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Showing 1–24 of 136 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Middle Aged Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Almonds on Immune Strength and Response to Flu Vaccination in Overweight Older Men and Postmenopausal Women: A Randomized Controlled Study

NCT05031663
View directory record Official record
Conditions
Immune Response, Inflammation
Interventions
Almond group, Control Group
Dietary Supplement
Lead sponsor
Loma Linda University
Other
Eligibility
40 Years to 70 Years
Enrollment
61 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Dec 8, 2025 · Synced Jul 21, 2026, 11:56 AM EDT
Completed Not applicable Interventional Results available

Pain Control After Cardiac Surgery Using Intravenous Acetaminophen

NCT01822821
View directory record Official record
Conditions
Pain
Interventions
IV Acetaminophen, Placebo
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 14, 2017 · Synced Jul 21, 2026, 11:56 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Improving Exercise Adherence With App Technology for At-Risk Adults Living in Rural Kansas and Nebraska

NCT07171255
View directory record Official record
Conditions
Sedentary Middle Age and Older Aged Adults
Interventions
RemoteEx+ Programming
Behavioral
Lead sponsor
Creighton University
Other
Eligibility
40 Years to 85 Years
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
2
States / cities
Emporia, Kansas • Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 11, 2025 · Synced Jul 21, 2026, 11:56 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Hemodynamic Study of Avanafil and Two α-Adrenergic Blockers,Doxazosin and Tamsulosin

NCT01100021
View directory record Official record
Conditions
Erectile Dysfunction
Interventions
Tamsulosin and avanafil, Doxazosin and avanafil
Drug
Lead sponsor
VIVUS LLC
Industry
Eligibility
40 Years to 65 Years · Male only
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Tempe, Arizona
Source: ClinicalTrials.gov public record
Updated Jan 6, 2011 · Synced Jul 21, 2026, 11:56 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Influence of Honey-flavored Yogurt on Low-grade Inflammation and Gut Health in Middle to Older Aged Women.

NCT04248127
View directory record Official record
Conditions
Overweight
Interventions
Honey sweetened yogurt, Sugar sweetened yogurt
Other
Lead sponsor
University of California, Davis
Other
Eligibility
45 Years to 65 Years · Female only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Jul 21, 2026, 11:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Weight Loss and Cognitive Function in Adults

NCT03685305
View directory record Official record
Conditions
Overweight and Obesity
Interventions
Hypocaloric diet with hunger reduction strategy, Hypocaloric diet without hunger reduction strategy
Behavioral
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
50 Years to 75 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Blacksburg, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 20, 2025 · Synced Jul 21, 2026, 11:56 AM EDT
Completed Not applicable Interventional Results available

A Study of the Safety and Effectiveness of JUVÉDERM VOLUMA® XC Injectable Gel for Cheek Augmentation Using Cannula

NCT03438266
View directory record Official record
Conditions
Age-related Volume Deficit in the Mid-face
Interventions
JUVÉDERM VOLUMA® XC injectable gel with cannula, JUVÉDERM VOLUMA® XC injectable gel with needle
Device
Lead sponsor
Allergan
Industry
Eligibility
35 Years to 65 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
7
States / cities
Los Angeles, California • Solana Beach, California • Miami, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 4, 2019 · Synced Jul 21, 2026, 11:56 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

[C-11]PiB PET Imaging in Alcohol Use Disorders

NCT03746366
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
[C-11], Pittsburgh Compound B
Radiation · Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
40 Years to 65 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 12, 2024 · Synced Jul 21, 2026, 11:56 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Assessing Urinary Hormones in Female Cancer Survivors

NCT03197532
View directory record Official record
Conditions
Effects of Chemotherapy
Interventions
Not listed
Lead sponsor
University of Pennsylvania
Other
Eligibility
20 Years to 50 Years · Female only
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2016
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 19, 2020 · Synced Jul 21, 2026, 11:56 AM EDT
Completed Not applicable Interventional

Escoge Salud (Choose Health): a Chronic Pain Self-Management Program in Middle to Older Age Hispanic Americans

NCT04554576
View directory record Official record
Conditions
Chronic Pain
Interventions
Chronic Disease Self-Management Program (CDSMP) for chronic pain in Spanish, Remote feedback active group, Remote feedback control group
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
40 Years to 80 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 30, 2022 · Synced Jul 21, 2026, 11:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Brief App-based Mobile Health and Well-being Intervention Among Middle-aged Adults

NCT04272138
View directory record Official record
Conditions
Meditation, Control Group
Interventions
Calm Meditation, Educational Podcast Control
Behavioral
Lead sponsor
Arizona State University
Other
Eligibility
40 Years to 64 Years
Enrollment
83 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Feb 27, 2022 · Synced Jul 21, 2026, 11:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cognitive Regulation Training and Exercise Trial

