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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Completed Phase 2 Interventional

The Effect of Thyroid Hormone on Drug Elimination in Cancer Patients

NCT00080574
View directory record Official record
Conditions
Thyroid Cancer
Interventions
Skin Biopsy
Procedure
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Sep 25, 2026, 4:13 AM EDT
Not yet recruiting Phase 2 Interventional

T4/T3 Therapy in Hypothyroidism

NCT07424183
View directory record Official record
Conditions
Hypothyroidism Primary
Interventions
Liothyronine (L-T3), Levothyroxine Sodium (LT4) Tablets, Liothyronine (LT3) placebo
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Sep 25, 2026, 4:13 AM EDT
Completed No phase listed Observational

Metabolic Effects of Synthetic Thyroid Hormone for Thyroid Cancer Treatment

NCT01441154
View directory record Official record
Conditions
Malignant Struma Ovarii, Papillary Thyroid Cancer, Hurthle Cell Thyroid Cancer, Follicular Thyroid Cancer, Tall Cell Variant Thyroid Cancer
Interventions
Not listed
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 99 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 27, 2020 · Synced Sep 25, 2026, 4:13 AM EDT
Completed Phase 2 Interventional Results available

Energy Metabolism in Thyroidectomized Patients

NCT04782856
View directory record Official record
Conditions
Thyroid Goiter, Hypothyroidism, Thyroid Cancer
Interventions
Levothyroxine, Liothyronine, Placebo
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 89 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 13, 2024 · Synced Sep 25, 2026, 4:13 AM EDT
Terminated No phase listed Observational

Thyroid Hormones in Critically Ill Children

NCT00664079
View directory record Official record
Conditions
Hypotension, Respiratory Failure
Interventions
Blood draws
Other
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
12 Months to 18 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 11, 2015 · Synced Sep 25, 2026, 4:13 AM EDT
Not yet recruiting Phase 4 Interventional

Discontinuation of Low-Dose Levothyroxine in Older Adults With Subclinical Hypothyroidism

NCT07787585
View directory record Official record
Conditions
Hypothyroidism
Interventions
Levothyroxine Pill, Placebo
Drug
Lead sponsor
Spyridoula Maraka
Other
Eligibility
65 Years and older
Enrollment
138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2031
U.S. locations
3
States / cities
Little Rock, Arkansas • Gainesville, Florida • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Sep 25, 2026, 4:13 AM EDT
Terminated Not applicable Interventional Results available

Combined Levothyroxine/Liothyronine Supplementation in Hypothyroid Patients With Brain Tumors

NCT00488644
View directory record Official record
Conditions
Hypothyroidism, Brain Tumor
Interventions
Levothyroxine, Liothyronine
Drug
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 23, 2013 · Synced Sep 25, 2026, 4:13 AM EDT
Completed Phase 2 Interventional

A Study Evaluating the Safety and Efficacy of Hormone Replacement Therapy With ST-1891 Compared to Levothyroxine in Patients With Primary Hypothyroidism

NCT05412979
View directory record Official record
Conditions
Hypothyroidism
Interventions
ST-1891, Levothyroxine
Drug
Lead sponsor
Sention Therapeutics, LLC
Industry
Eligibility
18 Years to 75 Years
Enrollment
490 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
39
States / cities
Greenbrae, California • Newhall, California • Denver, Colorado + 35 more
Source: ClinicalTrials.gov public record
Updated Aug 25, 2024 · Synced Sep 25, 2026, 4:13 AM EDT
Recruiting Not applicable Interventional

Optimizing Care for Older Adults Through Thyroid Hormone Deprescribing

NCT06629272
View directory record Official record
Conditions
Hypothyroidism
Interventions
D-THIO (Deprescribing Thyroid Hormone In Older Adults), Enhanced usual care
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
65 Years and older
Enrollment
900 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
3
States / cities
San Francisco, California • Ann Arbor, Michigan • Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Sep 25, 2026, 4:13 AM EDT
Withdrawn Not applicable Interventional

The Effect of Coffee on the Absorption of Thyroid Hormone in Patients With Thyroid Carcinoma

NCT01707056
View directory record Official record
Conditions
Thyroid Carcinoma, Hypothyroidism
Interventions
Black Coffee, Coffee with Milk, Black Tea, Water
Other
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years to 60 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
3
States / cities
Washington D.C., District of Columbia • Leonardtown, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 16, 2021 · Synced Sep 25, 2026, 4:13 AM EDT
Completed No phase listed Observational

Maternal Hypothyroidism in Pregnancy

NCT00818896
View directory record Official record
Conditions
Hypothyroidism
Interventions
Not listed
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
17 Years to 44 Years · Female only
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 18, 2012 · Synced Sep 25, 2026, 4:13 AM EDT
Recruiting Phase 2Phase 3 Interventional

A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants

NCT06345339
View directory record Official record
Conditions
Hypothyroidism
Interventions
Armour Thyroid, Levothyroxine
Drug
Lead sponsor
AbbVie
Industry
Eligibility
18 Years to 75 Years
Enrollment
2,800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
134
States / cities
Birmingham, Alabama • Bonita, California • Burbank, California + 109 more
Source: ClinicalTrials.gov public record
Updated Jan 4, 2026 · Synced Sep 25, 2026, 4:13 AM EDT
Completed Phase 2 Interventional Results available

