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Showing 1–24 of 55 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Polypharmacy Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Using Pharmacogenetics to Identify Patients With Polypharmacy at Risk of Medication Adverse Effects

NCT03748355
View directory record Official record
Conditions
Psychiatric Disorder
Interventions
Pharmacogentic Analysis
Genetic
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 10, 2020 · Synced Jul 21, 2026, 6:09 PM EDT
Recruiting Not applicable Interventional

Pediatric Medication Therapy Management Trial

NCT05761847
View directory record Official record
Conditions
Child, Only, Disabilities Multiple, Medication Interaction, Medication Compliance, Medication Administered in Error
Interventions
Pediatric Medication Therapy Management (pMTM)
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
2 Years to 18 Years
Enrollment
371 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Jul 21, 2026, 6:09 PM EDT
Completed Not applicable Interventional Results available

Development & Pilot of the Technology-Enabled Alliance for Medication Therapy Management

NCT04575155
View directory record Official record
Conditions
Polypharmacy
Interventions
TEAM Strategy
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
50 Years and older
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 25, 2024 · Synced Jul 21, 2026, 6:09 PM EDT
Completed Not applicable Interventional

Improving Wisely - Polypharmacy

NCT03857100
View directory record Official record
Conditions
Adverse Drug Event
Interventions
Audit and feedback - letter and report
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
Not listed
Enrollment
11,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 22, 2021 · Synced Jul 21, 2026, 6:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Aligning Medications With What Matters Most

NCT04938648
View directory record Official record
Conditions
Polypharmacy, Alzheimer Disease and Related Dementias
Interventions
Pharmacist-led deprescribing intervention
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
65 Years and older
Enrollment
138 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
2
States / cities
Aurora, Colorado • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Jul 21, 2026, 6:09 PM EDT
Not listed Phase 4 Interventional

Evaluation of Belimumab Impact on a BLyS Activity Signature Test in the Absence of Confounding Polypharmacy

NCT02270970
View directory record Official record
Conditions
Systemic Lupus Erythematosus
Interventions
belimumab
Biological
Lead sponsor
Oklahoma Medical Research Foundation
Other
Eligibility
16 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Dec 6, 2017 · Synced Jul 21, 2026, 6:09 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Psychological and Clinical Factors That Predict Intent to Deprescribe Medications Among Older Adults

NCT04676282
View directory record Official record
Conditions
Polypharmacy, Aging
Interventions
Hypothetical Scenario
Other
Lead sponsor
University of Michigan
Other
Eligibility
65 Years and older
Enrollment
10,184 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 12, 2022 · Synced Jul 21, 2026, 6:09 PM EDT
Active, not recruiting Not applicable Interventional

Effectiveness of PGx Testing

NCT04120480
View directory record Official record
Conditions
Polypharmacy
Interventions
Pharmacogenomic test
Diagnostic Test
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years to 79 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 1, 2024 · Synced Jul 21, 2026, 6:09 PM EDT
Completed Phase 1Phase 2 Interventional

Decreasing Polypharmacy in Older Adults With Curable Cancers Trial

NCT05046171
View directory record Official record
Conditions
Cancer
Interventions
Pharmacist-led deprescribing, Patient education
Other
Lead sponsor
University of Rochester
Other
Eligibility
65 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced Jul 21, 2026, 6:09 PM EDT
Completed Not applicable Interventional Results available

Drug Reduction in Older Patients: The DROP Trial

NCT03722017
View directory record Official record
Conditions
Geriatric Assessment, Frail Elderly, Skilled Nursing Facilities, Patient-centered Care
Interventions
Deprescribing intervention
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
50 Years and older
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 26, 2024 · Synced Jul 21, 2026, 6:09 PM EDT
Completed No phase listed Observational

YouScript IMPACT Registry

NCT02191358
View directory record Official record
Conditions
Adverse Drug Events, Adverse Drug Reactions, Drug Interaction Potentiation, Drug Metabolism, Poor, CYP2D6-RELATED, Drug Metabolism, Poor, CYP2C19-RELATED, Cytochrome P450 Enzyme Deficiency, Cytochrome P450 CYP2D6 Enzyme Deficiency, Cytochrome P450 CYP2C9 Enzyme Deficiency, Cytochrome P450 CYP2C19 Enzyme Deficiency, Cytochrome P450 CYP3A Enzyme Deficiency, Poor Metabolizer Due to Cytochrome P450 CYP2C9 Variant, Poor Metabolizer Due to Cytochrome P450 CYP2C19 Variant, Poor Metabolizer Due to Cytochrome P450 CYP2D6 Variant
Interventions
Not listed
Lead sponsor
Genelex Corporation
Industry
Eligibility
65 Years and older
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
7
States / cities
Garden Grove, California • Denver, Colorado • Lexington, Kentucky + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 28, 2017 · Synced Jul 21, 2026, 6:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

ALIGN: Aligning Medications With What Matters Most (Demonstration)

NCT06335953
View directory record Official record
Conditions
Polypharmacy, Alzheimer's Disease and Related Dementias, Mild Cognitive Impairment
Interventions
Pharmacist-led deprescribing intervention
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
65 Years and older
Enrollment
360 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 9, 2025 · Synced Jul 21, 2026, 6:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Adapting the Shed-MEDS Deprescribing Intervention to Dementia Care in Assisted Living

