ClinicalTrials.gov record
Niraparib in the Treatment of Patients With Advanced PALB2 Mutated Tumors
ClinicalTrials.gov ID: NCT05169437
Public ClinicalTrials.gov record NCT05169437. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Single-Arm Phase-II Study of Niraparib in Locally Advanced or Metastatic Solid Tumor Patients With PALB2 Mutations
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to further evaluate the efficacy and safety of niraparib in patients with locally advanced or metastatic solid tumors and a pathogenic or likely pathogenic tumor PALB2 (tPALB2) mutation.
Study identification
- NCT ID
- NCT05169437
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 22 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 15, 2022 (Actual)
- Primary completion
- Aug 6, 2024 (Actual)
- Completion
- Aug 27, 2024 (Actual)
- Last update posted
- Oct 29, 2025
2022 – 2024
United States locations
- U.S. sites
- 80
- U.S. states
- 30
- U.S. cities
- 72
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Yuma Regional Medical Center | Yuma | Arizona | 85364 | — |
| Highlands Oncology | Springdale | Arkansas | 72762 | — |
| Memorial Care Medical Center | Fountain Valley | California | 92708 | — |
| St Joseph Heritage Health - Fullerton | Fullerton | California | 92835 | — |
| University of California San Diego | La Jolla | California | 92093-0698 | — |
| MemorialCare | Long Beach | California | 90806 | — |
| Cancer and Blood Specialty Clinic | Los Alamitos | California | 90720 | — |
| Cancer and Blood Specialty | Los Alamitos | California | 90720 | — |
| University of California Los Angeles | Los Angeles | California | 90404 | — |
| St Joseph Health Medical Group - Napa | Napa | California | 94558 | — |
| Ventura County Hematology Oncology Specialists | Oxnard | California | 93030 | — |
| Sharp Healthcare | San Diego | California | 92123 | — |
| Ridley-Tree Cancer Center | Santa Barbara | California | 93105 | — |
| St Joseph Health Medical Group - Santa Rosa | Santa Rosa | California | 95403 | — |
| Hartford Healthcare | Hartford | Connecticut | 06102 | — |
| Eastern Connecticut Hematology and Oncology | Norwich | Connecticut | 06360 | — |
| Holy Cross | Fort Lauderdale | Florida | 33308 | — |
| Cancer Specialists of North Florida | Jacksonville | Florida | 32256 | — |
| Ocala Community Cancer Center | Ocala | Florida | 34474 | — |
| University Cancer & Blood Center | Athens | Georgia | 30607 | — |
| Hawaii Cancer Care | Honolulu | Hawaii | 96813 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| Northwest Oncology & Hematology | Rolling Meadows | Illinois | 60008 | — |
| Fort Wayne Medical Oncology and Hematology | Fort Wayne | Indiana | 46845 | — |
| Goshen Health | Goshen | Indiana | 46526 | — |
| Community Health Network | Indianapolis | Indiana | 46250 | — |
| Beacon Health System | South Bend | Indiana | 46601 | — |
| Pontchartrain Cancer Center | Hammond | Louisiana | 70403 | — |
| The Center for Cancer and Blood Disorders - Maryland | Bethesda | Maryland | 20817 | — |
| Frederick Health | Frederick | Maryland | 21702 | — |
| Maryland Oncology Hematology | Rockville | Maryland | 20850 | — |
| Southcoast Health | Fairhaven | Massachusetts | 02719 | — |
| Sparrow Health | Lansing | Michigan | 48912 | — |
| Central Care Cancer Center | Bolivar | Missouri | 65613 | — |
| Mosaic Life Care | Saint Joseph | Missouri | 64507 | — |
| Oncology Hematology Associates | Springfield | Missouri | 65807 | — |
| Nebraska Cancer Specialists | Omaha | Nebraska | 68130 | — |
| OptumCare Cancer Care | Las Vegas | Nevada | 89102 | — |
| New Jersey Cancer Care and Blood Disorders | Belleville | New Jersey | 07109 | — |
| Englewood Health | Englewood | New Jersey | 07631 | — |
| Summit Medical Group | Florham Park | New Jersey | 07932 | — |
| Novant Health Inc. - Charlotte | Charlotte | North Carolina | 28204 | — |
| Southeastern Medical Oncology Center | Goldsboro | North Carolina | 27534 | — |
| Novant Health Inc. - Winston-Salem | Winston-Salem | North Carolina | 27103 | — |
| Aultman Medical Group | Canton | Ohio | 44708 | — |
| TriHealth | Cincinnati | Ohio | 45220 | — |
| University Hospitals Seidman | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic - Taussig Cancer Center | Cleveland | Ohio | 44195 | — |
| OhioHealth | Columbus | Ohio | 43214 | — |
| The Toledo Clinic | Toledo | Ohio | 43623 | — |
| Oklahoma Cancer Specialists | Tulsa | Oklahoma | 74146 | — |
| Oregon Oncology Specialists | Salem | Oregon | 97301 | — |
| Gettysburg Cancer Center | Gettysburg | Pennsylvania | 17325 | — |
| Bon Secours - St. Francis Cancer Center | Greenville | South Carolina | 29607 | — |
| Avera Cancer Institute | Sioux Falls | South Dakota | 57105 | — |
| Sanford Health | Sioux Falls | South Dakota | 57117 | — |
| Baptist Cancer Center | Memphis | Tennessee | 38120 | — |
| Vanderbilt University | Nashville | Tennessee | 37232 | — |
| Texas Oncology - Austin Midtown | Austin | Texas | 78705 | — |
| Texas Oncology - Austin Central Pharmacy | Austin | Texas | 78731 | — |
| Texas Oncology - South Austin | Austin | Texas | 78745 | — |
| Mary Crowley Cancer Research | Dallas | Texas | 75230 | — |
| Texas Oncology - Baylor Charles A. Sammons Cancer Center | Dallas | Texas | 75246 | — |
| The University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Oncology Consultants | Houston | Texas | 77030 | — |
| Texas Oncology - Longview Cancer Center | Longview | Texas | 75601 | — |
| Texas Oncology - Palestine Cancer Center | Palestine | Texas | 75801 | — |
| Texas Oncology - Paris Cancer Center | Paris | Texas | 75460 | — |
| Lumi Research | Sugar Land | Texas | 77479 | — |
| Texas Oncology - Tyler Pharmacy | Tyler | Texas | 75702 | — |
| Community Cancer Trials of Utah | Ogden | Utah | 84405 | — |
| Utah Cancer Specialists | Salt Lake City | Utah | 84106 | — |
| Inova Schar Institute | Fairfax | Virginia | 22031 | — |
| Hematology Oncology Associates of Fredericksburg | Fredericksburg | Virginia | 22408 | — |
| Virginia Cancer Institute | Richmond | Virginia | 23229 | — |
| Virginia Cancer Institute | Richmond | Virginia | 23230 | — |
| PeaceHealth | Bellingham | Washington | 98225 | — |
| Northwest Medical Specialties | Tacoma | Washington | 98405 | — |
| ThedaCare | Appleton | Wisconsin | 54911 | — |
| SSM Health | Madison | Wisconsin | 53717 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05169437, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 29, 2025 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05169437 live on ClinicalTrials.gov.