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Showing 1–21 of 21 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Rhytids Clear all
Not listed Phase 4 Interventional Accepts healthy volunteers

A Clinical Study Comparing Restylane® Silk and Belotero Balance® for the Treatment of Superficial, Vertical Perioral Lines

NCT02818556
View directory record Official record
Conditions
Perioral Rhytids
Interventions
Restalyne Silk, Belotero Balance
Drug
Lead sponsor
The Maas Clinic
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2016
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 28, 2016 · Synced Jul 22, 2026, 12:45 PM EDT
Completed Not applicable Interventional Results available

Fractional Radiofrequency for the Treatment and Reduction of Acne Scars and Wrinkles

NCT04057768
View directory record Official record
Conditions
Acne Scars - Mixed Atrophic and Hypertrophic, Wrinkle
Interventions
Venus Viva
Device
Lead sponsor
Venus Concept
Industry
Eligibility
22 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jun 28, 2021 · Synced Jul 22, 2026, 12:45 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Comparison of Escalating Doses of IncobotulinumtoxinA (Xeomin®) in the Treatment of Glabellar Rhytids

NCT01583478
View directory record Official record
Conditions
Skin Aging, Elastosis Senilis
Interventions
incobotulinumtoxinA
Biological
Lead sponsor
The Maas Clinic
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 29, 2014 · Synced Jul 22, 2026, 12:45 PM EDT
Recruiting Not applicable Interventional

2910 nm Erbium-Doped Fluoride Fiber Glass Laser for the Treatment of Advanced Perioral Lines and Wrinkles

NCT07222397
View directory record Official record
Conditions
Photodamaged Skin, Rhytids, Lines Skin, Wrinkles and Rhytides
Interventions
Laser Resurfacing
Device
Lead sponsor
FA Corporation
Industry
Eligibility
50 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced Jul 22, 2026, 12:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

RHA® Redensity With New Anesthetic Agent - Perioral Rhytids

NCT04069585
View directory record Official record
Conditions
Aging, Pain
Interventions
RHA® Redensity with new anesthetic agent, RHA® Redensity with lidocaine
Device
Lead sponsor
Teoxane SA
Industry
Eligibility
22 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
3
States / cities
Beverly Hills, California • Coral Gables, Florida • Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 23, 2022 · Synced Jul 22, 2026, 12:45 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Upper Facial Remodeling With Perlane-L and Dysport

NCT01354743
View directory record Official record
Conditions
Mild to Moderate Temporal Atrophy, Moderate to Severe Glabellar Rhytids, Moderate to Severe Periorbital Rhytids
Interventions
Dysport, Perlane L
Drug · Device
Lead sponsor
Beer, Kenneth R., M.D., PA
Individual
Eligibility
40 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
West Palm Beach, Florida
Source: ClinicalTrials.gov public record
Updated Sep 25, 2013 · Synced Jul 22, 2026, 12:45 PM EDT
Completed Not applicable Interventional

Laser Spot Treatment of Perioral Rhytids

NCT01986634
View directory record Official record
Conditions
Facial Aging
Interventions
Laser Treatment
Procedure
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Lyndhurst, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 4, 2023 · Synced Jul 22, 2026, 12:45 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

RHA® Redensity With New Anesthetic Agent Perioral Rhytids (PAS)

NCT06378086
View directory record Official record
Conditions
Pain, Aging
Interventions
RHA® Redensity with new anesthetic agent, RHA® Redensity with lidocaine
Device
Lead sponsor
Teoxane SA
Industry
Eligibility
22 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
2
States / cities
Birmingham, Alabama • New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 10, 2025 · Synced Jul 22, 2026, 12:45 PM EDT
Completed Phase 4 Interventional

Comparative Study of Reconstituted JUVÉDERM® Ultra vs COSMODERM® 1 for Lip and Cheek Lines, Folds or Wrinkles

NCT01212809
View directory record Official record
Conditions
Intrinsic Aging of Skin
Interventions
Juvéderm Ultra, Cosmoderm 1
Device
Lead sponsor
Steven Fagien
Other
Eligibility
25 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Boca Raton, Florida
Source: ClinicalTrials.gov public record
Updated Sep 11, 2011 · Synced Jul 22, 2026, 12:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

RHA Redensity - Perioral Rhytids

NCT03092219
View directory record Official record
Conditions
Perioral Rhytids, Aging, Wrinkle
Interventions
TEOSYAL RHA Redensity
Device
Lead sponsor
Teoxane SA
Industry
Eligibility
22 Years and older
Enrollment
202 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
6
States / cities
Beverly Hills, California • Santa Monica, California • Coral Gables, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 21, 2023 · Synced Jul 22, 2026, 12:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Injection Technique Assessment of Restylane Silk With Lidocaine for Lip Augmentation

