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Showing 1–24 of 44 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Patent Ductus Arteriosus Clear all
Active, not recruiting Phase 3 Interventional Results available

Management of the PDA Trial

NCT03456336
View directory record Official record
Conditions
Infant, Premature, Patent Ductus Arteriosus, Infant, Newborn, Diseases, Patent Ductus Arteriosus After Premature Birth
Interventions
Active Treatment, Expectant Management
Other
Lead sponsor
NICHD Neonatal Research Network
Network
Eligibility
48 Hours to 21 Days
Enrollment
482 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
19
States / cities
Birmingham, Alabama • Palo Alto, California • San Diego, California + 15 more
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Sep 24, 2026, 3:52 AM EDT
Terminated Phase 4 Interventional Results available

Curosurf and Survanta Treatment(CAST)of RDS in Very Premature Infants

NCT00767039
View directory record Official record
Conditions
Prematurity, Respiratory Distress Syndrome, Patent Ductus Arteriosus
Interventions
Survanta (beractant), Curosurf (poractant)
Drug
Lead sponsor
Alan Fujii
Other
Eligibility
Up to 8 Hours
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 2, 2011 · Synced Sep 24, 2026, 3:52 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Near Infrared Spectroscopy to Determine Patent Ductus Arteriosus Closure

NCT03026192
View directory record Official record
Conditions
Patent Ductus Arteriosus
Interventions
near infrared spectroscopy
Device
Lead sponsor
Albany Medical College
Other
Eligibility
1 Minute to 1 Week
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Jan 22, 2019 · Synced Sep 24, 2026, 3:52 AM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

The Arch Watch Study: An Integrated Evaluation of Hemodynamics in Infants With Suspected Coarctation of the Aorta

NCT05880576
View directory record Official record
Conditions
Coarctation of the Aorta, Aortic Arch Obstruction
Interventions
Monitoring using resonance Raman spectroscopy, pulse oximetry, blood pressure, and near-infrared spectroscopy
Device
Lead sponsor
Boston Children's Hospital
Other
Eligibility
0 Days to 60 Days
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Sep 24, 2026, 3:52 AM EDT
Active, not recruiting No phase listed Observational

PDA for Kidneys Study

NCT06658496
View directory record Official record
Conditions
Patent Ductus Arteriosus, Congenital Heart Disease
Interventions
Near Infrared Spectroscopy
Device
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
1 Minute to 7 Days
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 20, 2026 · Synced Sep 24, 2026, 3:52 AM EDT
Not listed Phase 3 Interventional

Selective Early Medical Treatment of Patent Ductus Arteriosus in Extremely Low Gestational Age Infants: A Pilot RCT

NCT05011149
View directory record Official record
Conditions
Patent Ductus Arteriosus After Premature Birth
Interventions
Ibuprofen
Drug
Lead sponsor
IWK Health Centre
Other
Eligibility
Up to 72 Hours
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
3
States / cities
Orange, California • San Diego, California • Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jun 20, 2024 · Synced Sep 24, 2026, 3:52 AM EDT
Terminated Phase 2Phase 3 Interventional Results available

Fenoldopam to Prevent Renal Dysfunction in Indomethacin Treated Preterm Infants

NCT02620761
View directory record Official record
Conditions
Patent Ductus Arteriosus (PDA), Acute Kidney Injury (AKI)
Interventions
Fenoldopam, 0.9%NS
Drug
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
0 Days to 28 Days
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Sep 15, 2022 · Synced Sep 24, 2026, 3:52 AM EDT
Terminated Phase 2 Interventional Results available

Randomized Controlled Trial to Evaluate the Safety and Efficacy of Acetaminophen in Preterm Infants Used in Combination With Ibuprofen for Closure of the Ductus Arteriosus

NCT03701074
View directory record Official record
Conditions
Patent Ductus Arteriosus, Preterm Infant, Bronchopulmonary Dysplasia
Interventions
Ibuprofen and acetaminophen, Ibuprofen and placebo
Drug
Lead sponsor
University of South Alabama
Other
Eligibility
5 Days to 21 Days
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Mobile, Alabama
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Sep 24, 2026, 3:52 AM EDT
Completed Not applicable Interventional

