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ClinicalTrials.gov public records Last synced Sep 6, 2026, 6:48 AM EDT

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Showing 1–24 of 529 matching trials from the live ClinicalTrials.gov search.
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Withdrawn Phase 2 Interventional

Whether Proton Pump Inhibitors, Administered Prior to or After Surgery, Can Reduce the Incidence and/or Severity of Difficulty Swallowing Foods and/or Liquids,Following Anterior Cervical Surgery

NCT03488147
View directory record Official record
Conditions
Dysphagia, GERD, Degenerative Joint Disease
Interventions
Esomeprazole, Placebo Oral Tablet
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 22, 2020 · Synced Sep 6, 2026, 6:48 AM EDT
Not listed Phase 1Phase 2 Interventional

Single Ascending Dose Study in Participants With LCA10

NCT03872479
View directory record Official record
Conditions
Leber Congenital Amaurosis 10, Inherited Retinal Dystrophies, Eye Diseases, Hereditary, Retinal Disease, Retinal Degeneration, Vision Disorders, Eye Disorders Congenital
Interventions
EDIT-101
Drug
Lead sponsor
Editas Medicine, Inc.
Industry
Eligibility
3 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
5
States / cities
Miami, Florida • Boston, Massachusetts • Ann Arbor, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 4, 2022 · Synced Sep 6, 2026, 6:48 AM EDT
Not listed Not applicable Interventional

SPIRA™-A 3D and HCT/p DBM vs. Medtronic Divergent™-L/Perimeter™ and Recombinant BMP-2

NCT04566874
View directory record Official record
Conditions
Degenerative Disc Disease, Spinal Stenosis, Spondylolisthesis, Scoliosis
Interventions
ALIF
Device
Lead sponsor
Camber Spine Technologies
Industry
Eligibility
22 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
2
States / cities
Philadelphia, Pennsylvania • Plano, Texas
Source: ClinicalTrials.gov public record
Updated Sep 27, 2020 · Synced Sep 6, 2026, 6:48 AM EDT
Terminated Not applicable Interventional Results available

Post-op Treatment With Hyaluronic Acid Injections

NCT01256788
View directory record Official record
Conditions
Meniscus Tear, Chondropathy/Degenerative Joint Disease (DJD)
Interventions
Euflexxa, Saline
Device · Other
Lead sponsor
The Hawkins Foundation
Other
Eligibility
40 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 7, 2019 · Synced Sep 6, 2026, 6:48 AM EDT
Completed Not applicable Interventional Results available

Investigation of Sacroiliac Fusion Treatment (INSITE)

NCT01681004
View directory record Official record
Conditions
Degenerative Sacroiliitis, Sacroiliac Joint Disruption
Interventions
iFuse Implant System, Non-surgical management
Device · Other
Lead sponsor
SI-BONE, Inc.
Industry
Eligibility
21 Years to 70 Years
Enrollment
159 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
19
States / cities
La Jolla, California • Newport Beach, California • Denver, Colorado + 16 more
Source: ClinicalTrials.gov public record
Updated Aug 24, 2017 · Synced Sep 6, 2026, 6:48 AM EDT
Completed Not applicable Interventional Results available

Safety and Efficacy of the CarboClear Pedicle Screw System

NCT02626624
View directory record Official record
Conditions
Degenerative Disc Disease, Spondylolisthesis, Grade 1
Interventions
Implantation of the CarboClear Pedicle Screw System
Device
Lead sponsor
CarboFix Orthopedics Ltd.
Industry
Eligibility
21 Years to 72 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
5
States / cities
Boston, Massachusetts • Rochester, Minnesota • Brooklyn, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 26, 2025 · Synced Sep 6, 2026, 6:48 AM EDT
Terminated Not applicable Interventional Results available

Dynesys Spinal System Post Market 522 Study

NCT01528072
View directory record Official record
Conditions
Degenerative Spondylolisthesis, Pseudoarthrosis
Interventions
Dynesys Spinal System
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
20 Years to 80 Years
Enrollment
153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
9
States / cities
Belleville, Illinois • Baltimore, Maryland • New York, New York + 5 more
Source: ClinicalTrials.gov public record
Updated Jan 28, 2020 · Synced Sep 6, 2026, 6:48 AM EDT
Completed Not applicable Interventional

A 16 Week Evaluation of the Novartis Health Management Tool (HMT) in Age Related Macular Degeneration (AMD)

NCT01542866
View directory record Official record
Conditions
Age Related Macular Degeneration (AMD)
Interventions
Health Management Tool (HMT)
Other
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
Not listed
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
23
States / cities
Beverly Hills, California • Sacramento, California • Torrance, California + 20 more
Source: ClinicalTrials.gov public record
Updated Jul 11, 2018 · Synced Sep 6, 2026, 6:48 AM EDT
Completed No phase listed Observational

