A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants

ClinicalTrials.gov ID: NCT06345339

Public ClinicalTrials.gov record NCT06345339. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 6, 2026, 7:55 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 2/3 Multicenter, Double Blinded, Randomized, Dose-conversion, Active Control Study Examining the Efficacy and Safety of Armour Thyroid Compared to Synthetic T4 for the Treatment of Adults With Primary Hypothyroidism

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This study will evaluate the efficacy and safety of Armour Thyroid treatment compared with synthetic T4 in subjects who have primary hypothyroidism and are currently stabilized (i.e., in-range thyroid-stimulating hormone \[TSH\]) on synthetic T4 treatment. This study will also therefore evaluate the efficacy and safety of dose conversion from synthetic T4 therapy to Armour Thyroid therapy.

Study identification

NCT ID: NCT06345339
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2, Phase 3
Lead sponsor: AbbVie; Industry
Enrollment: 2,800 participants

Conditions and interventions

Conditions

Hypothyroidism

Interventions

Armour Thyroid Drug
Levothyroxine Drug

Drug

Eligibility (public fields only)

Age range: 18 Years to 75 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Apr 25, 2024
Primary completion: Aug 31, 2027
Completion: May 31, 2028
Last update posted: Jan 4, 2026

2024 – 2028

United States locations

U.S. sites: 134
U.S. states: 31
U.S. cities: 112

Facility	City	State	ZIP	Site status
Central Research Associates /ID# 255719	Birmingham	Alabama	35205	Recruiting
UAB Hospital /ID# 262565	Birmingham	Alabama	35233-1932	Recruiting
Kaiser San Diego Dept Endocrinology, SCPMG /ID# 262552	Bonita	California	91902-1230	Recruiting
Facey Medical Foundation - Burbank /ID# 262104	Burbank	California	91505-4554	Recruiting
John Muir Medical Center /ID# 257103	Concord	California	94520	Recruiting
Diagnamics Inc. /ID# 262680	Encinitas	California	92024	Recruiting
Providence - St. Jude Medical Center /ID# 256520	Fullerton	California	92835	Recruiting
NorCal Medical Research /ID# 256512	Greenbrae	California	94904	Recruiting
Velocity Clinical Research - Huntington Park /ID# 259044	Huntington Park	California	90255-2951	Recruiting
Scripps Whittier Diabetes Institute /ID# 259215	La Jolla	California	92037	Recruiting
Facey Medical Foundation /ID# 260863	Mission Hills	California	91345	Recruiting
Hoag Memorial Hospital Presbyterian /ID# 260990	Newport Beach	California	92663	Recruiting
Diabetes Associates Medical Group /ID# 256949	Orange	California	92866-2862	Recruiting
Western University of Health Sciences /ID# 262183	Pomona	California	91766	Recruiting
Research at Mills-Peninsula Medical Center - Sutter Health /ID# 258825	San Mateo	California	94404	Recruiting
Care Access - Santa Clarita /ID# 262573	Santa Clarita	California	91321	Recruiting
Facey Medical Foundation - Valencia /ID# 262102	Santa Clarita	California	91355-4462	Recruiting
Olive View UCLA Medical Center /ID# 259092	Sylmar	California	91342-1437	Recruiting
The Lundquist Institute at Harbor-UCLA Medical Center /ID# 262572	Torrance	California	90502	Completed
Diablo Clinical Research /ID# 261329	Walnut Creek	California	94598	Recruiting
