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Showing 1–24 of 46 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Nasolabial Folds Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

RHA® 4 NLF Cannula

NCT04754646
View directory record Official record
Conditions
Wrinkle, Nasolabial Fold, Aging
Interventions
Split-face injection of RHA® 4 with a cannula into a single NLF., Split-face injection of RHA® 4 with a needle (TSK 27G x ½") into the contralateral NLF.
Device
Lead sponsor
Teoxane SA
Industry
Eligibility
22 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
4
States / cities
Encinitas, California • West Palm Beach, Florida • Chapel Hill, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 8, 2023 · Synced Jul 22, 2026, 2:06 AM EDT
Completed Not applicable Interventional Results available

TEOSYAL® RHA Global Action, TEOSYAL® RHA Deep Lines, and Juvéderm® Ultra XC for the Correction of Nasolabial Folds

NCT02195427
View directory record Official record
Conditions
Nasolabial Folds, Wrinkles
Interventions
TEOSYAL® RHA Global Action, TEOSYAL® RHA Deep Lines
Device
Lead sponsor
Teoxane SA
Industry
Eligibility
22 Years and older
Enrollment
148 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
5
States / cities
Birmingham, Alabama • Beverly Hills, California • Santa Monica, California + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 24, 2018 · Synced Jul 22, 2026, 2:06 AM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Injection Assistance Device Versus Manual Injections for Delivery of Dermal Fillers

NCT01492140
View directory record Official record
Conditions
Correction of Nasolabial Folds
Interventions
Subdermal Injection, Artiste Assisted Injection System
Procedure · Device
Lead sponsor
TKL Research, Inc.
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
3
States / cities
New York, New York • Houston, Texas • Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Dec 13, 2011 · Synced Jul 22, 2026, 2:06 AM EDT
Recruiting Not applicable Interventional

CelluJuve® for the Treatment of Moderate to Severe NLFs

NCT07545980
View directory record Official record
Conditions
Nasolabial Fold Wrinkles
Interventions
CelluJuve®
Device
Lead sponsor
Spiderwort Biotechnologies Inc.
Industry
Eligibility
22 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Jul 22, 2026, 2:06 AM EDT
Terminated Phase 4 Interventional Results available

Evaluate Efficacy, Safety & Subject Satisfaction of Pain Management With Pliaglis® Cream for Dermal Filler Injections

NCT00716443
View directory record Official record
Conditions
Nasolabial Folds
Interventions
tetracaine 7% / lidocaine 7% cream (Pliaglis® Cream), benzocaine 20% / lidocaine 6% / tetracaine 4% ointment
Drug
Lead sponsor
Galderma R&D
Industry
Eligibility
30 Years to 65 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
4
States / cities
Aventura, Florida • West Palm Beach, Florida • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 22, 2022 · Synced Jul 22, 2026, 2:06 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Multicenter Study of the Safety and Effectiveness of Dermal Filler, Belotero®.

NCT00876265
View directory record Official record
Conditions
Facial Wrinkles
Interventions
Belotero, Zyplast
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
6
States / cities
Birmingham, Alabama • Los Angeles, California • San Francisco, California + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 25, 2013 · Synced Jul 22, 2026, 2:06 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Evaluation of Pain With Lidocaine-Mixed Radiesse® Injectable Dermal Filler

NCT01012661
View directory record Official record
Conditions
Nasolabial Folds
Interventions
Radiesse® Injectable Dermal Filler Mixed with Lidocaine, Radiesse® Injectable Dermal Filler without Lidocaine
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
2
States / cities
Rockville, Maryland • New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 25, 2013 · Synced Jul 22, 2026, 2:06 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Pilot Evaluation of Platelet Rich Fibrin Matrix (PRFM) for the Correction of Nasolabial Folds

NCT00874094
View directory record Official record
Conditions
Nasolabial Folds
Interventions
Platelet rich fibrin matrix
Biological
Lead sponsor
The New York Eye & Ear Infirmary
Other
Eligibility
25 Years to 75 Years · Female only
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Chappaqua, New York
Source: ClinicalTrials.gov public record
Updated Jul 11, 2013 · Synced Jul 22, 2026, 2:06 AM EDT
Completed Not applicable Interventional Results available

