- Conditions
- Head and Neck Cancer
- Interventions
- Questionnaires, Acupuncture, Electroencephalogram (EEG)
- Behavioral · Procedure
- Lead sponsor
- M.D. Anderson Cancer Center
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 30 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2014 – 2022
- U.S. locations
- 1
- States / cities
- Houston, Texas
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Showing 1–19
of 19
matching trials from the live ClinicalTrials.gov search.
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- Conditions
- Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands
- Interventions
- AAV2-hAQP1
- Genetic
- Lead sponsor
- MeiraGTx, LLC
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 276 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2024 – 2032
- U.S. locations
- 7
- States / cities
- Gilbert, Arizona • Miami, Florida • Iowa City, Iowa + 4 more
- Conditions
- Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands
- Interventions
- AAV2-hAQP1 Concentration 1, AAV2-hAQP1 Concentration 2, Placebo, AAV2-hAQP1 Concentration 3, AAV2-hAQP1 Concentration 4
- Genetic · Other
- Lead sponsor
- MeiraGTx, LLC
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 276 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2026
- U.S. locations
- 18
- States / cities
- Gilbert, Arizona • Duarte, California • Miami, Florida + 14 more
- Conditions
- Head and Neck Cancer
- Interventions
- filgrastim, pegfilgrastim, cisplatin, docetaxel, fluorouracil, conventional surgery, radiation therapy
- Biological · Drug · Procedure + 1 more
- Lead sponsor
- Masonic Cancer Center, University of Minnesota
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 4 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2006 – 2008
- U.S. locations
- 1
- States / cities
- Minneapolis, Minnesota
- Conditions
- Head and Neck Cancer, Xerostomia
- Interventions
- Pilocarpine, ALTENS
- Drug · Procedure
- Lead sponsor
- Radiation Therapy Oncology Group
- Network
- Eligibility
- 18 Years and older
- Enrollment
- 196 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2008 – 2014
- U.S. locations
- 16
- States / cities
- San Francisco, California • New Haven, Connecticut • Atlanta, Georgia + 11 more
- Conditions
- Head and Neck Cancer
- Interventions
- MRI sialography, Parotid Duct Sparing Radiation Therapy Planning, Parotid Sparing Radiation Therapy Planning
- Device · Other
- Lead sponsor
- UNC Lineberger Comprehensive Cancer Center
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 98 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2030
- U.S. locations
- 1
- States / cities
- Chapel Hill, North Carolina
- Conditions
- Radiation-Induced Xerostomia, Head and Neck Cancer, Radiation Toxicity, Oral Complications of Chemotherapy and Head/Neck Radiation
- Interventions
- Standard Oral Hygiene, Standard Oral Hygiene + True Acupuncture, Standard Oral Hygiene + Sham Acupuncture
- Other
- Lead sponsor
- Wake Forest University Health Sciences
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 258 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2012 – 2022
- U.S. locations
- 36
- States / cities
- Burbank, California • San Francisco, California • San Jose, California + 26 more
- Conditions
- Parotid Salivary Dysfunction
- Interventions
- Gene Transfer, AdhAQP1
- Genetic · Drug
- Lead sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
- NIH
- Eligibility
- 18 Years and older
- Enrollment
- 17 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2006 – 2018
- U.S. locations
- 1
- States / cities
- Bethesda, Maryland
- Conditions
- Xerostomia, Head and Neck Cancer
- Interventions
- Bone Marrow Aspiration, Ultrasound Imaging of Salivary Glands, Salivary Assay, Quality of Life Instruments
- Procedure · Diagnostic Test · Other
- Lead sponsor
- University of Wisconsin, Madison
- Other
- Eligibility
- 18 Years to 89 Years
- Enrollment
- 12 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2019 – 2021
- U.S. locations
- 1
- States / cities
- Madison, Wisconsin
- Conditions
- Xerostomia
- Interventions
- Cevimeline
