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ClinicalTrials.gov public records Last synced Nov 14, 2026, 9:29 PM EST

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Showing 1–24 of 181 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Lumbar Degenerative Disease Clear all

Conditions: Low Back Pain, Lumbosacral Radiculopathy, Lumbar Disc Degeneration, Lumbar Disc Herniation, Stenosis, Spondylolisthesis, Spondylolysis, Deformity of Spine
Interventions: Exparel, Bupivacaine; Drug
Lead sponsor: Virtua Health, Inc.; Other
Eligibility: 18 Years and older
Enrollment: 19 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Mount Holly, New Jersey

Conditions: Degenerative Disc Disease (DDD)
Interventions: FLD, Control; Device
Lead sponsor: AxioMed Spine Corporation; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2018
U.S. locations: 12
States / cities: Los Angeles, California • San Diego, California • Loveland, Colorado + 9 more

Conditions: Spondylolisthesis
Interventions: Not listed
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 171 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Conditions: Lumbar Degenerative Disc Disease
Interventions: In this evaluation, no interventions are performed. It is a data collection effort only. The "procedure" for this study is the data collection effort.; Other
Lead sponsor: Spineology, Inc; Industry
Eligibility: 21 Years to 80 Years
Enrollment: 197 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 10
States / cities: Fremont, California • Loma Linda, California • Napa, California + 7 more

Conditions: Spinal Diseases
Interventions: MAVERICK™ Disc, LT-CAGE® Lumbar Tapered Fusion Device and INFUSE® Bone Graft; Device
Lead sponsor: Medtronic Spinal and Biologics; Industry
Eligibility: 18 Years to 70 Years
Enrollment: 577 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2010
U.S. locations: 32
States / cities: Huntsville, Alabama • Daly City, California • Los Angeles, California + 29 more

Conditions: Degenerative Disc Disease, Spinal Stenosis, Spondylolisthesis, Scoliosis
Interventions: ALIF; Device
Lead sponsor: Camber Spine Technologies; Industry
Eligibility: 22 Years to 75 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 2
States / cities: Philadelphia, Pennsylvania • Plano, Texas

Conditions: Spondylosis, Cervical Spondylosis, Spondylolisthesis, Herniated Nucleus Pulposus, Degenerative Disc Disease
Interventions: ViBone; Other
Lead sponsor: Elutia Inc.; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 118 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 4
States / cities: San Diego, California • Danbury, Connecticut • Annapolis, Maryland + 1 more

Conditions: Degenerative Disc Disease, Spondylolisthesis, Spinal Stenosis Lumbar
Interventions: FIBERGRAFT BG Matrix; Device
Lead sponsor: Prosidyan, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 102 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2023
U.S. locations: 9
States / cities: Long Beach, California • Wellington, Florida • Paducah, Kentucky + 5 more

Conditions: Lumbar Degenerative Disc Disease, Lumbar Spinal Stenosis, Lumbar Spondylolisthesis, Lumbar Spinal Deformity, Lumbar Spondylosis
Interventions: Interbody cage (titanium), Interbody cage (PEEK); Device
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years and older
Enrollment: 53 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Degenerative Disc Disease
Interventions: ILIF; Procedure
Lead sponsor: NuVasive; Industry
Eligibility: 40 Years and older
Enrollment: 77 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2014
U.S. locations: 8
States / cities: Phoenix, Arizona • Santa Monica, California • Gainesville, Florida + 5 more

Conditions: Delirium, Lumbar Radiculopathy, Lumbar Osteoarthritis, Lumbar Spine Disc Degeneration
Interventions: Light sedation with propofol, Induction with propofol, Maintenance anesthetic using a volatile anesthetic, Muscle relaxant during maintenance anesthesia, Pain control with fentanyl, Bispectral Index (BIS) monitoring for depth of anesthesia, Spinal Anesthesia, Midazolam administered during spinal anesthesia, Cerebrospinal fluid collection, Administration of intrathecal morphine; Procedure
Lead sponsor: Johns Hopkins University; Other
Eligibility: 65 Years and older
Enrollment: 218 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Degenerative Lumbar Spinal Stenosis, Degenerative Disc Disease, Degenerative Spondylolisthesis, Degenerative Disease
Interventions: Ropivacaine, Epinephrine, Clonidine, and Ketorolac Injection Cocktail, Placebo; Drug · Other
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years to 88 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Degenerative Disc Disease (DDD)
Interventions: Lumbar Interbody Fusion Devices; Device
Lead sponsor: Spine and Scoliosis Research Associates; Other
Eligibility: 18 Years to 110 Years
Enrollment: 465 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 4
States / cities: San Francisco, California • New York, New York • Charlotte, North Carolina + 1 more

Conditions: Low Back Pain, Herniation, Disc, Sciatic Radiculopathy, Intervertebral Disc Stenosis of Neural Canal, Intervertebral Disc Injury
Interventions: NSSD, Sham NSSD; Device
Lead sponsor: University of South Florida; Other
Eligibility: 18 Years to 65 Years
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: Stanford, California • Tampa, Florida

