ClinicalTrials.gov record
Effect of Naltrexone Hydrochloride ER and Bupropion Hydrochloride ER Combination (Contrave®/Mysimba®) on Major Adverse Cardiovascular Events (MACE)
ClinicalTrials.gov ID: NCT06098079
Public ClinicalTrials.gov record NCT06098079. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase IV Study to Assess the Effect of Naltrexone Hydrochloride Extended Release (ER) and Bupropion Hydrochloride ER Combination (Contrave®/Mysimba®) on the Occurrence of Major Adverse Cardiovascular Events
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
A randomized, double-blinded, placebo controlled study intended to capture cardiovascular outcomes during real-world use of naltrexone/bupropion (NB).
Study identification
- NCT ID
- NCT06098079
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 8,600 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 3, 2024 (Actual)
- Primary completion
- Jan 2029 (Estimated)
- Completion
- Jul 2029 (Estimated)
- Last update posted
- Mar 31, 2026
2024 – 2029
United States locations
- U.S. sites
- 140
- U.S. states
- 32
- U.S. cities
- 114
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| TrialMed Birmingham (DRS) | Birmingham | Alabama | 35211 | — |
| Accel Research Sites Network | Birmingham | Alabama | 35216 | — |
| Cullman Clinical Trials | Cullman | Alabama | 35055 | — |
| AMR Mobile | Mobile | Alabama | 36608 | — |
| Velocity Clinical Research, Mobile | Mobile | Alabama | 36608 | — |
| Sun City Research | Glendale | Arizona | 85304 | — |
| Cardiovascular Consultants/NextStage Clinical Research | Glendale | Arizona | 85306 | — |
| Desert Clinical Research | Mesa | Arizona | 85213 | — |
| Velocity Clinical Research, Phoenix | Phoenix | Arizona | 85006 | — |
| Fiel Family & Sports Medicine CCT Research | Tempe | Arizona | 85283 | — |
| Synexus Clinical Research US; Inc. | Tucson | Arizona | 85741 | — |
| Velocity Clinical Research, Gardena | Anderson | California | 90247 | — |
| Velocity Clinical Research | Chula Vista | California | 91911 | — |
| Velocity Clinical Research, Huntington Park | Huntington Park | California | 90255 | — |
| Velocity Clinical Research, San Diego | La Mesa | California | 91942 | — |
| Chemidox Clinical Trials Inc. | Lancaster | California | 93534 | — |
| Long Beach Clinical Trials | Long Beach | California | 90806 | — |
| Velocity Clinical Research | Los Angeles | California | 90057 | — |
| Valley Vitality Ventures | Manteca | California | 95350 | — |
| National Institute of Clinical Research, Inc. | Pomona | California | 91768 | — |
| Velocity Clinical Research, San Bernardino | San Bernardino | California | 92408 | — |
| Velocity Clinical Research at Coastal Heart Medical Group | Santa Ana | California | 92704 | — |
| Velocity Clinical Research of Santa Ana | Santa Ana | California | 92704 | — |
| Velocity Clinical Research, Van Nuys | Van Nuys | California | 91405 | — |
| Providere Research | West Covina | California | 91790 | — |
| Velocity Clinical Research, Denver | Englewood | Colorado | 80110 | — |
| ABMED Clinical Research | Cape Coral | Florida | 33914 | — |
| LMG Research | Coral Gables | Florida | 33134 | — |
| JY Research Institute | Cutler Bay | Florida | 33189 | — |
| Delray Physician Center | Delray Beach | Florida | 33445 | — |
| D&H Doral Research Center | Doral | Florida | 33122 | — |
| Accel Research Sites Network - Edgewater | Edgewater | Florida | 32132 | — |
| Velocity Clinical Research (New Smyrna Beach) | Edgewater | Florida | 32132 | — |
| IMRC Fort Lauderdale | Fort Lauderdale | Florida | 33316 | — |
| Southwest General Healthcare Center | Fort Myers | Florida | 33907 | — |
| G+C Research Group | Hialeah | Florida | 33010 | — |
| Qway Research | Hialeah | Florida | 33010 | — |
