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ClinicalTrials.gov public records Last synced May 22, 2026, 5:44 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 344 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Lower Extremity Injury Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
ACL Injury, Hip Injuries
Interventions
Physical Therapy, Monitored Work-out, Moxy Oxygen Sensor Device
Procedure · Device
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
14 Years to 30 Years
Enrollment
226 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
2
States / cities
Avon, Ohio • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced May 22, 2026, 5:44 AM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Amputation, Amputation, Traumatic, Amputation; Traumatic, Leg, Lower
Interventions
Compliant Adaptive Energy Storage and Return Foot, AllPro
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 26, 2024 · Synced May 22, 2026, 5:44 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Injury
Interventions
Narrative, Control
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 21, 2016 · Synced May 22, 2026, 5:44 AM EDT
Terminated Phase 3 Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Knee Injury
Interventions
Primary injury site, Backfill site
Other
Lead sponsor
RTI Surgical
Industry
Eligibility
18 Years to 55 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 3, 2014 · Synced May 22, 2026, 5:44 AM EDT
Completed Phase 3 Interventional
View directory record Official record
Conditions
Hip Fracture
Interventions
PLX-PAD, Placebo
Drug
Lead sponsor
Pluristem Ltd.
Industry
Eligibility
0 Years to 90 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
3
States / cities
Sacramento, California • Denver, Colorado • Indiana, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced May 22, 2026, 5:44 AM EDT
Terminated Not applicable Interventional Results available
View directory record Official record
Conditions
Wound
Interventions
Omnilux, Omnilux Sham
Device
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 90 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 22, 2019 · Synced May 22, 2026, 5:44 AM EDT
Completed Phase 2 Interventional
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury
Interventions
Anatomic Double-Bundle ACL Reconstruction, Anatomic Single-Bundle ACL Reconstruction
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
14 Years to 50 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 4, 2016 · Synced May 22, 2026, 5:44 AM EDT
Recruiting Early Phase 1 Interventional
View directory record Official record
Conditions
Spinal Cord Injuries, Spinal Cord Injury, Spinal Cord Injury Cervical, Spinal Cord Injury Thoracic
Interventions
Transcutaneous spinal stimulation at 100 Hz, Transcutaneous spinal stimulation at 50 Hz, Transcutaneous spinal stimulation at 50 Hz and single dose of baclofen, Transcutaneous spinal stimulation at 50 Hz and single dose of tizanidine, Sham transcutaneous spinal stimulation
Device · Combination Product
Lead sponsor
University of Mississippi Medical Center
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
2
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Jun 30, 2024 · Synced May 22, 2026, 5:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Occupational Injuries, Heat Stress, Leg Injury, Back Injuries
Interventions
Rapid Heat Condition, Gradual Heat Condition
Other
Lead sponsor
Louisiana State University Health Sciences Center Shreveport
Other
Eligibility
18 Years to 57 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Shreveport, Louisiana
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced May 22, 2026, 5:44 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Hip Fractures, Myocardial Injury
Interventions
Accelerated medical clearance and surgery
Other
Lead sponsor
Population Health Research Institute
Other
Eligibility
45 Years and older
Enrollment
1,100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
19
States / cities
Chandler, Arizona • Davis, California • New Haven, Connecticut + 15 more
Source: ClinicalTrials.gov public record
Updated Sep 30, 2025 · Synced May 22, 2026, 5:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Healthy, Lower Limb Injury, Post-Traumatic Osteoarthritis
Interventions
Carbon Fiber Custom Dynamic Orthosis (CDO)
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 65 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced May 22, 2026, 5:44 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Shin Splint, Running-related Injury
Interventions
In-Field Gait-Training, Home Exercise
Behavioral
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 45 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 17, 2022 · Synced May 22, 2026, 5:44 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Lower Extremity Injuries
Interventions
Visual Feedback
Other
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Iowa City, Iowa • Everett, Washington
Source: ClinicalTrials.gov public record
Updated Dec 30, 2025 · Synced May 22, 2026, 5:44 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Ankle Injury, Foot Injury, Lower Extremity Injury
Interventions
