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ClinicalTrials.gov public records Last synced Sep 25, 2026, 4:13 AM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Regurgitation Clear all
Recruiting No phase listed Observational

Comparative Imaging Assessment of Valvular Heart Disease

NCT04126018
View directory record Official record
Conditions
Valve Heart Disease, Aortic Stenosis, Aortic Regurgitation
Interventions
MRI with strain measurement, Echocardiography
Diagnostic Test
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 90 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 12, 2026 · Synced Sep 25, 2026, 4:13 AM EDT
Active, not recruiting Not applicable Interventional

The JenaValve ALIGN-AR Pivotal Trial

NCT04415047
View directory record Official record
Conditions
Aortic Regurgitation, Aortic Valve Insufficiency, Aortic Insufficiency, Aortic Valve Disease
Interventions
JenaValve Trilogy Heart Valve System
Device
Lead sponsor
JenaValve Technology, Inc.
Industry
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2028
U.S. locations
30
States / cities
Tucson, Arizona • Los Angeles, California • San Diego, California + 25 more
Source: ClinicalTrials.gov public record
Updated Sep 12, 2022 · Synced Sep 25, 2026, 4:13 AM EDT
Recruiting Not applicable Interventional

VenusP-Valve Pivotal Study (PROTEUS STUDY)

NCT06010563
View directory record Official record
Conditions
Pulmonary Regurgitation
Interventions
Transcatheter pulmonary valve implantation (TPVI), VenusP-ValveTM System
Device
Lead sponsor
Venus MedTech (HangZhou) Inc.
Industry
Eligibility
12 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2034
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Feb 27, 2025 · Synced Sep 25, 2026, 4:13 AM EDT
Recruiting Not applicable Interventional

CorMatrix Cor TRICUSPID ECM Valve Replacement - Pivotal Study

NCT05742906
View directory record Official record
Conditions
Tricuspid Valve Disease, Tricuspid Valve Insufficiency
Interventions
Tricuspid valve replacement with the Cor TRICUSPID ECM Valve
Device
Lead sponsor
Corvivo Cardiovascular, Inc.
Industry
Eligibility
Not listed
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
2
States / cities
Indianapolis, Indiana • New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 1, 2025 · Synced Sep 25, 2026, 4:13 AM EDT
Completed No phase listed Observational Results available

Contour 3D®/TriAd® Tricuspid Annuloplasty Ring Post-Market Clinical Trial

NCT01585779
View directory record Official record
Conditions
Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency
Interventions
Contour 3D® implant for tricuspid valve repair, Tri-Ad® implant for tricuspid valve repair
Device
Lead sponsor
Medtronic Cardiovascular
Industry
Eligibility
18 Years to 85 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
3
States / cities
Aventura, Florida • Ann Arbor, Michigan • Asheville, North Carolina
Source: ClinicalTrials.gov public record
Updated May 9, 2017 · Synced Sep 25, 2026, 4:13 AM EDT
Not listed Not applicable Interventional

AltaValve Early Feasibility Study Protocol

NCT03997305
View directory record Official record
Conditions
Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation, Mitral Incompetence
Interventions
AltaValve
Device
Lead sponsor
4C Medical Technologies, Inc.
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
12
States / cities
Tucson, Arizona • Thousand Oaks, California • Washington D.C., District of Columbia + 9 more
Source: ClinicalTrials.gov public record
Updated Aug 31, 2023 · Synced Sep 25, 2026, 4:13 AM EDT
Completed Not applicable Interventional Results available

The CLASP Study Edwards PASCAL TrAnScatheter Mitral Valve RePair System Study

NCT03170349
View directory record Official record
Conditions
Mitral Valve Regurgitation
Interventions
Mitral Valve Repair
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
8
States / cities
Los Angeles, California • Aurora, Colorado • Evanston, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Sep 25, 2026, 4:13 AM EDT
Recruiting No phase listed Observational

Secondary Mitral Regurgitation Treatment With MitraClip and Assessment by Cardiac Magnetic Resonance