Study of XP-8121 For the Treatment of Adult Subjects With Hypothyroidism

NCT05823012
View directory record Official record
Conditions
Hypothyroidism
Interventions
levothyroxine sodium
Drug
Lead sponsor
Xeris Pharmaceuticals
Industry
Eligibility
18 Years to 65 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
6
States / cities
Chula Vista, California • Montclair, California • Miami Lakes, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 2, 2025 · Synced Sep 25, 2026, 4:13 AM EDT
Completed Phase 4 Interventional

Study of Radioiodine (131-I) Uptake Following Administration of Thyrogen and Hypothyroid States During Thyroid Hormone Withdrawal.

NCT00001730
View directory record Official record
Conditions
Hypothyroidism, Thyroid Neoplasms
Interventions
Thyrogen
Drug
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2000
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Sep 25, 2026, 4:13 AM EDT
Withdrawn Phase 4 Interventional

Mean Percentage of Levothyroxine Dosage Increase in Patients With Hypothyroidism Started on Enteral Feeding

NCT02577367
View directory record Official record
Conditions
Hypothyroidism
Interventions
Levothyroxine
Drug
Lead sponsor
Jocelyne Karam
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Sep 21, 2021 · Synced Sep 25, 2026, 4:13 AM EDT
Completed Phase 4 Interventional Results available

Levothyroxine Sodium in Thyroidectomized Patients Taking Proton Pump Inhibitors

NCT03094416
View directory record Official record
Conditions
Hypothyroidism;Postablative
Interventions
levothyroxine sodium capsule, Proton pump inhibitor (PPI), Levothyroxine Sodium (LT4) Tablets
Drug
Lead sponsor
IBSA Institut Biochimique SA
Industry
Eligibility
18 Years to 65 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
9
States / cities
La Jolla, California • Ventura, California • Washington D.C., District of Columbia + 6 more
Source: ClinicalTrials.gov public record
Updated Apr 4, 2022 · Synced Sep 25, 2026, 4:13 AM EDT
Withdrawn Not applicable Interventional

Effect of Soy Intake on Cardiovascular Disease Biomarkers in Subclinical Hypothyroid Participants

NCT02024906
View directory record Official record
Conditions
Cardiovascular Disease, Subclinical Hypothyroid
Interventions
soy protein isolate (SPI), milk protein isolate (MPI)
Dietary Supplement
Lead sponsor
Jill Hamilton-Reeves, PhD RD LD
Other
Eligibility
25 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Sep 22, 2015 · Synced Sep 25, 2026, 4:13 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Early Levothyroxine Post Radioactive Iodine

NCT01950260
View directory record Official record
Conditions
Graves' Disease
Interventions
Levothyroxine, Placebo
Drug · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 28, 2019 · Synced Sep 25, 2026, 4:13 AM EDT
Recruiting No phase listed Observational

Natural History of Thyroid Function Disorders

NCT00001159
View directory record Official record
Conditions
Hyperthyroidism, Hypothyroidism, Grave's Disease
Interventions
Not listed
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
6 Months to 98 Years
Enrollment
2,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 1977
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Sep 25, 2026, 4:13 AM EDT
Completed Not applicable Interventional Results available

Mechanistic Study of Subclinical Hypothyroidism In the Elderly

NCT02399475
View directory record Official record
Conditions
Subclinical Hypothyroidism
Interventions
Levothyroxine, Liothyronine, Thyrotropin-Releasing Hormone
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
70 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 8, 2021 · Synced Sep 25, 2026, 4:13 AM EDT
Terminated Phase 4 Interventional Results available

Levothyroxine Replacement With Liquid Gel Capsules vs Tablets Post-thyroidectomy

NCT02946918
View directory record Official record
Conditions
Thyroid Cancer, Postsurgical Hypothyroidism
Interventions
Levothyroxine
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 30, 2020 · Synced Sep 25, 2026, 4:13 AM EDT
Completed No phase listed Observational

TSH Receptor Mutations Among a Consanguineous Community

NCT00747760
View directory record Official record
Conditions
Hypothyroidism
Interventions
Not listed
Lead sponsor
HaEmek Medical Center, Israel
Other
Eligibility
Not listed
Enrollment
209 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 10, 2008 · Synced Sep 25, 2026, 4:13 AM EDT
Terminated No phase listed Observational

Is Levothyroxine Alone Adequate Thyroid Hormone Replacement?

NCT02567877
View directory record Official record
Conditions
Postsurgical Hypothyroidism, Hypothyroidism
Interventions
thyroidectomy, levothyroxine in thyroidectomy patients
Procedure · Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 75 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 7, 2023 · Synced Sep 25, 2026, 4:13 AM EDT
Completed Not applicable Interventional Results available

Thyroid Hormone Dose Adjustment in Pregnancy

NCT00230802
View directory record Official record
Conditions
Pregnancy, Hypothyroidism
Interventions
Anticipatory dose increase of levothyroxine, levothyroxine
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
Female only
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 22, 2016 · Synced Sep 25, 2026, 4:13 AM EDT