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Conditions: Left Ventricular Systolic Dysfunction, Congestive Heart Failure, Ischemic and Non-ischemic Cardiomyopathy, Sudden Cardiac Death Primary Prevention
Interventions: Not listed
Lead sponsor: Seattle Institute for Cardiac Research; Other
Eligibility: 18 Years to 90 Years
Enrollment: 1,855 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Bellevue, Washington

Conditions: Menopausal Women
Interventions: Not listed
Lead sponsor: Yale University; Other
Eligibility: 42 Years to 58 Years · Female only
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2010
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Death, Sudden, Cardiac
Interventions: Implantable cardioverter-defibrillator (ICD); Device
Lead sponsor: Rhode Island Hospital; Other
Eligibility: 18 Years and older
Enrollment: 450 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2020
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Heart Failure
Interventions: LMI 1195; Drug
Lead sponsor: Lantheus Medical Imaging; Industry
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: New York, New York

Conditions: Tetralogy of Fallot, Ventricular Tachycardia, Sudden Cardiac Death
Interventions: Electroanatomic substrate mapping; Diagnostic Test
Lead sponsor: Boston Children's Hospital; Other
Eligibility: Not listed
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Death, Sudden, Cardiac
Interventions: Defibrillation using the ASSURE wearable cardioverter defibrillator therapy delivered via a waveform delivery test system; Device
Lead sponsor: Kestra Medical Technologies, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 4
States / cities: Anchorage, Alaska • Ann Arbor, Michigan • St Louis, Missouri + 1 more

Conditions: Sudden Cardiac Arrest
Interventions: High School Students Survey; Other
Lead sponsor: Kansas City Heart Rhythm Research Foundation; Other
Eligibility: 12 Years to 25 Years
Enrollment: 5,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Overland Park, Kansas

Conditions: Sudden Cardiac Death, Sudden Cardiac Arrest, Heart Failure, Heart Failure Low Output
Interventions: Wearable Cardioverter Defibrillator; Device
Lead sponsor: Zoll Medical Corporation; Industry
Eligibility: 18 Years and older
Enrollment: 602 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 39
States / cities: Birmingham, Alabama • West Hills, California • Fernandina Beach, Florida + 34 more

Conditions: Coronary Artery Disease, Left Ventricular Dysfunction, Sudden Cardiac Death
Interventions: Not listed
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 5,764 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2026
U.S. locations: 86
States / cities: Anchorage, Alaska • Glendale, Arizona • Phoenix, Arizona + 76 more

Conditions: Cardiac Arrest, Sudden
Interventions: ASSURE™ Wearable Cardioverter Defibrillator (WCD); Device
Lead sponsor: Kestra Medical Technologies, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 130 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 10
States / cities: Anchorage, Alaska • Hammond, Louisiana • Takoma Park, Maryland + 7 more

Conditions: LQT2 Syndrome
Interventions: Eleclazine, Placebo; Drug
Lead sponsor: Gilead Sciences; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Muscular Dystrophy, Arrhythmia, Sudden Cardiac Death
Interventions: Screening; Other
Lead sponsor: Indiana University; Other
Eligibility: 18 Years and older
Enrollment: 448 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1996 – 2015
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Sudden Cardiac Arrest
Interventions: Jewel Patch Wearable Cardioverter Defibrillator (P-WCD); Device
Lead sponsor: Element Science, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 322 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 30
States / cities: Jonesboro, Arkansas • Little Rock, Arkansas • Hartford, Connecticut + 25 more

Conditions: Out-Of-Hospital Cardiac Arrest, Heart Arrest, Heart Diseases, Cardiovascular Diseases
Interventions: PulsePoint notification; Other
Lead sponsor: Dr. Steven Brooks; Other
Eligibility: Not listed
Enrollment: 340 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Sudden Cardiac Death, Bradycardia
Interventions: AV Therapy Assessment-B301 investigational device; Device
Lead sponsor: Boston Scientific Corporation; Industry
Eligibility: 18 Years and older
Enrollment: 211 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2011
U.S. locations: 36
States / cities: Anchorage, Alaska • Larkspur, California • Orlando, Florida + 32 more

Conditions: Sudden Cardiac Arrest
Interventions: Not listed
Lead sponsor: Duke University; Other
Eligibility: 19 Years and older
Enrollment: 59 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 2
States / cities: Burlington, North Carolina • Durham, North Carolina