NCT05956665
View directory record Official record
Conditions
Polypharmacy, Dementia, Quality of Life
Interventions
Shed-MEDS deprescribing intervention
Behavioral
Lead sponsor
Vanderbilt University
Other
Eligibility
65 Years and older
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
2
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Jul 21, 2026, 6:09 PM EDT
Completed Not applicable Interventional Results available

Reducing Treatment Risk in Older Adults With Diabetes

NCT04585191
View directory record Official record
Conditions
Type 2 Diabetes Treated With Insulin, Hypoglycemia, Primary Health Care, Polypharmacy
Interventions
Conversation Aid, Attention Control Educational Handout
Behavioral · Other
Lead sponsor
Kaiser Permanente
Other
Eligibility
75 Years and older
Enrollment
450 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
4
States / cities
San Francisco, California • San Leandro, California • Union City, California + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 20, 2025 · Synced Jul 21, 2026, 6:09 PM EDT
Recruiting No phase listed Observational

Interprofessional Pharmacogenomics (IPGx) Registry and Repository

NCT06726590
View directory record Official record
Conditions
Diabetes, Cholesterol, Cancer, Blood Pressure Disorders, Heart Disease, Respiratory Ilness, COPD, Adverse Drug Reaction (ADR), Poly Pharmacy
Interventions
Not listed
Lead sponsor
Texas A&M University
Other
Eligibility
18 Years and older
Enrollment
3,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Bryan, Texas
Source: ClinicalTrials.gov public record
Updated Sep 11, 2025 · Synced Jul 21, 2026, 6:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Shared Decision Making About Medication Use for People With Multiple Health Problems

NCT05156073
View directory record Official record
Conditions
Polypharmacy, Dementia, Multiple Chronic Conditions, Deprescribing, Mild Cognitive Impairment
Interventions
Educational Materials
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
65 Years and older
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Reading, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 26, 2024 · Synced Jul 21, 2026, 6:09 PM EDT
Completed Not applicable Interventional Results available

MIDAS Cluster Randomized Controlled Trial of Implementation Strategies to Optimize Use of Medications in VA Clinical Settings

NCT05065502
View directory record Official record
Conditions
Polypharmacy, Insomnia, Anticoagulants
Interventions
Academic Detailing (AD), LEAP
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Jul 21, 2026, 6:09 PM EDT
Completed No phase listed Observational Results available

Parent-Reported Symptom Assessments in Children Taking Multiple Medications

NCT03849066
View directory record Official record
Conditions
Neurologic Disorder, Chronic Disease, Pediatric Disorder
Interventions
Parent-Reported Symptom Assessment
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
1 Day to 17 Years
Enrollment
136 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 20, 2023 · Synced Jul 21, 2026, 6:09 PM EDT
Completed Not applicable Interventional

Care Planning for Older Persons With Multiple Conditions: Encouraging a Tailored Approach (COMET): Stage II

NCT02501967
View directory record Official record
Conditions
Polypharmacy
Interventions
COMET
Other
Lead sponsor
Yale University
Other
Eligibility
65 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 23, 2016 · Synced Jul 21, 2026, 6:09 PM EDT
Recruiting Phase 1 Interventional

HIV and Alcohol Research Center Focused on Polypharmacy (HARP) Pilot 2 (2nd HARP Pilot Intervention)

NCT06513819
View directory record Official record
Conditions
Hiv, Alcohol Drinking, Fall, Cannabis Use
Interventions
Information Motivation Behavioral and Motivational Interviewing (IMB-MI) technique
Behavioral
Lead sponsor
Yale University
Other
Eligibility
50 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Jul 21, 2026, 6:09 PM EDT
Withdrawn Phase 2 Interventional

Polypharmacy-related Adverse Events in Critically Ill Children

NCT03293927
View directory record Official record
Conditions
Delirium
Interventions
Fentanyl, Dexmedetomidine
Drug
Lead sponsor
Duke University
Other
Eligibility
2 Years to 17 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 17, 2019 · Synced Jul 21, 2026, 6:09 PM EDT
Completed Not applicable Interventional

Preemptive Pharmacogenomics Testing Among Geriatric Patients

NCT05091879
View directory record Official record
Conditions
Polypharmacy, Pharmacogenomic Testing
Interventions
Multigene pharmacogenomics test
Genetic
Lead sponsor
Geisinger Clinic
Other
Eligibility
65 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Danville, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Jul 21, 2026, 6:09 PM EDT
Recruiting Not applicable Interventional

Improving Medication Management in World Trade Center Responders

NCT07022990
View directory record Official record
Conditions
Polypharmacy
Interventions
Educational brochure for deprescribing
Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
50 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 14, 2025 · Synced Jul 21, 2026, 6:09 PM EDT
Completed Not applicable Interventional

Characteristics and Clinical Implications of a Clinical Decision Support System

NCT03295097
View directory record Official record
Conditions
Chronic Illness, Opioid Use, Palliative Care
Interventions
Clinical Decision Support System
Other
Lead sponsor
Hospice of Henderson County, Inc.
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
2
States / cities
New York, New York • Flat Rock, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 16, 2021 · Synced Jul 21, 2026, 6:09 PM EDT