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Conditions: Congenital Heart Disease, Viremia, Virus Diseases, Enterovirus, Enterovirus Infections, Heart Defects, Congenital, Heart Diseases, Prenatal Infection, Diabetes, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1, Diabetes Mellitus, Pregnancy in Diabetic, Pregnancy Complications, Prenatal
Interventions: Stool and Blood Specimen Collection, Follow-up Medical Record Review; Other
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 114 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 2
States / cities: St Louis, Missouri

Conditions: Down Syndrome, Edwards Syndrome, Patau Syndrome, Turner Syndrome
Interventions: Not listed
Lead sponsor: Sequenom, Inc.; Industry
Eligibility: 18 Years and older · Female only
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Denver, Colorado

Conditions: Trisomy 13, Trisomy 18, Trisomy 21, Aneuploidy
Interventions: Blood Draw; Procedure
Lead sponsor: Natera, Inc.; Industry
Eligibility: Female only
Enrollment: 937 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2023
U.S. locations: 24
States / cities: Birmingham, Alabama • Los Angeles, California • San Francisco, California + 16 more

Conditions: Congenital Heart Disease
Interventions: Not listed
Lead sponsor: Columbia University; Other
Eligibility: Up to 50 Years
Enrollment: 51 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2016
U.S. locations: 1
States / cities: New York, New York

Conditions: Congenital Heart Disease, Disorder of Fetus or Newborn
Interventions: Methylprednisolone, Placebo; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: Up to 30 Days
Enrollment: 190 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2018
U.S. locations: 2
States / cities: Atlanta, Georgia • Charleston, South Carolina

Conditions: Aortic Stenosis, Hypoplastic Left Heart Syndrome
Interventions: Fetal Aortic Valvuloplasty; Procedure
Lead sponsor: University of California, San Francisco; Other
Eligibility: 16 Years and older · Female only
Enrollment: 9 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2022
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Down Syndrome (Trisomy 21), Edwards Syndrome (Trisomy 18), Patau Syndrome (Trisomy 13), Turner Syndrome
Interventions: Not listed
Lead sponsor: Sequenom, Inc.; Industry
Eligibility: 18 Years and older · Female only
Enrollment: 1,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 7
States / cities: La Jolla, California • San Diego, California • San Jose, California + 4 more

Conditions: Down Syndrome (Trisomy 21), Edward's Syndrome (Trisomy 18), Patau Syndrome (Trisomy 13), Klinefelter Syndrome (47, XXY), and Other Chromosome, Abnormalities.
Interventions: Not listed
Lead sponsor: Lenetix Medical Screening Laboratory; Industry
Eligibility: 18 Years and older · Female only
Enrollment: 1,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009
U.S. locations: 7
States / cities: Rockville, Maryland • Moristown, New Jersey • Mineola, New York + 3 more

Conditions: Atrial Flutter, Tachycardia, Supraventricular, Tachycardia, Atrial Ectopic, Tachycardia, Reciprocating, Tachycardia Atrial, Tachycardia, Atrioventricular Nodal Reentry, Tachycardia, Paroxysmal, Fetal Hydrops
Interventions: Prospective observational cohorts; Other
Lead sponsor: Edgar Jaeggi; Other
Eligibility: 16 Years to 50 Years · Female only
Enrollment: 330 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2025
U.S. locations: 18
States / cities: Phoenix, Arizona • San Francisco, California • Denver, Colorado + 15 more

Conditions: Down Syndrome, Edwards Syndrome
Interventions: Maternal blood screening test for fetal aneuploidy; Other
Lead sponsor: Sequenom, Inc.; Industry
Eligibility: 18 Years and older · Female only
Enrollment: 5,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 25
States / cities: Mesa, Arizona • Phoenix, Arizona • Tucson, Arizona + 18 more

Conditions: Trisomy 13, Trisomy 18, Trisomy 21, Sex Chromosome Abnormalities
Interventions: Not listed
Lead sponsor: Natera, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 99 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2019
U.S. locations: 4
States / cities: Boston, Massachusetts • Glen Cove, New York • New York, New York + 1 more

Conditions: Perinatal Death, Respiratory Distress Syndrome, Newborn, Hypoxic-Ischemic Encephalopathy, Neonatal Seizure, Meconium Aspiration Syndrome, Intracranial Hemorrhages, Neonatal Hypotension
Interventions: Room air; Other
Lead sponsor: Loma Linda University; Other
Eligibility: 18 Years to 55 Years · Female only
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Loma Linda, California

Conditions: Parent Mental Health
Interventions: PHM™ Pathway; Behavioral
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 57 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Fetal Arrhythmia, Abnormality in Fetal Heart Rate or Rhythm, Long QT Syndrome
Interventions: magnetocardiography, postnatal ECG, fetal echocardiography; Device
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 60 Years · Female only
Enrollment: 39 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Down Syndrome, Edwards Syndrome
Interventions: Maternal Blood Draw; Other
Lead sponsor: Progenity, Inc.; Industry
Eligibility: 18 Years to 54 Years · Female only
Enrollment: 340 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 10
States / cities: Campbell, California • Long Beach, California • Denver, Colorado + 6 more