| Conveinent Medical Research | Hialeah | Florida | 33013 | — |
| Ilumina Medical Research | Kissimmee | Florida | 34744 | — |
| Altus Research | Lake Worth | Florida | 33461 | — |
| D&H Pompano Research Center, LLC | Margate | Florida | 33063 | — |
| Optimal Research, LLC. - Melbourne | Melbourne | Florida | 32934 | — |
| Advanced Clinical Research | Miami | Florida | 33156 | — |
| Medical Research Center Westchester | Miami | Florida | 33165 | — |
| Century Research | Miami | Florida | 33173 | — |
| ITB Research | Miami | Florida | 33173 | — |
| Entrust Clinical Research | Miami | Florida | 33176 | — |
| Janus Clinical Research | Miami | Florida | 33186 | — |
| Miami Beach Clinical Research | Miami Beach | Florida | 33141 | — |
| Innovia Research Center | Miramar | Florida | 33027 | — |
| Healix Clinical Research | New Smyrna Beach | Florida | 32168 | — |
| Biscayne Clinical Research Inc | North Miami | Florida | 33169 | — |
| IMRC At Palmetto Bay | Palmetto Bay | Florida | 33157 | — |
| New Horizons Research | Palmetto Bay | Florida | 33176 | — |
| Best Choice Medical and Research Services | Pembroke Pines | Florida | 33024 | — |
| Bolanos Clnical Research | Pembroke Pines | Florida | 33028 | — |
| Cordova Research Institute | Sweetwater | Florida | 33182 | — |
| D&H Tamarac Research Center, LLC | Tamarac | Florida | 33321 | — |
| Synexus Clinical Research US, Inc. - The Villages | The Villages | Florida | 32162 | — |
| Advanced Clinical Research Atlanta | Atlanta | Georgia | 30309 | — |
| Clincept Clinical Research | Columbus | Georgia | 31904 | — |
| Accel Research Sites (ARSN) - Neurostudies | Decatur | Georgia | 30030 | — |
| Velocity Clinical Research, Savannah | Savannah | Georgia | 31406 | — |
| NextStage Clinical Research-Chicago | Glen Ellyn | Illinois | 60137 | — |
| JAELEX Research | Round Lake Beach | Illinois | 60073 | — |
| Indiana Medical Research Institute | Merriville | Indiana | 46410 | — |
| Velocity Clinical Research | Valparaiso | Indiana | 46383 | — |
| Velocity Clinical Research | Sioux City | Iowa | 51106 | — |
| AMR - El Dorado | El Dorado | Kansas | 67042 | — |
| Velocity Clinical Research, Kansas City | Kansas City | Kansas | 66210 | — |
| AMR Wichita West | Wichita | Kansas | 67205 | — |
| AMR Wichita East | Wichita | Kansas | 67207 | — |
| Wichita Surgical Specialists | Wichita | Kansas | 67214 | — |
| Velocity Clinical Research | Baton Rouge | Louisiana | 70809 | — |
| Velocity Clinical Research | Covington | Louisiana | 70433 | — |
| Velocity Clinical Research | Lafayette | Louisiana | 70508 | — |
| AMR New Orleans | New Orleans | Louisiana | 70119 | — |
| Velocity Clinical Research, New Orleans | New Orleans | Louisiana | 70119 | — |
| Velocity Clinical Research | Slidell | Louisiana | 70458 | — |
| Regenerative Orthopedics and Sports Medicine- NextStage Clinical Research | North Bethesda | Maryland | 20852 | — |
| Praveen K Gupta, MD/Avacare | Rockville | Maryland | 20852 | — |
| Velocity Clinical Research, Rockville | Rockville | Maryland | 20854 | — |
| Activmed Practices and Research, Inc | Methuen | Massachusetts | 01844 | — |
| Dearborn Cardiology | Dearborn | Michigan | 48126 | — |
| Velocity Clinical Research | Gulfport | Mississippi | 39503 | — |
| Clay Platte Family Medicine | Kansas City | Missouri | 64151 | — |
| St. Louis Medical Professionals/CCT Research | St Louis | Missouri | 63119 | — |
| Velocity Clinical Research (St. Louis) | St Louis | Missouri | 63131 | — |
| Velocity Clinical Research, Grand Island | Grand Island | Nebraska | 68803 | — |
| Velocity Clinical Research at Pioneer Heart Institute | Lincoln | Nebraska | 68506 | — |
| Velocity Clinical Research | Lincoln | Nebraska | 68510 | — |
| Velocity Clinical Research, Norfolk | Norfolk | Nebraska | 68701 | — |
