Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 7, 2026, 12:27 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 159 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Mitral Valve Disease Clear all

Conditions: Isolated Aortic Stenosis, Mitral Regurgitation
Interventions: ©VoqX stethoscope; Device
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Heart Diseases, ASD - Atrial Septal Defect, VSD - Muscular Ventricular Septal Defect, PFO - Patent Foramen Ovale, PIVSD - Post Infarct Muscular Ventricular Septal Defect, Valvular Heart Disease
Interventions: Amplatzer™ Occlusion Devices, Epic™ Surgical Tissue Heart Valve devices; Device
Lead sponsor: Abbott Medical Devices; Industry
Eligibility: Not listed
Enrollment: 2,500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2039
U.S. locations: 13
States / cities: Los Angeles, California • Washington D.C., District of Columbia • Miami, Florida + 9 more

Conditions: Mitral Valve Failure
Interventions: Edwards SAPIEN 3 transcatheter heart valve, ASHI INTECC Astato XS 20; Device
Lead sponsor: National Heart, Lung, and Blood Institute (NHLBI); NIH
Eligibility: 21 Years and older
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2023
U.S. locations: 6
States / cities: Washington D.C., District of Columbia • Atlanta, Georgia • Detroit, Michigan + 3 more

Conditions: Aortic Stenosis, Disorder of Prosthetic Cardiac Valve, Aortic Valve Insufficiency, Mitral Valve Insufficiency, Hypertrophic Cardiomyopathy, Tricuspid Valve Insufficiency
Interventions: Blood Draw; Procedure
Lead sponsor: Mayo Clinic; Other
Eligibility: 21 Years and older
Enrollment: 378 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2020
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Mitral Valve Regurgitation
Interventions: Caisson TMVR System; Device
Lead sponsor: Caisson Interventional LLC; Industry
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2023
U.S. locations: 13
States / cities: Los Angeles, California • Washington D.C., District of Columbia • Delray Beach, Florida + 9 more

Conditions: Mitral Valve Regurgitation
Interventions: Not listed
Lead sponsor: National Heart, Lung, and Blood Institute (NHLBI); NIH
Eligibility: 21 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2018
U.S. locations: 2
States / cities: Bethesda, Maryland

Conditions: Mitral Valve Insufficiency
Interventions: Mitral valve surgery; Procedure
Lead sponsor: Atlantic Health System; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Morristown, New Jersey

Conditions: Aortic Valve Disease
Interventions: Blood draw; Other
Lead sponsor: Bassett Healthcare; Other
Eligibility: 18 Years and older
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Cooperstown, New York

Conditions: Postoperative Atrial Fibrillation
Interventions: Amiodarone, DC-cardioversion, Rate Control; Drug · Procedure
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 18 Years and older
Enrollment: 523 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 17
States / cities: Los Angeles, California • Atlanta, Georgia • Baltimore, Maryland + 13 more

Conditions: Mitral Annular Calcification, Mitral Stenosis, Mitral Regurgitation, Mitral Valve Disease
Interventions: Transseptal ViMAC; Device
Lead sponsor: Mayra Guerrero; Other
Eligibility: 18 Years and older
Enrollment: 210 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2030
U.S. locations: 16
States / cities: Gilbert, Arizona • Phoenix, Arizona • Tucson, Arizona + 12 more

Conditions: Mitral Valve Prolapse, Left Ventricular Fibrosis, Ventricular Arrhythmias
Interventions: Cardiac Magnetic Resonance Imaging, ZioPatch Monitoring, Myocardial Tissue Biopsy; Procedure · Device
Lead sponsor: Annetine Gelijns; Other
Eligibility: 60 Years and older
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 16
States / cities: Los Angeles, California • San Francisco, California • Stanford, California + 11 more

Conditions: Mitral Valve Insufficiency, Coronary Artery Disease
Interventions: MV Repair, MV Replacement, CABG; Other
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 18 Years and older
Enrollment: 368 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2027
U.S. locations: 16
States / cities: Los Angeles, California • Atlanta, Georgia • Baltimore, Maryland + 13 more

Conditions: Mitral Valve Disease
Interventions: Transcatheter Mitral Valve Replacement; Device
Lead sponsor: Mayra Guerrero; Other
Eligibility: 22 Years and older
Enrollment: 91 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 15
States / cities: Phoenix, Arizona • Los Angeles, California • Washington D.C., District of Columbia + 9 more

