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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Neurodevelopment Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Improving Brain Development in Medically Healthy Premature Infants

NCT00065364
View directory record Official record
Conditions
Premature Birth
Interventions
Newborn Individualized Developmental Care Assessment Program
Behavioral
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
28 Weeks to 33 Weeks
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2000
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 23, 2005 · Synced Jul 23, 2026, 10:07 AM EDT
Recruiting Not applicable Interventional

Impact of Hospital to Home: Optimizing Preterm Infant Environment for Surgical Neonates and Their Parents (H-HOPE)

NCT07372898
View directory record Official record
Conditions
Oral Feeding Outcomes, Neurodevelopment Outcome
Interventions
H-HOPE
Behavioral
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
1 Week to 8 Weeks
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Jul 23, 2026, 10:07 AM EDT
Completed No phase listed Observational

Developmental Impact of NICU Exposures (DINE)

NCT03061890
View directory record Official record
Conditions
Prematurity
Interventions
Not listed
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
Up to 12 Years
Enrollment
600 participants
Timeline
2017 – 2023
U.S. locations
11
States / cities
Jacksonville, Florida • Boston, Massachusetts • Minneapolis, Minnesota + 8 more
Source: ClinicalTrials.gov public record
Updated Oct 23, 2023 · Synced Jul 23, 2026, 10:07 AM EDT
Completed Not applicable Interventional Results available

A Study of Neurophysiologically Based Occupational Therapy Intervention (NBOTI) for Feeding in the NCCU.

NCT00766051
View directory record Official record
Conditions
Cerebral Palsy, Sensorimotor Deficits, Sensory Processing Disorder, Feeding Problems, Developmental Coordination Disorder, Picky Eaters, NICU
Interventions
The intervention group: Neurophysiologically Based Occupational Therapy Intervention (NBOTI)
Other
Lead sponsor
University of Utah
Other
Eligibility
29 Weeks to 44 Weeks
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
2
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jan 1, 2017 · Synced Jul 23, 2026, 10:07 AM EDT
Recruiting Phase 2 Interventional

Darbe Plus IV Iron to Decrease Transfusions While Maintaining Iron Sufficiency in Preterm Infants

NCT05340465
View directory record Official record
Conditions
Prematurity, Iron-deficiency, Iron Deficiency Anemia, Iron Malabsorption
Interventions
Darbepoetin Alfa, Low Molecular Weight Iron Dextran, Ferumoxytol injection, Oral iron supplements
Drug
Lead sponsor
University of Washington
Other
Eligibility
Up to 3 Days
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 25, 2026 · Synced Jul 23, 2026, 10:07 AM EDT
Recruiting No phase listed Observational

Optimizing Nutrition and Milk (Opti-NuM) Project

NCT06870981
View directory record Official record
Conditions
Very Low Birth Weight Baby, Early Nutrition and the Preterm Infant, Nutritional Requirements, Human Milk Fortification, Human Milk Microbiome, Human Milk Feeding, Human Milk Nutrition, Growth &Amp; Development
Interventions
Opti-NuM is an observational secondary use of data/samples study, the investigators will analyze information and specimens from the MaxiMoM platform RCTs. No interventions form part of this study.
Other
Lead sponsor
The Hospital for Sick Children
Other
Eligibility
1 Hour to 21 Days
Enrollment
1,100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2027
U.S. locations
2
States / cities
Palo Alto, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 10, 2025 · Synced Jul 23, 2026, 10:07 AM EDT
Active, not recruiting Not applicable Interventional

Trial of Indication-Based Transfusion of Red Blood Cells in ECMO

NCT05405426
View directory record Official record
Conditions
Extracorporeal Membrane Oxygenation, Red Blood Cell Transfusion, Organ Failure, Multiple
Interventions
Red blood cell transfusion
Other
Lead sponsor
Boston Children's Hospital
Other
Eligibility
0 Days to 6 Years
Enrollment
228 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
20
States / cities
Phoenix, Arizona • Little Rock, Arkansas • Los Angeles, California + 17 more
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Jul 23, 2026, 10:07 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Neurodevelopment in Infants With Complex Congenital Heart Defects