NCT07131631
View directory record Official record
Conditions
Heart Failure and Reduced Ejection Fraction, Functional Mitral Regurgitation
Interventions
Cardiac MRI
Diagnostic Test
Lead sponsor
Minneapolis Heart Institute Foundation
Other
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
5
States / cities
Minneapolis, Minnesota • Charlotte, North Carolina • Cincinnati, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Sep 25, 2026, 4:13 AM EDT
Enrolling by invitation No phase listed Observational

Outcome of Patients With Severe Functional TR According to Medical, Transcatheter or Surgical Treatment

NCT05825898
View directory record Official record
Conditions
Tricuspid Regurgitation
Interventions
Surgery or Transcatheter tricuspid valve intervention
Procedure
Lead sponsor
Ottawa Heart Institute Research Corporation
Other
Eligibility
18 Years and older
Enrollment
3,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
4
States / cities
Rochester, Minnesota • New York, New York
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Sep 25, 2026, 4:13 AM EDT
Completed Phase 2 Interventional Results available

Validation of Patient-reported Outcomes Measures for the Assessment of Gastroesophageal Reflux Disease (GERD) Symptoms

NCT00703534
View directory record Official record
Conditions
GERD, Acid Reflux Disease, Heartburn, Regurgitation
Interventions
AZD3355, Placebo, Gelusil®
Drug
Lead sponsor
AstraZeneca
Industry
Eligibility
18 Years to 70 Years
Enrollment
478 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
84
States / cities
Athens, Alabama • Tucson, Arizona • Little Rock, Arkansas + 81 more
Source: ClinicalTrials.gov public record
Updated Jun 19, 2011 · Synced Sep 25, 2026, 4:13 AM EDT
Completed Not applicable Interventional Results available

Early Feasibility Study of the Edwards FORMA Tricuspid Transcatheter Repair System

NCT02471807
View directory record Official record
Conditions
Tricuspid Valve Regurgitation
Interventions
Edwards FORMA Tricuspid Transcatheter Repair System
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2023
U.S. locations
5
States / cities
Los Angeles, California • Atlanta, Georgia • Rochester, Minnesota + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 27, 2023 · Synced Sep 25, 2026, 4:13 AM EDT
Recruiting No phase listed Observational

DELINEATE-Prospective

NCT07197736
View directory record Official record
Conditions
Valve Disease, Aortic, Mitral Regurgitation (MR), Aortic Stenosis, Valvular Heart Disease, Tricuspid Regurgitation (TR), Aortic Regurgitation
Interventions
Not listed
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Sep 25, 2026, 4:13 AM EDT
Withdrawn No phase listed Observational

Measurement of Tricuspid Regurgitation Volume for Assessment of Tricuspid Regurgitation Using 3D Transesophageal Echocardiography

NCT05130775
View directory record Official record
Conditions
Tricuspid Regurgitation
Interventions
Transesophageal echocardiograpgy
Other
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years and older
Timeline
2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 4, 2024 · Synced Sep 25, 2026, 4:13 AM EDT
Not listed Not applicable Interventional

Erector Spinae Plane Block for Minimally Invasive Mitral Valve Surgery

NCT04770961
View directory record Official record
Conditions
Mitral Regurgitation, Mitral Valve Insufficiency, Mitral Valve Prolapse
Interventions
Erector spinae plane catheter with 0.5% Ropivacaine, Erector spinae plane catheter with saline
Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 2, 2021 · Synced Sep 25, 2026, 4:13 AM EDT
Recruiting Not applicable Interventional

Home-Based Cardiac Rehabilitation Using a Novel Mobile Health Exercise Regimen Following Transcatheter Heart Valve Interventions

NCT06077201
View directory record Official record
Conditions
Valvular Heart Disease
Interventions
HBCR hands-off, HBCR interactive
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Sep 25, 2026, 4:13 AM EDT
Recruiting Not applicable Interventional

A Clinical Study of GeminiOne TEER System for the Treatment of Severe, Symptomatic MR.

