ClinicalTrials.gov record
A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants
ClinicalTrials.gov ID: NCT06345339
Public ClinicalTrials.gov record NCT06345339. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2/3 Multicenter, Double Blinded, Randomized, Dose-conversion, Active Control Study Examining the Efficacy and Safety of Armour Thyroid Compared to Synthetic T4 for the Treatment of Adults With Primary Hypothyroidism
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will evaluate the efficacy and safety of Armour Thyroid treatment compared with synthetic T4 in subjects who have primary hypothyroidism and are currently stabilized (i.e., in-range thyroid-stimulating hormone \[TSH\]) on synthetic T4 treatment. This study will also therefore evaluate the efficacy and safety of dose conversion from synthetic T4 therapy to Armour Thyroid therapy.
Study identification
- NCT ID
- NCT06345339
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 2,701 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 26, 2024 (Actual)
- Primary completion
- Sep 2027 (Estimated)
- Completion
- Jun 2028 (Estimated)
- Last update posted
- Oct 13, 2026
2024 – 2028
United States locations
- U.S. sites
- 134
- U.S. states
- 31
- U.S. cities
- 113
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Central Research Associates /ID# 255719 | Birmingham | Alabama | 35205 | — |
| UAB Hospital /ID# 262565 | Birmingham | Alabama | 35233-1932 | — |
| Kaiser San Diego Dept Endocrinology, SCPMG /ID# 262552 | Bonita | California | 91902-1230 | — |
| Facey Medical Foundation - Burbank /ID# 262104 | Burbank | California | 91505-4554 | — |
| John Muir Medical Center /ID# 257103 | Concord | California | 94520 | — |
| Diagnamics Inc. /ID# 262680 | Encinitas | California | 92024 | — |
| Providence - St. Jude Medical Center /ID# 256520 | Fullerton | California | 92835 | — |
| NorCal Medical Research /ID# 256512 | Greenbrae | California | 94904 | — |
| Velocity Clinical Research - Huntington Park /ID# 259044 | Huntington Park | California | 90255-2951 | — |
| Scripps Whittier Diabetes Institute /ID# 259215 | La Jolla | California | 92037 | — |
| Facey Medical Foundation /ID# 260863 | Mission Hills | California | 91345 | — |
| Hoag Memorial Hospital Presbyterian /ID# 260990 | Newport Beach | California | 92663 | — |
| Diabetes Associates Medical Group /ID# 256949 | Orange | California | 92866-2862 | — |
| Western University of Health Sciences /ID# 262183 | Pomona | California | 91766 | — |
| Research at Mills-Peninsula Medical Center - Sutter Health /ID# 258825 | San Mateo | California | 94404 | — |
| Care Access - Santa Clarita /ID# 262573 | Santa Clarita | California | 91321 | — |
| Facey Medical Foundation - Valencia /ID# 262102 | Santa Clarita | California | 91355-4462 | — |
| Olive View UCLA Medical Center /ID# 259092 | Sylmar | California | 91342-1437 | — |
| The Lundquist Institute at Harbor-UCLA Medical Center /ID# 262572 | Torrance | California | 90502 | — |
| Diablo Clinical Research /ID# 261329 | Walnut Creek | California | 94598 | — |
| San Fernando Valley Health Institute - West Hills /ID# 257363 | West Hills | California | 91307 | — |
| New England Research Associates - Bridgeport /ID# 262184 | Bridgeport | Connecticut | 06606 | — |