NCT02703948
View directory record Official record
Conditions
Lip Augmentation and Correction of Perioral Rhytids
Interventions
Restylane Silk with Lidocaine
Device
Lead sponsor
Galderma R&D
Industry
Eligibility
22 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
4
States / cities
Beverly Hills, California • San Diego, California • Miami, Florida + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 25, 2022 · Synced Jul 22, 2026, 12:45 PM EDT
Completed No phase listed Observational

Outcomes and Patient Experience After Soft Tissue Dermal Filler Injections

NCT01034956
View directory record Official record
Conditions
Rhytids, Wrinkles
Interventions
hyaluronic acid or calcium hydroxylapatite filler
Device
Lead sponsor
The New York Eye & Ear Infirmary
Other
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 30, 2012 · Synced Jul 22, 2026, 12:45 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Study to Determine How Long Restylane® Will Last After Initial Treatment With 2 Different Re-treatment Schedules.

NCT00765583
View directory record Official record
Conditions
Rhytids
Interventions
Restylane
Drug
Lead sponsor
Medicis Aesthetics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2009
U.S. locations
3
States / cities
Coral Gables, Florida • Chicago, Illinois • White Plains, New York
Source: ClinicalTrials.gov public record
Updated Sep 21, 2011 · Synced Jul 22, 2026, 12:45 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Efficacy Trial for the Reduction of Glabellar Lines

NCT02466178
View directory record Official record
Conditions
Rhytids in the Glabellar Region
Interventions
Serene RF System
Device
Lead sponsor
Serene Medical Inc
Industry
Eligibility
18 Years to 70 Years
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
5
States / cities
Palo Alto, California • San Mateo, California • New York, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 21, 2017 · Synced Jul 22, 2026, 12:45 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Pilot Evaluation of Platelet Rich Fibrin Matrix (PRFM) for the Correction of Nasolabial Folds

NCT00874094
View directory record Official record
Conditions
Nasolabial Folds
Interventions
Platelet rich fibrin matrix
Biological
Lead sponsor
The New York Eye & Ear Infirmary
Other
Eligibility
25 Years to 75 Years · Female only
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Chappaqua, New York
Source: ClinicalTrials.gov public record
Updated Jul 11, 2013 · Synced Jul 22, 2026, 12:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Safety and Efficacy of SofWave Treatment to Lift the Upper Lip and Improve the Peri-Oral Rhytids

NCT06104514
View directory record Official record
Conditions
Rhytides, Wrinkle
Interventions
Sofwave
Device
Lead sponsor
Sofwave Medical LTD
Industry
Eligibility
35 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
6
States / cities
Palo Alto, California • San Diego, California • Lincolnshire, Illinois + 3 more
Source: ClinicalTrials.gov public record
Updated May 14, 2025 · Synced Jul 22, 2026, 12:45 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Application of the Apsara Thermal Wand System

NCT00662389
View directory record Official record
Conditions
Tightening of Skin Laxity
Interventions
Apsara Thermal Wand System
Device
Lead sponsor
Apsara Medical Corporation
Industry
Eligibility
40 Years to 65 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 27, 2009 · Synced Jul 22, 2026, 12:45 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Evaluation of Efficacy and Safety of the triLift™ System

NCT05773924
View directory record Official record
Conditions
Skin Laxity, Wrinkle
Interventions
triLift system
Device
Lead sponsor
Lumenis Be Ltd.
Industry
Eligibility
35 Years to 55 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 16, 2023 · Synced Jul 22, 2026, 12:45 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

A Phase 4 Clinical Study to Investigate the Effectiveness and Safety of Skin Resurfacing

NCT07214272
View directory record Official record
Conditions
Skin Resurfacing
Interventions
Fraxel® FTX Laser System
Device
Lead sponsor
Bausch Health Americas, Inc.
Industry
Eligibility
21 Years to 60 Years
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
5
States / cities
La Jolla, California • Miami, Florida • Naperville, Illinois + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Jul 22, 2026, 12:45 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Evaluation of the Ulthera® System for Treatment of the Face and Neck

NCT01713907
View directory record Official record
Conditions
Wrinkles, Rhytids, Skin Laxity
Interventions
Ulthera® Treatment
Device
Lead sponsor
Ulthera, Inc
Industry
Eligibility
30 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 23, 2017 · Synced Jul 22, 2026, 12:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Skin Safety Profile of Different Exposure to the Light Emitting Diode (LED) in Healthy Subjects

NCT00818311
View directory record Official record
Conditions
Radiation Tolerance, Skin Aging, Rhytids
Interventions
LED GentleWaves®
Device
Lead sponsor
L'Oreal
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
Carrollton, Texas
Source: ClinicalTrials.gov public record
Updated Jan 6, 2009 · Synced Jul 22, 2026, 12:45 PM EDT