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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Presbyopia Clear all
Completed Not applicable Interventional Results available

Assessing the Clinical Performance of Two Frequent Replacement Silicone Hydrogel Multifocal Toric Contact Lenses

NCT05886907
View directory record Official record
Conditions
Refractive Errors, Presbyopia, Astigmatism
Interventions
Lehfilcon A multifocal toric contact lenses, Samfilcon A multifocal toric contact lenses, CLEAR CARE
Device
Lead sponsor
Alcon Research
Industry
Eligibility
40 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Johns Creek, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 30, 2024 · Synced Jul 21, 2026, 1:02 PM EDT
Completed Phase 2 Interventional Results available

A Study of Safety and Efficacy of UNR844 Chloride (UNR844-Cl) Eye Drops in Subjects With Presbyopia.

NCT03809611
View directory record Official record
Conditions
Presbyopia
Interventions
UNR844-Cl, Placebo
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
45 Years to 65 Years
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
14
States / cities
Mission Hills, California • Newport Beach, California • Largo, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated May 10, 2022 · Synced Jul 21, 2026, 1:02 PM EDT
Completed Not applicable Interventional

Clinical Outcomes Following Implantation of Tecnis Synergy and Symfony Intraocular Lens

NCT05541796
View directory record Official record
Conditions
Cataract
Interventions
Intraocular lens
Device
Lead sponsor
George O. Waring IV
Other
Eligibility
40 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Mt. Pleasant, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 22, 2024 · Synced Jul 21, 2026, 1:02 PM EDT
Completed Not applicable Interventional Results available

Clareon PanOptix Pro vs. Clareon PanOptix - Study B

NCT06401551
View directory record Official record
Conditions
Aphakia, Presbyopia
Interventions
CPO Pro IOL, CPO IOL, Cataract Surgery
Device · Procedure
Lead sponsor
Alcon Research
Industry
Eligibility
22 Years and older
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
8
States / cities
Torrance, California • Bloomfield Hills, Michigan • Kansas City, Missouri + 5 more
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Jul 21, 2026, 1:02 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Product Performance of a New Silicone Hydrogel Multifocal Contact Lens

NCT05660577
View directory record Official record
Conditions
Myopia and Hyperopia and Presbyopia
Interventions
new silicone hydrogel daily disposable multifocal contact lens, the Bausch + Lomb (kalifilcon A) Daily Disposable Multifocal Contact Lens
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
40 Years and older
Enrollment
301 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
20
States / cities
San Diego, California • San Francisco, California • Denver, Colorado + 16 more
Source: ClinicalTrials.gov public record
Updated Apr 8, 2024 · Synced Jul 21, 2026, 1:02 PM EDT
Completed Not applicable Interventional Results available

Vivity IOL: Emmetropia Compared to Monovision.

NCT05464732
View directory record Official record
Conditions
Presbyopia
Interventions
Vivity IOL emmetropia, Vivity IOL monovision
Device
Lead sponsor
Carolina Eyecare Physicians, LLC
Other
Eligibility
50 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Mt. Pleasant, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 23, 2025 · Synced Jul 21, 2026, 1:02 PM EDT
Completed No phase listed Observational

Analysis of Defocus Curve of Pre-Presbyopic and Emerging Presbyopic Patients

NCT04474782
View directory record Official record
Conditions
Presbyopia
Interventions
There is not an intervention
Diagnostic Test
Lead sponsor
Vance Thompson Vision
Other
Eligibility
37 Years to 48 Years
Enrollment
45 participants
Timeline
2019 – 2020
U.S. locations
1
States / cities
Sioux Falls, South Dakota
Source: ClinicalTrials.gov public record
Updated Mar 29, 2021 · Synced Jul 21, 2026, 1:02 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Phase 3 Evaluation of the Safety and Efficacy of LNZ100 & LNZ101 for the Treatment of Presbyopia

NCT05656027
View directory record Official record
Conditions
Presbyopia, Refractive Error, Eye Diseases, Near Vision
Interventions
Aceclidine+Brimonidine combination ophthalmic solution, Aceclidine ophthalmic solution, Brimonidine
Drug
Lead sponsor
LENZ Therapeutics, Inc
Other
Eligibility
45 Years to 75 Years
Enrollment
469 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
25
States / cities
Chandler, Arizona • Mesa, Arizona • Phoenix, Arizona + 20 more
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Jul 21, 2026, 1:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Evaluation of a Small Aperture Extended Depth of Focus Intraocular Lens

