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Showing 1–24 of 227 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Severe Obesity Clear all
Not listed Phase 2Phase 3 Interventional

The Effects of Exenatide After Gastric Restriction

NCT00872378
View directory record Official record
Conditions
Morbid Obesity
Interventions
Exenatide, Placebo
Drug
Lead sponsor
Advanced Specialty Care
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
2
States / cities
Bend, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 30, 2009 · Synced Jul 21, 2026, 2:19 PM EDT
Completed Phase 2 Interventional Results available

SMART Use of Medication for the Treatment of Adolescent Severe Obesity

NCT04007393
View directory record Official record
Conditions
Adolescent Obesity
Interventions
Lifestyle Modification Therapy (LSMT), Phentermine Pill, Topiramate Pill, Placebo
Behavioral · Drug
Lead sponsor
University of Minnesota
Other
Eligibility
12 Years to 17 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Jul 21, 2026, 2:19 PM EDT
Terminated No phase listed Observational

Studies of Biological Changes Related to Weight Loss After Gastric Bypass Surgery

NCT00120562
View directory record Official record
Conditions
Obesity, Morbid Obesity, Weight Loss
Interventions
Gastric Bypass Surgery
Procedure
Lead sponsor
Rockefeller University
Other
Eligibility
18 Years to 65 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2007
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 27, 2009 · Synced Jul 21, 2026, 2:19 PM EDT
Completed No phase listed Observational

Laparoscopic Revision From Biliopancreatic Diversion to Gastric Bypass

NCT01041456
View directory record Official record
Conditions
Metabolic and Nutritional Complications, Protein Malnutrition, Intestinal Malabsorptive Syndrome, Metabolic Bone Disease
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Fresno, California
Source: ClinicalTrials.gov public record
Updated Dec 31, 2009 · Synced Jul 21, 2026, 2:19 PM EDT
Completed Not applicable Interventional

Study of Weight Loss Using Gastric Stimulation in Obese Patients

NCT00200083
View directory record Official record
Conditions
Obesity, Morbid Obesity
Interventions
Transcend II Model 8848
Device
Lead sponsor
MedtronicNeuro
Industry
Eligibility
18 Years to 65 Years
Enrollment
190 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
8
States / cities
Washington D.C., District of Columbia • Gainsville, Florida • Chicago, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Mar 26, 2015 · Synced Jul 21, 2026, 2:19 PM EDT
Recruiting Early Phase 1 Interventional

Induction of Labor in Morbidly Obese Patients

NCT06199154
View directory record Official record
Conditions
Morbid Obesity, Pregnancy
Interventions
Misoprostol
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older · Female only
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2025 · Synced Jul 21, 2026, 2:19 PM EDT
Completed No phase listed Observational Results available

Taste Perception Pre and Post Bariatric Surgery

NCT01536197
View directory record Official record
Conditions
Morbid Obesity
Interventions
Gastric bypass, Gastric banding, Sleeve gastrectomy
Procedure
Lead sponsor
Washington University School of Medicine
Other
Eligibility
20 Years to 70 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 17, 2017 · Synced Jul 21, 2026, 2:19 PM EDT
Completed Not applicable Interventional

Laparoscopic Adjustable Gastric Banding as a Treatment for Morbid Obesity in Adolescents

NCT00592202
View directory record Official record
Conditions
Morbid Obesity
Interventions
Placement of an adjustable gastric band
Device
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
14 Years to 17 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2013
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 1, 2014 · Synced Jul 21, 2026, 2:19 PM EDT
Terminated Phase 3 Interventional Results available

Cardiovascular Outcomes Study of Naltrexone SR/Bupropion SR in Overweight and Obese Subjects With Cardiovascular Risk Factors (The Light Study)

NCT01601704
View directory record Official record
Conditions
Obesity, Overweight
Interventions
NB32, PBO, Weight Management Program
Drug · Behavioral
Lead sponsor
Orexigen Therapeutics, Inc
Industry
Eligibility
45 Years and older
Enrollment
8,910 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
224
States / cities
Birmingham, Alabama • Dothan, Alabama • Mobile, Alabama + 221 more
Source: ClinicalTrials.gov public record
Updated Feb 26, 2017 · Synced Jul 21, 2026, 2:19 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Weight Loss, Blood Sugar and Blood Lipid Effects of Tetrahydrocannabivarin (THCV) Impregnated Mucoadhesive Strips

NCT05574049
View directory record Official record
Conditions
Metabolic Syndrome, Morbid Obesity, Hypercholesterolemia, Hyperglycemia
Interventions
Tetrahydrocannabivarin, Placebo
Drug · Other
Lead sponsor
Medical Life Care Planners, LLC
Other
Eligibility
18 Years to 100 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Clearwater, Florida
Source: ClinicalTrials.gov public record
Updated Oct 9, 2022 · Synced Jul 21, 2026, 2:19 PM EDT
Completed Phase 4 Interventional

Aromatase Inhibitors and Weight Loss in Severely Obese Men With Hypogonadism

NCT03490513
View directory record Official record
Conditions
Hypogonadism, Hypogonadotropic, Obesity
Interventions
anastrozole (1 mg/day), Placebo
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
40 Years to 65 Years · Male only
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 6, 2025 · Synced Jul 21, 2026, 2:19 PM EDT
Completed No phase listed Observational

Anesthetic and Obstetric Outcomes in Morbidly Obese Pregnancy and Cesarean Delivery