NCT03104751
View directory record Official record
Conditions
Complex Congenital Heart Defect
Interventions
Not listed
Lead sponsor
Ohio State University
Other
Eligibility
1 Day to 30 Days
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 23, 2021 · Synced Jul 23, 2026, 10:07 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Neurodevelopment and Neuroimaging in Parenterally-fed Infants and Young Children

NCT00392730
View directory record Official record
Conditions
Parenteral Nutrition, Necrotizing Enterocolitis, Digestive System Abnormalities, Cholestasis
Interventions
Remove Mn from PN if evidence of increased brain Mn on MRI
Dietary Supplement
Lead sponsor
Vanderbilt University
Other
Eligibility
30 Days to 6 Years
Enrollment
122 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 18, 2013 · Synced Jul 23, 2026, 10:07 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

PANDA Gym: Automated Assessment of Neurodevelopment in Infants at Risk for Motor Disability

NCT04321200
View directory record Official record
Conditions
Pediatric ALL, Infant Development, Neurodevelopmental Disorders
Interventions
PANDA Gym, Mobile App
Diagnostic Test · Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
0 Months to 6 Months
Enrollment
1,700 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 22, 2025 · Synced Jul 23, 2026, 10:07 AM EDT
Recruiting Not applicable Interventional

Individualized Nutrition to Optimize Preterm Infant Growth and Neurodevelopment

NCT06266455
View directory record Official record
Conditions
Very Preterm Maturity of Infant, Very Low Birth Weight Infant
Interventions
Standardized Fortification, Adjustable Fortification
Dietary Supplement
Lead sponsor
Children's National Research Institute
Other
Eligibility
Up to 4 Weeks
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2034
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jul 10, 2025 · Synced Jul 23, 2026, 10:07 AM EDT
Recruiting Not applicable Interventional

The Impact of Music Medicine on Preterm Brain Development and Behavior

NCT06536296
View directory record Official record
Conditions
Infant Development, Language Development, Prematurity, Stress
Interventions
Music, Music and parent voice, Standard Care
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
24 Weeks to 30 Weeks
Enrollment
243 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2031
U.S. locations
2
States / cities
New Haven, Connecticut • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Jul 23, 2026, 10:07 AM EDT
Completed Not applicable Interventional

Prebiotic in Preterm Infants

NCT03306316
View directory record Official record
Conditions
Preterm Infant, Development, Infant, Nutrition
Interventions
Prebiotic, Dextrose Control
Dietary Supplement
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
7 Days to 10 Days
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 7, 2024 · Synced Jul 23, 2026, 10:07 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Childhood Autism Risks From Genetics and the Environment (The CHARGE Study)

NCT00106652
View directory record Official record
Conditions
Autism, Developmental Disabilities
Interventions
Not listed
Lead sponsor
National Institute of Environmental Health Sciences (NIEHS)
NIH
Eligibility
24 Months to 60 Months
Enrollment
2,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2017
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Sep 24, 2017 · Synced Jul 23, 2026, 10:07 AM EDT
Completed Not applicable Interventional

Iron Status and Myelination in Premature Infants

NCT00684697
View directory record Official record
Conditions
Neurodevelopmental Outcome
Interventions
iron
Dietary Supplement
Lead sponsor
University of Rochester
Other
Eligibility
Up to 32 Weeks
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2020
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Mar 1, 2021 · Synced Jul 23, 2026, 10:07 AM EDT
Terminated Phase 2Phase 3 Interventional Results available

