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ClinicalTrials.gov public records Last synced Oct 20, 2026, 11:38 AM EDT

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Showing 1–24 of 195 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Unconsciousness Clear all
Terminated Phase 4 Interventional Results available

Antiseizure Medication in Seizure Networks at Early Acute Brain Injury

NCT06081283
View directory record Official record
Conditions
Brain Injuries, Acute, Brain Injuries, Traumatic, Brain Ischemia, Brain Hypoxia, Hypoxia-Ischemia, Brain, Heart Arrest, Stroke, Intracranial Hemorrhages, Coma, Persistent Vegetative State
Interventions
Phenobarbital Sodium Injection, Levetiracetam, Lacosamide Injectable Product, Valproate Sodium, Fosphenytoin
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Months to 70 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 14, 2025 · Synced Oct 20, 2026, 11:38 AM EDT
Completed Not applicable Interventional Results available

Ambulatory Post-Syncope Arrhythmia Protection Feasibility Study

NCT02188147
View directory record Official record
Conditions
Syncope
Interventions
Short Term Wearable Defibrillator
Device
Lead sponsor
Zoll Medical Corporation
Industry
Eligibility
18 Years and older
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
6
States / cities
Danbury, Connecticut • Jacksonville, Florida • Minneapolis, Minnesota + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 21, 2023 · Synced Oct 20, 2026, 11:38 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

REsting and Stimulus-based Paradigms to Detect Organized NetworkS and Predict Emergence of Consciousness

NCT03504709
View directory record Official record
Conditions
Consciousness Disorder, Coma, Brain Injuries, Traumatic
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
79 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 21, 2024 · Synced Oct 20, 2026, 11:38 AM EDT
Completed No phase listed Observational

Tilt Table With Suspected Postural Orthostatic Tachycardia Syndrome (POTS) Subjects

NCT01617616
View directory record Official record
Conditions
Postural Orthostatic Tachycardia Syndrome, Syncope, Vasovagal, Neurocardiogenic Syncope
Interventions
Not listed
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
10 Years to 21 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 20, 2017 · Synced Oct 20, 2026, 11:38 AM EDT
Enrolling by invitation Not applicable Interventional

mindBEAGLE: Unlocking Functional Communication for Patients With Disorders of Consciousness

NCT06426602
View directory record Official record
Conditions
Disorders of Consciousness
Interventions
mindBEAGLE daily device use
Device
Lead sponsor
Amy Wagner
Other
Eligibility
16 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Oct 20, 2026, 11:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Presyncope (Syncope) Prevention Study

NCT04772755
View directory record Official record
Conditions
Syncope, Vasovagal
Interventions
Buzzy® and Electronic Game
Device
Lead sponsor
Duke University
Other
Eligibility
10 Years to 14 Years
Enrollment
338 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
2
States / cities
Atlanta, Georgia • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 16, 2023 · Synced Oct 20, 2026, 11:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Hypercapnia: Cognitive Effects and Monitoring

NCT01782625
View directory record Official record
Conditions
Hypercapnia, Exercise, Nitrogen Narcosis, Diving, Immersion
Interventions
NO exercise at depth, exercise at depth
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 50 Years · Male only
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 25, 2016 · Synced Oct 20, 2026, 11:38 AM EDT
Completed Phase 1Phase 2 Interventional Results available

A Randomized Double Blinded Study to Examine the Use of N-acetyl Cysteine for the Prevention and Treatment of HAAF in Patients With Type 1 Diabetes

NCT02206152
View directory record Official record
Conditions
Type 1 Diabetes, Hypoglycemia Unawareness
Interventions
N-acetyl cysteine, Placebo
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 65 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 31, 2020 · Synced Oct 20, 2026, 11:38 AM EDT
Not listed No phase listed Observational

Improving Management of Emergency Department Patients With Undifferentiated Syncope: Prospective Validation of the Canadian Syncope Risk Score

NCT05538143
View directory record Official record
Conditions
Syncope
Interventions
Comprehensive ED syncope/presyncope management tool
Other
Lead sponsor
Kaiser Permanente
Other
Eligibility
16 Years and older
Enrollment
4,000 participants
Timeline
2022 – 2024
U.S. locations
5
States / cities
Oakland, California • Richmond, California • Roseville, California + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 6, 2024 · Synced Oct 20, 2026, 11:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Dissecting De-automatization

NCT03456505
View directory record Official record
Conditions
Mindfulness
Interventions
Mindfulness Meditation Training, Active Listening
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 60 Years
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Oct 1, 2018 · Synced Oct 20, 2026, 11:38 AM EDT
Recruiting No phase listed Observational

Cerebral Autoregulation, Brain Perfusion, and Neurocognitive Outcomes After Traumatic Brain Injury

NCT06480838
View directory record Official record
Conditions
Traumatic Brain Injury With Loss of Consciousness, Brain Injury Traumatic Severe, Brain Injury Traumatic Moderate, TBI (Traumatic Brain Injury), TBI
Interventions
Not listed
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
3
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 2, 2026 · Synced Oct 20, 2026, 11:38 AM EDT
Completed Not applicable Interventional

PREPARE - Primary Prevention Parameters Evaluation

NCT00279279
View directory record Official record
Conditions
Tachycardia, Ventricular, Implantable Cardioverter Defibrillator (ICD), Fibrillation, Ventricular, Syncope
Interventions
Implanted Device
Device
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
700 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2006
U.S. locations
31
States / cities
Birmingham, Alabama • Mesa, Arizona • Phoenix, Arizona + 28 more
Source: ClinicalTrials.gov public record
Updated Oct 26, 2006 · Synced Oct 20, 2026, 11:38 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

