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ClinicalTrials.gov public records Last synced Oct 24, 2026, 8:38 AM EDT

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Showing 1–24 of 46 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Hypoplastic Left Heart Clear all
Completed No phase listed Observational Accepts healthy volunteers

Near-infrared Spectroscopy (NIRS) Neurodevelopmental Outcomes

NCT00464100
View directory record Official record
Conditions
Hypoplastic Left Heart Syndrome
Interventions
Not listed
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
4 Years to 5 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2013
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 15, 2019 · Synced Oct 24, 2026, 8:38 AM EDT
Completed No phase listed Observational

Genetic Determinants of Congenital Heart Disease Outcomes

NCT01656941
View directory record Official record
Conditions
Congenital Heart Disease, Hypoplastic Left Heart Syndrome, Hypoplastic Right Heart Syndrome, d-Transposition of the Great Arteries
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
Up to 30 Days
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
4
States / cities
Atlanta, Georgia • Ann Arbor, Michigan • Charleston, South Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 10, 2021 · Synced Oct 24, 2026, 8:38 AM EDT
Completed No phase listed Observational

NIRS in Neonatal Cardiac Surgery

NCT00166101
View directory record Official record
Conditions
Hypoplastic Left Heart, Surgery
Interventions
Not listed
Lead sponsor
Emory University
Other
Eligibility
1 Day to 1 Year
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2008
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 14, 2012 · Synced Oct 24, 2026, 8:38 AM EDT
Active, not recruiting Phase 2 Interventional Results available

Intramyocardial Injection of Autologous Umbilical Cord Blood Derived Mononuclear Cells During Surgical Repair of Hypoplastic Left Heart Syndrome

NCT03779711
View directory record Official record
Conditions
Hypoplastic Left Heart Syndrome
Interventions
Autologous (self) mononuclear cells derived from umbilical cord blood, Stage II Surgical repair
Biological · Procedure
Lead sponsor
Timothy J Nelson, MD, PhD
Other
Eligibility
Up to 12 Months
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
8
States / cities
Birmingham, Alabama • Los Angeles, California • Aurora, Colorado + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 8, 2025 · Synced Oct 24, 2026, 8:38 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Cerebral Anatomy, Hemodynamics and Metabolism

NCT02919956
View directory record Official record
Conditions
Hypoplastic Left Heart Syndrome
Interventions
Magnetic Resonance Imaging, Neurodevelopmental Testing
Other
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
3 Years and older
Enrollment
121 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 18, 2024 · Synced Oct 24, 2026, 8:38 AM EDT
Completed Not applicable Interventional

Impact of Early Intervention on Maternal Stress in Mothers of Fetuses Diagnosed With Single Ventricle Physiology

NCT02462434
View directory record Official record
Conditions
Heart Defects, Congenital, Hypoplastic Left Heart Syndrome, Single Ventricle Defect, Stress, Psychological
Interventions
Early palliative care team consultation
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 18, 2017 · Synced Oct 24, 2026, 8:38 AM EDT
Completed Not applicable Interventional

Umbilical Cord Blood Collection and Processing for Hypoplastic Left Heart Syndrome Patients

NCT01856049
View directory record Official record
Conditions
Hypoplastic Left Heart Syndrome (HLHS)
Interventions
Collection of umbilical cord blood
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
Female only
Enrollment
464 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2024
U.S. locations
2
States / cities
Rochester, Minnesota • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 10, 2025 · Synced Oct 24, 2026, 8:38 AM EDT
Not listed Phase 1Phase 2 Interventional

Lomecel-B Delivered During Stage II Surgery for Hypoplastic Left Heart Syndrome (ELPIS)

NCT03525418
View directory record Official record
Conditions
HLHS
Interventions
Longeveron Mesenchymal Stem Cells
Biological
Lead sponsor
Longeveron Inc.
Industry
Eligibility
1 Day to 1 Year
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
5
States / cities
Atlanta, Georgia • Baltimore, Maryland • Cincinnati, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 4, 2023 · Synced Oct 24, 2026, 8:38 AM EDT
Completed Not applicable Interventional Results available

Targeting Normoxia in Neonates With Cyanotic Congenital Heart Disease in the Intra-operative and Immediate Post-operative Period