San Fernando Valley Health Institute /ID# 257363	West Hills	California	91304-3837	Recruiting
New England Research Associates - Bridgeport /ID# 262184	Bridgeport	Connecticut	06606	Recruiting
Innovative Research of West Florida /ID# 257356	Clearwater	Florida	33756-2004	Recruiting
ALL Medical Research /ID# 256748	Cooper City	Florida	33024	Recruiting
Northeast Research Institute (NERI) /ID# 261841	Fleming Island	Florida	32003	Recruiting
Northeast Research Institute (NERI) /ID# 261846	Fleming Island	Florida	32003	Recruiting
The Center for Diabetes and Endocrine Care /ID# 255721	Fort Lauderdale	Florida	33312	Recruiting
Encore Medical Research LLC /ID# 256758	Hollywood	Florida	33021	Recruiting
East Coast Institute For Research - LaVilla - West Monroe Street /ID# 256972	Jacksonville	Florida	32204	Recruiting
The University of Florida Heal /ID# 257361	Jacksonville	Florida	32207-4966	Recruiting
East Coast Research - Jacksonville /ID# 256971	Jacksonville	Florida	32216	Recruiting
Encore Research Group-Jacksonville Center for Clinical Research /ID# 256147	Jacksonville	Florida	32216	Recruiting
Baptist Health Research Institute /ID# 260989	Jacksonville	Florida	32258	Recruiting
South Florida Wellness & Clinic /ID# 256513	Margate	Florida	33063	Recruiting
Med Research of Florida /ID# 257837	Miami	Florida	33186	Recruiting
Ocean Blue Medical Research Center, Inc /ID# 260438	Miami Springs	Florida	33166	Recruiting
Adult Medicine of Lake County - Mount Dora /ID# 257371	Mt. Dora	Florida	32757	Recruiting
Suncoast Clinical Research Pasco County /ID# 257018	New Port Richey	Florida	34652	Recruiting
West Orange Endocrinology /ID# 256139	Ocoee	Florida	34761-4547	Recruiting
Suncoast Clinical Research - Palm Harbor /ID# 256741	Palm Harbor	Florida	34684	Recruiting
Comprehensive Medical & Research Center /ID# 261678	Plantation	Florida	33317-2911	Recruiting
Northeast Research Institute - St. Augustine /ID# 261857	Saint Augustine	Florida	32080	Recruiting
Metabolic Research Inst /ID# 255729	West Palm Beach	Florida	33401	Recruiting
Grady Clinical Research Center Grady Memorial Hospital /ID# 258419	Atlanta	Georgia	30303	Recruiting
Atlanta Diabetes Associates /ID# 255736	Atlanta	Georgia	30318	Recruiting
East Coast Institute for Research - Canton /ID# 256974	Canton	Georgia	30114	Recruiting
Centricity Research - Endocrine Consultants Research /ID# 255738	Columbus	Georgia	31904	Recruiting
Physicians Research Associates, LLC /ID# 255675	Lawrenceville	Georgia	30046	Recruiting
The Jones Center Clinical Research /ID# 256529	Macon	Georgia	31210	Recruiting
Endocrine Research Solutions /ID# 256784	Roswell	Georgia	30076	Recruiting
Pacific Diabetes & Endocrine Center /ID# 259030	Honolulu	Hawaii	96813	Recruiting
Rocky Mountain Clinical Research, LLC /ID# 256753	Idaho Falls	Idaho	83404-7596	Recruiting
Northwestern University Feinberg School of Medicine /ID# 260677	Chicago	Illinois	60611-2927	Recruiting
West Broadway Clinic /ID# 256756	Council Bluffs	Iowa	51501-3822	Recruiting
Iowa Diabetes and Endocrinology Research Center /ID# 256750	West Des Moines	Iowa	50266	Recruiting
Cotton O'Neil Diabetes & Endocrinology /ID# 256749	Topeka	Kansas	66606	Recruiting
University of Louisville Hospital /ID# 262568	Louisville	Kentucky	40202	Recruiting
