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ClinicalTrials.gov public records Last synced Sep 5, 2026, 10:35 AM EDT

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Showing 1–24 of 134 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Conditions
Hypertension (Without Type 2 Diabetes Mellitus), High Blood Pressure, Male, Female, Adult, Cognition, Endothelial Function (Reactive Hyperemia), Oxidative Stress, Diet, Overweight, Body Composition Measurement, Gut Microbiome, Arterial Stiffness, Caucasian Whites, Inflammation, Microvascular Function
Interventions
Wild Blueberry, Placebo
Dietary Supplement
Lead sponsor
Georgia State University
Other
Eligibility
45 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Atlanta, Georgia
Not listed Not applicable Interventional Accepts healthy volunteers

Determinants of Changes in Arterial Load Following Exercise

NCT05820243
Conditions
Post-Exercise Hypotension
Interventions
Moderate Intensity Aerobic Exercise
Other
Lead sponsor
University of Delaware
Other
Eligibility
18 Years to 45 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Newark, Delaware
Conditions
Cardiovascular Diseases, Vascular Stiffness, Endothelial Dysfunction
Interventions
Not listed
Lead sponsor
Zhili hao
Other
Eligibility
45 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Norfolk, Virginia
Completed No phase listed Observational Accepts healthy volunteers

Vitamin D, Insulin Sensitivity, and Vascular Associations in Adolescents

NCT01041365
Conditions
Insulin Sensitivity, Flow-mediated Dilation, Arterial Stiffness
Interventions
Not listed
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
14 Years to 18 Years · Female only
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
Birmingham, Alabama
Conditions
Prehypertension, Stage-1 Hypertension
Interventions
Non-fat dairy, Add 4 servings fruit
Dietary Supplement
Lead sponsor
University of Texas at Austin
Other
Eligibility
35 Years to 80 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Austin, Texas
Conditions
Mood Disorders, Hypertension, Overweight and Obesity, Vascular Stiffness, Sleep, Elevated Blood Pressure
Interventions
Cardiovascular Assessments, Actigraphy, Laboratory assessments, Emotional/ Behavioural assessments
Diagnostic Test · Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
Up to 22 Years
Enrollment
37 participants
Timeline
2020 – 2022
U.S. locations
1
States / cities
Baltimore, Maryland
Completed Not applicable Interventional Accepts healthy volunteers

NightWare and Cardiovascular Health in Adults With PTSD

NCT05365607
Conditions
Posttraumatic Stress Disorder, Cardiovascular Diseases, Autonomic Dysfunction, Vascular Stiffness, Nightmare, Endothelial Dysfunction
Interventions
NightWare, Sham NightWare
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
22 Years to 99 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
2
States / cities
Aurora, Colorado • Denver, Colorado
Active, not recruiting Phase 1Phase 2 Interventional Accepts healthy volunteers

Fisetin to Improve Vascular Function in Older Adults

NCT06133634
Conditions
Aging, Endothelial Dysfunction, Arterial Stiffness
Interventions
Fisetin, Placebo
Dietary Supplement · Other
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
65 Years and older
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boulder, Colorado
Conditions
Atherosclerosis, Inflammation
Interventions
Sitagliptin, Placebo
Drug
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 40 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Los Angeles, California
Conditions
High Triglyceride Level, HIV Infection
Interventions
Lovaza
Drug
Lead sponsor
Tufts University
Other
Eligibility
18 Years and older
Enrollment
129 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Study of Febuxostat Effect on Blood Pressure in Patients With High Normal Blood Pressure

NCT01472692
Conditions
Prehypertension, Gout, Pulse Wave Velocity, Hypertension, 24 Hour Blood Pressure
Interventions
Febuxostat
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 50 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
San Diego, California
Conditions
Cardiovascular Disease
Interventions
ALT-711 (alagebrium chloride)
Drug
Lead sponsor
Synvista Therapeutics, Inc
Industry
Eligibility
50 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Baltimore, Maryland
Conditions
Transgenderism, Insulin Sensitivity/Resistance, Endothelial Dysfunction, Vascular Stiffness
Interventions
Not listed
Lead sponsor
University of Colorado, Denver
Other
Eligibility
9 Years to 14 Years · Male only
Enrollment
30 participants
Timeline
2020 – 2026
U.S. locations
1
States / cities
Aurora, Colorado
Conditions
Hypertension
Interventions
5g Cocoa Consumption, 10g Cocoa Consumption
Dietary Supplement
Lead sponsor
Griffin Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
2
States / cities
Derby, Connecticut • Boston, Massachusetts
Conditions
Hypertension, Cardiovascular Diseases, Vascular Diseases
Interventions
25 g of Freeze-dried Strawberry Powder, 50 g of Freeze-dried Strawberry Powder, Placebo Powder
Dietary Supplement
Lead sponsor
Florida State University
Other
Eligibility
45 Years to 65 Years · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Tallahassee, Florida
Completed No phase listed Observational Accepts healthy volunteers

Impact of Elastin Mediated Vascular Stiffness on End Organs

NCT02840448
Conditions
Williams Syndrome, Supravalvular Aortic Stenosis, Cardiovascular Disease
Interventions
Not listed
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
3 Years to 85 Years
Enrollment
159 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2024
U.S. locations
2
States / cities
Bethesda, Maryland • St Louis, Missouri
Terminated Phase 2 Interventional Results available

Acute Effects of Inhaled Treprostinil in Fontan Patients

NCT02769624
Conditions
Congenital Heart Disease
Interventions
Treprostinil, Placebo
Drug
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Cincinnati, Ohio
Conditions
Cardiovascular Disease
Interventions
Soy Protein Powder (25g/d), Placebo, Soy Protein Powder (50g/d)
Dietary Supplement
Lead sponsor
Penn State University
Other
Eligibility
35 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
University Park, Pennsylvania
Conditions
Obesity, Pre-hypertension, Hypertension
Interventions
L-citrulline supplementation, Whole Body Vibration Training
Dietary Supplement · Other
Lead sponsor
Florida State University
Other
Eligibility
50 Years to 70 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Tallahassee, Florida
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Sodium Nitrite to Treat Arterial Aging

NCT02022670
Conditions
Vascular Aging
Interventions
Placebo, Sodium Nitrite
Drug
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
50 Years to 79 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Boulder, Colorado
Completed No phase listed Observational Accepts healthy volunteers

Ventricular-Vascular Coupling in Heart Failure

NCT00207220
Conditions
Heart Failure With Preserved Ejection Fraction
Interventions
arterial tonometry, echocardiography
Procedure
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 80 Years
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2007
U.S. locations
1
States / cities
Boston, Massachusetts
Completed Not applicable Interventional Accepts healthy volunteers

Dose-dependent Effects of Second-hand Smoke on Vascular Function

NCT01007760
Conditions
Cardiovascular Disease
Interventions
Respirable suspended particles (RSP) PM 2.5 dose of second-hand smoke
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 40 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
San Francisco, California
Conditions
Blood Pressure
Interventions
Freeze-dried Blueberry Powder, Placebo
Dietary Supplement
Lead sponsor
Florida State University
Other
Eligibility
45 Years to 65 Years · Female only
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Tallahassee, Florida
Conditions
Arterial Stiffness, Blood Pressure, Dysbiosis, Inflammation, Permeability; Increased
Interventions
Freeze-dried grape powder, Placebo powder
Dietary Supplement · Other
Lead sponsor
University of California, Davis
Other
Eligibility
45 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Davis, California