NCT03590951
View directory record Official record
Conditions
Morbid Obesity, Cesarean Section Complications, Pregnancy Related
Interventions
Retrospective chart review
Other
Lead sponsor
Augusta University
Other
Eligibility
18 Years and older · Female only
Enrollment
771 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 17, 2018 · Synced Jul 21, 2026, 2:19 PM EDT
Completed Not applicable Interventional

Effect of CPAP on Fetal pH at Scheduled C-section in Morbidly Obese Women

NCT04993651
View directory record Official record
Conditions
Morbid Obesity, Cesarean Delivery Affecting Fetus
Interventions
CPAP
Device
Lead sponsor
Eastern Virginia Medical School
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Jul 21, 2026, 2:19 PM EDT
Completed No phase listed Observational

The TEMPO (Tracing the Effect of the MC4 Pathway in Obesity) Registry

NCT03479437
View directory record Official record
Conditions
Genetic Forms of Extreme Obesity
Interventions
Not listed
Lead sponsor
Rhythm Pharmaceuticals, Inc.
Industry
Eligibility
2 Years and older
Enrollment
303 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 3, 2021 · Synced Jul 21, 2026, 2:19 PM EDT
Terminated Phase 4 Interventional Results available

Naltrexone/Bupropion Cardiovascular Outcomes Study

NCT02638129
View directory record Official record
Conditions
Obesity, Cardiovascular Diseases
Interventions
Naltrexone HCl/Bupropion HCl ER, Placebo
Drug
Lead sponsor
Orexigen Therapeutics, Inc
Industry
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
139
States / cities
Alexander City, Alabama • Auburn, Alabama • Birmingham, Alabama + 136 more
Source: ClinicalTrials.gov public record
Updated Feb 26, 2017 · Synced Jul 21, 2026, 2:19 PM EDT
Completed Not applicable Interventional

Feasibility of a Multi Component Intervention in Patients With Severe Dyspnea and Obesity

NCT03836547
View directory record Official record
Conditions
COPD, Emphysema, Lung Diseases
Interventions
Coaching and Weight Loss for patients with dyspnea, Active Control
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
3
States / cities
Scottsdale, Arizona • Jacksonville, Florida • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 1, 2022 · Synced Jul 21, 2026, 2:19 PM EDT
Terminated Not applicable Interventional

Effects of a Novel Dietary Intervention on Body Composition After Laparoscopic Gastric Bypass Surgery

NCT01041261
View directory record Official record
Conditions
Obesity, Morbid Obesity
Interventions
BariatrX Essentials 360 Treatment
Dietary Supplement
Lead sponsor
MetaProteomics LLC
Industry
Eligibility
25 Years and older · Female only
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 12, 2012 · Synced Jul 21, 2026, 2:19 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Physical and Behavioral Traits of Overweight and Obese Adults

NCT00428987
View directory record Official record
Conditions
Obesity, Healthy Volunteers
Interventions
Not listed
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 100 Years
Enrollment
2,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2007
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Jul 21, 2026, 2:19 PM EDT
Completed No phase listed Observational Results available

Bariatric Surgery for Morbid Obesity

NCT00675558
View directory record Official record
Conditions
Obesity, Morbid Obesity
Interventions
Initial Surgery, Second Bariatric Surgery
Procedure
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 25, 2013 · Synced Jul 21, 2026, 2:19 PM EDT
Terminated No phase listed Observational

Study Evaluating Metabolic Syndrome in Subjects Undergoing Gastric Bypass Bariatric Syndrome

NCT00283374
View directory record Official record
Conditions
Morbid Obesity, Metabolic Disease
Interventions
Laparoscopic Roux-en-Y Gastric Bypass
Procedure
Lead sponsor
Wyeth is now a wholly owned subsidiary of Pfizer
Industry
Eligibility
18 Years to 55 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2005
U.S. locations
10
States / cities
Irvine, California • Orange, California • Atlanta, Georgia + 6 more
Source: ClinicalTrials.gov public record
Updated May 17, 2006 · Synced Jul 21, 2026, 2:19 PM EDT
Completed Phase 4 Interventional Results available

Post Implantation/Post Market Evaluation of the Swedish Adjustable Gastric Band

NCT00543140
View directory record Official record
Conditions
Morbid Obesity
Interventions
REALIZE™ Swedish Adjustable Gastric Band
Device
Lead sponsor
Ethicon Endo-Surgery
Industry
Eligibility
18 Years to 60 Years
Enrollment
303 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2015
U.S. locations
8
States / cities
La Jolla, California • Los Angeles, California • Miami, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Mar 8, 2016 · Synced Jul 21, 2026, 2:19 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Levofloxacin Pharmacokinetics (PK) in the Severely Obese

NCT00176306
View directory record Official record
Conditions
Obesity, Critical Illness
Interventions
Levofloxacin 750 mg IV
Drug
Lead sponsor
Joel Thompson, PhD
Other
Eligibility
18 Years to 55 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 5, 2018 · Synced Jul 21, 2026, 2:19 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Study to Determine Incidence of Hypoventilation in Patients Who Have Undergone Gastric Bypass

NCT00316446
View directory record Official record
Conditions
Morbid Obesity, Bariatric Surgery
Interventions
Not listed
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Sep 19, 2012 · Synced Jul 21, 2026, 2:19 PM EDT
Withdrawn No phase listed Observational

OnQ Pain Pump Effectiveness in Post Operative Pain Control in Bariatric Patients

NCT03159130
View directory record Official record
Conditions
Morbid Obesity
Interventions
Not listed
Lead sponsor
William Beaumont Army Medical Center
Federal
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated May 17, 2017 · Synced Jul 21, 2026, 2:19 PM EDT