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Showing 1–24 of 31 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Lumbosacral Radiculopathy Clear all
Not listed Not applicable Interventional

MORE in the Management of Lumbosacral Radiculopathy Symptoms: A Randomized Controlled Trial

NCT04818606
View directory record Official record
Conditions
Lumbar Radiculopathy
Interventions
Mindfulness Oriented Recovery Enhancement
Other
Lead sponsor
National University of Natural Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 25, 2021 · Synced Jul 21, 2026, 9:51 AM EDT
Enrolling by invitation No phase listed Observational

Qutenza 8% Capsaicin Topical System for the Treatment of Neuropathic Axial Lower Back Pain and Lumbosacral Radiculopathy

NCT06540456
View directory record Official record
Conditions
Lower Back Pain, Lumbosacral Radiculopathy
Interventions
Qutenza® 8% Capsaicin Topical System
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Summerville, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Jul 21, 2026, 9:51 AM EDT
Completed Not applicable Interventional

Does Magnetic Resonance Imaging (MRI) Improve Interventional Outcomes for Lumbosacral Radiculopathy?

NCT00826124
View directory record Official record
Conditions
Lumbosacral Radiculopathy
Interventions
Epidural steroid injection, Magnetic Resonance Imaging (MRI)
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 22, 2011 · Synced Jul 21, 2026, 9:51 AM EDT
Terminated Not applicable Interventional

Platelet Lysate vs Saline for Lumbosacral Radiculopathy

NCT06924853
View directory record Official record
Conditions
Lumbosacral Radiculopathy, Lumbar Radiculopathy
Interventions
Platelet lysate, Saline control
Other
Lead sponsor
Regenexx, LLC
Industry
Eligibility
18 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Broomfield, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Jul 21, 2026, 9:51 AM EDT
Completed Not applicable Interventional

Two Different Approaches During Fluoroscopically Guided Interlaminar Lumbar Epidural Steroid Injection

NCT01760317
View directory record Official record
Conditions
Unilateral Lumbosacral Radiculopathy Pain
Interventions
Midline vs Parasagittal Lumbar Epidural Steroid Injection
Procedure
Lead sponsor
Kenneth D Candido
Other
Eligibility
18 Years to 80 Years
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 4, 2015 · Synced Jul 21, 2026, 9:51 AM EDT
Terminated Phase 3 Interventional Results available

INFUSE®Bone Graft in Transforaminal Lumbar Interbody Fusion for Degenerative Disease of Lumbosacral Spine

NCT01415908
View directory record Official record
Conditions
Lumbar Spine Degeneration
Interventions
INFUSE Bone Graft, Iliac Crest Bone Graft
Device · Other
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
5
States / cities
Mesa, Arizona • Los Angeles, California • Gulf Breeze, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 17, 2016 · Synced Jul 21, 2026, 9:51 AM EDT
Not listed Phase 2 Interventional

Study of REN-1654 in Patients With Sciatica Pain

NCT00107055
View directory record Official record
Conditions
Sciatica, Herniated Disc, Radiculopathy
Interventions
REN-1654
Drug
Lead sponsor
Renovis
Industry
Eligibility
18 Years to 55 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
19
States / cities
Birmingham, Alabama • Tuscon, Arizona • Stanford, California + 15 more
Source: ClinicalTrials.gov public record
Updated Jun 23, 2005 · Synced Jul 21, 2026, 9:51 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

A Prospective Study to Compare Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Pain Relief

NCT03514277
View directory record Official record
Conditions
Low Back Pain, Lumbosacral Radiculopathy, Lumbar Disc Degeneration, Lumbar Disc Herniation, Stenosis, Spondylolisthesis, Spondylolysis, Deformity of Spine
Interventions
Exparel, Bupivacaine
Drug
Lead sponsor
Virtua Health, Inc.
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Mount Holly, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 5, 2021 · Synced Jul 21, 2026, 9:51 AM EDT
Completed Phase 3 Interventional

