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Showing 1–24 of 172 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Cooling Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Dermal Cooling System for Cryotherapy of Common Skin Conditions

NCT03282994
View directory record Official record
Conditions
Skin Lesion
Interventions
Dermal Cooling System
Device
Lead sponsor
R2 Dermatology
Industry
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
3
States / cities
Scottsdale, Arizona • Edina, Minnesota • Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 29, 2023 · Synced Sep 5, 2026, 8:15 PM EDT
Terminated Phase 2Phase 3 Interventional

COOL RCN: Cooling to Prevent Radiocontrast Nephropathy

NCT00306306
View directory record Official record
Conditions
Renal Failure, Kidney Failure, Renal Insufficiency
Interventions
Reprieve Endovascular Temperature Therapy System
Device
Lead sponsor
Radiant Medical
Industry
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Royal Oak, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 4, 2008 · Synced Sep 5, 2026, 8:15 PM EDT
Terminated Not applicable Interventional Results available

Diuretic/Cool Dialysate Trial

NCT02593526
View directory record Official record
Conditions
Chronic Kidney Insufficiency
Interventions
Bumetanide, Cool Dialysate
Drug · Other
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Jan 10, 2024 · Synced Sep 5, 2026, 8:15 PM EDT
Completed Not applicable Interventional

CoolCap Trial, Treatment of Perinatal Hypoxic-Ischemic Encephalopathy

NCT00383305
View directory record Official record
Conditions
Neonatal Hypoxic-Ischemic Encephalopathy (HIE)
Interventions
Cool-Cap
Device
Lead sponsor
Olympic Medical
Industry
Eligibility
1 Hour to 6 Hours
Enrollment
235 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2003
U.S. locations
19
States / cities
Little Rock, Arkansas • Oakland, California • San Diego, California + 15 more
Source: ClinicalTrials.gov public record
Updated Oct 2, 2006 · Synced Sep 5, 2026, 8:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Military Alerting System for Monitoring Body Temperature During Active Cooling

NCT04431596
View directory record Official record
Conditions
Hyperthermia
Interventions
Forearm cooling, Mist-fan cooling
Device · Other
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years to 35 Years · Male only
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Storrs, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 20, 2020 · Synced Sep 5, 2026, 8:15 PM EDT
Completed No phase listed Observational Results available

CoolCap Followup Study-Coordination of Participating Centers

NCT00581581
View directory record Official record
Conditions
Neonatal Encephalopathy
Interventions
Not listed
Lead sponsor
University of Rochester
Other
Eligibility
6 Years to 8 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Mar 7, 2013 · Synced Sep 5, 2026, 8:15 PM EDT
Completed Not applicable Interventional

S&B Heat Stress Pilot Protocols

NCT06094764
View directory record Official record
Conditions
Thermal Discomfort
Interventions
Group A, Group B
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 22, 2023 · Synced Sep 5, 2026, 8:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Semiconductor Heat Extraction Cooling

NCT04915859
View directory record Official record
Conditions
Hyperthermia
Interventions
Hand Cooling at 12-15 degrees celsius, Hand Cooling at 16-20 degrees celsius, hand and back cooling at 12-15 or 16-20 degrees celsius, Passive cooling
Other
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years to 45 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Storrs, Connecticut
Source: ClinicalTrials.gov public record
Updated May 30, 2022 · Synced Sep 5, 2026, 8:15 PM EDT
Terminated Not applicable Interventional Results available

Microwave Coagulation in Partial Nephrectomy Protocol

NCT01931462
View directory record Official record
Conditions
Cancer of Kidney
Interventions
Microwave pre-coagulation
Device
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 25, 2018 · Synced Sep 5, 2026, 8:15 PM EDT
Terminated Phase 2Phase 3 Interventional Results available

Hypothermia in Acute Stroke With Thrombolysis Imaging Evaluation of Revascularization

NCT01778855
View directory record Official record
Conditions
Acute Ischemic Stroke
Interventions
IV t-PA and normothermia, IV-tPA and hypothermia
Other · Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
22 Years to 82 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
3
States / cities
Los Angeles, California • San Diego, California • Sarasota, Florida
Source: ClinicalTrials.gov public record
Updated Apr 12, 2017 · Synced Sep 5, 2026, 8:15 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Measurement Skin Temperature During Pulsed Laser Exposure

NCT00540917
View directory record Official record
Conditions
Port-Wine Stain
Interventions
cooling spray during laser treatment
Procedure
Lead sponsor
University of California, Irvine
Other
Eligibility
7 Years to 75 Years
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2010
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Oct 31, 2022 · Synced Sep 5, 2026, 8:15 PM EDT
Completed Not applicable Interventional

Main Study: Influence on Plasticity of Brain Temperature Sub-Study: Phase Triggered Paired Associative Stimulation (PAS)

NCT02363296
View directory record Official record
Conditions
Healthy Volunteers
Interventions
TMS
Device
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 35 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2025
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 5, 2026, 8:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Non-Invasive Cooling of Fat Cells

NCT00762437
View directory record Official record
Conditions
Reduction of Unwanted Fat
Interventions
Zeltiq Dermal Cooling Device
Device
Lead sponsor
Zeltiq Aesthetics
Industry
Eligibility
18 Years and older
Enrollment
175 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
11
States / cities
Sacramento, California • San Diego, California • Washington D.C., District of Columbia + 8 more
Source: ClinicalTrials.gov public record
Updated May 24, 2025 · Synced Sep 5, 2026, 8:15 PM EDT
Terminated Phase 1Phase 2 Interventional Results available