Effectiveness and Safety of Princess FILLER Lidocaine in Correction of Nasolabial Folds (NLF)

NCT03990883
View directory record Official record
Conditions
Dermatological Non-Disease
Interventions
Princess Filler Lidocaine
Device
Lead sponsor
Croma-Pharma GmbH
Industry
Eligibility
22 Years and older
Enrollment
295 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
11
States / cities
Birmingham, Alabama • Beverly Hills, California • San Diego, California + 8 more
Source: ClinicalTrials.gov public record
Updated Feb 3, 2025 · Synced Jul 22, 2026, 2:06 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Radiesse® Injectable Dermal Filler for the Treatment of Nasolabial Folds in Persons of Color

NCT01012388
View directory record Official record
Conditions
Nasolabial Folds
Interventions
Radiesse® Injectable Dermal Filler
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
5
States / cities
Los Angeles, California • Chevy Chase, Maryland • Ypsilanti, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 25, 2013 · Synced Jul 22, 2026, 2:06 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Study to Determine How Long Restylane® Will Last After Initial Treatment With 2 Different Re-treatment Schedules.

NCT00765583
View directory record Official record
Conditions
Rhytids
Interventions
Restylane
Drug
Lead sponsor
Medicis Aesthetics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2009
U.S. locations
3
States / cities
Coral Gables, Florida • Chicago, Illinois • White Plains, New York
Source: ClinicalTrials.gov public record
Updated Sep 21, 2011 · Synced Jul 22, 2026, 2:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

DA-13-007 Versus Sculptra for the Treatment of Nasolabial Folds Wrinkles

NCT02310490
View directory record Official record
Conditions
Face; Atrophy
Interventions
DA-13-007 right with left side Sculptra left side, DA-13-007 left with left side Sculptra right side
Device
Lead sponsor
DermAvance
Industry
Eligibility
21 Years and older
Enrollment
161 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
4
States / cities
Bradenton, Florida • Coral Gables, Florida • Carmel, Indiana + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 31, 2024 · Synced Jul 22, 2026, 2:06 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

PREVELLE Shape (CX002) Dermal Filler Protocol

NCT00764257
View directory record Official record
Conditions
Correction of Nasolabial Folds and Lip Augmentation
Interventions
PREVELLE Shape, Restylane
Device
Lead sponsor
Mentor Worldwide, LLC
Industry
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2007
U.S. locations
1
States / cities
Santa Barbara, California
Source: ClinicalTrials.gov public record
Updated Dec 19, 2011 · Synced Jul 22, 2026, 2:06 AM EDT
Completed Not applicable Interventional Results available

A Safety and Effectiveness Study of JUVÉDERM VOLIFT® XC Versus Control for Moderate to Severe Nasolabial Folds

NCT01976663
View directory record Official record
Conditions
Moderate to Severe Nasolabial Folds
Interventions
JUVEDERM VOLIFT® XC, Control
Device
Lead sponsor
Allergan
Industry
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
7
States / cities
Birmingham, Alabama • Los Angeles, California • San Francisco, California + 3 more
Source: ClinicalTrials.gov public record
Updated May 9, 2019 · Synced Jul 22, 2026, 2:06 AM EDT
Completed Phase 4 Interventional Results available

Patient Satisfaction Study of Combined Facial Treatment With BOTOX® Cosmetic, JUVÉDERM® and LATISSE® (HARMONY Study)

NCT02176356
View directory record Official record
Conditions
Facial Rhytides, Crow's Feet Lines, Glabellar Lines, Nasolabial Fold
Interventions
onabotulinumtoxinA, bimatoprost ophthalmic solution 0.03%, JUVÉDERM® ULTRA XC, JUVÉDERM® ULTRA PLUS XC, JUVÉDERM® VOLUMA® XC
Biological · Drug · Device
Lead sponsor
Allergan
Industry
Eligibility
35 Years to 65 Years
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 8, 2019 · Synced Jul 22, 2026, 2:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Safety and Effectiveness of Sculptra Aesthetic for Correction of Nasolabial Folds.

