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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Disc Degeneration Clear all
Recruiting No phase listed Observational

Personalized Spine Study Group (PSSG) Registry

NCT04601363
View directory record Official record
Conditions
Scoliosis; Adolescence, Degenerative Disc Disease, Spinal Fusion, Kyphoscoliosis, Pseudoarthrosis of Spine, Spinal Stenosis, Kyphoses, Scheuermann
Interventions
Patient Specific Rod
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
10 Years to 85 Years
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2030
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 2, 2024 · Synced Jul 21, 2026, 11:35 PM EDT
Not listed Not applicable Interventional

OSTEOAMP Lumbar Fusion Intra-Patient Controlled Study

NCT05405374
View directory record Official record
Conditions
Lumbar Spine Disease, Lumbar Spondylolisthesis, Lumbar Spine Instability, Lumbar Spondylosis, Degenerative Disc Disease
Interventions
OSTEOAMP, Infuse
Other · Device
Lead sponsor
Bioventus LLC
Industry
Eligibility
21 Years to 80 Years
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
9
States / cities
New Haven, Connecticut • Wichita, Kansas • Paducah, Kentucky + 6 more
Source: ClinicalTrials.gov public record
Updated Aug 27, 2023 · Synced Jul 21, 2026, 11:35 PM EDT
Not listed Not applicable Interventional

Freedom Lumbar Disc in the Treatment of Lumbar Degenerative Disc Disease

NCT00775801
View directory record Official record
Conditions
Degenerative Disc Disease (DDD)
Interventions
FLD, Control
Device
Lead sponsor
AxioMed Spine Corporation
Industry
Eligibility
21 Years to 65 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2018
U.S. locations
12
States / cities
Los Angeles, California • San Diego, California • Loveland, Colorado + 9 more
Source: ClinicalTrials.gov public record
Updated Jan 22, 2018 · Synced Jul 21, 2026, 11:35 PM EDT
Not listed No phase listed Observational

InterFuse® S and T for the Treatment of Scoliosis, Spondylolisthesis and Degenerative Disc Disease (DDD)

NCT02659722
View directory record Official record
Conditions
Scoliosis, Back Pain
Interventions
InterFuse
Device
Lead sponsor
Vertebral Technologies, Inc.
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Nov 1, 2016 · Synced Jul 21, 2026, 11:35 PM EDT
Not listed Phase 2Phase 3 Interventional Accepts healthy volunteers

Fibrin for Chronic Multi-level Discogenic Low Back Pain

NCT04621799
View directory record Official record
Conditions
Low Back Pain, Disc Disease, Disc Degeneration, Radiculopathy, Annular Disc Tear
Interventions
Fibrin sealant
Drug
Lead sponsor
Pauza, Kevin, MD
Other
Eligibility
18 Years to 80 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Tyler, Texas
Source: ClinicalTrials.gov public record
Updated Nov 8, 2020 · Synced Jul 21, 2026, 11:35 PM EDT
Not listed No phase listed Observational

Injection of Autologous Bone Marrow Aspirate in Patients With Degenerative Disc Disease.

NCT05146583
View directory record Official record
Conditions
Lumbar Disc Disease
Interventions
Autologous bone marrow aspirate injected intradiscal after microdiscectomy, Discectomy only
Procedure
Lead sponsor
New York Presbyterian Hospital
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 20, 2021 · Synced Jul 21, 2026, 11:35 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating The Safety and Effectiveness of The NeoDisc™ Versus ACDF in Subjects With Single-Level Cervical Disc Disease

NCT00478088
View directory record Official record
Conditions
Cervical Disc Degenerative Disorder
Interventions
NeoDisc, Instrumented Anterior Cervical Discectomy and Fusion (ACDF)
Device
Lead sponsor
NuVasive
Industry
Eligibility
18 Years to 60 Years
Enrollment
488 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2012
U.S. locations
22
States / cities
La Jolla, California • Marina del Rey, California • Santa Monica, California + 19 more
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Jul 21, 2026, 11:35 PM EDT
Recruiting Phase 4 Interventional

Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery

NCT05029726
View directory record Official record
Conditions
Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Spondylolisthesis, Lumbar Spondylosis, Lumbar Radiculopathy, Lumbar Spine Instability, Synovial Cyst, Degenerative Disc Disease, Degenerative Spondylolisthesis, Degenerative Intervertebral Discs
Interventions
Bupivacaine-Epinephrine 0.25%-1:200,000 Injectable Solution plus clonidine, normal saline
Drug
Lead sponsor
John O'Toole
Other
Eligibility
18 Years to 80 Years
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Jul 21, 2026, 11:35 PM EDT
Withdrawn No phase listed Observational

