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Recruiting Phase 1Phase 2 Interventional

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

ClinicalTrials.gov ID: NCT04585750

Public ClinicalTrials.gov record NCT04585750. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 7, 2026, 2:37 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 1/2 Open-label, Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of PC14586 in Patients With Locally Advanced or Metastatic Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

Study identification

NCT ID
NCT04585750
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 1, Phase 2
Lead sponsor
PMV Pharmaceuticals, Inc
Industry
Enrollment
300 participants

Conditions and interventions

Interventions

  • pembrolizumab Drug
  • rezatapopt Drug

Drug

Eligibility (public fields only)

Age range
12 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Oct 28, 2020
Primary completion
Aug 14, 2026
Completion
Dec 30, 2027
Last update posted
Mar 11, 2026

2020 – 2027

United States locations

U.S. sites
32
U.S. states
19
U.S. cities
28
Facility City State ZIP Site status
University of California Irvine Chao Family Comprehensive Cancer Center Irvine California 92868 Recruiting
University of San Diego Moores Cancer Center La Jolla California 92093 Not yet recruiting
UCLA Jonsson Comprehensive Cancer Center Los Angeles California 90024 Recruiting
USC Norris Comprehensive Cancer Center Los Angeles California 90033 Recruiting
Rocky Mountain Cancer Center Denver Colorado 80218 Recruiting
Yale Cancer Center New Haven Connecticut 06519 Recruiting
Medical Oncology Hematology Consultants Newark Delaware 19713 Recruiting
University of Miami - Sylvester Comprehensive Cancer Center Miami Florida 33136 Recruiting
Advent Health Orlando Florida 32803 Not yet recruiting
Florida Cancer Specialists South Port Charlotte Florida 33980 Recruiting
Massachusetts General Hospital Boston Massachusetts 02114 Recruiting
Dana Farber Cancer Institute Boston Massachusetts 02215 Recruiting
Karmanos Cancer Institute Detroit Michigan 48201 Recruiting
Columbia University New York New York 10032 Not yet recruiting
Memorial Sloan Kettering New York New York 10065 Recruiting
Duke University Durham North Carolina 27705 Recruiting
The Cleveland Clinic Taussig Cancer Center Cleveland Ohio 44195 Recruiting
University of Oklahoma Oklahoma City Oklahoma 73104 Recruiting
Oregon Health & Science University (OHSU) Portland Oregon 97210 Recruiting
Abramson Cancer Center of the University of Pennsylvania Philadelphia Pennsylvania 19104 Recruiting
University of Pittsburgh Medical Center Pittsburgh Pennsylvania 15213 Not yet recruiting
WellSpan York Cancer Center York Pennsylvania 17403 Recruiting
Medical University of South Carolina Charleston South Carolina 29425 Terminated
Sarah Cannon Research Institute Nashville Tennessee 37203 Recruiting
New Experimental Therapeutics - NEXT Oncology Austin Texas 78705 Recruiting
UTSW - Moody Outpatient Center - Parkland Health Dallas Texas 75235 Not yet recruiting
UT Southwest Simmons Cancer Center Dallas Texas 75390 Recruiting
The University of Texas MD Anderson Cancer Center Houston Texas 77030 Recruiting
New Experimental Therapeutics of San Antonio - NEXT Oncology San Antonio Texas 78229 Recruiting
Virginia Cancer Specialists Fairfax Virginia 22031 Recruiting
University of Washington, Fred Hutchinson Cancer Center Seattle Washington 98109 Recruiting
University of Wisconsin Carbone Cancer Center Madison Wisconsin 53705 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 44 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT04585750, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Mar 11, 2026 · Synced May 7, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT04585750 live on ClinicalTrials.gov.

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