NCT03124667
View directory record Official record
Conditions
Patient Compliance
Interventions
Games, Videos
Behavioral
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
35 Years to 64 Years
Enrollment
233 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 9, 2020 · Synced Jul 21, 2026, 11:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

aeRobic Exercise and Cognitive Health

NCT02384993
View directory record Official record
Conditions
Alzheimer's Disease, Aging
Interventions
Enhanced Physical Activity
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
45 Years to 80 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 17, 2024 · Synced Jul 21, 2026, 11:56 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Safety & Efficacy of Nicotinamide Riboside Supplementation for Improving Physiological Function in Middle-Aged and Older Adults

NCT02921659
View directory record Official record
Conditions
Aging
Interventions
Niagen™, Placebo
Dietary Supplement
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
55 Years to 79 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Nov 30, 2016 · Synced Jul 21, 2026, 11:56 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Photobiomodulation & Ketogenic Diet for Treatment of Mid-periphery Retinal Disorders for Alzheimer's Disease Prevention

NCT03859245
View directory record Official record
Conditions
Diabetic Retinopathy (DR), Age-related Macular Degeneration (AMD), Mid-peripheral Drusen Formation, Diabetic Macular Edema (DME)
Interventions
Photobiomodulation, Ketogenic diet
Behavioral
Lead sponsor
Bristlecone Health, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Eagan, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 3, 2019 · Synced Jul 21, 2026, 11:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of a Sleep Debt in Middle-Aged and Older Adults

NCT00817700
View directory record Official record
Conditions
Sleep Restriction
Interventions
Sleep restriction
Other
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 75 Years
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 10, 2017 · Synced Jul 21, 2026, 11:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Assessing Balance Changes Following an Exercise Program Among Middle-Aged Adults

NCT03161236
View directory record Official record
Conditions
Balance Changes
Interventions
home exercise program, non exercise program
Other
Lead sponsor
Loma Linda University
Other
Eligibility
45 Years to 64 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jul 9, 2019 · Synced Jul 21, 2026, 11:56 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

The Miami Heart Study at Baptist Health South Florida

NCT02508454
View directory record Official record
Conditions
Cardiovascular Disease
Interventions
Not listed
Lead sponsor
Baptist Health South Florida
Other
Eligibility
40 Years to 65 Years
Enrollment
4,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2028
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 26, 2026 · Synced Jul 21, 2026, 11:56 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

The Effect of 3 Probiotic Strains on Bile Acids, Satiety, and Inflammation

NCT01879098
View directory record Official record
Conditions
Healthy
Interventions
Probiotic: Bacillus subtilis, Lactobacillus plantarum, Bifidobacterium animalis, Placebo
Dietary Supplement
Lead sponsor
University of Florida
Other
Eligibility
35 Years to 65 Years
Enrollment
155 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 9, 2014 · Synced Jul 21, 2026, 11:56 AM EDT
Completed Phase 2Phase 3 Interventional

Meru Health Ascend Mobile Intervention for Depression in Middle Aged and Older Adults

NCT03652948
View directory record Official record
Conditions
Depression, Depressive Symptoms
Interventions
Meru Health Ascend Program
Behavioral
Lead sponsor
Palo Alto Veterans Institute for Research
Other
Eligibility
40 Years to 120 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Mar 9, 2021 · Synced Jul 21, 2026, 11:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Citicoline, Creatine, and Omega-3 Effects in Middle Age Women

NCT01502813
View directory record Official record
Conditions
Cognitive Benefits
Interventions
Citicoline, Omega-3 Fatty Acids and Creatine
Drug
Lead sponsor
Deborah Yurgelun-Todd
Other
Eligibility
40 Years to 60 Years · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2019
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 21, 2021 · Synced Jul 21, 2026, 11:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Microgreen Consumption for Healthy Aging

NCT04239898
View directory record Official record
Conditions
Aging, Menopause, Healthy
Interventions
Red cabbage microgreens, Red beet microgreens
Other
Lead sponsor
Colorado State University
Other
Eligibility
45 Years to 70 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Fort Collins, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Jul 21, 2026, 11:56 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

B-Fit Intervention to Improve Brain Health

NCT03454074
View directory record Official record
Conditions
Health Behavior, Aging
Interventions
Problem-solving, Education
Behavioral
Lead sponsor
Washington State University
Other
Eligibility
40 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Pullman, Washington
Source: ClinicalTrials.gov public record
Updated Oct 8, 2018 · Synced Jul 21, 2026, 11:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Coconut Sugar Lowers Blood Pressure and Arterial Stiffness in Middle-aged and Older Adults

NCT05645991
View directory record Official record
Conditions
Aging, Blood Pressure, Arterial Stiffness
Interventions
Coconut Sap Powder (CSP), Placebo
Dietary Supplement
Lead sponsor
Ball State University
Other
Eligibility
40 Years to 80 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Muncie, Indiana
Source: ClinicalTrials.gov public record
Updated Dec 11, 2022 · Synced Jul 21, 2026, 11:56 AM EDT