| Innovative Research of West Florida /ID# 257356 | Clearwater | Florida | 33756-2004 | — |
| ALL Medical Research /ID# 256748 | Cooper City | Florida | 33024 | — |
| Northeast Research Institute (NERI) /ID# 261841 | Fleming Island | Florida | 32003 | — |
| Northeast Research Institute (NERI) /ID# 261846 | Fleming Island | Florida | 32003 | — |
| The Center for Diabetes and Endocrine Care /ID# 255721 | Fort Lauderdale | Florida | 33312 | — |
| Encore Medical Research /ID# 256758 | Hollywood | Florida | 33021 | — |
| East Coast Institute For Research - LaVilla - West Monroe Street /ID# 256972 | Jacksonville | Florida | 32204 | — |
| The University of Florida Heal /ID# 257361 | Jacksonville | Florida | 32207-4966 | — |
| East Coast Research - Jacksonville /ID# 256971 | Jacksonville | Florida | 32216 | — |
| Encore Research Group-Jacksonville Center for Clinical Research /ID# 256147 | Jacksonville | Florida | 32216 | — |
| Baptist Health Research Institute /ID# 260989 | Jacksonville | Florida | 32258 | — |
| South Florida Wellness & Clinic /ID# 256513 | Margate | Florida | 33063 | — |
| Med Research of Florida /ID# 257837 | Miami | Florida | 33186 | — |
| Ocean Blue Medical Research Center, Inc /ID# 260438 | Miami Springs | Florida | 33166 | — |
| Adult Medicine of Lake County - Mount Dora /ID# 257371 | Mt. Dora | Florida | 32757 | — |
| Suncoast Clinical Research Pasco County /ID# 257018 | New Port Richey | Florida | 34652 | — |
| West Orange Endocrinology /ID# 256139 | Ocoee | Florida | 34761-4547 | — |
| Suncoast Clinical Research - Palm Harbor /ID# 256741 | Palm Harbor | Florida | 34684 | — |
| Comprehensive Medical & Research Center /ID# 261678 | Plantation | Florida | 33317-2911 | — |
| Northeast Research Institute - St. Augustine /ID# 261857 | Saint Augustine | Florida | 32080 | — |
| Metabolic Research Inst /ID# 255729 | West Palm Beach | Florida | 33401 | — |
| Grady Clinical Research Center Grady Memorial Hospital /ID# 258419 | Atlanta | Georgia | 30303 | — |
| Atlanta Diabetes Associates /ID# 255736 | Atlanta | Georgia | 30318 | — |
| East Coast Institute for Research - Canton /ID# 256974 | Canton | Georgia | 30114 | — |
| Centricity Research - Endocrine Consultants Research /ID# 255738 | Columbus | Georgia | 31904 | — |
| Physicians Research Associates, LLC /ID# 255675 | Lawrenceville | Georgia | 30046 | — |
| The Jones Center Clinical Research /ID# 256529 | Macon | Georgia | 31210 | — |
| Endocrine Research Solutions /ID# 256784 | Roswell | Georgia | 30076 | — |
| Pacific Diabetes & Endocrine Center /ID# 259030 | Honolulu | Hawaii | 96813 | — |
| Rocky Mountain Clinical Research, LLC /ID# 256753 | Idaho Falls | Idaho | 83404-7596 | — |
| Northwestern Medicine - Northwestern Memorial Hospital /ID# 260677 | Chicago | Illinois | 60611 | — |
| West Broadway Clinic /ID# 256756 | Council Bluffs | Iowa | 51501-3822 | — |
| Iowa Diabetes and Endocrinology Research Center /ID# 256750 | West Des Moines | Iowa | 50266 | — |
| Cotton O Neil Diabetes and Endocrinology /ID# 256749 | Topeka | Kansas | 66606 | — |
| University of Louisville Hospital /ID# 262568 | Louisville | Kentucky | 40202 | — |
| Robley Rex VA Medical Center /ID# 262569 | Louisville | Kentucky | 40206 | — |
| Pennington Biomedical Research Center /ID# 262390 | Baton Rouge | Louisiana | 70808 | — |
