- Conditions
- Bipolar II Disorder, Bipolar II Disorder, Most Recent Episode Major Depressive
- Interventions
- Device: Stimulation-ON, Device: Stimulation-OFF, Device: Stimulation -ON Active Control
- Device
- Lead sponsor
- Andrew Krystal
- Other
- Eligibility
- 22 Years to 70 Years
- Enrollment
- 10 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2035
- U.S. locations
- 1
- States / cities
- San Francisco, California
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Showing 1–24
of 91
matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
- Conditions
- Major Depressive Disorders
- Interventions
- amibegron (SR58611A), placebo, paroxetine
- Drug
- Lead sponsor
- Sanofi
- Industry
- Eligibility
- 18 Years to 65 Years
- Enrollment
- 306 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2003 – 2004
- U.S. locations
- 1
- States / cities
- Bridgewater, New Jersey
- Conditions
- Depression
- Interventions
- Pramipexole (Mirapex), Placebo
- Drug
- Lead sponsor
- Massachusetts General Hospital
- Other
- Eligibility
- 18 Years to 75 Years
- Enrollment
- 65 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2003 – 2008
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- Bipolar Disorder
- Interventions
- Aripiprazole, Placebo
- Drug
- Lead sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
- Industry
- Eligibility
- 18 Years to 65 Years
- Timeline
- 2006 – 2007
- U.S. locations
- 1
- States / cities
- Durham, North Carolina
- Conditions
- Major Depressive Episode, Bipolar Depression, Bipolar Disorder, Mood Disorders
- Interventions
- NEST (NeoSync EEG Synchronized TMS)
- Device
- Lead sponsor
- Butler Hospital
- Other
- Eligibility
- 18 Years to 70 Years
- Enrollment
- 6 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2016 – 2018
- U.S. locations
- 1
- States / cities
- Providence, Rhode Island
- Conditions
- Major Depressive Disorder
- Interventions
- Rapastinel (225 mg/450 mg IV administration)
- Drug
- Lead sponsor
- Naurex, Inc, an affiliate of Allergan plc
- Industry
- Eligibility
- 18 Years to 75 Years
- Enrollment
- 61 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2014 – 2018
- U.S. locations
- 10
- States / cities
- Birmingham, Alabama • San Diego, California • Chicago, Illinois + 7 more
- Conditions
- Bipolar Depression
- Interventions
- Lumateperone (ITI-007), Placebo
- Drug
- Lead sponsor
- Intra-Cellular Therapies, Inc.
- Industry
- Eligibility
- 18 Years to 75 Years
- Enrollment
- 529 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2016 – 2020
- U.S. locations
- 42
- States / cities
- Rogers, Arkansas • Cerritos, California • Costa Mesa, California + 39 more
- Conditions
- Major Depressive Disorder
- Interventions
- Not listed
- Lead sponsor
- Cyberonics, Inc.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 795 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2006 – 2015
- U.S. locations
- 55
- States / cities
- Tucson, Arizona • Beverly Hills, California • Garden Grove, California + 46 more
- Conditions
- Depressive Episode, Depression, Depressive Disorder, Depressive Disorder, Major, Depression Mild
- Interventions
- MEB-001
- Device
- Lead sponsor
- Medibio Limited
- Industry
- Eligibility
- 22 Years to 75 Years
- Enrollment
- 715 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022 – 2024
- U.S. locations
- 13
- States / cities
- Bradenton, Florida • Blaine, Minnesota • Plymouth, Minnesota + 10 more
- Conditions
- Major Depressive Episode
- Interventions
- Diadem prototype
- Device
- Lead sponsor
- University of Utah
- Other
- Eligibility
- 18 Years to 65 Years
- Enrollment
- 20 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022 – 2024
- U.S. locations
- 1
- States / cities
- Salt Lake City, Utah
- Conditions
- Major Depressive Episode
- Interventions
- Frontoparietal Ultrabrief Right Unilateral (UBRUL-FP) electroconvulsive therapy, Temporoparietal Ultrabrief Right Unilateral (UBRUL-TP) electroconvulsive therapy
- Procedure
- Lead sponsor
- The George Institute
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 156 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2026
- U.S. locations
- 3
- States / cities
- Atlanta, Georgia • Augusta, Georgia • Charleston, South Carolina
- Conditions
- Major Depressive Disorder
- Interventions
- GLYX-13 5 mg/kg, GLYX-13 10 mg/kg, Placebo
- Drug
- Lead sponsor
- Naurex, Inc, an affiliate of Allergan plc
- Industry
- Eligibility
- 18 Years to 75 Years
- Enrollment
- 369 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2012 – 2014
- U.S. locations
- 26
- States / cities
- Birmingham, Alabama • Encino, California • Los Alamitos, California + 21 more