| Meridian Clinical Research - Velocity | Omaha | Nebraska | 68134 | — |
| Midwest Regional Health Services | Omaha | Nebraska | 68144 | — |
| Avacare | Las Vegas | Nevada | 89102 | — |
| Santa Rosa Urgent Care Primary Care/CCT Research | Las Vegas | Nevada | 89119 | — |
| Las Vegas Clinical Trials | North Las Vegas | Nevada | 89119 | — |
| ActivMed Practices and Research | Portsmouth | New Hampshire | 03801 | — |
| Velocity Clinical Research | Albuquerque | New Mexico | 87107 | — |
| Axces Research Group | Santa Fe | New Mexico | 87505 | — |
| Velocity Clinical Research | Binghamton | New York | 13905 | — |
| Synexus Clinical Research US, Inc. - New York | New York | New York | 10017 | — |
| Velocity Clinical Research | Vestal | New York | 13850 | — |
| Velocity Clinical Research, Durham | Durham | North Carolina | 27701 | — |
| Velocity Clinical Research | Beachwood | Ohio | 44122 | — |
| Velocity Clinical Research, Mt. Auburn | Cincinnati | Ohio | 45219 | — |
| Velocity Clinical Research, Cincinnati | Cincinnati | Ohio | 45242 | — |
| Velocity Clinical Research | Cincinnati | Ohio | 45246 | — |
| NexGen Research | Lima | Ohio | 45801 | — |
| NextStage Clinical Research - Tulsa | Tulsa | Oklahoma | 74136 | — |
| Velocity Clinical Research, Grants Pass | Grants Pass | Oregon | 97527 | — |
| Velocity Clinical Research, Medford | Medford | Oregon | 97504 | — |
| Hatboro Medical Associates/Avacare Research | Horsham | Pennsylvania | 19044 | — |
| Mercado Medical Practice/CCT Research | Philadelphia | Pennsylvania | 19111 | — |
| Velocity Clinical Research (Providence) | East Greenwich | Rhode Island | 02818 | — |
| Velocity Clinical Research | Anderson | South Carolina | 29621 | — |
| Velocity Clinical Research | Charleston | South Carolina | 29414 | — |
| Velocity Clinical Research | Columbia | South Carolina | 29204 | — |
| Velocity Clinical Research | Gaffney | South Carolina | 29340 | — |
| Velocity Clinical Research | Greenville | South Carolina | 29615 | — |
| Coastal Carolina Research Center | North Charleston | South Carolina | 29405 | — |
| Velocity Clinical Research, Spartanburg | Spartanburg | South Carolina | 29303 | — |
| Velocity Clinical Research, Union | Union | South Carolina | 29379 | — |
| Velocity Clinical Research, Abilene | Abilene | Texas | 79606 | — |
| Optimal Research, LLC. - Austin | Austin | Texas | 78705 | — |
| Velocity Clinical Research | Austin | Texas | 78759 | — |
| Advanced Cardiovascular Specialists/NextStage Clinical Research | Beaumont | Texas | 77702 | — |
| HDH Research | Houston | Texas | 77022 | — |
| All-American Orthopedics-NextStage Clinical Research | Houston | Texas | 77058 | — |
| NextStage Clinical Research-Lubbock/SWAT Surgical Associates-NextStage Clinical Research | Lubbock | Texas | 79410 | — |
| NextStage Clinical Research-Port Arthur/Gulf Coast Cardiology | Port Arthur | Texas | 77642 | — |
| Synexus Clinical Research US; Inc. | San Antonio | Texas | 78229 | — |
| Olympus Clinical Research | Sugarland | Texas | 77479 | — |
| Waco Cardiology Consultants | Waco | Texas | 76712 | — |
| Velocity Clinical Research, Salt Lake City | West Jordan | Utah | 84088 | — |
| Charlottesville Medical Research | Charlottesville | Virginia | 22911 | — |
| Velocity Clinical Research, Hampton | Hampton | Virginia | 23666 | — |
| AMR Norfolk | Norfolk | Virginia | 23502 | — |
| Velocity Clinical Research, Suffolk, VA | Suffolk | Virginia | 23435 | — |
| Evergreen Surgical | Eau Claire | Wisconsin | 54701 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06098079, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 31, 2026 · Synced Oct 30, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06098079 live on ClinicalTrials.gov.