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Showing 1–24 of 31 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Mitral Valve Failure Clear all
Completed Not applicable Interventional Results available

Magna® Mitral Pericardial Bioprostheses Post-Approval Study Protocol

NCT00853632
View directory record Official record
Conditions
Coronary Artery Disease, Mitral Valve Regurgitation, Mitral Valve Incompetence, Heart Failure
Interventions
CEP MAGNA MITRAL PERICARDIAL BIOPROSTHESES
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
329 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2024
U.S. locations
10
States / cities
Sacramento, California • Orlando, Florida • Chicago, Illinois + 7 more
Source: ClinicalTrials.gov public record
Updated May 13, 2025 · Synced Jul 21, 2026, 11:11 AM EDT
Withdrawn No phase listed Observational

Structural Heart and Valve Network PROSPECTIVE Registry

NCT03928639
View directory record Official record
Conditions
Mitral Valve Regurgitation, Heart Failure, Heart Valve Disease, Tricuspid Valve Regurgitation, Aortic Valve Stenosis
Interventions
Not listed
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
18 Years to 99 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 11, 2023 · Synced Jul 21, 2026, 11:11 AM EDT
Recruiting Not applicable Interventional

The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

NCT03142152
View directory record Official record
Conditions
Functional Mitral Regurgitation, Heart Failure, Mitral Valve Insufficiency, Heart Diseases, Cardiovascular Diseases, Heart Valve Diseases
Interventions
Carillon Mitral Contour System, Guideline Directed Heart Failure Medication
Device · Other
Lead sponsor
Cardiac Dimensions, Inc.
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2030
U.S. locations
75
States / cities
Gilbert, Arizona • Phoenix, Arizona • Tucson, Arizona + 61 more
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jul 21, 2026, 11:11 AM EDT
Not listed Not applicable Interventional

Caisson Transcatheter Mitral Valve Replacement (TMVR) System Early Feasibility Study

NCT02768402
View directory record Official record
Conditions
Mitral Valve Regurgitation
Interventions
Caisson TMVR System
Device
Lead sponsor
Caisson Interventional LLC
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
13
States / cities
Los Angeles, California • Washington D.C., District of Columbia • Delray Beach, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Jan 27, 2020 · Synced Jul 21, 2026, 11:11 AM EDT
Withdrawn Not applicable Interventional

Effects of Mitral Valve Repair With the Geoform Ring on Cardiomyopathy

NCT00428103
View directory record Official record
Conditions
Mitral Valve Regurgitation, Congestive Heart Failure, Cardiomyopathy
Interventions
3 dimensional echocardiography
Procedure
Lead sponsor
Juan Crestanello, MD
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 27, 2013 · Synced Jul 21, 2026, 11:11 AM EDT
Completed Not applicable Interventional Results available

EVEREST II Pivotal Study High Risk Registry (HRR)

NCT01940120
View directory record Official record
Conditions
Mitral Valve Insufficiency, Mitral Valve Regurgitation, Mitral Valve Incompetence, Mitral Regurgitation, Mitral Insufficiency
Interventions
Percutaneous mitral valve repair using MitraClip implant
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
2
States / cities
Evanston, Illinois • Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 6, 2018 · Synced Jul 21, 2026, 11:11 AM EDT
Not listed Phase 2 Interventional

Confirmation Trial of the Acorn CorCap Cardiac Support Device (CSD) at the Same Time as Mitral Valve Repair

NCT00630266
View directory record Official record
Conditions
Heart Failure
Interventions
CorCap CSD
Device
Lead sponsor
Acorn Cardiovascular, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2008
U.S. locations
11
States / cities
Santa Clara, California • Oak Lawn, Illinois • Ann Arbor, Michigan + 6 more
Source: ClinicalTrials.gov public record
Updated Jun 17, 2009 · Synced Jul 21, 2026, 11:11 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Feasibility Study of a Percutaneous Mitral Valve Repair System.

