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Type 2 Diabetes clinical trials

Directory of U.S. ClinicalTrials.gov public records for Type 2 Diabetes. Browse Type 2 Diabetes recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

ClinicalTrials.gov public records Last synced May 21, 2026, 2:23 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official matching trials
310
Shown on this page
12
Local recruiting
55
Local phase groups
6
The trial list below is retrieved from the live ClinicalTrials.gov search API for Type 2 Diabetes. Results on this page are currently sorted by Recently updated.

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Showing 1–12 of 310 matching trials for Type 2 Diabetes.
Indexed local directory records.

Phase distribution

Not applicable 131
Phase 3 49
Phase 4 46
Phase 2 31
Phase 1 18
Early Phase 1 1

Top locations

Dallas, Texas 59 San Antonio, Texas 50 Miami, Florida 46 Houston, Texas 42 Los Angeles, California 32 Las Vegas, Nevada 32

Top sponsors

Eli Lilly and Company 30 AstraZeneca 11 The University of Texas Health Science Center at San Antonio 10 University of Colorado, Denver 10 Emory University 9 AdventHealth Translational Research Institute 8

Top therapies

Semaglutide 15 Dulaglutide 12 Tirzepatide 12 Metformin 10 Orforglipron 8 Sitagliptin 8

Indexed official records

Open in full search
Recruiting Not applicable Interventional

The GRoceries Aimed at Increasing Nutrition Study

NCT07167004
View directory record Official record
Conditions
Pre-diabetes, Pre-diabetic, Pre-diabetic State, Type 2 Diabetes, Type 2 Diabetes (T2DM), Type 2 Diabetes Mellitus, Type 2 Diabetes Mellitus (T2DM), Type II Diabetes, Type II Diabetes Mellitus
Interventions
Marketing Nudges + Dynamically Adapted Financial Incentives, Marketing Nudges Only
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
45 Years to 70 Years
Enrollment
216 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced May 20, 2026, 1:31 PM EDT
Recruiting No phase listed Observational

Fitbit and AI Chatbot in Sedentary Primary Care Patients With T2D

NCT07005362
View directory record Official record
Conditions
Artificial Intelegence, Remote Patient Monitoring, T2D, T2DM, T2DM (Type 2 Diabetes Mellitus), Type 2 Diabetes, Type 2 Diabetes Mellitus (T2DM)
Interventions
Fitbit and AI Chatbot, Routine Care
Behavioral · Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 80 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced May 19, 2026, 2:07 PM EDT
Recruiting Phase 3 Interventional

A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D)

NCT07400653
View directory record Official record
Conditions
Diabetes, Type 2, Obesity, Overweight, Overweight and/or Obesity, Type 2 Diabetes
Interventions
PF-08653944, Placebo
Drug · Other
Lead sponsor
Pfizer
Industry
Eligibility
18 Years and older
Enrollment
999 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
35
States / cities
Anaheim, California • Canoga Park, California • Cerritos, California + 30 more
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced May 20, 2026, 1:19 PM EDT
Recruiting Phase 2 Interventional

Phase 2 Trial of Icovamenib in Participants With Type 2 Diabetes Mellitus Who Are Not Achieving Glycemic Targets While Using GLP-1-Based Therapy

NCT07502508
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
Placebo, icovamenib 100 mg
Drug
Lead sponsor
Biomea Fusion Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
16
States / cities
Birmingham, Alabama • Canoga Park, California • Long Beach, California + 13 more
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced May 20, 2026, 12:28 AM EDT
Recruiting Phase 2 Interventional

Phase 2 Trial of Icovamenib in Participants With Type 2 Diabetes Who Are Not Achieving Glycemic Targets

NCT07502495
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
Placebo, icovamenib 100mg
Drug
Lead sponsor
Biomea Fusion Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
16
States / cities
Birmingham, Alabama • Canoga Park, California • Long Beach, California + 13 more
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced May 13, 2026, 11:12 AM EDT
Recruiting Phase 2 Interventional

Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D)

NCT07296484
View directory record Official record
Conditions
Cortisol Excess, Type 2 Diabetes
Interventions
Placebo, clofutriben
Drug
Lead sponsor
Sparrow Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
1,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
52
States / cities
Chandler, Arizona • Tucson, Arizona • Fountain Valley, California + 45 more
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced May 20, 2026, 10:10 AM EDT
Recruiting Phase 1 Interventional

SGLT2i, Pioglitazone, and Ketone Production in T2D

NCT07053319
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
Empagliflozin 25 MG plus Pioglitazone placebo, Empagliflozin 25 mg/d plus Pioglitazone (15/30 mg/d), Pioglitazone 15 mg increased to 30 mg after 2 weeks plus Empagliflozin Placebo, Pioglitazone placebo + Empagliflozin placebo
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
30 Years to 75 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced May 19, 2026, 6:32 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

A Study of LY4086940 in Healthy Participants and Participants With Overweight or Obesity, With or Without Type 2 Diabetes

NCT06945419
View directory record Official record
Conditions
Healthy, Obesity, Overweight, Type 2 Diabetes
Interventions
LY4086940, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years to 65 Years
Enrollment
216 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
4
States / cities
Daytona Beach, Florida • Miami, Florida • Dallas, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced May 20, 2026, 2:38 AM EDT
Recruiting Phase 3 Interventional

A Study of Dulaglutide (LY2189265) 3.0 mg and 4.5 mg in Pediatric Participants With Type 2 Diabetes Mellitus (AWARD-PEDS PLUS)

NCT06739122
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
Dulaglutide
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
10 Years to 17 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
41
States / cities
Tucson, Arizona • Little Rock, Arkansas • Los Angeles, California + 34 more
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced May 18, 2026, 5:17 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Youth-Onset Type 2 Diabetes and Heart Disease: The Young at Heart Prospective Cohort Study

NCT06730113
View directory record Official record
Conditions
Obesity, Type 2 Diabetes
Interventions
Not listed
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
12 Years to 25 Years
Enrollment
930 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2033
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced May 20, 2026, 2:38 AM EDT
Recruiting Not applicable Interventional

LINK-IT: Leveraging vIdeos and commuNity Health worKers to Improve Diabetes OuTcomes

NCT06319716
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
Community Health Worker (CHW) Support, Video-Based Diabetes Self-Management Education and Support (DSMES)
Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
540 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced May 20, 2026, 1:10 AM EDT
Recruiting Phase 1 Interventional

A Phase 1, Multiple Ascending Dose Study to Evaluate HMS1005 in Participants With Type 2 Diabetes

NCT07568678
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
HMS1005, Matching placebo
Drug
Lead sponsor
Hua Medicine Limited
Industry
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced May 20, 2026, 1:10 AM EDT

About this Type 2 Diabetes clinical trials directory page

What this page lists
U.S. ClinicalTrials.gov public records that list Type 2 Diabetes as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results
Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Type 2 Diabetes.
Where the data comes from
Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Related: all condition pages, browse by drug or therapy, browse by U.S. city, browse by sponsor, or open the full search for Type 2 Diabetes.