- Conditions
- Streptococcal Sepsis, Invasive Group A Beta-Haemolytic Streptococcal Disease, Necrotizing Soft Tissue Infection, Infection, Bloodstream, Infection, Bacterial, Streptococcal Toxic Shock Syndrome
- Interventions
- Linezolid, Clindamycin
- Drug
- Lead sponsor
- National Institutes of Health Clinical Center (CC)
- NIH
- Eligibility
- 18 Years to 100 Years
- Enrollment
- 1,000 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2024
- U.S. locations
- 1
- States / cities
- Bethesda, Maryland
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Showing 1–18
of 18
matching trials from the live ClinicalTrials.gov search.
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- Conditions
- Pneumonia, Necrotizing Soft Tissue Infection, Intraabdominal Infections, Infection Joint
- Interventions
- Blue Light
- Other
- Lead sponsor
- Washington University School of Medicine
- Other
- Eligibility
- 18 Years to 65 Years
- Enrollment
- 144 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2024 – 2026
- U.S. locations
- 1
- States / cities
- St Louis, Missouri
- Conditions
- Acute Kidney Injury, Peritonitis, Necrotizing Soft Tissue Infection
- Interventions
- Reltecimod 0.5 mg/kg, Placebo
- Drug
- Lead sponsor
- Atox Bio Ltd
- Industry
- Eligibility
- 18 Years to 85 Years
- Enrollment
- 58 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2018 – 2019
- U.S. locations
- 40
- States / cities
- Phoenix, Arizona • Tucson, Arizona • Little Rock, Arkansas + 33 more
- Conditions
- Necrotizing Soft Tissue Infections
- Interventions
- Negative Pressure Wound Therapy, Negative Pressure Wound Therapy with Instillation
- Device
- Lead sponsor
- HealthPartners Institute
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 30 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2026
- U.S. locations
- 1
- States / cities
- Saint Paul, Minnesota
- Conditions
- Necrotizing Soft Tissue Infections, Necrotizing Fasciitis, Fournier's Gangrene
- Interventions
- AB103 0.5 mg/kg, NaCl 0.9%
- Drug · Other
- Lead sponsor
- Atox Bio Ltd
- Industry
- Eligibility
- 12 Years and older
- Enrollment
- 290 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2015 – 2019
- U.S. locations
- 61
- States / cities
- Birmingham, Alabama • Phoenix, Arizona • Tucson, Arizona + 51 more
- Conditions
- Necrotizing Soft Tissue Infection
- Interventions
- Antibiotic duration (short course), Antibiotic duration (extended course)
- Other
- Lead sponsor
- University of California, Irvine
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 50 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2026
- U.S. locations
- 1
- States / cities
- Orange, California
- Conditions
- Fasciitis, Necrotizing, Severe Necrotizing Skin and Soft Tissue Infections, Fournier's Gangrene
- Interventions
- Daptomycin 6mg/kg/day
- Drug
- Lead sponsor
- University of Maryland, Baltimore
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 25 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2005 – 2008
- U.S. locations
- 1
- States / cities
- Baltimore, Maryland
- Conditions
- Abdominal Wound Dehiscence, Necrotizing Soft Tissue Infection, Lower Extremity Wound, Pilonidal Sinus, Anal Fistula, Hidradenitis Suppurativa, Pressure Injury
- Interventions
- Myriad Matrix™ and Myriad Morcells™
- Device
- Lead sponsor
- Aroa Biosurgery Limited
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 800 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022 – 2029
- U.S. locations
- 15
- States / cities
- Phoenix, Arizona • Los Angeles, California • Fort Myers, Florida + 11 more
- Conditions
- Necrotizing Soft Tissue Infection, Sepsis
- Interventions
- HAT, Placebo
- Drug
- Lead sponsor
- Ascension Health
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 10 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2021 – 2023
- U.S. locations
- 1
- States / cities
- Wichita, Kansas
- Conditions
- Necrotizing Fascitis
- Interventions
- Administration of indocyanine green (ICG) and fluorescence imaging
- Diagnostic Test
- Lead sponsor
- Eric R. Henderson
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 420 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2030
- U.S. locations
- 8
- States / cities
- Los Angeles, California • Stanford, California • Atlanta, Georgia + 5 more
- Conditions
- Necrotizing Soft Tissue Infections
- Interventions
- Not listed
- Lead sponsor
- Texas Tech University Health Sciences Center
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 35 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2013 – 2019
- U.S. locations
- 2
- States / cities
- Lubbock, Texas
- Conditions
- Necrotizing Fascitis
- Interventions
- Hyperbaric Oxygen Therapy
- Procedure
- Lead sponsor
- Corewell Health West
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 160 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2027
- U.S. locations
- 1
- States / cities
- Grand Rapids, Michigan
- Conditions
- Necrotizing Fascitis, Necrotizing Soft Tissue Infection
- Interventions
- Cytal® Wound Matrix, MicroMatrix®
- Device
- Lead sponsor
- Benjamin T. Miller
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 50 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2026
- U.S. locations
- 1
- States / cities
- Cleveland, Ohio
- Conditions
- Necrotizing Soft Tissue Infection
- Interventions
- Surgery
- Procedure
- Lead sponsor
- New York Medical College
- Other
- Eligibility
- 18 Years to 99 Years
- Enrollment
- 13 participants
- Timeline
- 2019 – 2020
- U.S. locations
- 1
- States / cities
- Valhalla, New York
- Conditions
- Pressure Injury, Venous Ulcer, Necrotizing Soft Tissue Infection, Diabetic Ulcers, Draining Wound
- Interventions
- MicroMatrix® Flex, MicroMatrix® UBM Particulate, Cytal® Wound Matrix 2-Layer
- Device
- Lead sponsor
- Integra LifeSciences Corporation
- Industry
- Eligibility
- 22 Years and older
- Enrollment
- 25 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2024 – 2025
- U.S. locations
- 3
- States / cities
- Aurora, Colorado • Washington D.C., District of Columbia • Lake Success, New York
- Conditions
- Necrotizing Soft Tissue Infections
- Interventions
- AB103, Placebo
- Drug
- Lead sponsor
- Atox Bio Ltd
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 43 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2011 – 2012
- U.S. locations
- 7
- States / cities
- Los Angeles, California • San Francisco, California • Gainesville, Florida + 4 more
- Conditions
- Necrosis
- Interventions
- Necrotizing soft tissue infections (NSTIs)
- Other
- Lead sponsor
- Methodist Health System
- Other
- Eligibility
- 18 Years to 89 Years
- Enrollment
- 1,010 participants
- Timeline
- 2019 – 2023
- U.S. locations
- 1
- States / cities
- Dallas, Texas
- Conditions
- Full-thickness Skin Defects, Degloving Injuries, Crush Injuries, Laceration of Skin, Surgical Wound, Skin Cancer, Cellulitis, Infection, Necrotizing Fasciitis, Gun Shot Wound
- Interventions
- Control Intervention (Conventional Autograft), Investigational Intervention (RECELL + more widely meshed autograft)
- Procedure · Device
- Lead sponsor
- Avita Medical
- Industry
- Eligibility
- 5 Years and older
- Enrollment
- 65 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2023
- U.S. locations
- 18
- States / cities
- Phoenix, Arizona • Tucson, Arizona • Orange, California + 14 more