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ClinicalTrials.gov public records Last synced May 22, 2026, 1:16 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 29 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Total Ankle Replacement Clear all
Recruiting Phase 3 Interventional
View directory record Official record
Conditions
Total Ankle Arthroplasty, Postsurgical Analgesia
Interventions
EXPAREL, 0.25% bupivacaine (HCl): 50 ml, 0.25% bupivacaine (HCl): 30 ml
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 22, 2026 · Synced May 22, 2026, 1:16 AM EDT
Completed No phase listed Observational
View directory record Official record
Conditions
Talus, Ankle Arthropathy
Interventions
Total Talus Replacement (TTR), Total Ankle Total Talus Replacement (TATTR), Total Ankle Total Talus Replacement + Subtalar Fusion (TATTR + STJ), Total Talus Replacement + Subtalar Fusion (TTR + STJ)
Procedure
Lead sponsor
Restor3D
Industry
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
2
States / cities
Paducah, Kentucky • Bellevue, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 20, 2024 · Synced May 22, 2026, 1:16 AM EDT
Suspended No phase listed Observational
View directory record Official record
Conditions
Rheumatoid Arthritis, Degenerative Arthritis, Post Traumatic Arthritis
Interventions
Integra Cadence Total Ankle System
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
9
States / cities
San Francisco, California • Sarasota, Florida • Buffalo, New York + 5 more
Source: ClinicalTrials.gov public record
Updated Nov 11, 2024 · Synced May 22, 2026, 1:16 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Osteoarthritis, Post-Traumatic Arthritis, Rheumatoid Arthritis
Interventions
Scandinavian Total Ankle Replacement (STAR)
Device
Lead sponsor
Link America, Inc.
Industry
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2001
U.S. locations
5
States / cities
Jacksonville, Florida • Iowa City, Iowa • Kansas City, Kansas + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 3, 2008 · Synced May 22, 2026, 1:16 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Tourniquet Hypertension, Intraoperative Hypertension, Total Ankle Arthroplasty, Ankle Fusion
Interventions
Mepivacaine, Perifemoral Injection of Local Anesthetic, Saline
Drug · Procedure
Lead sponsor
Duke University
Other
Eligibility
18 Years to 75 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 4, 2021 · Synced May 22, 2026, 1:16 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Osteoarthritis Ankle, Post-Traumatic Osteoarthritis of Ankle, Osteoarthritis of Ankle Secondary to Inflammatory Arthritis (Disorder)
Interventions
Hintermann Series H3 Total Ankle Replacement System
Device
Lead sponsor
DT MedTech, LLC
Industry
Eligibility
21 Years and older
Enrollment
232 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2029
U.S. locations
10
States / cities
Mission Hills, California • Sarasota, Florida • West Palm Beach, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Jun 24, 2024 · Synced May 22, 2026, 1:16 AM EDT
Recruiting No phase listed Observational
View directory record Official record
Conditions
Post Traumatic Arthritis, Osteoarthritis, Total Ankle Replacement, Total Ankle Prosthesis
Interventions
Total Ankle Replacement
Device
Lead sponsor
Stryker Trauma and Extremities
Industry
Eligibility
21 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2038
U.S. locations
4
States / cities
Morton Grove, Illinois • Louisville, Kentucky • Eugene, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced May 22, 2026, 1:16 AM EDT
Completed Phase 3 Interventional Results available
View directory record Official record
Conditions
Lower Extremity Surgery, Bunion, Metatarsophalangeal Fushion, Midfoot Fusion, Hindfoot Fushion, Total Ankle Arthroplasty
Interventions
Exparel, Bupivacaine Hydrochloride
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
5
States / cities
Phoenix, Arizona • Pasadena, California • Boston, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 17, 2022 · Synced May 22, 2026, 1:16 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Tourniquet Hypertension, Intraoperative Hypertension, Total Ankle Arthroplasty, Ankle Fusion
Interventions
Mepivacaine, Saline, Perifemoral Injection of Local Anesthetic
Drug · Procedure
Lead sponsor
Duke University
Other
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 22, 2026 · Synced May 22, 2026, 1:16 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers
View directory record Official record
Conditions
Ankle Osteoarthritis
Interventions
Not listed
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 85 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 23, 2024 · Synced May 22, 2026, 1:16 AM EDT
Completed No phase listed Observational
View directory record Official record
Conditions
Ankle Osteoarthritis
Interventions
Not listed
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
1,043 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 5, 2020 · Synced May 22, 2026, 1:16 AM EDT
Active, not recruiting No phase listed Observational
View directory record Official record
Conditions
Arthritis, Rheumatoid
Interventions
INFINITY™ with ADAPTIS™ Technology Total Ankle System
Device
Lead sponsor
Stryker Trauma and Extremities
