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Showing 1–24 of 92 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Procedural Pain Clear all
Completed Phase 4 Interventional

Skin Blood Flow Changes Using Laser Doppler Imager for Assessment of Pain and Analgesia in Newborn Infants

NCT00694174
View directory record Official record
Conditions
Procedural Pain
Interventions
sucrose 24% oral solution, sterile water
Drug
Lead sponsor
Children's Hospital of Michigan
Other
Eligibility
1 Day to 7 Days
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 9, 2008 · Synced Sep 5, 2026, 9:23 PM EDT
Recruiting Not applicable Interventional

The Effects of Endotracheal Suctioning on Pain and Serum Markers

NCT06692400
View directory record Official record
Conditions
Intensive Care Unit ICU, Intubation, Critical Illness, Mechanical Ventilation, Pain Measurement, Pain, Procedural, Oxidative Stress, Hypoxia, Biomarkers / Blood, Adult, Uric Acid, Sepsis, COVID, Influenza, Pneumonia
Interventions
endotracheal tube suctioning
Procedure
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Sep 5, 2026, 9:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Analgesic Properties of Oral Sucrose During Immunizations

NCT00446875
View directory record Official record
Conditions
Procedural Pain
Interventions
Administration of oral Sucrose, Administration of oral Placebo
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
3 Months to 11 Months
Enrollment
98 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 14, 2019 · Synced Sep 5, 2026, 9:23 PM EDT
Completed Phase 4 Interventional

Breast Milk vs Sucrose in Relieving Procedural Pain in Preterm Neonates During Blood Draw by Automated Heel Lance

NCT04898881
View directory record Official record
Conditions
Pain
Interventions
Breast Human Milk, 24 % Sucrose
Other
Lead sponsor
Wayne State University
Other
Eligibility
1 Day to 30 Days
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated May 23, 2021 · Synced Sep 5, 2026, 9:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Can Virtual Reality Reduce Pain and Anxiety During Blood Draw

NCT04449341
View directory record Official record
Conditions
Procedural Anxiety, Procedural Pain
Interventions
Oculus Go headset with Ocean Rift application
Device
Lead sponsor
C.R.Darnall Army Medical Center
Federal
Eligibility
18 Years to 50 Years
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Fort Hood, Texas
Source: ClinicalTrials.gov public record
Updated Jul 12, 2021 · Synced Sep 5, 2026, 9:23 PM EDT
Terminated Not applicable Interventional

Peri-procedural Smoking Cessation Program in Patients With Chronic Pain

NCT04605744
View directory record Official record
Conditions
Chronic Pain, Smoking
Interventions
Smoking cessation counseling
Behavioral
Lead sponsor
The Cooper Health System
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Camden, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 25, 2022 · Synced Sep 5, 2026, 9:23 PM EDT
Terminated Phase 3 Interventional

A Study of Oral Codeine Sulfate in Pediatric Patients With Post-procedural Pain

NCT01676493
View directory record Official record
Conditions
Pain
Interventions
Codeine
Drug
Lead sponsor
Roxane Laboratories
Industry
Eligibility
2 Years to 17 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 1, 2018 · Synced Sep 5, 2026, 9:23 PM EDT
Not listed Phase 3 Interventional

A Study to Evaluate Efficacy and Safety of MELT-300 for Procedural Sedation in Subjects Undergoing Cataract Extraction With Lens Replacement (CELR)

NCT06383273
View directory record Official record
Conditions
Cataract
Interventions
MELT-300 sublingual tablet, Midalozam sublingual tablet, Placebo sublingual tablet
Drug
Lead sponsor
Melt Pharmaceuticals
Industry
Eligibility
18 Years to 65 Years
Enrollment
528 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
12
States / cities
Chico, California • Grand Junction, Colorado • Jacksonville, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Aug 1, 2024 · Synced Sep 5, 2026, 9:23 PM EDT
Recruiting Not applicable Interventional

Virtual Reality as a Method for Pain and Anxiety Control During First Trimester Procedural Abortion

NCT07288047
View directory record Official record
Conditions
Abortion, First Trimester, Pain Management, Pain After Surgery, Satisfaction, Satisfaction With Care, Anxiety After Surgery
Interventions
VR headset, Usual Care
Device · Other
Lead sponsor
Study Investigator
Other
Eligibility
18 Years and older · Female only
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 5, 2026, 9:23 PM EDT
Enrolling by invitation Not applicable Interventional

Little NIRVANA for Pediatric Pain and Anxiety

NCT06795126
View directory record Official record
Conditions
Acute Pain, Procedural Anxiety, Pediatric ALL, Emergency Medicine, IV Access
Interventions
Little NIRVANA
Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
2 Years to 8 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Sep 5, 2026, 9:23 PM EDT
Recruiting Not applicable Interventional

Procedural Framing and Epidural Steroid Injection Outcomes

NCT07498140
View directory record Official record
Conditions
Lumbosacral Radiculopathy
Interventions
Behavioral manipulation of ESI expectations, No behavioral manipulation of ESI expectations, No behavioral manipulation of pharmacotherapy expectations
Behavioral · Other
Lead sponsor
Northwestern University
Other
Eligibility
Not listed
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Chicago, Illinois • Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Sep 5, 2026, 9:23 PM EDT
Completed No phase listed Observational

Balloon Cryotherapy vs. Radiofrequency Ablation Pain Study

NCT03387982
View directory record Official record
Conditions
Barrett Esophagus
Interventions
Not listed
Lead sponsor
Geisinger Clinic
Other
Eligibility
18 Years and older
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
4
States / cities
Queens, New York • Danville, Pennsylvania • Charleston, South Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 17, 2022 · Synced Sep 5, 2026, 9:23 PM EDT
Completed Not applicable Interventional

