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Showing 1–24 of 158 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Hypothermia Clear all
Active, not recruiting Not applicable Interventional

Sequential Hypo- and Normo-thermic Perfusion to Preserve Extended Criteria Donor Livers for Transplantation

NCT04023773
View directory record Official record
Conditions
Liver Transplantation
Interventions
Liver Machine Perfusion (MP) device
Device
Lead sponsor
Koji Hashimoto
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 25, 2024 · Synced Jul 21, 2026, 7:10 AM EDT
Completed Phase 1 Interventional Results available

Pilot Study of Head Cooling in Preterm Infants With Hypoxic Ischemic Encephalopathy

NCT00620711
View directory record Official record
Conditions
Hypoxic Ischemic Encephalopathy
Interventions
Olympic Cool Cap
Device
Lead sponsor
Vanderbilt University
Other
Eligibility
30 Minutes to 6 Hours
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 28, 2019 · Synced Jul 21, 2026, 7:10 AM EDT
Completed Not applicable Interventional

Hypothermia to Prevent High Intracranial Pressure in Patients With Acute Liver Failure

NCT00670124
View directory record Official record
Conditions
Acute Liver Failure, Intracranial Hypertension
Interventions
Hypothermia by the use of Blanketrol II, Cincinnati Sub-Zero
Device
Lead sponsor
Rigshospitalet, Denmark
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2011
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 4, 2014 · Synced Jul 21, 2026, 7:10 AM EDT
Completed Not applicable Interventional

CoolCap Trial, Treatment of Perinatal Hypoxic-Ischemic Encephalopathy

NCT00383305
View directory record Official record
Conditions
Neonatal Hypoxic-Ischemic Encephalopathy (HIE)
Interventions
Cool-Cap
Device
Lead sponsor
Olympic Medical
Industry
Eligibility
1 Hour to 6 Hours
Enrollment
235 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2003
U.S. locations
19
States / cities
Little Rock, Arkansas • Oakland, California • San Diego, California + 15 more
Source: ClinicalTrials.gov public record
Updated Oct 2, 2006 · Synced Jul 21, 2026, 7:10 AM EDT
Recruiting Not applicable Interventional

Pro-2-Cool Pivotal Trial II

NCT06929923
View directory record Official record
Conditions
Concussion, Mild
Interventions
Pro2Cool Device, Sham Cooling Garment Device
Device
Lead sponsor
TecTraum Inc.
Industry
Eligibility
13 Years to 21 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
3
States / cities
Ann Arbor, Michigan • Akron, Ohio • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Jul 21, 2026, 7:10 AM EDT
Terminated No phase listed Observational

The Ability of NIRS to Predict Brain Injury in Hypoxic Ischemic Encephalopathy

NCT03835039
View directory record Official record
Conditions
HIE - Perinatal Hypoxic - Ischemic Encephalopathy
Interventions
NIRS
Device
Lead sponsor
Albany Medical College
Other
Eligibility
1 Minute to 2 Years
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Mar 14, 2022 · Synced Jul 21, 2026, 7:10 AM EDT
Terminated Not applicable Interventional Results available

Optimizing (Longer, Deeper) Cooling for Neonatal Hypoxic-Ischemic Encephalopathy(HIE)

NCT01192776
View directory record Official record
Conditions
Infant, Newborn, Hypoxia, Brain, Hypoxia-Ischemia, Brain, Encephalopathy, Hypoxic-Ischemic, Hypoxic-Ischemic Encephalopathy, Ischemic-Hypoxic Encephalopathy
Interventions
Whole-body Cooling
Procedure
Lead sponsor
NICHD Neonatal Research Network
Network
Eligibility
Up to 6 Hours
Enrollment
364 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
19
States / cities
Birmingham, Alabama • Los Angeles, California • Palo Alto, California + 15 more
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Jul 21, 2026, 7:10 AM EDT
Terminated Phase 2Phase 3 Interventional

The Cooling And Surviving Septic Shock Study (CASS)

NCT01455116
View directory record Official record
Conditions
Septic Shock
Interventions
Mild Induced Hypothermia
Procedure
Lead sponsor
Danish Procalcitonin Study Group
Other
Eligibility
50 Years to 120 Years
Enrollment
433 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 21, 2016 · Synced Jul 21, 2026, 7:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Temperature Study in Cesarean Section

NCT01249014
View directory record Official record
Conditions
Cesarean Section, Hypothermia
Interventions
Warmed fluids, Fluid warmer and warming blanket, Belmont fluid warmer, Bair hugger warming blanket
Other · Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jun 7, 2018 · Synced Jul 21, 2026, 7:10 AM EDT
Recruiting Phase 4 Interventional

HOPE Against Cancer Recurrence in HCC

NCT06717919
View directory record Official record
Conditions
Liver Transplantation, HCC, Oncological Outcomes
Interventions
Hypothermic oxygenated perfusion, Conventional cold storage
Procedure
Lead sponsor
Philipp Dutkowski
Other
Eligibility
18 Years and older
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
2
States / cities
New York, New York • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Jul 21, 2026, 7:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Temperature Evaluation by MRI Thermometry During Cervical Cooling

NCT02431026
View directory record Official record
Conditions
Healthy
Interventions
Cooling pack activated Excel Cryo Cooling Collar
Device
Lead sponsor
University of Vermont
Other
Eligibility
18 Years to 60 Years
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Sep 6, 2016 · Synced Jul 21, 2026, 7:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Efficacy of Warming Garment in the Perioperative Period With Integrated Chemical Heat Packs to Maintain Normothermia