- Drug
- Lead sponsor
- American Academy of Otolaryngology-Head and Neck Surgery Foundation
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 54 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2007 – 2009
- U.S. locations
- 7
- States / cities
- Colorado Springs, Colorado • Urbana, Illinois • Kansas City, Kansas + 4 more
- Conditions
- Radiation-Induced Parotid Gland Hypofunction, Xerostomia Due to Radiotherapy, Head and Neck Cancer
- Interventions
- AAV2hAQP1: 1 x 10^11 vg/gland (single gland), AAV2hAQP1: 3 x 10^10 vg/gland (both glands), AAV2hAQP1: 3 x 10^11 vg/gland (single gland), AAV2hAQP1: 1 x 10^11 vg/gland (both glands), AAV2hAQP1: 1 x 10^12 vg/gland (single gland), AAV2hAQP1: 3 x 10^11 vg/gland (both glands), AAV2hAQP1: 3 x 10^12 vg/gland (single gland), AAV2hAQP1: 1 x 10^12 vg/gland (both glands)
- Drug
- Lead sponsor
- MeiraGTx UK II Ltd
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 24 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2019 – 2023
- U.S. locations
- 5
- States / cities
- Stanford, California • Louisville, Kentucky • Boston, Massachusetts + 2 more
- Conditions
- Radiation-induced Xerostomia
- Interventions
- Not listed
- Lead sponsor
- MeiraGTx, LLC
- Industry
- Eligibility
- 18 Years to 81 Years
- Enrollment
- 22 participants
- Timeline
- 2020 – 2027
- U.S. locations
- 3
- States / cities
- Stanford, California • Boston, Massachusetts • Charlotte, North Carolina
- Conditions
- Head And Neck Cancer
- Interventions
- Acupuncture - Group 1, Acupuncture - Group 2, Standard Care, Questionnaire
- Procedure · Other
- Lead sponsor
- M.D. Anderson Cancer Center
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 435 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2011 – 2026
- U.S. locations
- 1
- States / cities
- Houston, Texas
- Conditions
- Xerostomia Due to Radiotherapy (Disorder)
- Interventions
- Stromal Vascular Fraction, Usual Care
- Biological · Other
- Lead sponsor
- Midwestern Regional Medical Center
- Other
- Eligibility
- 21 Years and older
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2018 – 2020
- U.S. locations
- 1
- States / cities
- Zion, Illinois
- Conditions
- Head and Neck Carcinoma, Xerostomia
- Interventions
- Quality-of-Life Assessment, Transcutaneous Acupoint Electrical Stimulation
- Other · Procedure
- Lead sponsor
- Roswell Park Cancer Institute
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 30 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2014 – 2019
- U.S. locations
- 1
- States / cities
- Buffalo, New York
- Conditions
- Radiation-Induced Xerostomia and Hyposalivation
- Interventions
- RXRG001, Placebo
- Biological
- Lead sponsor
- RiboX Therapeutics Ltd.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 42 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2027
- U.S. locations
- 4
- States / cities
- Iowa City, Iowa • Baltimore, Maryland • New York, New York + 1 more
- Conditions
- Dental Caries
- Interventions
- silver diamine fluoride, 38%, Sodium fluoride gel, 5000 PPM
- Device
- Lead sponsor
- Texas A & M University Baylor College Of Dentistry
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 56 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022 – 2025
- U.S. locations
- 1
- States / cities
- Dallas, Texas
- Conditions
- Head and Neck Cancer, Radiation Toxicity, Xerostomia
- Interventions
- salivary gland transfer, Post-operative radiation therapy
- Procedure · Radiation
- Lead sponsor
- Radiation Therapy Oncology Group
- Network
- Eligibility
- 18 Years and older
- Enrollment
- 49 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2003 – 2016
- U.S. locations
- 9
- States / cities
- Gainesville, Florida • Miami, Florida • Springfield, Illinois + 5 more
- Conditions
- Squamous Cell Head and Neck Cancer, Radiation Induced Xerostomia, Salivary Hypofunction
- Interventions
- AAV2hAQP1
- Biological
- Lead sponsor
- MeiraGTx, LLC
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 17 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2015 – 2026
- U.S. locations
- 1
- States / cities
- Bethesda, Maryland