Robley Rex VA Medical Center /ID# 262569	Louisville	Kentucky	40206	Recruiting
L-MARC Research Center /ID# 255733	Louisville	Kentucky	40213-1014	Recruiting
Pennington Biomedical Research Center /ID# 262390	Baton Rouge	Louisiana	70808	Recruiting
Nola Care Clinical Research /ID# 260145	Metairie	Louisiana	70006-2930	Recruiting
Omega Clinical Research /ID# 260162	Metairie	Louisiana	70006-2930	Recruiting
Tufts Medical Center /ID# 262974	Boston	Massachusetts	02111-1552	Recruiting
Circle Health Diabetes and Endocrine Center /ID# 270461	Dracut	Massachusetts	01826	Recruiting
NECCR PrimaCare Research, LLC /ID# 256531	Fall River	Massachusetts	02721	Completed
Metro Detroit Endocrinology Center /ID# 260862	Dearborn	Michigan	48126	Recruiting
Michigan Healthcare Professionals /ID# 260859	Farmington Hills	Michigan	48334	Recruiting
Elite Clinical Research Center /ID# 256782	Flint	Michigan	48532	Recruiting
Diabetes and Endocrinology Specialists /ID# 259068	Chesterfield	Missouri	63017	Recruiting
University of Missouri Hospital /ID# 262562	Columbia	Missouri	65212	Recruiting
Jefferson City Medical Group /ID# 257099	Jefferson City	Missouri	65109	Recruiting
Mercy Research - Springfield /ID# 262385	Springfield	Missouri	65804	Recruiting
St. Louis University /ID# 262375	St Louis	Missouri	63104	Recruiting
Washington University-School of Medicine /ID# 262391	St Louis	Missouri	63110	Recruiting
Billings Clinic /ID# 258316	Billings	Montana	59101-0733	Recruiting
Mercury Street Medical /ID# 259632	Butte	Montana	59701-1652	Recruiting
Bryan Health Pine Lake Campus /ID# 259638	Lincoln	Nebraska	68516	Recruiting
Methodist Physicians Clinic /ID# 259276	Omaha	Nebraska	68114	Recruiting
Palm Research Center /ID# 256131	Las Vegas	Nevada	89148	Recruiting
Northern Nevada Endocrinology /ID# 259646	Reno	Nevada	89511	Recruiting
Southern New Hampshire Diabetes and Endocrinology /ID# 257841	Nashua	New Hampshire	03060	Recruiting
Albany Medical College- Endocrinology Washington Extension /ID# 256794	Albany	New York	12203	Recruiting
Research Foundation of SUNY - University of Buffalo /ID# 261019	Buffalo	New York	14203	Recruiting
NYC Research /ID# 258662	New York	New York	10001	Recruiting
Endocrine Assc Long Island PC /ID# 257357	Smithtown	New York	11787	Recruiting
Physician's East Endocrinology /ID# 256491	Greenville	North Carolina	27834	Recruiting
Carteret Medical Group /ID# 256869	Morehead City	North Carolina	28557	Recruiting
Lucas Research /ID# 256127	Morehead City	North Carolina	28557	Recruiting
Lucas Research /ID# 257061	Morehead City	North Carolina	28557	Recruiting
Accellacare - Salisbury /ID# 257019	Salisbury	North Carolina	28144-2735	Recruiting
Accellacare Wilmington /ID# 256744	Wilmington	North Carolina	28401	Recruiting
Diabetes and Endocrinology Associates of Stark County Inc /ID# 256751	Canton	Ohio	44718	Recruiting
Cleveland Clinic - Cleveland /ID# 262392	Cleveland	Ohio	44195	Recruiting
The Ohio State University Wexner Medical Center - CarePoint East /ID# 264061	Columbus	Ohio	43203	Recruiting
Lynn Institute of Norman /ID# 256785	Norman	Oklahoma	73072	Recruiting
Lynn Institute of Oklahoma City /ID# 263141	Oklahoma City	Oklahoma	73112	Recruiting
Diabetes & Endocrinology Consultants of Pennsylvania /ID# 259064	Feasterville-Trevose	Pennsylvania	19053	Recruiting
