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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Hypoxia Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Effect of a Single Session of Intermittent Hypoxia on Hematological Variables

NCT05898685
View directory record Official record
Conditions
Intermittent Hypoxia
Interventions
Intermittent hypoxia, Intermittent normoxia
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 80 Years
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jun 11, 2023 · Synced Sep 25, 2026, 7:39 AM EDT
Completed Not applicable Interventional

Phenotyping Mechanistic Pathways for Adverse Health Outcomes in Sleep Apnea

NCT04575740
View directory record Official record
Conditions
Sleep Apnea
Interventions
PAP
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
21 Years to 80 Years
Enrollment
209 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Sep 25, 2026, 7:39 AM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Sex Disparities in Hypoxic Vasodilation and Impact of Obesity

NCT05219799
View directory record Official record
Conditions
Obesity, Vasodilation, Healthy
Interventions
Propranolol Hydrochloride, Isoproterenol, Phentolamine Mesylate, Norepinephrine
Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 45 Years
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Sep 25, 2026, 7:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

SpO2 Accuracy Comparison of Smart Sock V. 2 SpO2 to Arterial Blood CO-Oximetry

NCT03630016
View directory record Official record
Conditions
Hypoxia
Interventions
Pulse oximetry with Owlet BabySat v1.0 sensor
Diagnostic Test
Lead sponsor
Owlet Baby Care, Inc.
Industry
Eligibility
18 Years to 50 Years
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Lehi, Utah
Source: ClinicalTrials.gov public record
Updated Jul 22, 2019 · Synced Sep 25, 2026, 7:39 AM EDT
Not listed Not applicable Interventional

Utah Study Evaluating Apneic Oxygenation for Emergency Department Intubation

NCT02961933
View directory record Official record
Conditions
Intubation
Interventions
Apneic oxygenation, Pre-oxgenation with NRB, NIPPV, BVM
Other
Lead sponsor
Intermountain Health Care, Inc.
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Murray, Utah
Source: ClinicalTrials.gov public record
Updated Feb 10, 2020 · Synced Sep 25, 2026, 7:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Intermittent Hypoxia (IH) on Metabolism and Dysglycemia, in Overweight/Obese Persons SCI

NCT02973438
View directory record Official record
Conditions
Spinal Cord Injuries, Obesity, Insulin Resistance
Interventions
Intermittent Hypoxia (IH), SHAM
Device
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 60 Years
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Dec 16, 2020 · Synced Sep 25, 2026, 7:39 AM EDT
Recruiting No phase listed Observational

Molecular Biology of Polycythemia and Thrombocytosis

NCT00722527
View directory record Official record
Conditions
Polycythemia, Thrombocytosis
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
Not listed
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2028
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 8, 2026 · Synced Sep 25, 2026, 7:39 AM EDT
Terminated Not applicable Interventional

Computer-assisted Oxygen Therapy Weaning in Critically Ill Children

NCT03550469
View directory record Official record
Conditions
Hyperoxia, Hypoxia
Interventions
Computer-assisted Oxygen Weaning
Device
Lead sponsor
Stanford University
Other
Eligibility
Up to 2 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Aug 28, 2022 · Synced Sep 25, 2026, 7:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Accuracy of Pulse Oximeters With Profound Hypoxia

NCT05322382
View directory record Official record
Conditions
SpO2
Interventions
A-line
Procedure
Lead sponsor
CardiacSense Ltd.
Industry
Eligibility
18 Years to 50 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 17, 2022 · Synced Sep 25, 2026, 7:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intermittent Hypoxia and Balance Control

NCT05463042
View directory record Official record
Conditions
Intermittent Hypoxia, Normoxia
Interventions
Intermittent Hypoxia, Normoxia (sham)
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 80 Years
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Nov 28, 2023 · Synced Sep 25, 2026, 7:39 AM EDT
Completed Not applicable Interventional

Acute Intermittent Hypoxia in Persons With Multiple Sclerosis

NCT04280484
View directory record Official record
Conditions
Multiple Sclerosis, Relapsing-Remitting
Interventions
Intermittent Hypoxia, Sham Hypoxia
Other
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 23, 2020 · Synced Sep 25, 2026, 7:39 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Clinical Utility of Serum Biomarkers for the Management of Neonatal Hypoxic Ischemic Encephalopathy (Control Levels)

NCT02349672
View directory record Official record
Conditions
Hypoxic Ischemic Encephalopathy
Interventions
blood sample
Procedure
Lead sponsor
University of Florida
Other
Eligibility
1 Day to 3 Days
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 20, 2018 · Synced Sep 25, 2026, 7:39 AM EDT
Completed Phase 1 Interventional

Sorafenib Tosylate and Hypoxia-Activated Prodrug TH-302 in Treating Patients With Advanced Kidney Cancer or Liver Cancer That Cannot Be Removed By Surgery

NCT01497444
View directory record Official record
Conditions
Kidney Cancer, Liver Cancer
Interventions
hypoxia-activated prodrug TH-302, sorafenib tosylate
Drug
Lead sponsor
Alliance for Clinical Trials in Oncology
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
2
States / cities
Scottsdale, Arizona • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 5, 2020 · Synced Sep 25, 2026, 7:39 AM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Study to Evaluate Effects of Investigational Drug on Oxygenation in Healthy Volunteers Under Hypoxic Conditions

NCT03051711
View directory record Official record
Conditions
Cardio-pulmonary Function
Interventions
GBT440
Drug
Lead sponsor
Global Blood Therapeutics
Industry
Eligibility
18 Years to 50 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 3, 2019 · Synced Sep 25, 2026, 7:39 AM EDT
Completed No phase listed Observational Results available

Retrospective Review of Mechanically Ventilated Patients Using a Continuous Data Collection System.