NCT00209339
View directory record Official record
Conditions
Mitral Valve Insufficiency, Mitral Valve Regurgitation, Mitral Valve Incompetence, Mitral Regurgitation, Mitral Insufficiency
Interventions
Percutaneous mitral valve repair (MitraClip Implant)
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2011
U.S. locations
1
States / cities
Evanston, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 6, 2018 · Synced Jul 21, 2026, 11:11 AM EDT
Not listed Not applicable Interventional

Evaluating Infrasonic Hemodynography

NCT04636892
View directory record Official record
Conditions
Aortic Stenosis, Mitral Regurgitation, Pulmonary Hypertension, Heart Failure, Systolic, Cardiovascular Diseases, Coronary Artery Disease
Interventions
MindMics earbud
Other
Lead sponsor
Scripps Health
Other
Eligibility
Not listed
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Apr 15, 2024 · Synced Jul 21, 2026, 11:11 AM EDT
Not listed Phase 1 Interventional

VIVID - Valvular and Ventricular Improvement Via iCoapsys Delivery - Feasibility Study

NCT00512005
View directory record Official record
Conditions
Mitral Valve Regurgitation, Left Ventricular Dysfunction, Heart Failure, Mitral Insufficiency, Mitral Incompetence, Ischemic Heart Disease
Interventions
Percutaneous mitral valve repair
Device
Lead sponsor
Myocor
Industry
Eligibility
18 Years to 85 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
4
States / cities
Atlanta, Georgia • Evanston, Illinois • Shawnee Mission, Kansas + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 23, 2009 · Synced Jul 21, 2026, 11:11 AM EDT
Completed Not applicable Interventional Results available

Pivotal Study of a Percutaneous Mitral Valve Repair System

NCT00209274
View directory record Official record
Conditions
Mitral Valve Insufficiency, Mitral Valve Regurgitation, Mitral Valve Incompetence, Mitral Regurgitation, Mitral Insufficiency
Interventions
Percutaneous mitral valve repair using MitraClip implant, Mitral valve repair or replacement surgery
Device · Procedure
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
279 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2014
U.S. locations
1
States / cities
Evanston, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 6, 2018 · Synced Jul 21, 2026, 11:11 AM EDT
Recruiting Not applicable Interventional

The CardioClip Study

NCT06241430
View directory record Official record
Conditions
Heart Failure With Reduced Ejection Fraction, Mitral Regurgitation
Interventions
CardioMEMS
Device
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 90 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Jul 21, 2026, 11:11 AM EDT
Terminated Not applicable Interventional Results available

Edwards Cardioband System ACTIVE Pivotal Clinical Trial (ACTIVE)

NCT03016975
View directory record Official record
Conditions
Functional Mitral Regurgitation, Mitral Regurgitation, Mitral Insufficiency
Interventions
Edwards Cardioband System, Guideline Directed Medical Therapy
Device · Drug
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
24
States / cities
Los Angeles, California • Palo Alto, California • Aurora, Colorado + 18 more
Source: ClinicalTrials.gov public record
Updated Nov 29, 2023 · Synced Jul 21, 2026, 11:11 AM EDT
Terminated Phase 3 Interventional Results available

Effectiveness of Surgical Mitral Valve Repair Versus Medical Treatment for People With Significant Mitral Regurgitation and Non-ischemic Congestive Heart Failure

NCT00608140
View directory record Official record
Conditions
Mitral Valve Insufficiency, Heart Failure
Interventions
Surgical mitral valvuloplasty with placement of annular ring (SMVR), Optimal medical therapy (OMT)
Procedure · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
8
States / cities
Atlanta, Georgia • Boston, Massachusetts • Minneapolis, Minnesota + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 3, 2018 · Synced Jul 21, 2026, 11:11 AM EDT
Completed Not applicable Interventional Results available

ProspeCtive, nOn-randoMized, MulticENter Clinical Evaluation of Edwards Pericardial Bioprostheses With a New Tissue Treatment Platform (COMMENCE)

NCT01757665
View directory record Official record
Conditions
Aortic Stenosis, Mitral Stenosis, Aortic Valve Insufficiency, Mitral Valve Insufficiency, Heart Failure
Interventions
Edwards Aortic and Mitral Bioprostheses Models 11000A and 11000M
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
777 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2026
U.S. locations
29
States / cities
Birmingham, Alabama • Los Angeles, California • Sacramento, California + 20 more
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Jul 21, 2026, 11:11 AM EDT
Not listed Not applicable Interventional

Early Feasibility Study for the Foldax TRIA Mitral Heart Valve Replacement

NCT04717570
View directory record Official record
Conditions
Mitral Valve Disease, Mitral Valve Stenosis, Mitral Valve Failure
Interventions
Foldax TRIA Mitral Valve
Device
Lead sponsor
Foldax, Inc
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
3
States / cities
Carmel, Indiana • Wichita, Kansas • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 12, 2023 · Synced Jul 21, 2026, 11:11 AM EDT
Terminated No phase listed Observational

A Feasibility Registry of Actigraphy Monitoring in Degenerative Mitral Regurgitation Subjects Receiving the MitraClip® Device