Treatment of Pain Associated With Lumbosacral Radiculopathy in Adults

NCT03727100
View directory record Official record
Conditions
Lumbosacral Radiculopathy
Interventions
Clonidine Micropellets, Sham
Combination Product · Other
Lead sponsor
Sollis Therapeutics, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
207 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
33
States / cities
Mobile, Alabama • Phoenix, Arizona • Scottsdale, Arizona + 28 more
Source: ClinicalTrials.gov public record
Updated Oct 5, 2023 · Synced Jul 21, 2026, 9:51 AM EDT
Recruiting Not applicable Interventional

Procedural Framing and Epidural Steroid Injection Outcomes

NCT07498140
View directory record Official record
Conditions
Lumbosacral Radiculopathy
Interventions
Behavioral manipulation of ESI expectations, No behavioral manipulation of ESI expectations, No behavioral manipulation of pharmacotherapy expectations
Behavioral · Other
Lead sponsor
Northwestern University
Other
Eligibility
Not listed
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Chicago, Illinois • Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Jul 21, 2026, 9:51 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Ibuprofen With or Without Dexamethasone for Acute Radicular Low Back Pain.

NCT05721027
View directory record Official record
Conditions
Radiculopathy, Lumbosacral Region, Back Pain With Radiation, Low Back Pain
Interventions
Ibuprofen 400 mg, Dexamethasone Oral, Educational Intervention
Drug · Behavioral
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years to 70 Years
Enrollment
132 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
2
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jul 21, 2026, 9:51 AM EDT
Recruiting Not applicable Interventional

Impact of Direct Current Electrical Stimulation on Treatment of Lumbosacral Radiculopathy

NCT06421558
View directory record Official record
Conditions
Radiculopathy Lumbar, Radiculopathy Sacral, Radiculopathy Multiple Sites
Interventions
Neubie Direct Current Electrical Stimulation Device, Transcutaneous Electrical Stimulation
Device
Lead sponsor
NeuFit - Neurological Fitness and Education
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
16
States / cities
Escondido, California • Cape Coral, Florida • Clearwater, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated Jul 28, 2024 · Synced Jul 21, 2026, 9:51 AM EDT
Completed Phase 1Phase 2 Interventional

Single Ascending Doses Study of KLS-2031 in Subjects With Neuropathic Pain From Lumbosacral Radiculopathy

NCT04238793
View directory record Official record
Conditions
Neuropathic Pain From Lumbosacral Radiculopathy
Interventions
KLS-2031, Placebo
Drug · Other
Lead sponsor
Kolon Life Science
Industry
Eligibility
18 Years to 75 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 28, 2024 · Synced Jul 21, 2026, 9:51 AM EDT
Completed Phase 3 Interventional Results available

Corticosteroid Lumbar Epidural Analgesia for Radiculopathy

NCT03372161
View directory record Official record
Conditions
Lumbosacral Radicular Pain
Interventions
SP-102, Placebo
Drug
Lead sponsor
Scilex Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
401 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
37
States / cities
Mobile, Alabama • Phoenix, Arizona • Tempe, Arizona + 30 more
Source: ClinicalTrials.gov public record
Updated Sep 18, 2022 · Synced Jul 21, 2026, 9:51 AM EDT
Completed No phase listed Observational

Long-Term Follow-up Safety of Clonidine Micropellets

NCT03776318
View directory record Official record
Conditions
Lumbosacral Radiculopathy
Interventions
Long-Term Safety Follow-up
Drug
Lead sponsor
Sollis Therapeutics, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
25
States / cities
Mobile, Alabama • Phoenix, Arizona • Tucson, Arizona + 21 more
Source: ClinicalTrials.gov public record
Updated Oct 5, 2023 · Synced Jul 21, 2026, 9:51 AM EDT
Completed Phase 2 Interventional

Evaluation of Efficacy and Safety of VX-548 for Painful Lumbosacral Radiculopathy (PLSR)