NCT03780244
View directory record Official record
Conditions
Nasolabial Folds
Interventions
Sculptra Aesthetic 8ml, Sculptra Aesthetic 5ml
Device
Lead sponsor
Galderma R&D
Industry
Eligibility
22 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
5
States / cities
Scottsdale, Arizona • Solana Beach, California • Bradenton, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Nov 13, 2022 · Synced Jul 22, 2026, 2:06 AM EDT
Not listed Phase 2 Interventional

Phase 2 Study of TAT4 Gel for Reduction of Nasolabial Folds

NCT02607670
View directory record Official record
Conditions
Nasolabial Folds
Interventions
TAT4 Gel, Matching placebo
Drug
Lead sponsor
Topokine Therapeutics, Inc.
Industry
Eligibility
35 Years to 60 Years
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 4, 2016 · Synced Jul 22, 2026, 2:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Safety and Effectiveness of Aquamid as Compared to Restylane for the Aesthetic Treatment of Nasolabial Folds

NCT00407914
View directory record Official record
Conditions
Facial Wrinkles
Interventions
Aquamid, Restylane
Device
Lead sponsor
Contura
Industry
Eligibility
18 Years and older
Enrollment
315 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
White Plains, New York
Source: ClinicalTrials.gov public record
Updated Oct 7, 2009 · Synced Jul 22, 2026, 2:06 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Belotero Post Approval Study

NCT01635855
View directory record Official record
Conditions
Nasolabial Folds
Interventions
Belotero®
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
117 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
9
States / cities
Birmingham, Alabama • Los Angeles, California • San Francisco, California + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 3, 2014 · Synced Jul 22, 2026, 2:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Study to Evaluate Safety and Efficacy of Revanesse® Ultra + vs Revanesse® Ultra for Correction of NLF

NCT02991040
View directory record Official record
Conditions
Nasolabial Fold Correction
Interventions
Revanesse Ultra+ (with lidocaine), Revanesse Ultra
Device
Lead sponsor
Prollenium Medical Technologies Inc.
Industry
Eligibility
22 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 10, 2019 · Synced Jul 22, 2026, 2:06 AM EDT
Completed Not applicable Interventional

Preliminary Safety and Effectiveness of SMI-01 as a Tissue Filler

NCT04534660
View directory record Official record
Conditions
Nasolabial Fold, Cheek Augmentation
Interventions
SMI-01
Device
Lead sponsor
Sofregen Medical, Inc.
Industry
Eligibility
22 Years to 65 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
2
States / cities
Encinitas, California • Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 30, 2024 · Synced Jul 22, 2026, 2:06 AM EDT
Completed Phase 3 Interventional

A Study to Compare Subject Comfort During and After Injections With the Study Products and the Safety of the Non-FDA Approved Product for the Correction of Nasolabial Folds (NLFs)

NCT00417469
View directory record Official record
Conditions
Facial Wrinkles
Interventions
NADGL
Device
Lead sponsor
Genzyme, a Sanofi Company
Industry
Eligibility
18 Years and older
Enrollment
45 participants
Timeline
2007
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 4, 2015 · Synced Jul 22, 2026, 2:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Safety & Tolerability Study That Compares Restylane to Restylane With Lidocaine While Correcting Wrinkles in the Nasolabial Folds

NCT00797459
View directory record Official record
Conditions
Nasolabial Folds
Interventions
Restylane and Restylane-L
Device
Lead sponsor
Medicis Global Service Corporation
Industry
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
3
States / cities
Coral Gables, Florida • Hunt Valley, Maryland • Mount Kisco, New York
Source: ClinicalTrials.gov public record
Updated Sep 5, 2013 · Synced Jul 22, 2026, 2:06 AM EDT
Completed Phase 3 Interventional Results available

Safety and Efficacy Study of Isolagen Therapy in the Treatment of Nasolabial Fold Wrinkles

NCT00655356
View directory record Official record
Conditions
Bilateral Nasolabial Fold Wrinkles
Interventions
Autologous Human Fibroblasts (azficel-T), Placebo
Biological
Lead sponsor
Castle Creek Biosciences, LLC.
Industry
Eligibility
18 Years and older
Enrollment
218 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
6
States / cities
Beverly Hills, California • San Diego, California • Snellville, Georgia + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 12, 2012 · Synced Jul 22, 2026, 2:06 AM EDT