Conditions: Heart Defects, Congenital, Anxiety in Pregnancy, Depression, Postpartum, Trauma, Psychological, Neurodevelopmental Disorders
Interventions: HeartGPS; Behavioral
Lead sponsor: Children's Hospital Medical Center, Cincinnati; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 2
States / cities: Los Angeles, California • Cincinnati, Ohio

Conditions: Cardiovascular Phenotype, Metabolic Phenotype, Hypertensive Disease, Psychological Phenotype, Audio
Interventions: Not listed
Lead sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); NIH
Eligibility: 18 Years to 99 Years · Female only
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Hypoplastic Left Heart Syndrome
Interventions: Fetal Aortic Valvuloplasty Procedure, Emerge Monorail and Over-The-Wire PTCA Dilatation Catheter, Trek RX and Mini Trek RX Coronary Dilatation Catheter; Procedure · Device
Lead sponsor: Mauro H. Schenone; Other
Eligibility: Up to 45 Years · Female only
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2027 – 2036
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Down Syndrome, Edwards Syndrome, Patau Syndrome, Klinefelter Syndrome, Turner Syndrome, DiGeorge Syndrome, Chromosome Deletion, Aneuploidy
Interventions: Blood sampling for Laboratory Developed Test (LDT) analysis; Other
Lead sponsor: Progenity, Inc.; Industry
Eligibility: 18 Years to 54 Years · Female only
Enrollment: 760 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 8
States / cities: Scottsdale, Arizona • Eunice, Louisiana • Brooklyn, New York + 5 more

Conditions: Fetus or Neonate Affected by Maternal Epidural Anesthesia During Labor and Delivery
Interventions: Lactated Ringer's; Drug
Lead sponsor: MetroHealth Medical Center; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 276 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Congenital Heart Disease
Interventions: Not listed
Lead sponsor: Medical College of Wisconsin; Other
Eligibility: Up to 12 Weeks
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2016
U.S. locations: 2
States / cities: Madison, Wisconsin • Milwaukee, Wisconsin

Conditions: Chromosome 13 Aneuploidy, Chromosome 18 Aneuploidy, Chromosome 21 Aneuploidy, Sex Chromosome Aberrations, Other Microdeletions
Interventions: Blood draw, Cheek swab/Saliva Sampling; Procedure
Lead sponsor: Natera, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 1,781 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Redwood City, California

Conditions: Congenital Heart Disease, Disorder of Fetus or Newborn
Interventions: methylprednisolone (IVMP), methylprednisolone (two doses IVMP); Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: Up to 30 Days
Enrollment: 77 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2011
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Pregnancy, Aneuploidy, Down Syndrome, Edwards Syndrome
Interventions: Not listed
Lead sponsor: Sequenom, Inc.; Industry
Eligibility: 18 Years and older · Female only
Enrollment: 2,502 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 30
States / cities: Mobile, Alabama • La Mesa, California • San Diego, California + 21 more

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Congenital Heart Anomaly Risk in Maternal Enteroviral Infection and Diabetes

Clinical Performance of the MaterniT21 PLUS LDT in Multiple Gestation Pregnancies

Prenatal Non-invasive Aneuploidy Test Utilizing SNPs Trial

Prenatal Effects of Congenital Heart Disease (CHD) on Neurodevelopmental Outcome

Corticosteroid Therapy in Neonates Undergoing Cardiopulmonary Bypass

Fetal Intervention for Aortic Stenosis and Evolving Hypoplastic Left Heart Syndrome

Non-Invasive Screening for Fetal Aneuploidy: A New Maternal Plasma Marker

Non-Invasive Determination of Fetal Chromosome Abnormalities

Prospective Observational Cohort Study of Fetal Atrial Flutter & Supraventricular Tachycardia

Non-Invasive Screening for Fetal Aneuploidy

High Risk Multiple Gestation Study

Maternal Hyperoxygenation for Intrapartum Fetal Heart Rate Tracing Abnormalities

Preparing Heart and Mind™: A Patient Engagement Pathway for Parents and Their Caregiving Partners After a Major Fetal Anomaly Diagnosis

Fetal and Neonatal Magnetophysiology

Non-Invasive Screening for Fetal Aneuploidy

HeartGPS: A Study Exploring the Effects of a Psychological Intervention for Parents and Their Babies After Prenatal Cardiac Diagnosis

Implications of Maternal 45,X Mosaicism as a Secondary Genomic Finding Following Cell-Free DNA Sequencing During Pregnancy: A Deep Phenotype Study

Fetal Aortic Valvuloplasty for Evolving Hypoplastic Left Heart Syndrome

Expanded Noninvasive Genomic Medical Assessment: The Enigma Study

Pulse Pressure and Post-epidural Fetal Heart Rate Changes

Parenting After Infant Congenital Heart Defect Diagnosis

Non-invasive Prenatal Diagnostic Validation Study

Preoperative Corticosteroid Therapy in Neonates Undergoing Cardiopulmonary Bypass

Noninvasive Screening for Fetal Aneuploidy: A New Maternal Plasma Marker