Enhanced Metal Reduction Techniques for Definitive CT Scanning to Assess Spinal Fusion With TM-Ardis

NCT02170558
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
TM- Ardis implant and Metal Reduction CT software
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years to 85 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Boise, Idaho
Source: ClinicalTrials.gov public record
Updated Jan 23, 2019 · Synced Jul 21, 2026, 11:35 PM EDT
Completed Not applicable Interventional Results available

Cellentra Viable Cell Bone Matrix (VCBM) Anterior Cervical Discectomy and Fusion Outcomes Study (VCBM/MaxAn)

NCT02182843
View directory record Official record
Conditions
Cervical Disc Degenerative Disorder
Interventions
Cellentra VCBM
Biological
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
6
States / cities
Phoenix, Arizona • Fort Wayne, Indiana • Paducah, Kentucky + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 14, 2019 · Synced Jul 21, 2026, 11:35 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Retrospective Review of Integrity Implants FlareHawk® for Lumbar Fusion

NCT04057235
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
FlareHawk Interbody Fusion System
Device
Lead sponsor
Integrity Implants Inc.
Industry
Eligibility
18 Years and older
Enrollment
129 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
3
States / cities
Savannah, Georgia • Charlotte, North Carolina • Akron, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 20, 2020 · Synced Jul 21, 2026, 11:35 PM EDT
Completed Phase 1Phase 2 Interventional

Study of 3 Doses of NeoFuse Combined With MasterGraft Granules in Subjects Requiring Posterolateral Lumbar Fusion (PLF)

NCT00549913
View directory record Official record
Conditions
Degenerative Disc Disease, Spondylolisthesis, Spinal Stenosis
Interventions
NeoFuse, posterolateral spinal fusion with instrumentation
Biological · Procedure
Lead sponsor
Mesoblast, Ltd.
Industry
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 28, 2020 · Synced Jul 21, 2026, 11:35 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

ISOVUE Comparative Trial

NCT07363759
View directory record Official record
Conditions
Lumbar Degenerative Disease, Lumbar Degenerative Disc Disease, Degenerative Spine
Interventions
ISOVUE 300 Observation, ISOVUE 300 Feedback
Procedure
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 100 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Jul 21, 2026, 11:35 PM EDT
Terminated Not applicable Interventional

Kineflex|C Artificial Disc System to Treat Cervical Degenerative Disc Disease (DDD)

NCT00374413
View directory record Official record
Conditions
Degenerative Disc Disease (DDD)
Interventions
Artificial disk, Artificial disc
Device
Lead sponsor
SpinalMotion
Industry
Eligibility
18 Years to 60 Years
Enrollment
343 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2013
U.S. locations
21
States / cities
Beverly Hills, California • Oakland, California • San Diego, California + 17 more
Source: ClinicalTrials.gov public record
Updated Sep 12, 2013 · Synced Jul 21, 2026, 11:35 PM EDT
Completed Phase 3 Interventional Results available

Placebo-controlled Study to Evaluate Rexlemestrocel-L Alone or Combined With Hyaluronic Acid in Participants With Chronic Low Back Pain

NCT02412735
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Rexlemestrocel-L, Rexlemestrocel-L + HA Mixture, Placebo
Drug
Lead sponsor
Mesoblast, Ltd.
Industry
Eligibility
18 Years and older
Enrollment
404 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
47
States / cities
Birmingham, Alabama • Huntsville, Alabama • Scottsdale, Arizona + 42 more
Source: ClinicalTrials.gov public record
Updated Oct 18, 2022 · Synced Jul 21, 2026, 11:35 PM EDT
Completed Phase 3 Interventional

rhBMP-2/CRM/CD HORIZON® Spinal System Pivotal Study

NCT00707265
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
rhBMP-2/CRM/CD HORIZON® Spinal System, Autograft/CD HORIZON® Spinal System
Device
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
18 Years and older
Enrollment
463 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2010
U.S. locations
28
States / cities
Phoenix, Arizona • Orange, California • Santa Monica, California + 25 more
Source: ClinicalTrials.gov public record
Updated May 9, 2023 · Synced Jul 21, 2026, 11:35 PM EDT
Enrolling by invitation No phase listed Observational