Inhaled Nitric Oxide and Neuroprotection in Premature Infants

NCT00515281
View directory record Official record
Conditions
Prematurity, Bronchopulmonary Dysplasia, Intraventricular Hemorrhage, Periventricular Leukomalacia
Interventions
inhaled nitric oxide, oxygen
Drug
Lead sponsor
University of Chicago
Other
Eligibility
2 Hours to 72 Hours
Enrollment
273 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 16, 2024 · Synced Jul 23, 2026, 10:07 AM EDT
Active, not recruiting No phase listed Observational

ARDS in Children and ECMO Initiation Strategies Impact on Neurodevelopment (ASCEND)

NCT05388708
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation
Interventions
ECMO support, PROSpect protocolized therapies
Device · Other
Lead sponsor
University of Michigan
Other
Eligibility
14 Days to 20 Years
Enrollment
550 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
72
States / cities
Birmingham, Alabama • Phoenix, Arizona • Little Rock, Arkansas + 62 more
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Jul 23, 2026, 10:07 AM EDT
Not yet recruiting Not applicable Interventional

BOND: Direct Breastfeeding to Enhance Maternal and Infant Health in Congenital Heart Disease

NCT07582848
View directory record Official record
Conditions
Congenital Heart Disease (CHD)
Interventions
Breastfeeding clinical practice guideline (CPG) for congenital heart disease (CHD)
Other
Lead sponsor
Carelon Research
Other
Eligibility
18 Years and older
Enrollment
266 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
8
States / cities
Phoenix, Arizona • Aurora, Colorado • Atlanta, Georgia + 5 more
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Jul 23, 2026, 10:07 AM EDT
Completed Not applicable Interventional Results available

Optimizing Individual Nutrition in Preterm Very Low Birth Weight Infants

NCT02372136
View directory record Official record
Conditions
Infant, Premature, Diseases, Infant, Small for Gestational Age
Interventions
Individualized Nutrition, Optimized nutrition
Dietary Supplement
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
Up to 7 Days
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 2, 2024 · Synced Jul 23, 2026, 10:07 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

PANDA (Pediatric Anesthesia & NeuroDevelopment Assessment) Study

NCT00881764
View directory record Official record
Conditions
Cognition - Other
Interventions
Inguinal hernia surgery, General anesthesia
Procedure
Lead sponsor
Columbia University
Other
Eligibility
8 Years to 15 Years
Enrollment
369 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2016
U.S. locations
4
States / cities
Boston, Massachusetts • New York, New York • Philadelphia, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 16, 2023 · Synced Jul 23, 2026, 10:07 AM EDT
Not listed No phase listed Observational

Study of Bedside EEG to Evaluate Brain Injury in Premature Newborns

NCT00516334
View directory record Official record
Conditions
Brain Injury, Seizures, Cerebral Palsy
Interventions
Not listed
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
1 Day to 36 Months
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 26, 2012 · Synced Jul 23, 2026, 10:07 AM EDT
Completed No phase listed Observational

Neurodevelopment of Hypoglycemic Neonates

NCT04875624
View directory record Official record
Conditions
Neonatal Hypoglycemia, Neurodevelopmental Disorders
Interventions
Bayley Scales of Infant and Toddler Development, Fourth Edition (Bayley-4)
Diagnostic Test
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Months to 24 Months
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced Jul 23, 2026, 10:07 AM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Neurodevelopmental Outcomes in Cerebral Visual Impairment

NCT07212010
View directory record Official record
Conditions
Cerebral Visual Impairment
Interventions
Not listed
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
6 Months to 72 Months
Enrollment
600 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2031
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 8, 2025 · Synced Jul 23, 2026, 10:07 AM EDT
Completed Not applicable Interventional

NDT Effectiveness Study

NCT05070910
View directory record Official record
Conditions
Cerebral Palsy, Neuromuscular Diseases, Neurodevelopment Treatment
Interventions
Therapy
Behavioral
Lead sponsor
MultiCare Health System Research Institute
Other
Eligibility
2 Years to 15 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Puyallup, Washington
Source: ClinicalTrials.gov public record
Updated Jan 30, 2023 · Synced Jul 23, 2026, 10:07 AM EDT