A Phase 3 Efficacy Study of Pilocarpine HCl Ophthalmic Solution (AGN-190584) in Participants With Presbyopia
Public ClinicalTrials.gov record NCT03857542. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Multicenter, Double-Masked, Randomized, Vehicle-Controlled, Parallel-Group Study Evaluating the Safety and Efficacy of AGN-190584 in Participants With Presbyopia
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This clinical study will evaluate pilocarpine hydrogen chloride (HCl) ophthalmic solution (AGN-190584) in an expanded participant population to establish efficacy, safety, and tolerability versus the vehicle-control when administered, over a 30-day study intervention period, once daily bilaterally in participants with presbyopia.
Study identification
- NCT ID
- NCT03857542
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 427 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 40 Years to 55 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 1, 2019 (Actual)
- Primary completion
- Sep 10, 2020 (Actual)
- Completion
- Sep 10, 2020 (Actual)
- Last update posted
- Dec 29, 2021
2019 – 2020
United States locations
- U.S. sites
- 35
- U.S. states
- 18
- U.S. cities
- 33
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Eye Center South | Dothan | Alabama | 36301 | — |
| M&M Eye Institute | Prescott | Arizona | 86301 | — |
| Walman Eye Center | Sun City | Arizona | 85351 | — |
| Milton M. Hom, OD, FAAO | Azusa | California | 91702 | — |
| Global Research Management | Glendale | California | 91204 | — |
| Advanced Vision Care | Los Angeles | California | 90067 | — |
| North Valley Eye Medical Group, Inc. | Mission Hills | California | 91345 | — |
| Eye Research Foundation | Newport Beach | California | 92663 | — |
| Corneal Consultants of Colorado | Littleton | Colorado | 80120 | — |
| Benjamin Knox Lambright, MD | Crystal River | Florida | 34429 | — |
| South Florida Vision Center | Fort Lauderdale | Florida | 33309 | — |
| Bowden Eye Associates | Jacksonville | Florida | 32256 | — |
| Mid Florida Eye Center | Mt. Dora | Florida | 32757 | — |
| Newsom Eye & Laser Center | Sebring | Florida | 33870 | — |
| Clayton Eye Center | Morrow | Georgia | 30260 | — |
| The Midwest Center for Sight | Des Plaines | Illinois | 60016 | — |
| Jacksoneye | Lake Villa | Illinois | 60046 | — |
| Kannarr Eye Care | Pittsburg | Kansas | 66762 | — |
| Heart of America Eyecare | Shawnee Mission | Kansas | 66204 | — |
| Cincinnati Eye Institute | Edgewood | Kentucky | 41017 | — |
| Chu Laser Eye Institute | Bloomington | Minnesota | 55420 | — |
| Silverstein Eye Centers | Kansas City | Missouri | 64133 | — |
| Moyes Eye Center | Kansas City | Missouri | 64154 | — |
| Tekwani Vision Center | St Louis | Missouri | 63128 | — |
| Amel Youssef, OD | Las Vegas | Nevada | 89117 | — |
| Debry Medical Services PC | Las Vegas | Nevada | 89128 | — |
| Bucci Laser Vision | Wilkes-Barre | Pennsylvania | 18702 | — |
| Waring Vision Institute | Mt. Pleasant | South Carolina | 29464 | — |
| University Eye Surgeons | Maryville | Tennessee | 37803 | — |
| Total Eye Care, PA | Memphis | Tennessee | 38119 | — |
| Keystone Research ltd. at Texan Eye | Austin | Texas | 78731 | — |
| The Cataract and Glaucoma Center | El Paso | Texas | 79902 | — |
| Texas Eye & Laser Ctr | Hurst | Texas | 76054 | — |
| Benjamin Travis Dastrup, MD | Ogden | Utah | 84403 | — |
| Vision Consultants and Surgeons | Falls Church | Virginia | 22046 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03857542, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 29, 2021 · Synced Oct 23, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03857542 live on ClinicalTrials.gov.