REcovery From DEXmedetomidine-induced Unconsciousness

NCT06003127
View directory record Official record
Conditions
Anesthesia, Healthy, Consciousness, Level Altered
Interventions
Transcranial Magnetic Stimulation-Electroencephalography
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Oct 20, 2026, 11:38 AM EDT
Completed Not applicable Interventional Results available

Amantadine + rTMS as a Neurotherapeutic for Disordered Consciousness

NCT02025439
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
rTMS, Amantadine
Device · Drug
Lead sponsor
Edward Hines Jr. VA Hospital
Federal
Eligibility
18 Years to 64 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
2
States / cities
Chicago, Illinois • Hines, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 24, 2020 · Synced Oct 20, 2026, 11:38 AM EDT
Completed Not applicable Interventional

Addressing Fear and Risk of Vasovagal Reactions Among High School Donors

NCT03835299
View directory record Official record
Conditions
Blood Donors
Interventions
Fear Intervention
Behavioral
Lead sponsor
Ohio University
Other
Eligibility
16 Years and older
Enrollment
4,035 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Athens, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 16, 2021 · Synced Oct 20, 2026, 11:38 AM EDT
Completed No phase listed Observational

Assessing Patient-provider Interactions During the Preoperative Anesthesia Consult

NCT04508543
View directory record Official record
Conditions
Racism, Healthcare Disparities, Minority Health
Interventions
Non-verbal communication score
Other
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Feb 13, 2025 · Synced Oct 20, 2026, 11:38 AM EDT
Recruiting Phase 2 Interventional

Restoration of Hypoglycemia Awareness With Metoclopramide

NCT03970720
View directory record Official record
Conditions
Hypoglycemia Unawareness
Interventions
Metoclopramide, Placebo
Drug
Lead sponsor
Simon Fisher
Other
Eligibility
20 Years to 60 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
2
States / cities
Lexington, Kentucky • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 20, 2026 · Synced Oct 20, 2026, 11:38 AM EDT
Completed No phase listed Observational

Prognostication of Recovery in Early Disorders of Consciousness After COVID-19

NCT04476589
View directory record Official record
Conditions
Covid19, Coma, Consciousness Disorder
Interventions
Functional MRI
Diagnostic Test
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
12 participants
Timeline
2020 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 4, 2023 · Synced Oct 20, 2026, 11:38 AM EDT
Completed No phase listed Observational

Validation of the San Francisco Syncope Rule

NCT00300625
View directory record Official record
Conditions
Syncope, Near Syncope
Interventions
Application of the San Francisco Syncope Rule
Procedure
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
21 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2005
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated May 15, 2018 · Synced Oct 20, 2026, 11:38 AM EDT
Active, not recruiting Not applicable Interventional

Intervention to Change Affect Recognition and Empathy

NCT05636020
View directory record Official record
Conditions
Traumatic Brain Injury, Concussion, Intermediate, Concussion, Severe, Concussion With LOC 31 to 59 Minutes, Concussion With Brief Loss of Consciousness, Traumatic Brain Injury With Brief Loss of Consciousness, Traumatic Brain Injury With Loss of Consciousness, Traumatic Brain Injury With Prolonged Loss of Consciousness, Traumatic Brain Injury (TBI); Concussion, Initial Encounter, Traumatic Brain Injury (TBI); Concussion, Subsequent Encounter, Traumatic Brain Injury With No Loss of Consciousness, Traumatic Brain Injury With Open Intracranial Wound, Traumatic Brain Injury With Moderate Loss of Consciousness
Interventions
ICARE Treatment
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Oct 20, 2026, 11:38 AM EDT
Not yet recruiting Not applicable Interventional

The Coma Family Program (COMA-F): A Resilience Program for Caregivers of Patients With Severe Acute Brain Injury

NCT07331324
View directory record Official record
Conditions
Caregiver Distress, Emotional Distress, Caregivers, Resilience, Coma, Brain Injury
Interventions
Coma Family Program 1, Coma Family Program 2
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
3
States / cities
Baltimore, Maryland • Boston, Massachusetts • Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 20, 2026 · Synced Oct 20, 2026, 11:38 AM EDT
Completed Phase 2 Interventional Results available

Amantadine to Speed Awakening After Cardiac Arrest

NCT02486211
View directory record Official record
Conditions
Coma, Heart Arrest, Anoxia
Interventions
Amantadine, Placebo
Drug
Lead sponsor
Jon Rittenberger, MD
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
4
States / cities
Portland, Maine • Boston, Massachusetts • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 4, 2019 · Synced Oct 20, 2026, 11:38 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Novel Approach for the Prevention of Hypoglycemia Associated Autonomic Failure (HAAF)

NCT03608163
View directory record Official record
Conditions
Diabetes Mellitus, Type 1, Hypoglycemia, Hypoglycemia Unawareness
Interventions
Naloxone, Diazoxide, Placebo (for Naloxone), Placebo (for Diazoxide)
Drug
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
21 Years to 55 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Sep 11, 2025 · Synced Oct 20, 2026, 11:38 AM EDT
Completed Not applicable Interventional

The COMA Family Program: A Skills-Based Resiliency Program for Caregivers of Patients With Severe Acute Brain Injuries

NCT05761925
View directory record Official record
Conditions
Coma, Emotional Distress
Interventions
COMA-F
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 25, 2025 · Synced Oct 20, 2026, 11:38 AM EDT