Closure of Patent Ductus Arteriosus With Indomethacin or Ibuprofen in Extreme Low Birth Weight Infants

NCT01758913
View directory record Official record
Conditions
Patent Ductus Arteriosus
Interventions
Ibuprofen
Drug
Lead sponsor
Taipei Medical University Hospital
Other
Eligibility
Up to 6 Months
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 2, 2013 · Synced Sep 24, 2026, 3:52 AM EDT
Terminated Phase 4 Interventional

Safety/Efficacy Study of Optimizing Ibuprofen Dosing to Achieve Higher PDA Closure Rates

NCT00961753
View directory record Official record
Conditions
Patent Ductus Arteriosus
Interventions
optimized ibuprofen, Standard Ibuprofen
Drug
Lead sponsor
OSF Healthcare System
Other
Eligibility
1 Day to 29 Days
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Peoria, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 27, 2014 · Synced Sep 24, 2026, 3:52 AM EDT
Recruiting Not applicable Interventional

Starlight Cardiovascular Lifeline Ductus Arteriosus Stent IDE Study

NCT07114718
View directory record Official record
Conditions
Congenital Heart Disease, Congenital Heart Disease (CHD)
Interventions
Ductus Arteriosus Stent
Device
Lead sponsor
Starlight Cardiovascular Inc
Industry
Eligibility
1 Minute to 6 Months
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
10
States / cities
Los Angeles, California • San Diego, California • Stanford, California + 7 more
Source: ClinicalTrials.gov public record
Updated Sep 13, 2026 · Synced Sep 24, 2026, 3:52 AM EDT
Completed Phase 3 Interventional

Trial of Indomethacin Prophylaxis in Preterm Infants (TIPP)

NCT00009646
View directory record Official record
Conditions
Infant, Very Low Birth Weight, Infant, Premature, Ductus Arteriosus, Patent
Interventions
Indomethacin, Placebo
Drug
Lead sponsor
NICHD Neonatal Research Network
Network
Eligibility
2 Hours to 6 Hours
Enrollment
1,202 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1993 – 2001
U.S. locations
9
States / cities
Birmingham, Alabama • Palo Alto, California • Miami, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Jun 7, 2015 · Synced Sep 24, 2026, 3:52 AM EDT
Completed Not applicable Interventional

NIT-OCCLUD PDA Phase II Sentinel Trial

NCT00828334
View directory record Official record
Conditions
Ductus Arteriosus, Patent
Interventions
Transcatheter PDA Coil
Device
Lead sponsor
PFM Medical, Inc
Industry
Eligibility
6 Months to 21 Years
Enrollment
357 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2007
U.S. locations
15
States / cities
Los Angeles, California • Madera, California • Orange, California + 12 more
Source: ClinicalTrials.gov public record
Updated Mar 22, 2018 · Synced Sep 24, 2026, 3:52 AM EDT
Withdrawn No phase listed Observational

Impact of Maternal-infant Therapeutics on Safety, Mortality, and Disability

NCT01028183
View directory record Official record
Conditions
Gastroesophageal Reflux, Presumed Sepsis, Patent Ductus Arteriosus, Chronic Lung Disease, Neurodevelopmental Impairment
Interventions
Not listed
Lead sponsor
Duke University
Other
Eligibility
Up to 5 Days
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 15, 2013 · Synced Sep 24, 2026, 3:52 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Efficacy of Implementing a Treatment Algorithm in Managing Patent Ductus Arteriosus (PDA) in the Extremely Low Birth Weight Neonatal Population.

NCT04379843
View directory record Official record
Conditions
PDA, Low; Birthweight, Extremely (999 Grams or Less)
Interventions
Not listed
Lead sponsor
Pediatrix
Other
Eligibility
Not listed
Enrollment
208 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
2
States / cities
Mesa, Arizona • Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 31, 2021 · Synced Sep 24, 2026, 3:52 AM EDT
Completed Not applicable Interventional Results available

Closure Of Patent Ductus Arteriosus With the AMPLATZER Duct Occluder the AMPLATZER® Duct Occluder