Conditions: Degenerative Disc Disease
Interventions: Rexlemestrocel-L, Rexlemestrocel-L + HA Mixture, Placebo; Drug
Lead sponsor: Mesoblast, Ltd.; Industry
Eligibility: 18 Years and older
Enrollment: 404 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2021
U.S. locations: 47
States / cities: Birmingham, Alabama • Huntsville, Alabama • Scottsdale, Arizona + 42 more

Conditions: Degenerative Spine Disease
Interventions: FIBERGRAFT™ Aeridyan Matrix Bone Graft Substitute, Demineralized Bone Matrix; Device
Lead sponsor: DePuy Synthes Products, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 316 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 5
States / cities: Sacramento, California • Chicago, Illinois • Lexington, Kentucky + 2 more

Conditions: Disc Degeneration
Interventions: MSC Treatment group 1 (low dose), MSC Treatment group 2 (high dose), Healthy Control (no treatment); Drug · Other
Lead sponsor: University Hospitals Cleveland Medical Center; Other
Eligibility: 18 Years to 80 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Lumbar Degenerative Disc Disease
Interventions: SB-01 For Injection, Sham Needle; Drug
Lead sponsor: Spine BioPharma, Inc; Industry
Eligibility: 18 Years and older
Enrollment: 417 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 30
States / cities: Birmingham, Alabama • Phoenix, Arizona • Napa, California + 24 more

Conditions: Spinal Degenerative Disorder
Interventions: Physical activity intervention, Usual care; Behavioral · Other
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Degenerative Disc Disease Lumbar, Spondylolisthesis, Grade 1
Interventions: Device: EVOS Lumbar Interbody System (EVOS-HA); Device
Lead sponsor: Invibio Ltd; Industry
Eligibility: 18 Years and older
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 2
States / cities: Charlotte, North Carolina • Philadelphia, Pennsylvania

Conditions: Degenerative Disc Disease
Interventions: INDEPENDENCE; Device
Lead sponsor: Globus Medical Inc; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: Temple, Texas

Conditions: Degenerative Disc Disease, Spondylolisthesis
Interventions: Prefix (AMPLEX) B2A Peptide Enhanced Ceramic Granules, Iliac crest autograft; Device · Other
Lead sponsor: BioSurface Engineering Technologies, Inc; Industry
Eligibility: 18 Years to 70 Years
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 6
States / cities: Durango, Colorado • Washington D.C., District of Columbia • Kansas City, Kansas + 3 more

Conditions: Lumbar Degenerative Disc Disease
Interventions: DIAM™ Spinal Stabilization System, Conservative care; Device · Procedure
Lead sponsor: Medtronic Spinal and Biologics; Industry
Eligibility: 18 Years to 70 Years
Enrollment: 311 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2018
U.S. locations: 29
States / cities: Scottsdale, Arizona • Beverly Hills, California • Los Angeles, California + 26 more

Conditions: Lumbar Degenerative Disc Disease
Interventions: PureGen Osteoprogenitor Cell Allograft; Biological
Lead sponsor: Alphatec Spine, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2011
U.S. locations: 3
States / cities: Beverly Hills, California • Middleton, Connecticut • Greensboro, North Carolina

Search by objective public record fields.

A Prospective Study to Compare Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Pain Relief

Freedom Lumbar Disc in the Treatment of Lumbar Degenerative Disc Disease

Validation of Appropriateness Criteria for the Surgical Treatment of Lumbar Degenerative Spondylolisthesis

Rampart Duo Clinical (RaDical) Post-Market Study

MAVERICK™ Total Disc Replacement- Pivotal Study

SPIRA™-A 3D and HCT/p DBM vs. Medtronic Divergent™-L/Perimeter™ and Recombinant BMP-2

ViBone in Cervical and Lumbar Spine Fusion

Prospective, Multi-center Study to Assess Posterolateral Fusion Using FIBERGRAFT

Lumbar Fusion With Nexxt Spine 3D-Printed Titanium Interbody Cages

An Evaluation of Interlaminar Lumbar Instrumented (ILIF™)

Shaping Anesthetic Techniques to Reduce Post-operative Delirium

Effect of RECK in Posterior Spinal Fusion

Retro Comparison of Subsidence Following Interbody Devices in Lumbar Spine

Non-surgical Spinal Decompression Therapy and Outcomes

Placebo-controlled Study to Evaluate Rexlemestrocel-L Alone or Combined With Hyaluronic Acid in Participants With Chronic Low Back Pain

FIBERGRAFT Aeridyan Posterolateral Fusion Study

Mesenchymal Stem Cells for Lumbar Degenerative Disc Disease

Moderate - Severe Degenerative Disc Disease Evaluation of the Lumbar Spine

Telehealth Activity Intervention After Lumbar Spine Surgery

A Clinical Study to Evaluate Safety and Performance of PEEK-OPTIMA™ HA Enhanced Interbody Cages in the Lumbar Spine

INDEPENDENCE Spacer for Lumbar Fusion

Pilot Study to Assess Safety/Preliminary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery

Study of the Safety and Effectiveness of DIAM™ Spinal Stabilization System Versus Conservative Care

Radiographic and Clinical Outcomes of PureGen in Posterior Lumbar (PLIF) and Transforaminal Interbody Fusion (TLIF)