NCT03633695
View directory record Official record
Conditions
Cataract, Presbyopia
Interventions
IC-8 IOL Group, Control Group
Device
Lead sponsor
AcuFocus, Inc.
Industry
Eligibility
22 Years and older
Enrollment
453 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
21
States / cities
Tucson, Arizona • Bakersfield, California • Laguna Hills, California + 18 more
Source: ClinicalTrials.gov public record
Updated Oct 23, 2022 · Synced Jul 21, 2026, 1:02 PM EDT
Completed No phase listed Observational

Vivity Outcomes in Patients With Early Stage Glaucoma

NCT04670575
View directory record Official record
Conditions
Glaucoma, Cataract, Presbyopia
Interventions
Cataract Surgery with Implantation of Vivity Extended Range of Vision IOL
Procedure
Lead sponsor
Vance Thompson Vision
Other
Eligibility
45 Years and older
Enrollment
27 participants
Timeline
2021 – 2022
U.S. locations
1
States / cities
Sioux Falls, South Dakota
Source: ClinicalTrials.gov public record
Updated May 19, 2024 · Synced Jul 21, 2026, 1:02 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Phase 3 Efficacy Study of LNZ100 & LNZ101 for the Treatment of Presbyopia

NCT05728944
View directory record Official record
Conditions
Presbyopia, Near Vision, Refractive Error, Eye Diseases
Interventions
Aceclidine+Brimonidine combination ophthalmic solution, Aceclidine ophthalmic solution, Vehicle
Drug
Lead sponsor
LENZ Therapeutics, Inc
Other
Eligibility
45 Years to 75 Years
Enrollment
229 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
17
States / cities
Dothan, Alabama • Scottsdale, Arizona • Glendale, California + 14 more
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Jul 21, 2026, 1:02 PM EDT
Not listed Phase 3 Interventional

A Clinical Trial to Evaluate a Corneal Inlay for the Improvement of Near and Intermediate Vision in Pseudophakic Presbyopic Subjects

NCT02668523
View directory record Official record
Conditions
Presbyopia, Pseudophakia
Interventions
Raindrop Near Vision Inlay
Device
Lead sponsor
ReVision Optics, Inc.
Industry
Eligibility
50 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
13
States / cities
Laguna Hills, California • Orange, California • Bradenton, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Jan 9, 2017 · Synced Jul 21, 2026, 1:02 PM EDT
Not listed Phase 4 Interventional

A Study to Evaluate the Raindrop Near Vision Inlay Under Flap or Within Pocket

NCT03376412
View directory record Official record
Conditions
Presbyopia
Interventions
Raindrop Near Vision Inlay
Device
Lead sponsor
Whitten Laser Eye
Other
Eligibility
40 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Dec 17, 2017 · Synced Jul 21, 2026, 1:02 PM EDT
Terminated Phase 3 Interventional Accepts healthy volunteers

Randomized Clinical Trial of Bifocal Lenses Versus Computer-specific Progressive Addition Lenses

NCT00585026
View directory record Official record
Conditions
Refractive Error, Presbyopia, Asthenopia, Eyeglasses
Interventions
D-28 bifocal lenses and frame, Progressive addition computer lenses and frame
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
40 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 14, 2011 · Synced Jul 21, 2026, 1:02 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Refitting Satisfied INFUSE One-Day Multifocal Wearers to DAILIES TOTAL1 Multifocal Contact Lenses

NCT07638943
View directory record Official record
Conditions
Contact Lens Comfort and Successful Refitting, Presbyopia
Interventions
DAILIES TOTAL1 Multifocal (delefilcon A)
Device
Lead sponsor
Gordon Schanzlin New Vision
Other
Eligibility
40 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Jul 21, 2026, 1:02 PM EDT
Completed Not applicable Interventional Results available

Single-center, Double-arm, Prospective Clinical Trial to Compare Visual Performance of Non-diffractive Extended Vision and Neutral Aspheric Monofocal Intraocular Lenses

