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Showing 1–23 of 23 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Extracorporeal Membrane Oxygenation Complication Clear all
Recruiting Not applicable Interventional

Platform of Randomized Adaptive Clinical Trials in Critical Illness

NCT05440851
View directory record Official record
Conditions
Respiratory Insufficiency, Extracorporeal Membrane Oxygenation Complication, Mechanical Ventilation Pressure High
Interventions
Ultra-Protective Ventilation Facilitated by Extracorporeal Support, Lung-Protective Ventilation (LPV), Driving Pressure-Limited Ventilation (DPL), Lung- and Diaphragm-Protective Ventilation and Sedation (LDPVS), Early Cohort corticosteroid dose, Extended Cohort corticosteroid dose, Usual care without routine corticosteroids, Usual care without extending corticosteroids, Usual care with fludrocortisone, Usual care without fludrocortisone, Drug 4 mL:, Drug 40 mg:, PEEP-20, PEEP-AOP, PEEP-10, VV ECMO-facilitated strategy of earlier awakening, extubation and rehabilitation, Electrical impedance tomography (EIT), no treatment / intervention arm is involved., Usual care, Early Routine IMT
Other · Drug
Lead sponsor
University Health Network, Toronto
Other
Eligibility
18 Years and older
Enrollment
6,250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
26
States / cities
Tucson, Arizona • Los Angeles, California • San Diego, California + 19 more
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Jul 21, 2026, 1:27 PM EDT
Completed No phase listed Observational

Echocardiographic Assessment of Function During ECMO Support

NCT01551849
View directory record Official record
Conditions
Cardiac Failure, Extracorporeal Membrane Oxygenation Complication
Interventions
Not listed
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
Not listed
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 20, 2017 · Synced Jul 21, 2026, 1:27 PM EDT
Not listed Phase 4 Interventional

Safety and Efficacy of Bivalirudin Versus Heparin for Systemic Anticoagulation in Extracorporeal Membrane Oxygenation

NCT03965208
View directory record Official record
Conditions
Extracorporeal Membrane Oxygenation Complication, Anticoagulants
Interventions
Bivalirudin, Unfractionated heparin
Drug
Lead sponsor
Legacy Health System
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated May 27, 2019 · Synced Jul 21, 2026, 1:27 PM EDT
Terminated No phase listed Observational

Renal Biomarkers to Predict Recovery Following Venoarterial Extracorporeal Membrane Oxygenation

NCT02978378
View directory record Official record
Conditions
Acute Kidney Injury
Interventions
biomarker levels
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years to 100 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 9, 2024 · Synced Jul 21, 2026, 1:27 PM EDT
Withdrawn Not applicable Interventional

Fixed Low-dose Heparin Versus Standard Adjusted-dose Heparin Infusion in Adults Receiving Venovenous ECMO With a Heparin Bonded Circuit.

NCT02966080
View directory record Official record
Conditions
Acute Respiratory Failure, Extracorporeal Membrane Oxygenation Complication, Bleeding
Interventions
HEP-IV
Drug
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 20, 2017 · Synced Jul 21, 2026, 1:27 PM EDT
Completed No phase listed Observational

Antibody Secreting Cell and Cyotokine Profiles in Neonates on ECMO

NCT00371241
View directory record Official record
Conditions
Persistent Fetal Circulation Syndrome, Diaphragmatic Hernia, Meconium Aspiration, Sepsis
Interventions
Not listed
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
1 Day to 30 Days
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 4, 2020 · Synced Jul 21, 2026, 1:27 PM EDT
Completed Not applicable Interventional

Low-Field Bedside Brain Magnetic Resonance Imaging in Pediatric Extracorporeal Membrane Oxygenation

NCT06074406
View directory record Official record
Conditions
Feasibility and Safety of a Low-field MRI, Acute Brain Injury, Extracorporeal Membrane Oxygenation Complication
Interventions
Hyperfine
Device
Lead sponsor
Children's Mercy Hospital Kansas City
Other
Eligibility
Up to 17 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Jul 21, 2026, 1:27 PM EDT
Completed Phase 4 Interventional Results available

ECMO Hemostatic Transfusions in Children

NCT05796557
View directory record Official record
Conditions
Extracorporeal Membrane Oxygenation Complication, Hemorrhage, Thromboembolism, Transfusion Adverse Reaction
Interventions
Platelet Transfusion
Biological
Lead sponsor
Yale University
Other
Eligibility
Up to 18 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
9
States / cities
Atlanta, Georgia • Iowa City, Iowa • Louisville, Kentucky + 5 more
Source: ClinicalTrials.gov public record
Updated May 30, 2025 · Synced Jul 21, 2026, 1:27 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Evaluation Of The Pharmacokinetics Of Antithrombin III In Neonates And Infants Undergoing CPB And ECMO Support

NCT02631174
View directory record Official record
Conditions
Extracorporeal Membrane Oxygenation Complication, Cardiopulmonary Bypass
Interventions
Antithrombin III
Drug
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
Up to 1 Year
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 24, 2019 · Synced Jul 21, 2026, 1:27 PM EDT
Completed No phase listed Observational

Hemofilter Life Span, ECLS And/or CRRT

NCT04193865
View directory record Official record
Conditions
Kidney Diseases, Acute Injury of Kidney, Renal Failure, Renal Insufficiency, Neonatal Renal Disorder (Disorder)
Interventions
Not listed
Lead sponsor
Medical University of South Carolina
Other
Eligibility
0 Days to 17 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 27, 2024 · Synced Jul 21, 2026, 1:27 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Effect of ECMO on the Pharmacokinetics of the Drugs and Their Clinical Efficacy