NCT06176196
View directory record Official record
Conditions
Painful Lumbosacral Radiculopathy
Interventions
VX-548, Placebo
Drug
Lead sponsor
Vertex Pharmaceuticals Incorporated
Industry
Eligibility
18 Years to 70 Years
Enrollment
218 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
54
States / cities
Phoenix, Arizona • Bakersfield, California • Banning, California + 48 more
Source: ClinicalTrials.gov public record
Updated Sep 30, 2025 · Synced Jul 21, 2026, 9:51 AM EDT
Completed Phase 2 Interventional

A Study of the Pharmacokinetics, Safety, and Preliminary Efficacy of MDT-15 in Subjects With Lumbosacral Radiculopathy

NCT01917825
View directory record Official record
Conditions
Sciatica, Lumbosacral Radiculopathy
Interventions
MDT-15
Drug
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
6
States / cities
Fort Lauderdale, Florida • Bloomington, Illinois • Carmel, Indiana + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 19, 2017 · Synced Jul 21, 2026, 9:51 AM EDT
Completed Not applicable Interventional

Chronic Lumbosacral Radiculopathy: Impact of an Analgesic Dietary Intervention on Pain & Function

NCT02531711
View directory record Official record
Conditions
Pain
Interventions
Diet A, Diet B
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 7, 2020 · Synced Jul 21, 2026, 9:51 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Soleus H-Reflex in Different Sitting Postures

NCT01744899
View directory record Official record
Conditions
Compression of Spinal Nerve Root, Spinal Disorder, Low Back Pain
Interventions
Sitting posture
Other
Lead sponsor
Texas Woman's University
Other
Eligibility
18 Years to 50 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 6, 2012 · Synced Jul 21, 2026, 9:51 AM EDT
Terminated Phase 3 Interventional

Sciatica Epidural Radiculopathy Experimental New Interventional TherapY Clonidine Micropellet

NCT05614648
View directory record Official record
Conditions
Lumbosacral Radiculopathy
Interventions
Clonidine Micropellets, Tuohy epidural needle
Drug · Device
Lead sponsor
Sollis Therapeutics, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
30
States / cities
Tucson, Arizona • La Jolla, California • Napa, California + 22 more
Source: ClinicalTrials.gov public record
Updated Apr 24, 2024 · Synced Jul 21, 2026, 9:51 AM EDT
Recruiting Not applicable Interventional

A Multicomponent Intervention for Patients With Lumbosacral Radiculopathy: Move-MORE

NCT07125027
View directory record Official record
Conditions
Lumbosacral Radiculopathy, Sciatica, Chronic Low Back Pain With a Neuropathic Component, Radiculopathy Lumbar, Chronic Pain (Back / Neck)
Interventions
Move-MORE
Behavioral
Lead sponsor
National University of Natural Medicine
Other
Eligibility
18 Years to 66 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 11, 2025 · Synced Jul 21, 2026, 9:51 AM EDT
Completed Not applicable Interventional Results available

Steroids Versus Gabapentin

NCT01495923
View directory record Official record
Conditions
Sciatica, Radiculopathy
Interventions
epidural steroid injection, Sham epidural steroid injection, Gabapentin, Placebo gabapentin
Procedure · Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
17 Years to 100 Years
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
3
States / cities
San Diego, California • Baltimore, Maryland • Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 10, 2017 · Synced Jul 21, 2026, 9:51 AM EDT
Terminated No phase listed Observational

Epidural Contrast Flow Patterns of TESI Using the Inferior-Anterior Position as the Final Needle Tip Position.

NCT01836770
View directory record Official record
Conditions
Lumbosacral Radiculopathy, Lumbar Herniated Nucleus Pulposus
Interventions
Not listed
Lead sponsor
George Washington University
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Mar 4, 2018 · Synced Jul 21, 2026, 9:51 AM EDT
Active, not recruiting No phase listed Observational

A Long-term, 3-Year, Follow-up Study for Patients Completing the KS-GIG-001-01 Study

NCT05613569
View directory record Official record
Conditions
Lumbosacral Radiculopathy
Interventions
KLS-2031
Drug
Lead sponsor
Kolon Life Science
Industry
Eligibility
Not listed
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 7, 2024 · Synced Jul 21, 2026, 9:51 AM EDT