NCT04452188
View directory record Official record
Conditions
Hypoplastic Left Heart Syndrome, Total Anomalous Pulmonary Venous Return, Truncus Arteriosus, Pulmonary Atresia With Ventricular Septal Defect, Transposition of the Great Arteries, Double Outlet Right Ventricle, Subpulmonary VSD, Tetralogy of Fallot, Double Outlet Right Ventricle With Subaortic Ventricular Septal Defect and Pulmonary Stenosis, Cardiopulmonary Bypass
Interventions
Normoxia (with controlled re-oxygenation), Standard of care ventilation
Other
Lead sponsor
University of Michigan
Other
Eligibility
Up to 29 Days
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 18, 2024 · Synced Oct 24, 2026, 8:38 AM EDT
Completed Not applicable Interventional Results available

Oxygen Consumption-based Assessments of Hemodynamics in Neonates Following Congenital Heart Surgery (Oxy-CAHN Study)

NCT02184169
View directory record Official record
Conditions
Transposition of the Great Vessels, Hypoplastic Left Heart Syndrome, Oxygen Consumption Based Assessment of Hemodynamics
Interventions
General Electric Healthcare E-COVX Gas Monitoring Module for VO2 Measurments, Edwards Continuous SVO2 Catheter and Monitoring System - 4.5 fr
Device
Lead sponsor
Boston Children's Hospital
Other
Eligibility
1 Day to 6 Months
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 4, 2020 · Synced Oct 24, 2026, 8:38 AM EDT
Completed No phase listed Observational

A Prospective Study of Patients With Hypoplastic Left Heart Syndrome (HLHS) Following Stage II Surgical Palliation

NCT01708863
View directory record Official record
Conditions
Hypoplastic Left Heart Syndrome
Interventions
Not listed
Lead sponsor
Timothy J Nelson, MD, PhD
Other
Eligibility
0 Months to 18 Months
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2020
U.S. locations
3
States / cities
Rochester, Minnesota • Oklahoma City, Oklahoma • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 5, 2020 · Synced Oct 24, 2026, 8:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

3D Modalities for Medical Student Education of Congenital Heart Disease

NCT07295730
View directory record Official record
Conditions
Tetralogy of Fallot (TOF), Hypoplastic Left Heart Syndrome (HLHS)
Interventions
3D-printed heart models and augmented reality
Other
Lead sponsor
Case Western Reserve University
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 26, 2025 · Synced Oct 24, 2026, 8:38 AM EDT
Withdrawn No phase listed Observational

Sleep Disordered Breathing in Children With Single Ventricle Physiology

NCT00156455
View directory record Official record
Conditions
Hypoplastic Left Heart Syndrome, Obstructive Sleep Apnea Syndrome, Single Ventricle Physiology
Interventions
Not listed
Lead sponsor
University of Rochester
Other
Eligibility
1 Month to 2 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2004
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Apr 30, 2015 · Synced Oct 24, 2026, 8:38 AM EDT
Terminated Phase 1 Interventional

Allogeneic hMSC Injection in Patients With Hypoplastic Left Heart Syndrome

NCT02398604
View directory record Official record
Conditions
Hypoplastic Left Heart Syndrome
Interventions
Allo-hMSCs, Placebo
Drug
Lead sponsor
Longeveron Inc.
Industry
Eligibility
Up to 30 Days
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 19, 2021 · Synced Oct 24, 2026, 8:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Fetal Intervention for Aortic Stenosis and Evolving Hypoplastic Left Heart Syndrome

NCT01736956
View directory record Official record
Conditions
Aortic Stenosis, Hypoplastic Left Heart Syndrome
Interventions
Fetal Aortic Valvuloplasty
Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
16 Years and older · Female only
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 9, 2023 · Synced Oct 24, 2026, 8:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Vitamin C on Endothelial Function and Exercise Capacity in Fontan-Palliated Patients

NCT00974025
View directory record Official record
Conditions
Fontan Procedure, Hypoplastic Left Heart Syndrome, Tricuspid Atresia
Interventions
Vitamin C, Placebo
Dietary Supplement
Lead sponsor
University of Michigan
Other
Eligibility
8 Years to 25 Years
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 1, 2017 · Synced Oct 24, 2026, 8:38 AM EDT
Completed Phase 3 Interventional