NCT03659513
View directory record Official record
Conditions
Hypoxia, Extracorporeal Membrane Oxygenation Complication
Interventions
Not listed
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 26, 2023 · Synced Jul 21, 2026, 1:27 PM EDT
Terminated No phase listed Observational

ECMO: Optimization of Its Use

NCT02280460
View directory record Official record
Conditions
Extracorporeal Membrane Oxygenation Complication
Interventions
Not listed
Lead sponsor
Renzo Loyaga Rendon
Other
Eligibility
18 Years and older
Enrollment
921 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2024
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 4, 2024 · Synced Jul 21, 2026, 1:27 PM EDT
Withdrawn Phase 1 Interventional

Bivalirudin vs Heparin in ECMO Patients

NCT03707418
View directory record Official record
Conditions
Extracorporeal Membrane Oxygenation Complication
Interventions
Heparin Sodium, Bivalirudin Injection [Angiomax]
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 18, 2021 · Synced Jul 21, 2026, 1:27 PM EDT
Not listed Not applicable Interventional

Biomarkers, Genomics, Physiology in Critically Ill and ECMO Patients

NCT04669444
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome, Cardiac Failure, Extracorporeal Membrane Oxygenation Complication, Respiratory Failure, Renal Failure, Critical Illness, Pulmonary Disease
Interventions
Ventilator
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jan 25, 2023 · Synced Jul 21, 2026, 1:27 PM EDT
Completed No phase listed Observational

Assessing Brain Injury Using Portable Magnetic Resonance Imaging (MRI)

NCT05469139
View directory record Official record
Conditions
Extracorporeal Membrane Oxygenation Complication, Acute Brain Injury
Interventions
Portable MRI acquisition
Diagnostic Test
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
2
States / cities
Baltimore, Maryland • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 12, 2024 · Synced Jul 21, 2026, 1:27 PM EDT
Terminated Not applicable Interventional Results available

Advanced Reperfusion Strategies for Refractory Cardiac Arrest

NCT03880565
View directory record Official record
Conditions
Cardiac Arrest, Extracorporeal Membrane Oxygenation Complication, Ventricular Fibrillation, Pulseless Ventricular Tachycardia, Out-Of-Hospital Cardiac Arrest
Interventions
Early Extracorporeal Membrane Oxygenation (ECMO) Facilitated Resuscitation, Standard Advanced Cardiac Life Support (ACLS) Resuscitation
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 9, 2022 · Synced Jul 21, 2026, 1:27 PM EDT
Recruiting Not applicable Interventional

ECMO ABI Detection With Hyperfine

NCT06469801
View directory record Official record
Conditions
Acute Brain Injury, Extracorporeal Membrane Oxygenation Complication, Hypoxia-Ischemia, Brain, Stroke, Acute
Interventions
Hyperfine
Device
Lead sponsor
Children's Mercy Hospital Kansas City
Other
Eligibility
0 Days to 17 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Jul 21, 2026, 1:27 PM EDT
Recruiting Not applicable Interventional

Transplantation of Autologously Derived Mitochondria Following Ischemia

NCT02851758
View directory record Official record
Conditions
Extracorporeal Membrane Oxygenation Complication
Interventions
autologous mitochondria transplantation
Other
Lead sponsor
Boston Children's Hospital
Other
Eligibility
Up to 17 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 4, 2026 · Synced Jul 21, 2026, 1:27 PM EDT
Terminated No phase listed Observational Results available

Bypass vs. Ecmo in Lung Transplantation (BELT)

NCT03021538
View directory record Official record
Conditions
Lung Transplant; Complications
Interventions
Extracorporeal Membrane Oxygenation, Cardiopulmonary Bypass
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 23, 2020 · Synced Jul 21, 2026, 1:27 PM EDT
Completed Not applicable Interventional

The ECMO-Free Trial

NCT05486559
View directory record Official record
Conditions
Extracorporeal Membrane Oxygenation Complication
Interventions
ECMO-free protocol, Usual Care
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
225 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
7
States / cities
San Diego, California • Stanford, California • Minneapolis, Minnesota + 4 more
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Jul 21, 2026, 1:27 PM EDT
Recruiting Not applicable Interventional

Continuous Compartment Pressure Monitoring for Compartment Syndrome in VA-ECMO Patients

NCT05830721
View directory record Official record
Conditions
Compartment Syndrome of Leg, Extracorporeal Membrane Oxygenation Complication, Limb Ischemia, Limb Ischemia, Critical
Interventions
MY01 + Standard of Care, 14-Gauge Slit Catheter + Standard of Care, Standard of Care
Device · Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Jul 21, 2026, 1:27 PM EDT
Completed Phase 4 Interventional Results available

Study Comparing Bivalirudin Versus Heparin in Neonatal and Pediatric ECMO

NCT03318393
View directory record Official record
Conditions
Extracorporeal Membrane Oxygenation Complication, Pediatric ALL, Anticoagulants
Interventions
Bivalirudin, Unfractionated heparin
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
1 Day to 18 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 30, 2023 · Synced Jul 21, 2026, 1:27 PM EDT
Recruiting Phase 1 Interventional

Hydrogen's Feasibility and Safety as a Therapy in ECPR

NCT05574296
View directory record Official record
Conditions
Cardiac Arrest, Extracorporeal Membrane Oxygenation, Reperfusion Injury
Interventions
Hydrogen, Usual care
Drug · Other
Lead sponsor
Boston Children's Hospital
Other
Eligibility
Not listed
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
4
States / cities
Washington D.C., District of Columbia • Boston, Massachusetts • Kansas City, Missouri + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 2, 2025 · Synced Jul 21, 2026, 1:27 PM EDT