| Nola Care Clinical Research /ID# 260145 | Metairie | Louisiana | 70006-2930 | — |
| Omega Clinical Research /ID# 260162 | Metairie | Louisiana | 70006-2930 | — |
| Tufts Medical Center. /ID# 262974 | Boston | Massachusetts | 02111-1552 | — |
| Circle Health Diabetes and Endocrine Center /ID# 270461 | Dracut | Massachusetts | 01826 | — |
| NECCR PrimaCare Research, LLC /ID# 256531 | Fall River | Massachusetts | 02721 | — |
| Metro Detroit Endocrinology Center /ID# 260862 | Dearborn | Michigan | 48126 | — |
| Michigan Healthcare Professionals /ID# 260859 | Farmington Hills | Michigan | 48334 | — |
| Elite Clinical Research Center /ID# 256782 | Flint | Michigan | 48532 | — |
| Diabetes and Endocrinology Specialists /ID# 259068 | Chesterfield | Missouri | 63017 | — |
| University of Missouri Hospital /ID# 262562 | Columbia | Missouri | 65212 | — |
| Jefferson City Medical Group /ID# 257099 | Jefferson City | Missouri | 65109 | — |
| Mercy Research - Springfield /ID# 262385 | Springfield | Missouri | 65804 | — |
| St. Louis University /ID# 262375 | St Louis | Missouri | 63104 | — |
| Washington University /ID# 262391 | St Louis | Missouri | 63110 | — |
| Billings Clinic /ID# 258316 | Billings | Montana | 59101-0733 | — |
| Mercury Street Medical /ID# 259632 | Butte | Montana | 59701-1652 | — |
| Bryan Health Pine Lake Campus /ID# 259638 | Lincoln | Nebraska | 68516 | — |
| Methodist Physicians Clinic /ID# 259276 | Omaha | Nebraska | 68114 | — |
| Palm Research Center /ID# 256131 | Las Vegas | Nevada | 89148 | — |
| Northern Nevada Endocrinology /ID# 259646 | Reno | Nevada | 89511 | — |
| Southern New Hampshire Diabetes and Endocrinology /ID# 257841 | Nashua | New Hampshire | 03060 | — |
| Albany Medical College- Endocrinology Washington Extension /ID# 256794 | Albany | New York | 12203 | — |
| Research Foundation of SUNY - University of Buffalo /ID# 261019 | Buffalo | New York | 14203 | — |
| NYC Research /ID# 258662 | New York | New York | 10001 | — |
| Endocrine Assc Long Island PC /ID# 257357 | Smithtown | New York | 11787 | — |
| Physician's East Endocrinology /ID# 256491 | Greenville | North Carolina | 27834 | — |
| Monroe Biomedical Research /ID# 255733 | Monroe | North Carolina | 28112 | — |
| Carteret Medical Group /ID# 256869 | Morehead City | North Carolina | 28557 | — |
| Centricity Research - Morehead city /ID# 256127 | Morehead City | North Carolina | 28557 | — |
| Centricity Research - Morehead city /ID# 257061 | Morehead City | North Carolina | 28557 | — |
| Accellacare - Salisbury /ID# 257019 | Salisbury | North Carolina | 28144-2735 | — |
| Accellacare - Tradd Court - Wilmington /ID# 256744 | Wilmington | North Carolina | 28401 | — |
| Diabetes and Endocrinology Associates of Stark County Inc /ID# 256751 | Canton | Ohio | 44718 | — |
| Cleveland Clinic - Cleveland /ID# 262392 | Cleveland | Ohio | 44195 | — |
| The Ohio State University Wexner Medical Center - CarePoint East /ID# 264061 | Columbus | Ohio | 43203 | — |
| Lynn Institute of Norman /ID# 256785 | Norman | Oklahoma | 73072 | — |
| Lynn Institute of Oklahoma City /ID# 263141 | Oklahoma City | Oklahoma | 73112 | — |
| Diabetes & Endocrinology Consultants of Pennsylvania /ID# 259064 | Feasterville-Trevose | Pennsylvania | 19053 | — |
| Thomas Jefferson University Hospital /ID# 256834 | Philadelphia | Pennsylvania | 19107 | — |