NCT04591054
View directory record Official record
Conditions
Cataract, Presbyopia
Interventions
Extended Vision IOL, Neutral Aspheric Monofocal IOL
Device
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years to 95 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 20, 2023 · Synced Jul 21, 2026, 1:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

1-Week Dispensing Evaluation of Kalifilcon A Daily Disposable Multifocal Compared to Ultra for Presbyopia

NCT05325931
View directory record Official record
Conditions
Presbyopia
Interventions
kalifilcon A Daily Disposable Multifocal, samfilcon A for Presbyopia
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
40 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Apr 12, 2022 · Synced Jul 21, 2026, 1:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Assessment of a Customized Free-form Progressive Addition Lens Spectacle

NCT01234207
View directory record Official record
Conditions
Presbyopia
Interventions
Standard, non-free-form, non-customized PAL spectacles, Individually customized free-form surfaced PAL spectacles
Device
Lead sponsor
University of California, Berkeley
Other
Eligibility
39 Years to 80 Years
Enrollment
95 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Apr 17, 2017 · Synced Jul 21, 2026, 1:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Clinical Trial of The VisAbility Micro Insert System for Presbyopic Patients

NCT02374671
View directory record Official record
Conditions
Presbyopia
Interventions
VisAbility Micro Insert
Device
Lead sponsor
Refocus Group, Inc.
Industry
Eligibility
45 Years to 60 Years
Enrollment
365 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
14
States / cities
Orange, California • San Diego, California • Honolulu, Hawaii + 10 more
Source: ClinicalTrials.gov public record
Updated Jan 5, 2020 · Synced Jul 21, 2026, 1:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pilot Dispensing Study of Two Marketed Daily Disposable Multifocal Contact Lenses

NCT07076160
View directory record Official record
Conditions
Visual Acuity, Presbyopia
Interventions
INFUSE® One Day Multifocal, ACUVUE® OASYS MAX 1-Day Multifocal Contact Lens
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
74 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
7
States / cities
Jacksonville, Florida • Longwood, Florida • Maitland, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Jul 21, 2026, 1:02 PM EDT
Completed Not applicable Interventional Results available

Clinical Performance Evaluation of Two Frequent Replacement Silicone Hydrogel Multifocal Toric Contact Lenses

NCT06461455
View directory record Official record
Conditions
Presbyopia, Astigmatism
Interventions
Lehfilcon A multifocal for astigmatism contact lenses, Samfilcon A multifocal for astigmatism contact lenses, CLEAR CARE® Cleaning & Disinfecting Solution
Device
Lead sponsor
Alcon Research
Industry
Eligibility
40 Years and older
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
11
States / cities
Oakland, California • San Francisco, California • Maitland, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Jul 21, 2026, 1:02 PM EDT
Completed No phase listed Observational Results available

Symfony/Synergy IOL Combination Outcomes

NCT05604781
View directory record Official record
Conditions
Bilateral Cataract, Presbyopia
Interventions
Symfony & Synergy IOL combination
Device
Lead sponsor
Center For Sight
Other
Eligibility
50 Years and older
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
2
States / cities
Venice, Florida • Mt. Pleasant, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 17, 2024 · Synced Jul 21, 2026, 1:02 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Clinical Evaluation of the Lenstec SBL-3 Multifocal Intraocular Lens

NCT02487160
View directory record Official record
Conditions
Cataracts, Presbyopia
Interventions
SBL-3 multifocal intraocular lens, Control monofocal intraocular lens
Device
Lead sponsor
Lenstec Incorporated
Industry
Eligibility
22 Years and older
Enrollment
499 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
13
States / cities
Dothan, Alabama • Santa Maria, California • Cape Coral, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated May 22, 2023 · Synced Jul 21, 2026, 1:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of an Investigational Multifocal Lens

NCT02223754
View directory record Official record
Conditions
Presbyopia
Interventions
lotrafilcon B, etafilcon A
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
371 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
20
States / cities
Montgomery, Alabama • Mission Viejo, California • Jacksonville, Florida + 16 more
Source: ClinicalTrials.gov public record
Updated Jun 18, 2018 · Synced Jul 21, 2026, 1:02 PM EDT