Topiramate in Neonates Receiving Whole Body Cooling for Hypoxic Ischemic Encephalopathy

NCT01765218
View directory record Official record
Conditions
Hypoxic Ischemic Encephalopathy
Interventions
Topiramate, Placebo
Drug
Lead sponsor
Kristin R Hoffman
Other
Eligibility
Up to 6 Hours
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2022
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jun 10, 2024 · Synced Sep 5, 2026, 8:15 PM EDT
Terminated Not applicable Interventional

Cooling Helmets to Decrease Concussion Symptoms

NCT05473897
View directory record Official record
Conditions
Concussion, Mild, TBI (Traumatic Brain Injury)
Interventions
Catalyst Cryohelmet
Device
Lead sponsor
Corewell Health South
Other
Eligibility
19 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Saint Joseph, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 28, 2024 · Synced Sep 5, 2026, 8:15 PM EDT
Recruiting Not applicable Interventional

Evaluation of Scalp Cooling During Chemotherapy on Quality of Life and the Potential Role of Single Nucleotide Variations on Chemotherapy-Induced Alopecia and Hair Regrowth in the Appalachian Highlands Region

NCT07422376
View directory record Official record
Conditions
Alopecia
Interventions
Paxman Scalp Cooling System
Device
Lead sponsor
Charles Mays
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Kingsport, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Sep 5, 2026, 8:15 PM EDT
Completed Phase 3 Interventional Results available

Aspirin for Exercise in Multiple Sclerosis (ASPIRE)

NCT03824938
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
Aspirin 650mg Oral Capsule, Acetaminophen Tablet 650mg, Placebo
Drug · Other
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 26, 2023 · Synced Sep 5, 2026, 8:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Bilateral; Flank Study With Crown Cooling Insert

NCT02554760
View directory record Official record
Conditions
Body Fat Disorder
Interventions
The ZELTIQ CoolSculpting System
Device
Lead sponsor
Zeltiq Aesthetics
Industry
Eligibility
22 Years to 65 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Oct 25, 2020 · Synced Sep 5, 2026, 8:15 PM EDT
Recruiting Not applicable Interventional

Cryoablation vs Lumpectomy in T1 Breast Cancers

NCT05505643
View directory record Official record
Conditions
Breast Cancer, Breast Neoplasm
Interventions
Endocare SlimLine Cryoprobe, Lumpectomy
Device · Procedure
Lead sponsor
Washington University School of Medicine
Other
Eligibility
50 Years and older · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2033
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Sep 5, 2026, 8:15 PM EDT
Withdrawn Not applicable Interventional

A Pilot Study to Evaluate the Use of the AMMA Portable Scalp Cooling System From Cooler Heads

NCT05365243
View directory record Official record
Conditions
Alopecia, Chemotherapy-induced Alopecia, Hair Loss, Breast Cancer, Gynecologic Cancer
Interventions
AMMA Portalbe Scalp Cooling System
Device
Lead sponsor
Cooler Heads Care Inc.
Government
Eligibility
21 Years and older · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
White Plains, New York
Source: ClinicalTrials.gov public record
Updated Aug 14, 2023 · Synced Sep 5, 2026, 8:15 PM EDT
Completed Not applicable Interventional

Study of Endorectal Cooling During RARP to Minimize Trauma and Promote Earlier Return to Continence

NCT01920035
View directory record Official record
Conditions
Incontinence
Interventions
UroCool (Local cooling/hypothermia)
Device
Lead sponsor
ZOLL Circulation, Inc., USA
Industry
Eligibility
18 Years and older · Male only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
2
States / cities
Duarte, California • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 19, 2020 · Synced Sep 5, 2026, 8:15 PM EDT
Not listed Not applicable Interventional Results available

Scalp Cooling to Prevent Chemo-induced Hair Loss

NCT01986140
View directory record Official record
Conditions
Breast Cancer, Alopecia
Interventions
PAXMAN Orbis Scalp Cooler, Control No treatment
Device · Other
Lead sponsor
Julie Nangia
Other
Eligibility
18 Years and older · Female only
Enrollment
236 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2022
U.S. locations
7
States / cities
Morristown, New Jersey • New York, New York • Cleveland, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 26, 2021 · Synced Sep 5, 2026, 8:15 PM EDT
Withdrawn Phase 2 Interventional

Pilot RCT of Therapeutic Hypothermia Plus Neuromuscular Blockade in COVID-19 Patients With ARDS

NCT03376854
View directory record Official record
Conditions
Respiratory Distress Syndrome, Adult, Sars-CoV2
Interventions
Hypothermia, Neuromuscular Blocking Agents, Standard of Care
Device · Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 29, 2021 · Synced Sep 5, 2026, 8:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of the Dermal Cooling System for the Enhanced Treatment of Benign Pigmented Lesions and Common Skin Conditions

NCT04493021
View directory record Official record
Conditions
Pigmentation
Interventions
Dermal Cooling System
Device
Lead sponsor
R2 Dermatology
Industry
Eligibility
18 Years and older
Enrollment
137 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Pleasanton, California
Source: ClinicalTrials.gov public record
Updated Aug 29, 2023 · Synced Sep 5, 2026, 8:15 PM EDT