NCT00583596
View directory record Official record
Conditions
Patent Ductus Arteriosus (PDA)
Interventions
Device closure with AMPLATZER Duct Occluder, Objective Performance Criteria
Device · Other
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
6 Months to 18 Years
Enrollment
436 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2009
U.S. locations
24
States / cities
Birmingham, Alabama • San Diego, California • Denver, Colorado + 21 more
Source: ClinicalTrials.gov public record
Updated Jun 28, 2023 · Synced Sep 24, 2026, 3:52 AM EDT
Terminated Not applicable Interventional Results available

Timing of PDA Closure and Respiratory Outcome in Premature Infants

NCT00802685
View directory record Official record
Conditions
Patent Ductus Arteriosus
Interventions
Early ibuprofen, Late ibuprofen expectant group (placebo)
Drug · Other
Lead sponsor
University of Miami
Other
Eligibility
1 Day to 14 Days
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Feb 4, 2014 · Synced Sep 24, 2026, 3:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pocket Echocardiography System (PES) for Detection of PDA in Neonates

NCT01790750
View directory record Official record
Conditions
Patent Ductus Arteriosus
Interventions
PES first, then FFES
Device
Lead sponsor
University of Florida
Other
Eligibility
1 Day to 90 Days
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 10, 2014 · Synced Sep 24, 2026, 3:52 AM EDT
Completed Not applicable Interventional

Chest Shielding in Premature Infants During Phototherapy

NCT02552927
View directory record Official record
Conditions
Patent Ductus Arteriosus in Premature Infants
Interventions
Chest shield with aluminum foil (CALF), SHIELD
Device
Lead sponsor
University of Rochester
Other
Eligibility
23 Weeks to 33 Weeks
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Sep 17, 2020 · Synced Sep 24, 2026, 3:52 AM EDT
Not listed Not applicable Interventional

Radiation-Free Heart Catheterization Using MRI

NCT02739087
View directory record Official record
Conditions
Aortic Coarctation, Cardiomyopathy, Atrial Septal Defect, Aortic Stenosis, Post Heart Transplant Catheter Procedure, Patent Ductus Arteriosus
Interventions
MRI guided cardiac catheterization, Magnetic resonance imaging
Procedure · Device
Lead sponsor
Joshua Kanter
Other
Eligibility
Not listed
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2024
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Feb 5, 2024 · Synced Sep 24, 2026, 3:52 AM EDT
Terminated Not applicable Interventional Results available

Preliminary Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low-weight Infants

NCT03982342
View directory record Official record
Conditions
Patent Ductus Arteriosus
Interventions
Cather closure of patent ductus arteriosus (PDA), Conservative management of patent ductus arteriosus (PDA)
Device · Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
14 Days to 28 Days
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
2
States / cities
Columbus, Ohio • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 6, 2024 · Synced Sep 24, 2026, 3:52 AM EDT
Completed No phase listed Observational

Splanchnic and Renal Tissue Oxygenation During Enteral Feedings in Neonates With Patent Ductus Arteriosus

NCT03551600
View directory record Official record
Conditions
Infant, Premature, Congenital Heart Disease, Patent Ductus Arteriosus, Necrotizing Enterocolitis
Interventions
Near-infrared spectroscopy (NIRS)
Procedure
Lead sponsor
University of Utah
Other
Eligibility
12 Days to 6 Months
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
3
States / cities
Murray, Utah • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 3, 2023 · Synced Sep 24, 2026, 3:52 AM EDT
Active, not recruiting No phase listed Observational

Early Prediction of Spontaneous Patent Ductus Arteriosus (PDA) Closure and PDA-Associated Outcomes

NCT03782610
View directory record Official record
Conditions
Patent Ductus Arteriosus, Preterm Infant, Bronchopulmonary Dysplasia, Neurodevelopmental Abnormality
Interventions
Not listed
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
Up to 72 Hours
Enrollment
526 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
4
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Sep 24, 2026, 3:52 AM EDT
Completed No phase listed Observational

Treatment of a PDA With Acetaminophen in Preterm Neonates: Exploring Various Indications

NCT03289390
View directory record Official record
Conditions
Patent Ductus Arteriosus
Interventions
Acetaminophen
Drug
Lead sponsor
Albany Medical College
Other
Eligibility
23 Weeks to 30 Weeks
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Jan 12, 2020 · Synced Sep 24, 2026, 3:52 AM EDT