NCT07086534
View directory record Official record
Conditions
Mitral Regurgitation
Interventions
GeminiOne Transcatheter Edge-to-Edge Repair (TEER) System
Device
Lead sponsor
Sierra Valve LLC
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
Thousand Oaks, California
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Sep 25, 2026, 4:13 AM EDT
Completed No phase listed Observational

The Bronx-Valve Registry

NCT05453526
View directory record Official record
Conditions
Valvular Heart Disease
Interventions
Not listed
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
330,570 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2019
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Feb 2, 2025 · Synced Sep 25, 2026, 4:13 AM EDT
Completed Not applicable Interventional Results available

EndoMAXX Endoluminal Valve Technology (EVT) Compared to EndoMAXX

NCT02159898
View directory record Official record
Conditions
Malignant Esophageal Strictures
Interventions
EndoMAXX Endoluminal Valve Technology (EVT), EndoMAXX
Device
Lead sponsor
Merit Medical Systems, Inc.
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
7
States / cities
Aurora, Colorado • Gainesville, Florida • Indianapolis, Indiana + 4 more
Source: ClinicalTrials.gov public record
Updated Jun 6, 2018 · Synced Sep 25, 2026, 4:13 AM EDT
Active, not recruiting Not applicable Interventional

TRIcvalve biCAVal Valve System for Severe Tricuspid Regurgitation (TRICAV-I)

NCT06137807
View directory record Official record
Conditions
Tricuspid Regurgitation, Tricuspid Valve Disease
Interventions
TricValve® Transcatheter Bicaval Valve System
Device
Lead sponsor
P+F Products + Features USA Inc.
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
36
States / cities
Phoenix, Arizona • Tucson, Arizona • San Diego, California + 31 more
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 25, 2026, 4:13 AM EDT
Active, not recruiting Not applicable Interventional

Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair

NCT02803957
View directory record Official record
Conditions
Mitral Valve Insufficiency
Interventions
NeoChord DS1000, Surgical Mitral Valve Repair
Device
Lead sponsor
NeoChord
Industry
Eligibility
21 Years and older
Enrollment
585 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2027
U.S. locations
14
States / cities
Sacramento, California • Stanford, California • Washington D.C., District of Columbia + 10 more
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Sep 25, 2026, 4:13 AM EDT
Active, not recruiting Not applicable Interventional

Edwards EVOQUE Eos MISCEND Study

NCT02718001
View directory record Official record
Conditions
Mitral Valve Regurgitation (Degenerative or Functional)
Interventions
Edwards EVOQUE Eos Mitral Valve Replacement System
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
123 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2033
U.S. locations
16
States / cities
Burlingame, California • Los Angeles, California • San Francisco, California + 13 more
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Sep 25, 2026, 4:13 AM EDT
Terminated Phase 3 Interventional Results available

Effectiveness of Surgical Mitral Valve Repair Versus Medical Treatment for People With Significant Mitral Regurgitation and Non-ischemic Congestive Heart Failure

NCT00608140
View directory record Official record
Conditions
Mitral Valve Insufficiency, Heart Failure
Interventions
Surgical mitral valvuloplasty with placement of annular ring (SMVR), Optimal medical therapy (OMT)
Procedure · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
8
States / cities
Atlanta, Georgia • Boston, Massachusetts • Minneapolis, Minnesota + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 3, 2018 · Synced Sep 25, 2026, 4:13 AM EDT
Withdrawn No phase listed Observational

The Role of Echocardiographic Contrast (Optison) in Enhancing Tricuspid Regurgitation Spectral Doppler Signals

NCT02560116
View directory record Official record
Conditions
Hypertension, Pulmonary
Interventions
Not listed
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Jan 20, 2016 · Synced Sep 25, 2026, 4:13 AM EDT
Completed No phase listed Observational

Tetralogy of Fallot Seed Grant

NCT00722826
View directory record Official record
Conditions
Pulmonary Regurgitation After Repair of Tetralogy of Fallot
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
13 Years and older
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2007
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 1, 2015 · Synced Sep 25, 2026, 4:13 AM EDT