NCT02858245
View directory record Official record
Conditions
Mitral Regurgitation
Interventions
No intervention - registry
Other
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
8
States / cities
Phoenix, Arizona • Los Angeles, California • Aurora, Colorado + 5 more
Source: ClinicalTrials.gov public record
Updated May 6, 2018 · Synced Jul 21, 2026, 11:11 AM EDT
Active, not recruiting Not applicable Interventional Results available

PARTNER 3 Trial - Mitral Valve in Valve

NCT03193801
View directory record Official record
Conditions
Mitral Valve Insufficiency, Mitral Valve Disease, Mitral Valve Regurgitation, Heart Failure
Interventions
Edwards SAPIEN 3 transcatheter valve, Model 9600TFX
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
Not listed
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2031
U.S. locations
9
States / cities
Atlanta, Georgia • Chicago, Illinois • Evanston, Illinois + 6 more
Source: ClinicalTrials.gov public record
Updated Nov 4, 2025 · Synced Jul 21, 2026, 11:11 AM EDT
Not listed Not applicable Interventional

Caisson Transcatheter Mitral Valve Replacement (TMVR)

NCT03661398
View directory record Official record
Conditions
Mitral Regurgitation, Mitral Valve Disease, Mitral Valve Failure, Mitral Disease, Valve Heart Disease, Valve Disease, Heart
Interventions
Transcatheter Mitral Valve Replacement
Device
Lead sponsor
Caisson Interventional LLC
Industry
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 27, 2020 · Synced Jul 21, 2026, 11:11 AM EDT
Completed Not applicable Interventional Results available

NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation

NCT03015194
View directory record Official record
Conditions
Mitral Valve Failure
Interventions
Edwards SAPIEN 3 transcatheter heart valve, ASHI INTECC Astato XS 20
Device
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
21 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
6
States / cities
Washington D.C., District of Columbia • Atlanta, Georgia • Detroit, Michigan + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 14, 2023 · Synced Jul 21, 2026, 11:11 AM EDT
Completed Phase 2 Interventional

RESTOR-MV: Randomized Evaluation of a Surgical Treatment for Off-Pump Repair of the Mitral Valve

NCT00120276
View directory record Official record
Conditions
Mitral Valve Regurgitation, Left Ventricular Dysfunction, Heart Failure
Interventions
Less invasive mitral valve repair
Device
Lead sponsor
Myocor
Industry
Eligibility
18 Years to 80 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2004
U.S. locations
10
States / cities
Atlanta, Georgia • Springfield, Illinois • Ann Arbor, Michigan + 6 more
Source: ClinicalTrials.gov public record
Updated May 6, 2009 · Synced Jul 21, 2026, 11:11 AM EDT
Recruiting No phase listed Observational

In Search of Best Practices for Patients With Heart Failure and Secondary Mitral Regurgitation: An Evaluation of the Inova Heart Failure Treatment Algorithm

NCT06675448
View directory record Official record
Conditions
Mitral Regurgitation, Valvular Heart Disease, Heart Failure
Interventions
MitraClip, Moderate MR
Device · Other
Lead sponsor
Inova Health Care Services
Other
Eligibility
18 Years to 99 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2030
U.S. locations
1
States / cities
Falls Church, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 2, 2025 · Synced Jul 21, 2026, 11:11 AM EDT
Completed No phase listed Observational

Cardiac Output Pulmonary Arterial Catheter Compared to FloWave™ 1000

NCT00665301
View directory record Official record
Conditions
Congestive Heart Failure, Ischemic Cardiomyopathy, Mitral Valve Prolapse, Mitral Regurgitation, Aortic Valve Disease, Tricuspid Regurgitation
Interventions
Not listed
Lead sponsor
Woolsthorpe Technologies, LLC
Industry
Eligibility
18 Years to 95 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
3
States / cities
Nashville, Tennessee • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 7, 2008 · Synced Jul 21, 2026, 11:11 AM EDT
Completed Not applicable Interventional Results available

Real World Expanded Multicenter Study of the MitraClip® System (REALISM)

NCT01931956
View directory record Official record
Conditions
Mitral Valve Insufficiency, Mitral Valve Regurgitation, Mitral Valve Incompetence, Mitral Regurgitation, Mitral Insufficiency
Interventions
MitraClip® implant
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
965 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2018
U.S. locations
38
States / cities
Los Angeles, California • Mountain View, California • Sacramento, California + 31 more
Source: ClinicalTrials.gov public record
Updated Dec 3, 2018 · Synced Jul 21, 2026, 11:11 AM EDT