- Conditions
- Bipolar Disorder I or II With a Major Depressive Episode
- Interventions
- ALTO-100, Placebo
- Drug
- Lead sponsor
- Alto Neuroscience
- Industry
- Eligibility
- 18 Years to 70 Years
- Enrollment
- 200 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2024 – 2026
- U.S. locations
- 27
- States / cities
- Chandler, Arizona • Phoenix, Arizona • Yuma, Arizona + 22 more
- Conditions
- Major Depression, Depressive Episodes
- Interventions
- CATCH-IT
- Behavioral
- Lead sponsor
- Benjamin Van Voorhees, MD, MPH
- Other
- Eligibility
- 13 Years to 18 Years
- Enrollment
- 1,142 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2012 – 2016
- U.S. locations
- 7
- States / cities
- Chicago, Illinois • Evanston, Illinois • Oak Lawn, Illinois + 3 more
- Conditions
- Major Depressive Disorder
- Interventions
- GLYX-13
- Drug
- Lead sponsor
- Naurex, Inc, an affiliate of Allergan plc
- Industry
- Eligibility
- 18 Years to 65 Years
- Enrollment
- 115 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2011 – 2012
- U.S. locations
- 1
- States / cities
- Evanston, Illinois
- Conditions
- Major Depressive Episode
- Interventions
- Text Messaging Intervention
- Other
- Lead sponsor
- University of Massachusetts, Worcester
- Other
- Eligibility
- 16 Years to 45 Years · Female only
- Enrollment
- 40 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2024 – 2025
- U.S. locations
- 1
- States / cities
- Worcester, Massachusetts
- Conditions
- Bipolar Disorder, Bipolar I Depression, Bipolar II Depression, Bipolar Depression, Depression, Major Depressive Episode
- Interventions
- Lithium
- Drug
- Lead sponsor
- Brigham and Women's Hospital
- Other
- Eligibility
- 18 Years to 60 Years
- Enrollment
- 81 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2017 – 2025
- U.S. locations
- 1
- States / cities
- Cleveland, Ohio
- Conditions
- Depressive Disorder, Major, Borderline Personality Disorder
- Interventions
- Left Dorsolateral Prefrontal Cortex (L-DLPFC), Dorsomedial Prefrontal Cortex (DMPFC), Sham Stimulation
- Device
- Lead sponsor
- Stanford University
- Other
- Eligibility
- 18 Years to 80 Years
- Enrollment
- 45 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2021 – 2026
- U.S. locations
- 1
- States / cities
- Stanford, California
- Conditions
- Major Depressive Disorder, Suicidal Ideation
- Interventions
- paliperidone, lithium, Placebo
- Drug
- Lead sponsor
- University of Alabama at Birmingham
- Other
- Eligibility
- 19 Years to 65 Years
- Enrollment
- 54 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2010 – 2014
- U.S. locations
- 1
- States / cities
- Birmingham, Alabama
- Conditions
- Major Depressive Disorder
- Interventions
- Sham TMS + Cognitive therapy, Active TMS + Cognitive therapy
- Device
- Lead sponsor
- National Institute of Mental Health (NIMH)
- NIH
- Eligibility
- 18 Years to 75 Years
- Enrollment
- 32 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2018 – 2025
- U.S. locations
- 1
- States / cities
- Bethesda, Maryland
- Conditions
- Bipolar Depression, Major Depressive Disorder
- Interventions
- Lumateperone, Placebos
- Drug
- Lead sponsor
- Intra-Cellular Therapies, Inc.
- Industry
- Eligibility
- 18 Years to 75 Years
- Enrollment
- 488 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2022
- U.S. locations
- 13
- States / cities
- Garden Grove, California • Oceanside, California • Sherman Oaks, California + 10 more
- Conditions
- Major Depressive Disorder
- Interventions
- L-methylfolate, Selective serotonin reuptake inhibitor (SSRI), Serotonin and norepinephrine reuptake inhibitor (SNRI)
- Drug
- Lead sponsor
- Pamlab, Inc.
- Industry
- Eligibility
- 18 Years to 70 Years
- Enrollment
- 242 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2009 – 2011
- U.S. locations
- 1
- States / cities
- Houston, Texas
- Conditions
- Depressive Disorder, Major, Unipolar Depression
- Interventions
- Deep Brain Stimulation, Libra Deep Brain Stimulation System
- Device
- Lead sponsor
- Abbott Medical Devices
- Industry
- Eligibility
- 21 Years to 70 Years
- Enrollment
- 125 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2008 – 2015
- U.S. locations
- 11
- States / cities
- Stanford, California • Chicago, Illinois • Worcester, Massachusetts + 8 more
- Conditions
- Bipolar I Disorder
- Interventions
- LB-102, Placebo
- Drug · Other
- Lead sponsor
- LB Pharmaceuticals Inc.
- Industry
- Eligibility
- 18 Years to 65 Years
- Enrollment
- 320 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2028
- U.S. locations
- 26
- States / cities
- Bentonville, Arkansas • Little Rock, Arkansas • Bellflower, California + 23 more