Clobazam in Patients With Lennox-Gastaut Syndrome
Public ClinicalTrials.gov record NCT00518713. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Double-Blind, Placebo-Controlled, Efficacy and Safety Study of Clobazam in Patients With Lennox-Gastaut Syndrome
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the safety and efficacy of clobazam as adjunctive therapy in the treatment of seizures which lead to drop attacks (drop seizures) in patients 2 to 60 years of age with Lennox-Gastaut Syndrome (LGS). Patients will be enrolled at approximately 65 sites in the U.S. and ex-US for up to 23 weeks. Patients will be randomly assigned to either a low, medium or high dose, or placebo. The study will include a baseline period, a titration period and a maintenance period. After the maintenance period, patients will either continue into an open-label extension study or enter the taper period with a final visit 1 week after the last dose.
Study identification
- NCT ID
- NCT00518713
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 238 participants
Conditions and interventions
Conditions
Interventions
- Clobazam Low Dose Drug
- Clobazam Medium Dose Drug
- Clobazam High Dose Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 2 Years to 60 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 2007 (Type not available)
- Primary completion
- Dec 2009 (Actual)
- Completion
- Apr 2010 (Actual)
- Last update posted
- Feb 9, 2012
2007 – 2010
United States locations
- U.S. sites
- 34
- U.S. states
- 23
- U.S. cities
- 29
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Huntsville | Alabama | 35081 | — |
| St. Joseph's Hospital and Medical Center | Phoenix | Arizona | 85013 | — |
| Phoenix Children's Hospital | Phoenix | Arizona | 85216 | — |
| Childrens Hospital Los Angeles | Los Angeles | California | 90027 | — |
| The Children's Hospital | Aurora | Colorado | 80045 | — |
| Children's National Medical Center | Washington D.C. | District of Columbia | 20010 | — |
| Pediatric Neurology and Epilepsy Center | Loxahatchee Groves | Florida | 33470 | — |
| Child Neurology Center of NW FL | Pensacola | Florida | 32504 | — |
| University of South Florida | Tampa | Florida | 33606 | — |
| Pediatric Epilepsy & Neurology Specialists | Tampa | Florida | 33609 | — |
| Medical College of Georgia | Augusta | Georgia | 30912 | — |
| Pediatric Neurology of Idaho Children's Specialty Center | Boise | Idaho | 83712 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| Children's Memorial Hospital | Chicago | Illinois | 61516 | — |
| University of Kentucky, Kentucky Clinic, Department of Neurology | Lexington | Kentucky | 40536-0284 | — |
| LSU Health Sciences Center | Shreveport | Louisiana | 71103 | — |
| Mid-Atlantic Epilepsy and Sleep Center | Bethesda | Maryland | 20817 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Minnesota Epilepsy Group | Saint Paul | Minnesota | 55012 | — |
| The Comprehensive Epilepsy Care Center for Children and Adults | Chesterfield | Missouri | 63017 | — |
| Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| Robert Wood Johnson University Hospital | New Brunswick | New Jersey | 08901 | — |
| St. Joseph's Regional Medical Center | Paterson | New Jersey | 07503 | — |
| Clinical Research Center of New Jersey (CRCNJ) | Voorhees Township | New Jersey | 08043 | — |
| University of Rochester Medical Center | Rochester | New York | 14450 | — |
| University Neurology, Inc. | Cincinnati | Ohio | 45219 | — |
| The Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | 19104 | — |
| Jefferson Epilepsy Center | Philadelphia | Pennsylvania | 19107 | — |
| UTMG Pediatric Neurology | Memphis | Tennessee | 38105 | — |
| Children's Medical Center at UT Southwestern-Dallas | Dallas | Texas | 75235 | — |
| Cook Children's Health Care System | Fort Worth | Texas | 76104 | — |
| Baylor College of Medicine Pediatric Neurology | Houston | Texas | 77030 | — |
| Virginia Commonwealth University | Richmond | Virginia | 23298-0211 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 19 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00518713, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 9, 2012 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00518713 live on ClinicalTrials.gov.