Oral Sucrose Versus Glucose for Procedural Pain in Premature Neonates

NCT01894659
View directory record Official record
Conditions
Neonatal Procedural Pain
Interventions
24% oral sucrose, 30% oral glucose
Other
Lead sponsor
Loma Linda University
Other
Eligibility
Up to 7 Days
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Sep 1, 2020 · Synced Sep 5, 2026, 9:23 PM EDT
Completed Not applicable Interventional Results available

Local Injection of Pain Medication to Reduce Pain After Bone Marrow Procedures in Pediatric Neuroblastoma Patients

NCT02924324
View directory record Official record
Conditions
Neuroblastoma
Interventions
propofol, ropivacaine, Wong-Baker FACES® Pain Rating Scale, Post-procedural quality of life (QOL)
Device · Drug · Behavioral
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
3 Years to 18 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 7, 2022 · Synced Sep 5, 2026, 9:23 PM EDT
Withdrawn Not applicable Interventional

Using Peripheral Nerve Stimulation (PNS) to Treat Chronic Post-surgical Pain (CPSP) After Knee Surgery

NCT04670042
View directory record Official record
Conditions
Injury; Nerve, Peripheral, Multiple, Chronic Post-Procedural Pain, Total Knee Arthroplasty, Surgery, Knee Injuries, Knee Pain Chronic, Postoperative Pain, Chronic Postoperative Pain
Interventions
SPRINT® Peripheral Nerve Stimulation (PNS) System (510k Cleared)
Device
Lead sponsor
Stanford University
Other
Eligibility
21 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Oct 19, 2022 · Synced Sep 5, 2026, 9:23 PM EDT
Completed Phase 4 Interventional Results available

Effectiveness of IV Acetaminophen and IV Ibuprofen in Reducing Post Procedural Pain in the UFE Procedure

NCT02227316
View directory record Official record
Conditions
Symptomatic Uterine Fibroids and Adenomyosis
Interventions
IV Ibuprofen, IV Acetaminophen, Intravenous placebo/Intravenous placebo
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 60 Years · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
2
States / cities
Los Angeles, California • Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Jun 7, 2018 · Synced Sep 5, 2026, 9:23 PM EDT
Completed Phase 2Phase 3 Interventional

VR for Burn Dressing Changes at Home

NCT04548635
View directory record Official record
Conditions
Burns, Acute Pain, Procedural Pain
Interventions
VR-PAT
Device
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
5 Years to 17 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 29, 2024 · Synced Sep 5, 2026, 9:23 PM EDT
Completed Not applicable Interventional

Virtual Reality in Burn Pain Management

NCT00593086
View directory record Official record
Conditions
Burns, Pain
Interventions
Pain management, Standard of care/no virtual reality game
Procedure · Other
Lead sponsor
United States Army Institute of Surgical Research
Federal
Eligibility
18 Years to 65 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 26, 2013 · Synced Sep 5, 2026, 9:23 PM EDT
Terminated Phase 3 Interventional Results available

Sublingual Fentanyl and Procedural Burn Pain

NCT02241486
View directory record Official record
Conditions
Burn Pain
Interventions
Sublingual Fentanyl Spray
Drug
Lead sponsor
Loyola University
Other
Eligibility
18 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 27, 2017 · Synced Sep 5, 2026, 9:23 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Efficacy of IV Lidocaine at Alleviating Pain Associated With Propofol Infusion in Pediatric Patients Undergoing Sedation

NCT00786916
View directory record Official record
Conditions
Pain
Interventions
normal saline, lidocaine
Drug
Lead sponsor
Akron Children's Hospital
Other
Eligibility
2 Years to 7 Years
Enrollment
109 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Akron, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 26, 2015 · Synced Sep 5, 2026, 9:23 PM EDT
Recruiting Not applicable Interventional

Offset Mechanisms in Evaluation of Lumbar Medial Branch Blocks

NCT05961800
View directory record Official record
Conditions
Pain, Chronic, Facet Joint Pain, Pain, Procedural, Analgesia
Interventions
Cutaneous Probe, Quantitative Sensory Testing, Computer Tasks
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 26, 2026 · Synced Sep 5, 2026, 9:23 PM EDT
Recruiting Not applicable Interventional

Oral Surgery Virtual Reality Glasses Study

NCT06723158
View directory record Official record
Conditions
Procedural Anxiety, Procedural Pain
Interventions
Virtual reality (VR) glasses with relaxation module
Other
Lead sponsor
Boston University
Other
Eligibility
16 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 26, 2026 · Synced Sep 5, 2026, 9:23 PM EDT
Completed Phase 4 Interventional Results available

Addition of Buprenorphine to Paracervical Block for Pain Control During Osmotic Dilator Insertion

NCT04254081
View directory record Official record
Conditions
Procedural Pain, Buprenorphine, Adjuvants, Anesthesia, Dilation and Evacuation, Analgesics
Interventions
Buprenorphine 0.15 MG, Lidocaine 1% Injectable Solution
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older · Female only
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 31, 2023 · Synced Sep 5, 2026, 9:23 PM EDT
Enrolling by invitation Not applicable Interventional

VR-PAT During Home Burn Dressings - Multisite

NCT05673551
View directory record Official record
Conditions
Burns, Acute Pain, Procedural Pain, Injuries, Pediatric ALL
Interventions
VR-PAT
Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
6 Years to 17 Years
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
2
States / cities
Columbus, Ohio • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Sep 5, 2026, 9:23 PM EDT