A Research Study to See How Well New Weekly Medicine IcoSema, Which is a Combination of Insulin Icodec and Semaglutide, Controls Blood Sugar Levels in People With Type 2 Diabetes (T2D), Compared to Daily Insulin Glargine (COMBINE 4)
Public ClinicalTrials.gov record NCT06269107. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A 40-week Study Comparing the Efficacy and Safety of Once Weekly IcoSema and Daily Insulin Glargine 100 Units/mL in Participants With Type 2 Diabetes Inadequately Controlled on Oral Anti Diabetic Drugs COMBINE 4
Study identification
- NCT ID
- NCT06269107
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Novo Nordisk A/S
- Industry
- Enrollment
- 485 participants
Conditions and interventions
Conditions
Interventions
- IcoSema Drug
- Insulin glargine Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 14, 2024
- Primary completion
- May 26, 2025
- Completion
- Jul 7, 2025
- Last update posted
- Apr 8, 2026
2024 – 2025
United States locations
- U.S. sites
- 33
- U.S. states
- 15
- U.S. cities
- 30
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Scripps Whittier Diabetes Inst | La Jolla | California | 92037 | — |
| First Valley Med Grp Lancaster | Lancaster | California | 93534 | — |
| Clinical Trials Research_Sacramento | Lincoln | California | 95821 | — |
| Desert Oasis Hlthcr Med Group | Palm Springs | California | 91355 | — |
| Desert Oasis Hlthcr Med Group | Palm Springs | California | 92262 | — |
| Northeast Research Institute | Fleming Island | Florida | 32003 | — |
| Clinical Research of Cent FL | Winter Haven | Florida | 33880 | — |
| Atlanta Diabetes Associates | Atlanta | Georgia | 30318 | — |
| Endo Res Solutions Inc | Roswell | Georgia | 30076 | — |
| Elite Clinical Trials | Blackfoot | Idaho | 83221 | — |
| Cedar-Crosse Research Center | Chicago | Illinois | 60607 | — |
| Endeavor Health | Skokie | Illinois | 60077 | — |
| Cotton-O'Neil Diab & Endo Ctr | Topeka | Kansas | 66606 | — |
| Methodist Phys. Clinic | Omaha | Nebraska | 68114 | — |
| Albuquerque Clin Trials, Inc. | Albuquerque | New Mexico | 87102 | — |
| AMC Community Endocrinology | Albany | New York | 12203 | — |
| Southgate Medical Group, LLP | West Seneca | New York | 14224 | — |
| Physician's East Endocrinology | Greenville | North Carolina | 27834 | — |
| Diab & Endo Assoc of Stark Co | Canton | Ohio | 44718 | — |
| Advanced Medical Research | Maumee | Ohio | 43537 | — |
| New Venture Medical Research | Wadsworth | Ohio | 44281-9236 | — |
| Holston Medical Group | Kingsport | Tennessee | 37660 | — |
| Amarillo Med Spec LLP | Amarillo | Texas | 79106 | — |
| Velocity Clinical Research- Cedar Park | Austin | Texas | 78759 | — |
| Velocity Clinical Res-Dallas | Dallas | Texas | 75230 | — |
| North Texas Endocrine Center | Dallas | Texas | 75231 | — |
| Diabetes and Thyroid Ctr of FW | Fort Worth | Texas | 76132 | — |
| Fmc Science, Llc | Lampasas | Texas | 76550 | — |
| Quality Research Inc | San Antonio | Texas | 78209 | — |
| Flourish Research | San Antonio | Texas | 78229 | — |
| Consano Clinical Research, LLC | Shavano Park | Texas | 78231 | — |
| Wade Family Medicine | Bountiful | Utah | 84010 | — |
| TPMG Clinical Research | Newport News | Virginia | 23606 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 67 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06269107, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 8, 2026 · Synced May 20, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06269107 live on ClinicalTrials.gov.