NCT02905708
View directory record Official record
Conditions
Hypothermia
Interventions
Air-Activated heating packs, Forced Air Warming Device
Device
Lead sponsor
Dr K Services PC
Other
Eligibility
18 Years to 80 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Norwalk, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 13, 2017 · Synced Jul 21, 2026, 7:10 AM EDT
Completed Not applicable Interventional Results available

Holding, Stress, and Bonding During Therapeutic Hypothermia

NCT03079284
View directory record Official record
Conditions
Hypoxic-Ischemic Encephalopathy
Interventions
Holding during cooling
Other
Lead sponsor
Alexa Craig
Other
Eligibility
24 Hours to 3 Days
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Portland, Maine
Source: ClinicalTrials.gov public record
Updated Sep 3, 2025 · Synced Jul 21, 2026, 7:10 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Temperature Changes During Induction of General Anesthesia in Pediatric Patients

NCT00710320
View directory record Official record
Conditions
Hypothermia
Interventions
Covered and uncovered anesthesia induction
Procedure
Lead sponsor
University of Oklahoma
Other
Eligibility
6 Months to 3 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Feb 3, 2010 · Synced Jul 21, 2026, 7:10 AM EDT
Withdrawn Not applicable Interventional

Mild Hypothermia for COVID-19 ARDS

NCT04570462
View directory record Official record
Conditions
COVID19 ARDS
Interventions
Hypothermia Via Cooling Machine- Arctic Sun 5000
Other
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Jun 28, 2021 · Synced Jul 21, 2026, 7:10 AM EDT
Terminated Phase 2 Interventional Results available

Mild Hypothermia and Supplemental Magnesium Sulfate Infusion in Severe Traumatic Brain Injury (TBI) Subjects

NCT01333488
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Arctic Sun, Magnesium Sulfate
Device · Drug
Lead sponsor
United States Department of Defense
Federal
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Hollywood, Florida
Source: ClinicalTrials.gov public record
Updated Oct 27, 2015 · Synced Jul 21, 2026, 7:10 AM EDT
Completed Not applicable Interventional Results available

Neonatal Warming to Prevent Hypothermia

NCT04827394
View directory record Official record
Conditions
Hypothermia
Interventions
Neonatal warming mattress, Sterile polyethylene wrap
Device
Lead sponsor
University of Oklahoma
Other
Eligibility
Up to 55 Years · Female only
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 30, 2024 · Synced Jul 21, 2026, 7:10 AM EDT
Completed Phase 1 Interventional

FEIBA and Use of Blood Products in Cardiac Surgery

NCT02577614
View directory record Official record
Conditions
Cardiovascular Disease
Interventions
FEIBA, Normal Saline
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 100 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 13, 2020 · Synced Jul 21, 2026, 7:10 AM EDT
Completed Not applicable Interventional

Bridge to HOPE: Hypothermic Oxygenated Perfusion Versus Cold Storage Prior to Liver Transplantation

NCT05045794
View directory record Official record
Conditions
End Stage Liver DIsease, Liver Failure
Interventions
VitaSmart Liver Machine Perfusion System, Static cold storage
Device · Other
Lead sponsor
Bridge to Life Ltd.
Industry
Eligibility
18 Years and older
Enrollment
219 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
16
States / cities
San Bernardino, California • San Francisco, California • Stanford, California + 13 more
Source: ClinicalTrials.gov public record
Updated Jun 11, 2024 · Synced Jul 21, 2026, 7:10 AM EDT
Completed Not applicable Interventional Results available

California Transport Cooling Trial

NCT01683383
View directory record Official record
Conditions
Hypoxic Ischemic Encephalopathy
Interventions
Device (servo-regulated cooling), Control (standard practice)
Device · Other
Lead sponsor
Stanford University
Other
Eligibility
Up to 6 Hours
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
9
States / cities
Loma Linda, California • Madera, California • Oakland, California + 5 more
Source: ClinicalTrials.gov public record
Updated Dec 7, 2014 · Synced Jul 21, 2026, 7:10 AM EDT
Completed No phase listed Observational

A Prospective Analysis of the Effect of Therapeutic Hypothermia After Cardiac Arrest

NCT00676598
View directory record Official record
Conditions
Cardiac Arrest
Interventions
Not listed
Lead sponsor
Advocate Hospital System
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Oak Lawn, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 5, 2012 · Synced Jul 21, 2026, 7:10 AM EDT
Completed Phase 2 Interventional

Effect of Xenon and Therapeutic Hypothermia, on the Brain and on Neurological Outcome Following Brain Ischemia in Cardiac Arrest Patients

NCT00879892
View directory record Official record
Conditions
Ischemic Brain Injury
Interventions
xenon, Hypothermia
Drug · Other
Lead sponsor
Turku University Hospital
Government
Eligibility
18 Years to 80 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 18, 2015 · Synced Jul 21, 2026, 7:10 AM EDT
Completed No phase listed Observational

Circulating-water Garment With Forced-air Warming and Circulating-water Mattress During Abdominal Surgery

NCT00651898
View directory record Official record
Conditions
Hypothermia
Interventions
Not listed
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 29, 2016 · Synced Jul 21, 2026, 7:10 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Non-Invasive System to Deliver Therapeutic Hypothermia for Protection Against Noise-Induced Hearing Loss

NCT06729632
View directory record Official record
Conditions
Noise Exposure, Noise-induced Hearing Loss, Noise; Adverse Effect, Mild Therapeutic Hypothermia, Cooling, Occupational Exposure, Occupational Health, Hidden Hearing Loss
Interventions
Cold pack-delivered mild therapeutic hypothermia
Device
Lead sponsor
Restorear Devices LLC
Industry
Eligibility
18 Years to 55 Years
Enrollment
116 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 1, 2025 · Synced Jul 21, 2026, 7:10 AM EDT