Thomas Jefferson University Hospital /ID# 256834	Philadelphia	Pennsylvania	19107	Recruiting
Jefferson Health - Roosevelt Boulevard /ID# 256837	Philadelphia	Pennsylvania	19114-1025	Recruiting
Guthrie Robert Packer Hospital /ID# 261838	Sayre	Pennsylvania	18840	Recruiting
TMA Headlands LLC /ID# 259800	Myrtle Beach	South Carolina	29572	Recruiting
Carolina Endocrine Associates Llc /ID# 259640	North Charleston	South Carolina	29406-9823	Recruiting
Palmetto Clinical Research - Summerville /ID# 258845	Summerville	South Carolina	29485	Recruiting
Chattanooga Medical Research /ID# 257631	Chattanooga	Tennessee	37404-3239	Recruiting
PMG Research of Knoxville /ID# 256854	Knoxville	Tennessee	37938	Recruiting
University of Tennessee Health Science Center /ID# 259825	Memphis	Tennessee	38103	Recruiting
Lifedoc Research /ID# 262975	Memphis	Tennessee	38115	Recruiting
Mid State Endocrine Associates /ID# 259641	Nashville	Tennessee	37203	Recruiting
Texas Diabetes and Endocrinology - Central Austin /ID# 255728	Austin	Texas	78731	Recruiting
Texas Diabetes and Endocrinology - South Austin /ID# 255723	Austin	Texas	78749	Recruiting
Brusco, Corpus Christi, TX /ID# 256746	Corpus Christi	Texas	78414	Recruiting
North TX Endocrine Center /ID# 255737	Dallas	Texas	75231	Recruiting
Research Institute Dallas /ID# 256126	Dallas	Texas	75231	Completed
Academy of Diabetes, Thyroid and Endocrine /ID# 255735	El Paso	Texas	79935	Recruiting
Diabetes and Thyroid Center of Ft. Worth /ID# 256781	Fort Worth	Texas	76132	Recruiting
Juno Research /ID# 259238	Houston	Texas	77040	Recruiting
Biopharma Informatic - Houston - Business Center Drive /ID# 256149	Houston	Texas	77043	Recruiting
PlanIt Research, PLLC /ID# 259221	Houston	Texas	77079-2204	Recruiting
Endocrine and Psychiatry Cente /ID# 259631	Houston	Texas	77095	Recruiting
Tekton Research - Irving /ID# 260988	Irving	Texas	75039	Recruiting
Southern Endocrinology Associates /ID# 256795	Mesquite	Texas	75149	Recruiting
Texas Diabetes and Endocrinology /ID# 255722	Round Rock	Texas	78681	Recruiting
Northeast Clinical Research of San Antonio, LLC /ID# 256868	San Antonio	Texas	78233	Recruiting
Diabetes & Glandular Disease Clinic /ID# 255734	San Antonio	Texas	78237	Recruiting
Consano Clinical Research, LLC /ID# 256138	Shavano Park	Texas	78231	Recruiting
Texas Valley Clinical Research /ID# 261476	Weslaco	Texas	78596	Recruiting
Advanced Research Institute /ID# 259821	Ogden	Utah	84405-6779	Recruiting
The University of Vermont Medical Center /ID# 256533	South Burlington	Vermont	05403	Recruiting
Virginia Endocrinology Research /ID# 259623	Chesapeake	Virginia	23321	Recruiting
Richmond VA Medical Center /ID# 262386	Richmond	Virginia	23249	Recruiting
Salem VA Medical Center /ID# 262387	Salem	Virginia	24153	Recruiting
Rainier Clinical Research /ID# 255802	Renton	Washington	98055	Recruiting
MultiCare Rockwood Clinic /ID# 255951	Spokane	Washington	99202	Recruiting
MultiCare Institute for Research & Innovation /ID# 255954	Tacoma	Washington	98405	Completed

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 5 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06345339, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Jan 4, 2026 · Synced Sep 6, 2026

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