| Northeast Endocrine Metabolic Associates /ID# 256837 | Philadelphia | Pennsylvania | 19114 | — |
| Guthrie Robert Packer Hospital /ID# 261838 | Sayre | Pennsylvania | 18840 | — |
| TMA Headlands LLC /ID# 259800 | Myrtle Beach | South Carolina | 29572 | — |
| Carolina Endocrine Associates Llc /ID# 259640 | North Charleston | South Carolina | 29406-9823 | — |
| Palmetto Clinical Research - Summerville /ID# 258845 | Summerville | South Carolina | 29485 | — |
| Chattanooga Medical Research /ID# 257631 | Chattanooga | Tennessee | 37404-3239 | — |
| PMG Research of Knoxville - Knoxville /ID# 256854 | Knoxville | Tennessee | 37938 | — |
| University of Tennessee Health Science Center /ID# 259825 | Memphis | Tennessee | 38103 | — |
| Lifedoc Research /ID# 262975 | Memphis | Tennessee | 38115 | — |
| Mid State Endocrine Associates /ID# 259641 | Nashville | Tennessee | 37203 | — |
| Texas Diabetes and Endocrinology - Central Austin /ID# 255728 | Austin | Texas | 78731 | — |
| Texas Diabetes and Endocrinology - South Austin /ID# 255723 | Austin | Texas | 78749 | — |
| Brusco, Corpus Christi, TX /ID# 256746 | Corpus Christi | Texas | 78414 | — |
| North TX Endocrine Center /ID# 255737 | Dallas | Texas | 75231 | — |
| Research Institute Dallas /ID# 256126 | Dallas | Texas | 75231 | — |
| Academy of Diabetes, Thyroid and Endocrine /ID# 255735 | El Paso | Texas | 79935 | — |
| Diabetes and Thyroid Center of Ft. Worth /ID# 256781 | Fort Worth | Texas | 76132 | — |
| Juno Research /ID# 259238 | Houston | Texas | 77040 | — |
| Biopharma Informatic - Houston - Business Center Drive /ID# 256149 | Houston | Texas | 77043 | — |
| PlanIt Research /ID# 259221 | Houston | Texas | 77079-2204 | — |
| Endocrine and Psychiatry Cente /ID# 259631 | Houston | Texas | 77095 | — |
| Tekton Research - Irving /ID# 260988 | Irving | Texas | 75039 | — |
| Southern Endocrinology Associates /ID# 256795 | Mesquite | Texas | 75149 | — |
| Texas Diabetes and Endocrinology /ID# 255722 | Round Rock | Texas | 78681 | — |
| Northeast Clinical Research of San Antonio, LLC /ID# 256868 | San Antonio | Texas | 78233 | — |
| Diabetes and Glandular Disease Clinic /ID# 255734 | San Antonio | Texas | 78237 | — |
| Consano Clinical Research, LLC /ID# 256138 | Shavano Park | Texas | 78231 | — |
| Texas Valley Clinical Research /ID# 261476 | Weslaco | Texas | 78596 | — |
| Advanced Research Institute /ID# 259821 | Ogden | Utah | 84405-6779 | — |
| The University of Vermont Medical Center /ID# 256533 | South Burlington | Vermont | 05403 | — |
| Virginia Endocrinology Research /ID# 259623 | Chesapeake | Virginia | 23321 | — |
| Richmond VA Medical Center /ID# 262386 | Richmond | Virginia | 23249 | — |
| Salem VA Medical Center /ID# 262387 | Salem | Virginia | 24153 | — |
| Rainier Clinical Research /ID# 255802 | Renton | Washington | 98055 | — |
| MultiCare Rockwood Clinic /ID# 255951 | Spokane | Washington | 99202 | — |
| MultiCare Institute for Research and Innovation /ID# 255954 | Tacoma | Washington | 98405 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 5 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06345339, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 13, 2026 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06345339 live on ClinicalTrials.gov.