49 AM EDT
Completed No phase listed Observational
View directory record Official record
Conditions
Cardiac Arrest With Successful Resuscitation
Interventions
IQool
Device
Lead sponsor
Adam Frisch
Other
Eligibility
18 Years and older
Enrollment
38 participants
Timeline
2019 – 2021
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 16, 2021 · Synced May 22, 2026, 12:49 AM EDT
Completed Phase 2Phase 3 Interventional Results available
View directory record Official record
Conditions
Brain Death, Organ Donors, Lung Transplantation
Interventions
Naloxone, Normal saline
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
13 Years to 70 Years
Enrollment
199 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
4
States / cities
Denver, Colorado • Metairie, Louisiana • St Louis, Missouri + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 30, 2020 · Synced May 22, 2026, 12:49 AM EDT
Recruiting No phase listed Observational
View directory record Official record
Conditions
Cardiac Arrest
Interventions
Continuous SjO2 monitoring with a PediaSat Oximetry Catheter, Intermittent SjO2 monitoring with a PediaSat Oximetry Catheter
Device · Diagnostic Test
Lead sponsor
Byron Drumheller
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced May 22, 2026, 12:49 AM EDT
Completed Phase 2 Interventional Results available
View directory record Official record
Conditions
Status Epilepticus, Electrographic, Coma
Interventions
Vigabatrin Only Product
Drug
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 80 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 22, 2024 · Synced May 22, 2026, 12:49 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Cardiac Arrest With Successful Resuscitation
Interventions
Decision Aid for Surrogate Decision Makers of Comatose Survivors of Cardiac Arrest
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 89 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 14, 2023 · Synced May 22, 2026, 12:49 AM EDT
Recruiting No phase listed Observational
View directory record Official record
Conditions
Cardiac Arrest
Interventions
Not listed
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years to 89 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2027
U.S. locations
5
States / cities
San Francisco, California • New Haven, Connecticut • Gainesville, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced May 22, 2026, 12:49 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers
View directory record Official record
Conditions
Traumatic Brain Injury, Intracerebral Haemorrhage, Subarachnoid Haemorrhagic Stroke
Interventions
Auditory stimuli
Diagnostic Test
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2030
U.S. locations
2
States / cities
Miami, Florida • New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 3, 2025 · Synced May 22, 2026, 12:49 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Brain Death
Interventions
venous blood gas
Procedure
Lead sponsor
MemorialCare Health System
Other
Eligibility
1 Week and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Long Beach, California
Source: ClinicalTrials.gov public record
Updated Oct 2, 2022 · Synced May 22, 2026, 12:49 AM EDT