Posterior Lateral Fusion (PLF) With Dynesys

NCT00791180
View directory record Official record
Conditions
Spondylolisthesis
Interventions
Not listed
Lead sponsor
Zimmer Biomet
Industry
Eligibility
20 Years to 80 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 28, 2011 · Synced Sep 6, 2026, 6:48 AM EDT
Terminated Not applicable Interventional Results available

Clinical Outcomes of Lumbar Degenerative Disc Disease in Active-Duty U.S. Service Personnel

NCT01028300
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
ProDisc™-L Total Disc Replacement (TDR)
Device
Lead sponsor
Synthes USA HQ, Inc.
Industry
Eligibility
18 Years to 50 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 1, 2016 · Synced Sep 6, 2026, 6:48 AM EDT
Completed No phase listed Observational

CHARITE™ vs. ALIF 5-Year Follow-up

NCT00215332
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
CHARITE
Device
Lead sponsor
DePuy Spine
Industry
Eligibility
Not listed
Enrollment
367 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
10
States / cities
Los Angeles, California • Golden, Colorado • Chicago, Illinois + 7 more
Source: ClinicalTrials.gov public record
Updated Apr 12, 2015 · Synced Sep 6, 2026, 6:48 AM EDT
Terminated No phase listed Observational

Prospective, Observational Registry of Renaissance-guided Spine Surgeries

NCT02212899
View directory record Official record
Conditions
Degenerative Spine Disease, Spinal Deformity
Interventions
Not listed
Lead sponsor
Mazor Robotics
Industry
Eligibility
6 Years to 90 Years
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
4
States / cities
Jacksonville, Florida • Memphis, Tennessee • Houston, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 4, 2020 · Synced Sep 6, 2026, 6:48 AM EDT
Not yet recruiting Not applicable Interventional

VR-Cognitive Behavioral Therapy Prehabilitation for Spinal Deformity Surgery

NCT07777679
View directory record Official record
Conditions
Degenerative Spine Disease, Spinal Stenosis Lumbar
Interventions
Virtual Reality-Based CBT Prehabilitation (VR-CBT), CBT Prehabilitation without Virtual Reality
Behavioral
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years to 75 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Irvine, California • Newport Beach, California
Source: ClinicalTrials.gov public record
Updated Aug 23, 2026 · Synced Sep 6, 2026, 6:48 AM EDT
Completed Not applicable Interventional Results available

Augment® Injectable Bone Graft Compared to Autologous Bone Graft as a Bone Regeneration Device in Hindfoot Fusions

NCT01305356
View directory record Official record
Conditions
Degenerative Joint Disease, Congenital Deformity, Arthritis, Osteoarthritis, Rheumatoid Arthritis
Interventions
Augment® Injectable Bone Graft, Autologous bone graft
Device · Procedure
Lead sponsor
BioMimetic Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
299 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
20
States / cities
Tucson, Arizona • San Francisco, California • Glenview, Illinois + 16 more
Source: ClinicalTrials.gov public record
Updated Dec 25, 2018 · Synced Sep 6, 2026, 6:48 AM EDT
Completed Not applicable Interventional Results available

Study of the Safety and Effectiveness of the Artificial Cervical Disc - Low Profile Device at Two Adjacent Levels

NCT00637156
View directory record Official record
Conditions
Cervical Degenerative Disc Disease, Radiculopathy, Myelopathy
Interventions
PRESTIGE LP device at two adjacent levels, Bi-level fusion with ATLANTIS Cervical Plate System
Device
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
18 Years and older
Enrollment
397 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2018
U.S. locations
29
States / cities
Huntsville, Alabama • Beverly Hills, California • Colton, California + 26 more
Source: ClinicalTrials.gov public record
Updated Apr 30, 2018 · Synced Sep 6, 2026, 6:48 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Cooled RF Lesion MRI Characteristics

NCT03631030
View directory record Official record
Conditions
Arthritis;Lumbosacral, Osteo Arthritis Knee, Sacroiliitis, Hip Osteoarthritis, Arthritis, Degenerative
Interventions
Cooled radiofrequency ablation
Device
Lead sponsor
International Spine, Pain and Performance Center
Other
Eligibility
21 Years and older
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Arlington, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 6, 2019 · Synced Sep 6, 2026, 6:48 AM EDT
Terminated Not applicable Interventional Results available

Visionaire™ Versus Standard Instrumentation Safety and Efficacy in Total Knee Arthroplasty (TKA)