Conditions: Syncope
Interventions: Short Term Wearable Defibrillator; Device
Lead sponsor: Zoll Medical Corporation; Industry
Eligibility: 18 Years and older
Enrollment: 39 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2020
U.S. locations: 6
States / cities: Danbury, Connecticut • Jacksonville, Florida • Minneapolis, Minnesota + 3 more

Conditions: Sudden Cardiac Arrest, Emergency Care
Interventions: Standard of Care; Diagnostic Test
Lead sponsor: Philips Clinical & Medical Affairs Global; Industry
Eligibility: Not listed
Enrollment: 103 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Epilepsy, Seizures, Syncope, Channelopathy, Cardiomyopathies
Interventions: Not listed
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 50 Years
Enrollment: 600 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2031
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Heart Failure, Systolic
Interventions: Not listed
Lead sponsor: Todd M Koelling, MD; Other
Eligibility: 18 Years and older
Enrollment: 452 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Heart Failure With Reduced Ejection Fraction (HFrEF), Sudden Cardiac Death, Ventricular Arrhythmia, Implantable Cardioverter Defibrillator (ICD), Beta-blocker Therapy, Cardiomyopathy
Interventions: Metoprolol Succinate, Carvedilol; Drug
Lead sponsor: University of Rochester; Other
Eligibility: 18 Years and older
Enrollment: 2,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2031
U.S. locations: 13
States / cities: Scottsdale, Arizona • Rome, Georgia • Shawnee Mission, Kansas + 9 more

Conditions: Cardiac Arrest, Heart Arrest, Sudden Cardiac Arrest, Cardiopulmonary Arrest, Death, Sudden, Cardiac, Cardiopulmonary Resuscitation, CPR, Extracorporeal Cardiopulmonary Resuscitation, Extracorporeal Membrane Oxygenation
Interventions: Expedited Transport With Mechanical CPR; Device
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 70 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Heart Failure With Reduced Ejection Fraction
Interventions: ICD implantation; Procedure
Lead sponsor: University of Rochester; Other
Eligibility: 18 Years and older
Enrollment: 3,290 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 13
States / cities: Portland, Maine • Baltimore, Maryland • Boston, Massachusetts + 10 more

Conditions: Sudden Cardiac Death
Interventions: Electrophysiology study (EPS), Standard Care, Cardiac Magnetic Resonance (CMR); Procedure · Other
Lead sponsor: Western Sydney Local Health District; Other
Eligibility: 18 Years to 85 Years
Enrollment: 1,058 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2029
U.S. locations: 1
States / cities: Boston, Massachusetts

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SCD-HeFT 10 Year Follow-up

Study of Early Hormone Replacement Therapy on Risk Factors for Sudden Cardiac Death

Sodium Channel Splicing in Heart Failure Trial (SOCS-HEFT) Prospective Study

Trial to Determine Imaging Parameters of LMI1195 in Heart Failure Patients at Low and High Risk of Defibrillator Firing

Electroanatomic Interactions Between Transcatheter Pulmonary Valve Prostheses and Anatomic Isthmuses in Repaired Tetralogy of Fallot

ASSURE WCD Clinical Evaluation - Conversion Efficacy Study

HS Students Mandatory Universal Student Instruction in CPR Appraised Learning- Is the Mandate Working?

Heart Failure Optimization Study

PRE-DETERMINE Cohort Study

ASSURE WCD Clinical Evaluation - Detection and Safety Study

Study to Evaluate the Effect of Eleclazine on QT, Safety, and Tolerability in Participants With Long QT2 Syndrome

Arrhythmias in Myotonic Muscular Dystrophy

The Jewel IDE Study

The PulsePoint Study

REASSURE AV Registry

Educational Videos to Improve Patient Decision Making and Race Disparities in Implantable Cardioverter Defibrillator Use

Ambulatory Post-Syncope Arrhythmia Protection Feasibility Study

Tempus Pro Monitor Registry

Genetic Markers of Cardiovascular Disease in Epilepsy

Patient and Physician Survey Determinants of Appropriate ICD Utilization

Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter Defibrillator

ECPR for Refractory Out-Of-Hospital Cardiac Arrest

Comparative Effectiveness of Prophylactic ICD Versus Non-ICD Therapy

Programmed Ventricular Stimulation to Risk Stratify for Early Cardioverter-Defibrillator (ICD) Implantation to Prevent Tachyarrhythmias Following Acute Myocardial Infarction (PROTECT-ICD)