AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis

ClinicalTrials.gov ID: NCT06665165

Public ClinicalTrials.gov record NCT06665165. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 4:30 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Phase 1, Randomized, Double-blind, Placebo-controlled, Multiple Ascending Dose Study to Evaluate Safety, Tolerability, PK and PD of Antisense Oligonucleotide AMX0114 Administered to Adult Participants With Amyotrophic Lateral Sclerosis

Study identification

NCT ID: NCT06665165
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1
Lead sponsor: Amylyx Pharmaceuticals Inc.; Industry
Enrollment: 48 participants

Conditions and interventions

Conditions

Interventions

AMX0114 Drug
Placebo Other

Drug · Other

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Apr 6, 2025
Primary completion: Jan 31, 2027
Completion: Sep 30, 2027
Last update posted: Apr 13, 2026

2025 – 2027

United States locations

U.S. sites: 10
U.S. states: 8
U.S. cities: 10

Facility	City	State	ZIP	Site status
University of California, San Diego	La Jolla	California	92093	Recruiting
Georgetown University Hospital Pasquerilla Healthcare Center	Washington D.C.	District of Columbia	20007	Recruiting
University of Florida	Gainesville	Florida	32611	Recruiting
Mayo Clinic in Florida	Jacksonville	Florida	32224	Recruiting
Orlando Regional Medical Center, Orlando Health Neuroscience Institute	Orlando	Florida	32806	Recruiting
Massachusetts General Hospital, Healey & AMG Center for ALS	Boston	Massachusetts	02114	Recruiting
Mayo Clinic in Rochester	Rochester	Minnesota	55905	Recruiting
Temple University of the Commonwealth System of Higher Education	Philadelphia	Pennsylvania	19140	Recruiting
Alliance for Multispecialty Research, LLC	Knoxville	Tennessee	37909	Recruiting
Houston Methodist Neurological Institute	Houston	Texas	77030	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06665165, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 13, 2026 · Synced May 8, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06665165 live on ClinicalTrials.gov.

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