Mental Health App
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
13 Years to 18 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Oct 20, 2025 · Synced May 22, 2026, 5:44 AM EDT
Active, not recruiting Phase 3 Interventional
View directory record Official record
Conditions
Lower Limb or Combined Lower Limb and Upper Limb Spasticity Due to Stroke or Traumatic Brain Injury
Interventions
NT 201, Placebo
Drug
Lead sponsor
Merz Pharmaceuticals GmbH
Industry
Eligibility
18 Years to 85 Years
Enrollment
603 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
15
States / cities
Birmingham, Alabama • Little Rock, Arkansas • Downey, California + 11 more
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced May 22, 2026, 5:44 AM EDT
Not yet recruiting Phase 4 Interventional
View directory record Official record
Conditions
Fracture Arm, Fracture Closed of Lower End of Forearm, Unspecified, Fracture Elbow, Fracture Fixation, Fracture Fixation, Internal, Fracture Forearm, Fracture Distal Radius
Interventions
Lidocaine Infusion, Standard of Care (SOC)
Drug · Other
Lead sponsor
Nemours Children's Clinic
Other
Eligibility
3 Years to 18 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Wilmington, Delaware
Source: ClinicalTrials.gov public record
Updated Apr 26, 2026 · Synced May 22, 2026, 5:44 AM EDT
Recruiting Phase 2 Interventional
View directory record Official record
Conditions
Foot Injuries and Disorders, Ankle Injuries and Disorders, Achilles Tendon Injury
Interventions
medrol dosepak, HYDROcodone Oral Tablet
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years to 95 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Atlanta, Georgia • Johns Creek, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 8, 2026 · Synced May 22, 2026, 5:44 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Ankle Sprain, Ankle Injuries, Sprain
Interventions
proximal tibiofibular manipulation, distal tibiofibular manipulation, no intervention
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 50 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 23, 2010 · Synced May 22, 2026, 5:44 AM EDT
Active, not recruiting Not applicable Interventional
View directory record Official record
Conditions
Phantom Limb Pain, Phantom Pain, Phantom Sensation, Phantom Limb Syndrome With Pain, Phantom Pain Following Amputation of Lower Limb, Phantom Pain Following Amputation of Upper Limb, Amputation, Upper Limb Amputation at the Hand, Upper Limb Amputation at the Wrist, Upper Limb Amputation Below Elbow (Injury), Upper Limb Amputation Above Elbow (Injury), Lower Limb Amputation Knee, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury), Lower Limb Amputation at Ankle (Injury)
Interventions
Coapt Phantom Limb Pain Management System
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 13, 2025 · Synced May 22, 2026, 5:44 AM EDT
Completed No phase listed Observational
View directory record Official record
Conditions
Traumatic Amputation of Lower Extremity
Interventions
Not listed
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years to 60 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
10
States / cities
San Francisco, California • Tampa, Florida • Baltimore, Maryland + 7 more
Source: ClinicalTrials.gov public record
Updated Mar 23, 2021 · Synced May 22, 2026, 5:44 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Instability; Ankle (Ligaments) (Old Injury), Sprain of Ankle
Interventions
Uneven Treadmill Intervention, Standard of Care Physical Therapy
Other
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years to 49 Years
Enrollment
312 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Oceanside, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 17, 2025 · Synced May 22, 2026, 5:44 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Knee Pain, Hip Pain, Ankle Pain, Lumbopelvic Pain
Interventions
lumbosacral joint manipulation, lumbar passive range of motion, No active intervention
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 50 Years
Enrollment
106 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2009
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 23, 2010 · Synced May 22, 2026, 5:44 AM EDT
Completed No phase listed Observational Accepts healthy volunteers
View directory record Official record
Conditions
Strain of Muscle and/or Tendon of Lower Leg, Fracture of Lower Leg, Crushing Injury of Lower Leg, Fracture Malunion - Ankle and/ or Foot, Complete Tear, Ankle and/or Foot Ligament, Pathological Fracture - Ankle and/or Foot, Loose Body in Joint of Ankle and/or Foot
Interventions
Not listed
Lead sponsor
Jose Soberon, MD
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Oct 13, 2015 · Synced May 22, 2026, 5:44 AM EDT
Completed No phase listed Observational Accepts healthy volunteers
View directory record Official record
Conditions
Lower Extremity Musculoskeletal Injury
Interventions
Not listed
Lead sponsor
High Point University
Other
Eligibility
18 Years to 23 Years
Enrollment
359 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
High Point, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 2, 2015 · Synced May 22, 2026, 5:44 AM EDT