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Showing 1–24 of 87 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Unipolar Major Depression Clear all
Withdrawn Phase 1 Interventional

Title: Safety and Feasibility of Individualized Low Amplitude Seizure Therapy (iLAST)

NCT03895658
View directory record Official record
Conditions
Unipolar Depression
Interventions
MRI, MagPro TMS stimulator and coil, Thymatron (R) System IV paired with 4X1 HDECT
Device
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
22 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 26, 2025 · Synced Sep 6, 2026, 2:29 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Ketamine + Mindfulness for Depression

NCT05168735
View directory record Official record
Conditions
Depression, Unipolar
Interventions
Intravenous Ketamine, Brief Mindfulness Exercises, Academic Exercises
Drug · Behavioral
Lead sponsor
Rebecca Price
Other
Eligibility
18 Years to 65 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 19, 2024 · Synced Sep 6, 2026, 2:29 PM EDT
Completed Phase 3 Interventional

Triiodothyronine (T3) Supplementation in the Treatment of Bipolar and Unipolar Depression.

NCT00158990
View directory record Official record
Conditions
Major Depression, Bipolar Disorder, Unipolar Depression
Interventions
triiodothyronine, sertraline
Drug
Lead sponsor
Hadassah Medical Organization
Other
Eligibility
18 Years to 70 Years
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2007
U.S. locations
1
States / cities
Princeton, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 3, 2007 · Synced Sep 6, 2026, 2:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Tracking Depression Symptoms With a Health Chatbot

NCT03990389
View directory record Official record
Conditions
Depression, Postpartum, Depression, Unipolar
Interventions
Chatbot Intervention
Device
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
2
States / cities
Chicago, Illinois • Skokie, Illinois
Source: ClinicalTrials.gov public record
Updated May 11, 2022 · Synced Sep 6, 2026, 2:29 PM EDT
Terminated Not applicable Interventional Results available

Deep Brain Stimulation for Major Depressive Disorder

NCT00617162
View directory record Official record
Conditions
Depressive Disorder, Major, Unipolar Depression
Interventions
Deep Brain Stimulation, Libra Deep Brain Stimulation System
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
21 Years to 70 Years
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2015
U.S. locations
11
States / cities
Stanford, California • Chicago, Illinois • Worcester, Massachusetts + 8 more
Source: ClinicalTrials.gov public record
Updated Apr 7, 2024 · Synced Sep 6, 2026, 2:29 PM EDT
Completed Phase 2 Interventional

Riluzole to Treat Major Depression

NCT00026052
View directory record Official record
Conditions
Depression
Interventions
riluzole
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
Not listed
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2003
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Sep 6, 2026, 2:29 PM EDT
Terminated Phase 2 Interventional Results available

The Antidepressant Efficacy of the Anticholinergic Scopolamine

NCT00369915
View directory record Official record
Conditions
Unipolar Depression, Bipolar Depression
Interventions
Scopolamine
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 55 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 9, 2016 · Synced Sep 6, 2026, 2:29 PM EDT
Withdrawn Phase 4 Interventional

The Effects of Vilazodone on Glutamate in the Anterior Cingulate Cortex in Anxious Unipolar Depressives

NCT02028026
View directory record Official record
Conditions
Major Depressive Disorder, Anxiety, Comorbidity
Interventions
Vilazodone, Citalopram
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 50 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 7, 2016 · Synced Sep 6, 2026, 2:29 PM EDT
Completed Not applicable Interventional

A Waitlist-Controlled Trial of the Unified Protocol for the Treatment of Emotional Disorders in Adolescents

NCT00628888
View directory record Official record
Conditions
Anxiety Disorders, Depression
Interventions
Unified Protocol for Adolescents (UP-A)
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
12 Years to 18 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Dec 18, 2014 · Synced Sep 6, 2026, 2:29 PM EDT
Completed No phase listed Observational

PET Whole Body Distribution Studies Using [11C]CUMI

NCT01132872
View directory record Official record
Conditions
Depression, Major Depression, Unipolar Depression, Anxiety Disorder, Anxiety Disorders
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Sep 6, 2026, 2:29 PM EDT
Recruiting Not applicable Interventional

Transcranial Direct Current Stimulation for Depression

NCT07042217
View directory record Official record
Conditions
Unipolar Depression
Interventions
transcranial direct current stimulation (tDCS) and mindfulness instruction, Sham tDCS and Mindfulness
Device
Lead sponsor
Soterix Medical
Industry
Eligibility
22 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Woodbridge, New Jersey
Source: ClinicalTrials.gov public record
Updated Nov 9, 2025 · Synced Sep 6, 2026, 2:29 PM EDT
Completed Phase 1 Interventional Results available