Industry
Eligibility
22 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2035
U.S. locations
13
States / cities
Gilbert, Arizona • Rancho Mirage, California • Aurora, Colorado + 10 more
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced May 22, 2026, 1:16 AM EDT
Enrolling by invitation No phase listed Observational
View directory record Official record
Conditions
Avascular Necrosis of the Talus, Talar Osteochondral Defect of Ankle, Talar Dysfunction
Interventions
Total Talus Replacement (TTR)
Device
Lead sponsor
Restor3D
Industry
Eligibility
22 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2031
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced May 22, 2026, 1:16 AM EDT
Not listed Not applicable Interventional
View directory record Official record
Conditions
Ankle Arthritis, Ankle Arthropathy
Interventions
Intra-articular injection, Peripheral nerve block
Procedure
Lead sponsor
Slocum Research & Education Foundation
Other
Eligibility
40 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 17, 2018 · Synced May 22, 2026, 1:16 AM EDT
Completed No phase listed Observational
View directory record Official record
Conditions
Post-Traumatic Osteoarthritis of Ankle, Ankle Osteoarthritis, Ankle Injuries
Interventions
Osteochondral allograft ankle
Procedure
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 55 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 16, 2022 · Synced May 22, 2026, 1:16 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers Results available
View directory record Official record
Conditions
Ankle Arthroplasty, Prosthesis User, Joint Disease
Interventions
Total Ankle Replacement Prosthesis
Device
Lead sponsor
Georgia Institute of Technology
Other
Eligibility
18 Years to 79 Years
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated May 27, 2021 · Synced May 22, 2026, 1:16 AM EDT
Terminated No phase listed Observational Results available
View directory record Official record
Conditions
Arthritis, Rheumatoid
Interventions
Not listed
Lead sponsor
Stryker Trauma and Extremities
Industry
Eligibility
21 Years and older
Enrollment
155 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
9
States / cities
Rancho Mirage, California • Fort Collins, Colorado • Libertyville, Illinois + 6 more
Source: ClinicalTrials.gov public record
Updated Feb 13, 2025 · Synced May 22, 2026, 1:16 AM EDT
Withdrawn Not applicable Interventional
View directory record Official record
Conditions
Ankle Osteoarthritis
Interventions
Total Ankle Replacement
Procedure
Lead sponsor
John Femino
Other
Eligibility
18 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Dec 19, 2023 · Synced May 22, 2026, 1:16 AM EDT
Active, not recruiting Early Phase 1 Interventional
View directory record Official record
Conditions
Ankle Arthrodesis, MTP Arthrodesis
Interventions
Vitamin D3
Drug
Lead sponsor
Prisma Health-Midlands
Other
Eligibility
18 Years to 99 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
2
States / cities
Charleston, South Carolina • Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 8, 2025 · Synced May 22, 2026, 1:16 AM EDT
Terminated Not applicable Interventional
View directory record Official record
Conditions
Arthritis, Infection of Total Ankle Joint Prosthesis
Interventions
INBONE™ Total Ankle Prosthesis with Long Talar Stem
Device
Lead sponsor
Stryker Trauma and Extremities
Industry
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 21, 2014 · Synced May 22, 2026, 1:16 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available
View directory record Official record
Conditions
Rheumatoid Arthritis of Ankle, Osteoarthritis of Ankle, Traumatic Arthritis of Ankle
Interventions
Not listed
Lead sponsor
Orthopaedic Associates of Michigan, PC
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 19, 2012 · Synced May 22, 2026, 1:16 AM EDT
Active, not recruiting No phase listed Observational
View directory record Official record
Conditions
End-stage Ankle Arthritis (ESAA), Osteoarthritis (OA)
Interventions
Ankle Arthrodesis, Ankle Arthroplasty
Procedure
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
21 Years to 89 Years
Enrollment
516 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2027
U.S. locations
6
States / cities
Fort Collins, Colorado • Grand Rapids, Michigan • Edina, Minnesota + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 7, 2025 · Synced May 22, 2026, 1:16 AM EDT
Active, not recruiting Not applicable Interventional
View directory record Official record
Conditions
Degenerative Arthritis, Rheumatoid Arthritis, Post Traumatic Arthritis
Interventions
Zimmer Trabecular Metal Total Ankle System
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2027
U.S. locations
5
States / cities
Sacramento, California • Grand Rapids, Michigan • Charlotte, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced May 22, 2026, 1:16 AM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Ankle Osteoarthritis
Interventions
Salto-Talaris Total Ankle Replacement, STAR Total Ankle Replacement
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years to 95 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2020
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 4, 2021 · Synced May 22, 2026, 1:16 AM EDT