NCT01084772
View directory record Official record
Conditions
Degenerative Arthritis of Knee
Interventions
VISIONAIRE Total Knee Arthroplasty, Standard Total Knee Arthroplasty
Other
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
Not listed
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
6
States / cities
Park Ridge, Illinois • Springfield, Illinois • St Louis, Missouri + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 2, 2020 · Synced Sep 6, 2026, 6:48 AM EDT
Completed Phase 3 Interventional

MAVERICK™ Total Disc Replacement- Pivotal Study

NCT00635843
View directory record Official record
Conditions
Spinal Diseases
Interventions
MAVERICK™ Disc, LT-CAGE® Lumbar Tapered Fusion Device and INFUSE® Bone Graft
Device
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
18 Years to 70 Years
Enrollment
577 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2010
U.S. locations
32
States / cities
Huntsville, Alabama • Daly City, California • Los Angeles, California + 29 more
Source: ClinicalTrials.gov public record
Updated Aug 1, 2013 · Synced Sep 6, 2026, 6:48 AM EDT
Completed Phase 2 Interventional Results available

Evaluation of Oral Minocycline in the Treatment of Geographic Atrophy Associated With Age-Related Macular Degeneration

NCT02564978
View directory record Official record
Conditions
Age-Related Macular Degeneration
Interventions
Minocycline
Drug
Lead sponsor
National Eye Institute (NEI)
NIH
Eligibility
55 Years and older
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 17, 2025 · Synced Sep 6, 2026, 6:48 AM EDT
Withdrawn Phase 1Phase 2 Interventional Accepts healthy volunteers

Effect of RECK in Posterior Spinal Fusion

NCT06447194
View directory record Official record
Conditions
Degenerative Lumbar Spinal Stenosis, Degenerative Disc Disease, Degenerative Spondylolisthesis, Degenerative Disease
Interventions
Ropivacaine, Epinephrine, Clonidine, and Ketorolac Injection Cocktail, Placebo
Drug · Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 88 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 30, 2025 · Synced Sep 6, 2026, 6:48 AM EDT
Completed Phase 3 Interventional

Efficacy and Safety Study of Naproxcinod in Subjects With Osteoarthritis of the Knee

NCT00504127
View directory record Official record
Conditions
Osteoarthritis
Interventions
Naproxcinod 375 mg bid, Naproxcinod 750 mg bid, Naproxen 500 mg bid, placebo
Drug
Lead sponsor
NicOx
Industry
Eligibility
40 Years and older
Enrollment
1,020 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2007
U.S. locations
73
States / cities
Chandler, Arizona • Tempe, Arizona • Tucson, Arizona + 70 more
Source: ClinicalTrials.gov public record
Updated Jun 16, 2011 · Synced Sep 6, 2026, 6:48 AM EDT
Completed No phase listed Observational

Osteocel® Plus in Anterior Cervical Discectomy and Fusion (ACDF)

NCT00942045
View directory record Official record
Conditions
Degenerative Disc Disease in Cervical Spine
Interventions
Biologic - Osteocel Plus
Biological
Lead sponsor
NuVasive
Industry
Eligibility
18 Years to 70 Years
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
17
States / cities
La Jolla, California • Redwood City, California • San Diego, California + 14 more
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Sep 6, 2026, 6:48 AM EDT
Completed Not applicable Interventional

Study of Subtalar Arthrodesis Using AlloStem® Versus Autologous Bone Graft

NCT01413061
View directory record Official record
Conditions
Degenerative Osteoarthritis, Post-traumatic; Arthrosis, Rheumatoid Arthritis & Other Inflammatory Polyarthropathies, Rheumatoid Arthritis of Subtalar Joint
Interventions
Subtalar Arthrodesis
Procedure
Lead sponsor
AlloSource
Industry
Eligibility
18 Years to 80 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2018
U.S. locations
5
States / cities
Baltimore, Maryland • Grand Rapids, Michigan • Edina, Minnesota + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 12, 2018 · Synced Sep 6, 2026, 6:48 AM EDT
Terminated Phase 4 Interventional

Validity and Reliability of Diagnostic Findings of SI Joint Blocking

NCT01874236
View directory record Official record
Conditions
SI Joint Pain
Interventions
0.75% bupivacaine, .75% bupivacaine
Drug
Lead sponsor
SI-BONE, Inc.
Industry
Eligibility
21 Years to 75 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
7
States / cities
Mount Vernon, Illinois • Lexington, Kentucky • Cleveland, Ohio + 4 more
Source: ClinicalTrials.gov public record
Updated Sep 23, 2019 · Synced Sep 6, 2026, 6:48 AM EDT