Heart Failure Optimization Study
Public ClinicalTrials.gov record NCT03016754. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is designed as a multi-center prospective observational study of newly diagnosed Heart Failure (HF) patients to test the hypothesis that additional Ejection Fraction (EF) recovery occurs between 90 and 180 days as Guideline Directed Medical Therapy (GDMT) is achieved. Although the study doesn't start until day 90, all eligible, consenting patients will be entered into a registry at the start of wearable cardioverter defibrillator (WCD) use. The pre-study registry will allow us to collect early (90 day) outcomes and data in those patients who are likely to be eligible for the study at day 90, or are eligible, but refuse the study at day 90.
Study identification
- NCT ID
- NCT03016754
- Recruitment status
- Completed
- Study type
- Observational
- Phase
- Not listed
- Enrollment
- 602 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 1, 2017 (Actual)
- Primary completion
- Jun 1, 2022 (Actual)
- Completion
- Jun 1, 2022 (Actual)
- Last update posted
- Mar 24, 2025
2017 – 2022
United States locations
- U.S. sites
- 39
- U.S. states
- 20
- U.S. cities
- 37
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| UAB Division of Cardiovascular Disease | Birmingham | Alabama | 35294 | — |
| Study Site | West Hills | California | 91307 | — |
| Baptist Heart Specialists | Fernandina Beach | Florida | 32034 | — |
| Baptist Heart Specialists | Jacksonville | Florida | 32207 | — |
| Baptist Heart Specialists | Jacksonville Beach | Florida | 32250 | — |
| Institute of Cardiovascular Research | Ocala | Florida | 34471 | — |
| Research Physicians Network Alliance | Orlando | Florida | 32825 | — |
| Study Site | St. Petersburg | Florida | 33709 | — |
| Fox Valley Clinical Research Center | Aurora | Illinois | 60506 | — |
| Chicago Medical Research, LLC | Hazel Crest | Illinois | 60429 | — |
| Unity Point Health-Methodist | Peoria | Illinois | 61602 | — |
| Cardiovascular Research of Northwest Indiana, LLC | Munster | Indiana | 46321 | — |
| Beacon Medical Group clinical Research | South Bend | Indiana | 26554 | — |
| Saint Joseph London | London | Kentucky | 40741 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Covenant Medical Center, Inc. | Saginaw | Michigan | 48602 | — |
| Jackson Heart Clinic | Jackson | Mississippi | 39216 | — |
| Saint Luke's Hospital of Kansas City | Kansas City | Missouri | 64111 | — |
| SSM Health Heart & Vascular | Lake Saint Louis | Missouri | 63367 | — |
| St. Louis Heart and Vascular | St Louis | Missouri | 63136 | — |
| Hackensack Meridian Health | Hackensack | New Jersey | 07601 | — |
| AtlantiCare Regional Medical Center | Pomona | New Jersey | 08240 | — |
| Lourdes Cardiology Services | Voorhees Township | New Jersey | 08043 | — |
| Trinity Medical Center | Buffalo | New York | 14215 | — |
| SJH Cardiology | Liverpool | New York | 13088 | — |
| UNC Chapel Hill | Chapel Hill | North Carolina | 27599 | — |
| City Cardiology Associates | Barberton | Ohio | 44203 | — |
| Drexel University | Philadelphia | Pennsylvania | 19102 | — |
| Temple University Hospital | Philadelphia | Pennsylvania | 19140 | — |
| Guthrie Medical Group, P.C. | Sayre | Pennsylvania | 18840 | — |
| Carolina Heart Specialists | Lancaster | South Carolina | 29720 | — |
| Sanford Health | Sioux Falls | South Dakota | 57104 | — |
| Methodist University Hospital (MUH) and Methodist OliveBranch (MOB) | Memphis | Tennessee | 38104 | — |
| Methodist South (MS) University Hospital | Memphis | Tennessee | 38116 | — |
| Parkway Cardiology | Oak Ridge | Tennessee | 37830 | — |
| Texas Health Research & Education Institute | Dallas | Texas | 75231 | — |
| Mission Research Insitute | New Braunfels | Texas | 78130 | — |
| Providence Health Center | Waco | Texas | 76712 | — |
| St. Mary's Medical Center | Huntington | West Virginia | 25702 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 28 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03016754, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 24, 2025 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03016754 live on ClinicalTrials.gov.