NCT02184208
View directory record Official record
Conditions
Mechanical Ventilation, Acute Respiratory Distress Syndrome, Hypoxic Respiratory Failure
Interventions
Not listed
Lead sponsor
Boston Children's Hospital
Other
Eligibility
1 Day to 35 Years
Enrollment
278 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 4, 2018 · Synced Sep 25, 2026, 7:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Physiological Adaptations to Simulated Intermittent Altitude on Human Health and Performance

NCT03743610
View directory record Official record
Conditions
Altitude Hypoxia
Interventions
Simulated altitude, Placebo simulated altitude
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Feb 19, 2024 · Synced Sep 25, 2026, 7:39 AM EDT
Recruiting Phase 2 Interventional

buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest

NCT05851391
View directory record Official record
Conditions
Hypoxia-Ischemia, Brain, Heart Arrest, Status Epilepticus, Refractory Status Epilepticus, Seizures, Anoxic-Ischemic Encephalopathy, Anoxia-Ischemia, Cerebral
Interventions
Burst Suppression EEG Target Intravenous Anesthesia, Seizure Suppression EEG Target Intravenous Anesthesia
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Sep 25, 2026, 7:39 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effects of Ferrous Sulfate on the Pharmacokinetics of AKB-6548

NCT02327546
View directory record Official record
Conditions
Healthy Volunteers
Interventions
AKB-6548, Ferrous Sulfate
Drug
Lead sponsor
Akebia Therapeutics
Industry
Eligibility
18 Years to 55 Years · Male only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Kalamazoo, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 13, 2018 · Synced Sep 25, 2026, 7:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Oxygen for Intrauterine Resuscitation of Category II Fetal Heart Tracings

NCT02741284
View directory record Official record
Conditions
Electronic Fetal Monitoring, Fetal Hypoxia, Fetal-Placental Circulation
Interventions
Room air, 10L Oxygen by nonrebreather mask
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older · Female only
Enrollment
114 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 25, 2021 · Synced Sep 25, 2026, 7:39 AM EDT
Terminated Not applicable Interventional Results available

Optimizing (Longer, Deeper) Cooling for Neonatal Hypoxic-Ischemic Encephalopathy(HIE)

NCT01192776
View directory record Official record
Conditions
Infant, Newborn, Hypoxia, Brain, Hypoxia-Ischemia, Brain, Encephalopathy, Hypoxic-Ischemic, Hypoxic-Ischemic Encephalopathy, Ischemic-Hypoxic Encephalopathy
Interventions
Whole-body Cooling
Procedure
Lead sponsor
NICHD Neonatal Research Network
Network
Eligibility
Up to 6 Hours
Enrollment
364 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
19
States / cities
Birmingham, Alabama • Los Angeles, California • Palo Alto, California + 15 more
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Sep 25, 2026, 7:39 AM EDT
Terminated Phase 3 Interventional

Early Inhaled Nitric Oxide for Respiratory Failure in Newborns

NCT00005773
View directory record Official record
Conditions
Infant, Newborn, Hypertension, Pulmonary, Persistent Fetal Circulation Syndrome, Pneumonia, Aspiration, Respiratory Distress Syndrome, Newborn, Respiratory Insufficiency
Interventions
Inhaled Nitric Oxide, Standard iNO therapy
Drug
Lead sponsor
NICHD Neonatal Research Network
Network
Eligibility
Up to 14 Days
Enrollment
302 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2003
U.S. locations
18
States / cities
Birmingham, Alabama • Phoenix, Arizona • Palo Alto, California + 14 more
Source: ClinicalTrials.gov public record
Updated Sep 25, 2017 · Synced Sep 25, 2026, 7:39 AM EDT
Recruiting Not applicable Interventional

Dose Optimization Study of Acute Intermittent Hypoxia in Spinal Cord Injury

NCT07739992
View directory record Official record
Conditions
Spinal Cord Injuries (SCI)
Interventions
Sham AIH, Acute Intermittent Hypoxia (AIH) 15, Acute Intermittent Hypoxia (AIH) 23
Other
Lead sponsor
Milap Sandhu
Other
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Sep 25, 2026, 7:39 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Study of Erythromycin in GER-Associated Apnea of the Newborn

NCT01825473
View directory record Official record
Conditions
Gastroesophageal Reflux, Apnea, Bradycardia
Interventions
Erythromycin, Multi-channel intra-luminal impedance (MII) pH monitoring, Placebo (D5W)
Drug · Device
Lead sponsor
University of Virginia
Other
Eligibility
14 Days and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 4, 2013 · Synced Sep 25, 2026, 7:39 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Prolonged Hypoxic Breathing in Healthy Volunteers: a Safety Study

NCT02860975
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Inhaled Nitrogen
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 40 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 26, 2026 · Synced Sep 25, 2026, 7:39 AM EDT