Independent directory Public ClinicalTrials.gov records United States
Clear filters
ClinicalTrials.gov public records Last synced Jul 21, 2026, 11:17 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 41 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Conditions
Cognition Disorders in Old Age, Mild Cognitive Impairment, Cognitive Decline
Interventions
Niagen, Placebo Comparator
Dietary Supplement
Lead sponsor
Steven E Arnold, MD
Other
Eligibility
60 Years and older
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Charlestown, Massachusetts
Conditions
Mild Cognitive Impairment, Subjective Memory Decline
Interventions
Tai Chi, Preventing Loss of Independence through Exercise (PLIE), Health and Wellness Education
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
55 Years and older
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
San Francisco, California
Conditions
Subjective Cognitive Concerns, Mild Cognitive Impairment, Mild Behavioral Impairment, Healthy Aging
Interventions
AROMHA Brain Health Test
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 100 Years
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Active, not recruiting Not applicable Interventional

Internet-based Mind-Body Training for Brain Health

NCT07019402
Conditions
Subjective Cognitive Decline
Interventions
Internet-based Mindfulness-Based Stress Reduction (iMBSR), Internet-based Lifestyle Education (iLifeEd)
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
50 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Completed No phase listed Observational Accepts healthy volunteers

Brain Health Together: Development and Pilot Test

NCT06914947
Conditions
Cognitive Impairment, Subjective Cognitive Decline, Mild Cognitive Impairment (MCI)
Interventions
Brain Health Together
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
65 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
San Francisco, California
Recruiting Not applicable Interventional Accepts healthy volunteers

Natives Engaged in Alzheimers Research - 'Ike Kupuna

NCT05534607
Conditions
Mild Cognitive Impairment, Subjective Cognitive Impairment
Interventions
Ola Mau i ka Hula
Behavioral
Lead sponsor
University of Hawaii
Other
Eligibility
50 Years to 75 Years
Enrollment
192 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
3
States / cities
Honolulu, Hawaii • Wailuku, Hawaii
Recruiting Phase 1 Interventional Accepts healthy volunteers

CogT pSOPT Intervention Study

NCT06005038
Conditions
Mild Cognitive Impairment, Subjective Cognitive Impairment
Interventions
pSOPT, MLA
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
60 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Palo Alto, California
Completed Not applicable Interventional Accepts healthy volunteers

Modulation Effects of Baduanjin Exercise on Subjective Cognitive Decline

NCT04009382
Conditions
Cognitive Decline
Interventions
Baduanjin Exercise, Cognitive Fitness Program
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
50 Years to 80 Years
Enrollment
124 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
Charlestown, Massachusetts
Conditions
Subjective Cognitive Decline
Interventions
Neurotrack Virtual Cognitive Health Program
Behavioral
Lead sponsor
Evidation Health
Industry
Eligibility
60 Years to 75 Years
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
San Mateo, California
Conditions
Subjective Memory Loss in Older Persons
Interventions
Cerefolin NAC (a medical food), Cerefolin NAC placebo
Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
60 Years and older
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Chicago, Illinois
Conditions
Subjective Cognitive Impairment
Interventions
P-tau217, Standard of Care
Diagnostic Test · Other
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
50 Years and older
Enrollment
7,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
New York, New York
Conditions
Mild Cognitive Impairment
Interventions
Curcumin, aerobic yoga, non aerobic yoga, Placebo
Drug · Behavioral · Dietary Supplement
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
50 Years to 90 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
West Los Angeles, California
Conditions
Cognitively Normal Older Adults, Hypertension, Subjective Cognitive Decline, Family History of Dementia
Interventions
Angiotensin II Receptor Blockers (ARBs, losartan) and Calcium Channel Blockers (CCB, amlodipine), PCP
Drug · Other
Lead sponsor
Rong Zhang
Other
Eligibility
60 Years to 85 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
1
States / cities
Dallas, Texas
Conditions
Health, Subjective, Gastrointestinal Dysfunction, Cardiovascular Risk Factor, Autoimmune Diseases, Dental Diseases, Hormone Disturbance, Neurocognitive Dysfunction
Interventions
Supplements and/or medical foods, Behavioral change support program, Food plan
Dietary Supplement · Behavioral · Other
Lead sponsor
Metagenics, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Gig Harbor, Washington
Recruiting Phase 1Phase 2 Interventional Accepts healthy volunteers

FACE Phase II (a Stage II Trial)

NCT07130669
Conditions
MCI, Subjective Cognitive Decline (SCD), Mild Behavioral Impairment
Interventions
Cognitive Remediation, Cognitive Remediation II
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
60 Years to 89 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Palo Alto, California
Completed No phase listed Observational Accepts healthy volunteers

Personal Lifestyle Engine (PLX) - Personal Lifestyle Medicine Center (PLMC)

NCT04007939
Conditions
Health, Subjective, Gastrointestinal Dysfunction, Cardiovascular Risk Factor, Autoimmune Diseases, Dental Diseases, Hormone Disturbance, Neurocognitive Dysfunction
Interventions
Not listed
Lead sponsor
Metagenics, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Gig Harbor, Washington
Conditions
Mild Cognitive Impairment, Subjective Cognitive Decline (SCD)
Interventions
VR sessions
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
55 Years to 90 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Houston, Texas
Not listed Not applicable Interventional

Electronic Memory and Management Aid

NCT05696756
Conditions
Subjective Cognitive Complaints, Mild Cognitive Impairment
Interventions
Personalized Web-based training for EMMA app, Motivational Interviewing: Clinician Support
Behavioral
Lead sponsor
Washington State University
Other
Eligibility
50 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Pullman, Washington
Conditions
Chemo Brain, Chemotherapy-related Cognitive Impairment, Chemo Fog, Breast Cancer, Chemobrain
Interventions
Transdermal nicotine, Placebo Transdermal Patch
Drug · Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
35 Years to 80 Years · Female only
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Nashville, Tennessee
Conditions
Mild Cognitive Impairment, Alzheimer Disease, Subjective Cognitive Decline (SCD)
Interventions
Green Activity Program
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
45 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Bloomington, Indiana
Conditions
Chronic Pain, Physical Activity, Older Adults, Mild Cognitive Impairment
Interventions
MBCT+w, ALED
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
50 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Neural Control of Gait & Navigation in ADRD

NCT06501820
Conditions
Aging
Interventions
Transcranial direct current stimulation
Device
Lead sponsor
University of Florida
Other
Eligibility
65 Years to 89 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
Gainesville, Florida
Enrolling by invitation Not applicable Interventional

The Digital Memory Notebook

NCT04240665
Conditions
Prodromal Alzheimer's Disease, Mild Cognitive Impairment, Subjective Cognitive Complaints
Interventions
Digital Memory Notebook (DMN) Application
Behavioral
Lead sponsor
University of California, Davis
Other
Eligibility
60 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Sacramento, California
Completed Not applicable Interventional Results available

Family Automated Voice Reorientation Study

NCT03128671
Conditions
Delirium, Cognitive Impairment, Health, Subjective, Sleep
Interventions
FAVoR Intervention
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
3
States / cities
Miami, Florida • Tampa, Florida