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Head and Neck Cancer clinical trials

Directory of U.S. ClinicalTrials.gov public records for Head and Neck Cancer. Browse Head and Neck Cancer recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By the Clinical Trials Finder editorial team Guidance last reviewed June 10, 2026 Data synced August 30, 2026 Report an issue

ClinicalTrials.gov public records Last synced Aug 29, 2026, 11:02 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official matching trials
170
Shown on this page
12
Local recruiting
92
Local phase groups
6
The trial list below is retrieved from the live ClinicalTrials.gov search API for Head and Neck Cancer. Results on this page are currently sorted by Recently updated.

How Head and Neck Cancer studies are organized in the registry

Most records use the formal phrase “squamous cell carcinoma of the head and neck” or the abbreviation HNSCC, and site-specific terms like “oropharyngeal” mark distinct subsets. HPV status is a common population-defining label in this portfolio, and combined-modality studies (radiation plus systemic therapy) are frequent.

  • 54% of the 170 locally indexed Head and Neck Cancer records are currently marked recruiting.
  • The most common phase group in the local index is Phase 2 (66 records).
  • The most frequent sponsor is M.D. Anderson Cancer Center (12 records).
  • The most listed study location is Houston, Texas (37 records).
Terms that often appear in related listings

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Filter and sort this condition

These controls apply only within Head and Neck Cancer. Default order is Recently updated. Add location, sponsor, treatment, or recruitment status to narrow this condition page further.

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Showing 1–12 of 170 matching trials for Head and Neck Cancer.
Indexed local directory records.

Indexed official records

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Conditions
Head and Neck Cancer, Liver Cancer, Prostate Cancer, Recurrent Adenocarcinoma
Interventions
MRI Simulator, Radiation Therapy
Device · Radiation
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2030
U.S. locations
2
States / cities
Boston, Massachusetts
Conditions
Head and Neck Cancer
Interventions
Cemiplimab, cemiplimab+fianlimab
Drug
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Conditions
Brain Cancer, Breast Cancer, Colorectal Cancer, Gastric Cancer, Genitourinary Cancer, Gynecologic Cancer, Head and Neck Cancer, Hodgkin Lymphoma, Kidney Cancer, Leukemia, Liver Cancer, Lung Cancer, Lymphoid Leukemia, Melanoma, Mycosis Fungoides, Myeloma Multiple, Non-hodgkin Lymphoma, Ovarian Cancer, Pancreas Cancer, Prostate Cancer, Sarcoma, Urinary Bladder Cancer
Interventions
Placebo, Riluzole
Drug
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Orange, California
Conditions
Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma HNSCC
Interventions
Accelerated radiotherapy, Conventional radiotherapy
Radiation
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
3
States / cities
Charlotte, North Carolina • Winston-Salem, North Carolina • Milwaukee, Wisconsin
Conditions
Head and Neck Cancer, Non Small Cell Lung Carcinoma NSCLC, Prostate Cancer
Interventions
Biograph Vision Quadra scanner, PET/CT
Diagnostic Test
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
7
States / cities
Basking Ridge, New Jersey • Middletown, New Jersey • Montvale, New Jersey + 4 more
Conditions
Breast Cancer, Head and Neck Cancer, Oligoprogressive, Other Cancer, Sarcoma
Interventions
Ablative local therapy
Device
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2033
U.S. locations
1
States / cities
Sacramento, California
Conditions
Gynecologic Cancer, Gynecologic Tumor, Head and Neck Cancer, Head and Neck Tumor, Melanoma, Ovarian Cancer, Thoracic Cancer, Thoracic Tumor
Interventions
Enhanced usual care, IM@Home
Behavioral
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
324 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
7
States / cities
Basking Ridge, New Jersey • Middletown, New Jersey • Montvale, New Jersey + 4 more
Conditions
Head and Neck Cancer
Interventions
NYU Electronic Patient Visit Assessment (ePVA), Usual Care
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
5
States / cities
Kansas City, Kansas • New York, New York • Philadelphia, Pennsylvania + 1 more
Conditions
Head and Neck Cancer, Head and Neck Cancers, Lip Cancer, Lip Neoplasms, Lung Cancer
Interventions
Phlebotomy, Tumor biopsy
Procedure
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2027
U.S. locations
1
States / cities
Stanford, California
Conditions
Breast Cancer, Clonal Cytopenia of Undetermined Significance, Clonal Hematopoiesis of Indeterminate Potential (CHIP), Colorectal (Colon or Rectal) Cancer, Endometrial Adenocarcinoma, Esophageal Adenocarcinoma, Gastric (Stomach) Cancer, Head and Neck Cancer, Lung Cancer (Diagnosis), Osteochondroma, Ovarian Adenocarcinoma, Sarcoma, Solid Cancers, Spitz Nevus, Therapy-Related Acute Myeloid Leukemia, Therapy-Related MDS, Uterine Adenocarcinoma
Interventions
Samples
Other
Lead sponsor
Dana-Farber Cancer Institute
Other
Eligibility
18 Years and older
Enrollment
5,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2035
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Advanced Solid Tumors Cancer, Bladder Cancer, Cancer, Colorectal Cancer, DMMR Colorectal Cancer, Endometrial Cancer, Head and Neck Cancer, Immunotherapy, Kidney Cancer, Liver Cancer, MSI-H Colorectal Cancer, Melanoma (Skin Cancer), NSCLC (Non-small-cell Lung Cancer), Skin Cancer, TNBC, Triple Negative Breast Cancer
Interventions
Biopsy
Procedure
Lead sponsor
Elephas
Industry
Eligibility
18 Years and older
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2038
U.S. locations
8
States / cities
Fort Smith, Arkansas • Frederick, Maryland • Springfield, Missouri + 4 more
Conditions
Brain Tumor, Head and Neck Cancer
Interventions
MRI, Neurocognitive Testing, substructure informed planning
Diagnostic Test · Other · Radiation
Lead sponsor
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Other
Eligibility
1 Year to 26 Years
Enrollment
338 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2035
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Baltimore, Maryland

About this Head and Neck Cancer clinical trials directory page

What this page lists
U.S. ClinicalTrials.gov public records that list Head and Neck Cancer as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results
Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Head and Neck Cancer.
Where the data comes from
Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Related: all condition pages, browse by drug or therapy, browse by U.S. city, browse by sponsor, or open the full search for Head and Neck Cancer.