Natural Matrix Protein™ (NMP™) Fibers in Cervical and Lumbar Interbody Fusion

NCT06000319
View directory record Official record
Conditions
Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis
Interventions
Natural Matrix Protein (NMP) Fibers, Lumbar interbody fusion, Cervical interbody fusion
Biological · Procedure
Lead sponsor
Induce Biologics USA Inc.
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Jasper, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 17, 2025 · Synced Jul 21, 2026, 11:35 PM EDT
Recruiting Phase 1Phase 2 Interventional

Safety, Tolerability, and Effectiveness of Intramuscular Injection of CELZ-201-DDT for the Treatment of Chronic Lower Back Pain

NCT06053242
View directory record Official record
Conditions
Chronic Low-back Pain, Degenerative Disc Disease
Interventions
CELZ-201-DDT, Placebo
Drug · Other
Lead sponsor
Creative Medical Technology Holdings Inc
Industry
Eligibility
18 Years to 80 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Aventura, Florida
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Jul 21, 2026, 11:35 PM EDT
Completed Phase 4 Interventional Results available

Study Of Disc Anaesthesia For The Preoperative Diagnosis Of Chronic Lower Back Pain

NCT00443781
View directory record Official record
Conditions
Low Back Pain
Interventions
functional anesthetic discography, provocative discography
Procedure
Lead sponsor
Medtronic Spine LLC
Industry
Eligibility
21 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
10
States / cities
Huntsville, Alabama • Beverly Hills, California • Escondido, California + 7 more
Source: ClinicalTrials.gov public record
Updated Jan 4, 2021 · Synced Jul 21, 2026, 11:35 PM EDT
Not listed Phase 2Phase 3 Interventional

Bone Marrow Concentrate (BMC) Injection in Intervertebral Discs

NCT04559295
View directory record Official record
Conditions
Low Back Pain, Disc Disease, Disc Degeneration, Arthropathy Vertebrae, Sacral Disorder, Radiculopathy, Spinal Stenosis
Interventions
Bone Marrow Concentrate
Biological
Lead sponsor
Stem Cures
Other
Eligibility
18 Years to 60 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 21, 2020 · Synced Jul 21, 2026, 11:35 PM EDT
Completed No phase listed Observational

Evaluation Of Spinelink® Fixation In The Treatment Of Degenerative Spondylolisthesis And Spinal Instability

NCT00726310
View directory record Official record
Conditions
Degenerative Disc Disease, Degenerative Spondylolisthesis
Interventions
SpineLink® , SpineLink® II
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
Not listed
Enrollment
202 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2009
U.S. locations
2
States / cities
San Diego, California • Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 12, 2020 · Synced Jul 21, 2026, 11:35 PM EDT
Terminated No phase listed Observational

Single Position Spine Surgery Registry

NCT04839783
View directory record Official record
Conditions
Spine Fusion, Spinal Stenosis, Degenerative Disc Disease
Interventions
Not listed
Lead sponsor
Spine and Scoliosis Research Associates
Other
Eligibility
18 Years to 100 Years
Enrollment
234 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
5
States / cities
Boston, Massachusetts • New York, New York • Wilmington, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 19, 2025 · Synced Jul 21, 2026, 11:35 PM EDT
Completed No phase listed Observational

An Evaluation of Interlaminar Lumbar Instrumented (ILIF™)

NCT01019057
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
ILIF
Procedure
Lead sponsor
NuVasive
Industry
Eligibility
40 Years and older
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
8
States / cities
Phoenix, Arizona • Santa Monica, California • Gainesville, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Jul 21, 2026, 11:35 PM EDT
Not listed Phase 3 Interventional

Wallis Stabilization System for Low Back Pain

NCT00484458
View directory record Official record
Conditions
Low Back Pain
Interventions
Interspinous process and dynamic stabilization (Wallis System), Total Disc Replacement
Device
Lead sponsor
Zimmer Spine
Industry
Eligibility
18 Years to 60 Years
Enrollment
340 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2014
U.S. locations
11
States / cities
Beverly Hills, California • Encinitas, California • Boulder, Colorado + 8 more
Source: ClinicalTrials.gov public record
Updated Oct 3, 2011 · Synced Jul 21, 2026, 11:35 PM EDT