Antidepressant Effects of NR2B in Major Depression

NCT00472576
View directory record Official record
Conditions
Major Depression
Interventions
MK-0657, Placebo
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 55 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 2, 2012 · Synced Sep 6, 2026, 2:29 PM EDT
Completed Not applicable Interventional

Feasibility and Tolerability of Adjunct Chronotherapy in Depressed Inpatients

NCT02088580
View directory record Official record
Conditions
Non-Psychotic Unipolar Depression, Bipolar Depression
Interventions
Triple Chronotherapy
Procedure
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 1, 2015 · Synced Sep 6, 2026, 2:29 PM EDT
Not listed No phase listed Observational

Machine Learning to Predict Clinical Response to TMS

NCT03847688
View directory record Official record
Conditions
Depression, Unipolar
Interventions
Transcranial Magnetic Stimulation
Device
Lead sponsor
Brown University
Other
Eligibility
18 Years to 65 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Feb 24, 2019 · Synced Sep 6, 2026, 2:29 PM EDT
Suspended Phase 1 Interventional

Low Field Magnetic Stimulation (LFMS) in Mood Disorders: 6 Treatments

NCT01557192
View directory record Official record
Conditions
Bipolar Depression, Unipolar Depression
Interventions
Low Field Magnetic Stimulation Device
Device
Lead sponsor
Mclean Hospital
Other
Eligibility
21 Years to 55 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2020
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 12, 2016 · Synced Sep 6, 2026, 2:29 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Chronobiology and Depression: Circadian Analytics as a Biomarker for Depressive Subtypes

NCT03538275
View directory record Official record
Conditions
Depression, Bipolar, Depression, Unipolar, Healthy
Interventions
Monitoring test
Other
Lead sponsor
Medibio Limited
Industry
Eligibility
18 Years to 75 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 25, 2023 · Synced Sep 6, 2026, 2:29 PM EDT
Terminated Phase 4 Interventional Results available

Open-Label Pilot Study to Examine the Value of Substituting Quetiapine for Benzodiazepines

NCT01244711
View directory record Official record
Conditions
Major Depression, Generalized Anxiety Disorder
Interventions
quetiapine
Drug
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 65 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 2, 2015 · Synced Sep 6, 2026, 2:29 PM EDT
Completed Not applicable Interventional Results available

Treating Major Depression With Yoga: A Prospective, Randomized Controlled Pilot Trial

NCT01210651
View directory record Official record
Conditions
Depression, Unipolar
Interventions
Hatha Yoga Practice Group, Attention Control Education Group
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
14 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 10, 2017 · Synced Sep 6, 2026, 2:29 PM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers

Cholinergic Modulation of Condition and Emotion in Mood Disorders: Functional Neuroimaging Studies

NCT00055575
View directory record Official record
Conditions
Mood Disorders, Healthy, Unipolar Depression, Bipolar Depression
Interventions
Scopolamine Nasal Spray
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 55 Years
Enrollment
197 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2015
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 21, 2021 · Synced Sep 6, 2026, 2:29 PM EDT
Completed Not applicable Interventional Results available

Reaching and Engaging Depressed Senior Center Clients (REDS)

NCT03246789
View directory record Official record
Conditions
Depression, Unipolar, Mental Health Disorder
Interventions
Engage-M, Wellness in Mind and Body
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
55 Years to 100 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 18, 2022 · Synced Sep 6, 2026, 2:29 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Maternal Mindfulness: Depression and Postpartum Pain

NCT05400382
View directory record Official record
Conditions
Depression, Unipolar, Pain, Postoperative
Interventions
Mindfulness
Behavioral
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Champaign, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Sep 6, 2026, 2:29 PM EDT
Not listed Not applicable Interventional

Mindfulness Based Cognitive Therapy for Chronic Pain and Comorbid Unipolar Depression

NCT01473615
View directory record Official record
Conditions
Major Depressive Disorder, Dysthymic Disorder, Depressive Disorder NOS, Chronic Pain
Interventions
Mindfulness Based Cognitive Therapy
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 6, 2013 · Synced Sep 6, 2026, 2:29 PM EDT
Completed Phase 4 Interventional Results available

Ketamine as an Augmentation Strategy for Electroconvulsive Therapy (ECT) in Depression

NCT01881763
View directory record Official record
Conditions
Unipolar Depression, Bipolar Depression
Interventions
Ketamine, Methohexital
Drug
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 70 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
1
States / cities
Glen Oaks, New York
Source: ClinicalTrials.gov public record
Updated Mar 8, 2023 · Synced Sep 6, 2026, 2:29 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Antidepressant Effects on cAMP Specific Phosphodiesterase (PDE4) in Depressed Patients

NCT00369798
View directory record Official record
Conditions
Major Depressive Disorder, Healthy
Interventions
PET scan, Rolipram
Procedure · Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 55 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2016
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 4, 2018 · Synced Sep 6, 2026, 2:29 PM EDT