Study of Triostat in Infants During Heart Surgery

NCT00027417
View directory record Official record
Conditions
Heart Defects, Congenital
Interventions
Liothyronine sodium/triiodothyronine, Cardiopulmonary bypass and cardiac surgery
Drug · Procedure
Lead sponsor
Michael Portman
Other
Eligibility
Up to 2 Years
Enrollment
195 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2007
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 5, 2013 · Synced Oct 24, 2026, 8:38 AM EDT
Terminated Phase 1 Interventional

Cold Heart Study: A Randomized Pilot Trial of Surfactant Therapy

NCT04181255
View directory record Official record
Conditions
Congenital Heart Disease, Hypoplastic Left Heart Syndrome
Interventions
Curosurf, Sham
Drug
Lead sponsor
University of Michigan
Other
Eligibility
1 Day to 12 Weeks
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 13, 2023 · Synced Oct 24, 2026, 8:38 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Erythropoetin Neuroprotection for Neonatal Cardiac Surgery

NCT00513240
View directory record Official record
Conditions
Congenital Heart Disease, Hypoplastic Left Heart Syndrome, Transposition of the Great Arteries, Aortic Arch Hypoplasia or Interruption
Interventions
Erythropoetin, Normal saline
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
1 Day to 30 Days
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2015
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 7, 2020 · Synced Oct 24, 2026, 8:38 AM EDT
Terminated No phase listed Observational

Examining Developmental Changes in Heart Contractions of Children With Congenital Heart Defects

NCT00860327
View directory record Official record
Conditions
Hypoplastic Left Heart Syndrome, Tetralogy of Fallot
Interventions
Not listed
Lead sponsor
Emory University
Other
Eligibility
1 Day to 1 Year
Enrollment
375 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2016
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 22, 2016 · Synced Oct 24, 2026, 8:38 AM EDT
Completed No phase listed Observational

Cardiac Biomarkers in Patients With Single Ventricle Physiology

NCT03678909
View directory record Official record
Conditions
Hypoplastic Left Heart, Congenital Heart Disease, Cyanotic Congenital Heart Disease, Cardiac Disease
Interventions
Norwood Palliation / DKS / Damus-Kaye-Stansel procedure
Procedure
Lead sponsor
Baylor College of Medicine
Other
Eligibility
Up to 2 Months
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 3, 2020 · Synced Oct 24, 2026, 8:38 AM EDT
Terminated Phase 1Phase 2 Interventional

Use of Oxandrolone to Promote Growth in Infants With HLHS

NCT04090697
View directory record Official record
Conditions
Hypoplastic Left Heart, Congenital Heart Disease
Interventions
Oxandrolone
Drug
Lead sponsor
Carelon Research
Other
Eligibility
Up to 14 Days
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
9
States / cities
Atlanta, Georgia • Boston, Massachusetts • Ann Arbor, Michigan + 6 more
Source: ClinicalTrials.gov public record
Updated May 23, 2024 · Synced Oct 24, 2026, 8:38 AM EDT
Completed No phase listed Observational

Evaluation of Panel Reactive Antibody in Children Following Stage I Palliation for Hypoplastic Left Heart Syndrome

NCT01135485
View directory record Official record
Conditions
Congenital Heart Disease
Interventions
Not listed
Lead sponsor
University of Pennsylvania
Other
Eligibility
8 Years to 18 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 2, 2017 · Synced Oct 24, 2026, 8:38 AM EDT
Recruiting Phase 2 Interventional

Two-Year Study of the Safety and Efficacy of the Second-Generation Tissue Engineered Vascular Grafts

NCT04467671
View directory record Official record
Conditions
HLH - Hypoplastic Left Heart Syndrome, DORV, DILV - Double Inlet Left Ventricle, Mitral Atresia, Tricuspid Atresia, Unbalanced AV Canal, Single-ventricle, Heart Defects, Congenital, Cardiovascular Abnormalities, Cardiovascular Diseases, Heart Diseases
Interventions
Tissue Engineered Vascular Grafts
Combination Product
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
Not listed
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 27, 2025 · Synced Oct 24, 2026, 8:38 AM EDT