Conditions: Calcific Aortic Stenosis, Calcific Aortic Stenosis - Bicuspid Valve, Aortic Valve Disease, Aortic Valve Calcification, Aortic Diseases, Aortic Aneurysm, Aortic Valve Cusp Abnormality, Aortic Valve Disease Mixed, Aortic Valve Insufficiency
Interventions: Patients scheduled to undergo aortic valve replacement or aortic surgery at BIDMC will be approached for participation in this study.; Procedure
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 20 Years and older
Enrollment: 1,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Mitral Regurgitation, Mitral Valve Disease, Mitral Valve Failure, Mitral Disease, Valve Heart Disease, Valve Disease, Heart
Interventions: Transcatheter Mitral Valve Replacement; Device
Lead sponsor: Caisson Interventional LLC; Industry
Eligibility: 18 Years and older
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2025
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Anti-coagulation Therapy, DVT, Pulmonary Embolism, Joint Surgery Multiple, Atrial Fibrillation, Prosthetic Replacement of Mitral Valve
Interventions: Warfarin GenoSTAT Test; Device
Lead sponsor: Iverson Genetic Diagnostics, Inc.; Industry
Eligibility: 65 Years and older
Enrollment: 3,800 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 56
States / cities: Birmingham, Alabama • Glendale, Arizona • Phoenix, Arizona + 51 more

Conditions: Pulmonary Hypertension, Mitral Valve Disease
Interventions: Not listed
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2014
U.S. locations: 2
States / cities: Chicago, Illinois • Durham, North Carolina

Conditions: Mitral Regurgitation
Interventions: Cardiovalve Transfemoral Mitral Valve; Device
Lead sponsor: Cardiovalve Ltd.; Industry
Eligibility: 18 Years to 84 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 2
States / cities: Atlanta, Georgia • New York, New York

Conditions: Coronary Artery Bypass Grafting, Mitral Valve Surgery, Low Cardiac Output Syndrome
Interventions: Levosimendan, Placebo; Drug
Lead sponsor: Tenax Therapeutics, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 882 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 49
States / cities: Burlington, Alabama • Huntsville, Alabama • Sacramento, California + 41 more

Conditions: Mitral Valve Insufficiency
Interventions: ARTO System; Device
Lead sponsor: Mvrx, Inc.; Industry
Eligibility: 21 Years to 85 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Sacramento, California

Conditions: Mitral Regurgitation, Mitral Valve Insufficiency, Mitral Valve Prolapse
Interventions: Erector spinae plane catheter with 0.5% Ropivacaine, Erector spinae plane catheter with saline; Procedure
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 75 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Coronary Artery Bypass Grafting, Heart Diseases, Heart Valve Diseases
Interventions: Not listed
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 18 Years to 100 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1999 – 2007
U.S. locations: 1
States / cities: New York, New York

Conditions: Symptomatic Functional MR 3 or Greater
Interventions: This study will evaluate the safety and functionality of the AMEND™ Trans-Septal System for annuloplasty as a therapy for mitral regurgitation.; Device
Lead sponsor: Valcare Medical Ltd.; Industry
Eligibility: 21 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 11
States / cities: Phoenix, Arizona • La Jolla, California • Atlanta, Georgia + 8 more

Conditions: Aortic Regurgitation, Mitral Regurgitation, Aortic Stenosis
Interventions: CMR, Quality of Life Questionnaire; Diagnostic Test · Other
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years to 90 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2030
U.S. locations: 1
States / cities: Cleveland, Ohio

Search by objective public record fields.

A Study to Evaluate a Computerized Stethoscope Called ©Voqx to Diagnose Heart Disease

Abbott Structural Heart Device Registry

NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation

Biomarkers in Aortic Stenosis - B.A.S.S.

Caisson Transcatheter Mitral Valve Replacement (TMVR) System Early Feasibility Study

New Techniques to Evaluate Mitral Regurgitation

MRI as a Predictor of Outcomes in Patients Undergoing Mitral Valve Surgery

Podocan and Wnt Pathway in the Development of Aortopathy in Bicuspid Valve Disease

Rate Control Versus Rhythm Control For Postoperative Atrial Fibrillation

The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves).

PRIMARY Ancillary Substudy

Long Term Follow Up for CTSN Mitral Valve Repair Studies

Mitral Implantation of TRAnscatheter vaLves

Identification of Genetic Causes of Calcific Aortic Valve Disease

Caisson Transcatheter Mitral Valve Replacement (TMVR)

Warfarin Adverse Event Reduction For Adults Receiving Genetic Testing at Therapy INitiation (WARFARIN)

Symptomatic Pulmonary Arterial Hypertension After Mitral Valve Surgery

Cardiovalve Transfemoral Mitral Valve System

Levosimendan in Patients With Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery On Cardiopulmonary Bypass

MitrAl ValvE RepaIr Clinical Trial (MAVERIC Trial) - United States

Erector Spinae Plane Block for Minimally Invasive Mitral Valve Surgery

The Short Form-36: Pre- Versus Post-Surgical Administration in Cardiac Surgery Patients

AMEND TS Early Feasibility Study

Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease